CN108524839A - Trigone is fresh to carry spray-dried powders medicine materical crude slice - Google Patents

Trigone is fresh to carry spray-dried powders medicine materical crude slice Download PDF

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Publication number
CN108524839A
CN108524839A CN201810733335.2A CN201810733335A CN108524839A CN 108524839 A CN108524839 A CN 108524839A CN 201810733335 A CN201810733335 A CN 201810733335A CN 108524839 A CN108524839 A CN 108524839A
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CN
China
Prior art keywords
trigone
fresh
medicine materical
materical crude
crude slice
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CN201810733335.2A
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Chinese (zh)
Inventor
徐漫
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Individual
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Individual
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Priority to CN201810733335.2A priority Critical patent/CN108524839A/en
Publication of CN108524839A publication Critical patent/CN108524839A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/902Sparganiaceae (Bur-reed family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/13Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of " trigone is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that:Trigone medicinal material harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.

Description

Trigone is fresh to carry spray-dried powders medicine materical crude slice
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of trigone medicine materical crude slice.
Background technology
Sparganium stoloniferum is Sparganiaceae plant rhizoma scirpiSparganium stoloniferumBuch.-Ham. drying Stem tuber has the effect of blood-breaking, Xiao Ji Zhi Tong.This product Zhu Yong Yu abdominal mass and lump, dysmenorrhoea, blood stasis closed, chest impediment and cardialgia, The treatment of dyspepsia distending pain is a herb common on tcm clinical practice.The processing method of traditional trigone is:After medicinal material is excavated, It cleans, prunes crust, dry, be packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Such medicine materical crude slice body Product is big, and Hygienic Standard is poor, is easy to make moist, mildew, is unfavorable for taking care of, storage and transportation cost are high.In addition, such medicine materical crude slice matter Amount stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, develop a kind of stable quality it is reliable, Storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action novel trigone medicine materical crude slice, it is imperative.City at present Trigone medicine materical crude slice, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both with Traditional medicine materical crude slice is raw material, and quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes;It is dense Contracting particle can only extract water-soluble components.
Invention content
The invention discloses a kind of " trigone is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that:In trigone medicinal material After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~ The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.02 ~ 1.10 concentrate.The concentrate of gained is spray-dried, control dried object water content is to be crushed within 10%, crosses 60 Mesh sieves, and is vacuum-packed to get finished product.The clinical general usage amount of this powder decoction pieces is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, Can directly it enter in pill, powder, capsule and tablet, to substantially increase the convenience and compliance of Clinical practice, favorably In the treatment of clinical acute disease.
The present invention solve traditional trigone medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular Piece is more preferable.
Specific embodiment
It after trigone medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will The concentrate of gained is spray-dried, until water content is 10%, is crushed, and is crossed 60 mesh sieve, is vacuum-packed to get finished product.

Claims (2)

1. a kind of trigone is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that:After the harvesting of trigone medicinal material, clean in time, Impurity and the dis-medicinal part such as silt are removed, in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness, addition 1 ~ The water of 5 times of 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 are added in the gained dregs of a decoction The water of ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, and are concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;Gained concentrate is spray-dried, It is to be crushed within 10% to control dried object water content, crosses 60 mesh sieve, is vacuum-packed to get finished product.
2. trigone according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that:Clinic generally uses Amount is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
CN201810733335.2A 2018-07-06 2018-07-06 Trigone is fresh to carry spray-dried powders medicine materical crude slice Withdrawn CN108524839A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810733335.2A CN108524839A (en) 2018-07-06 2018-07-06 Trigone is fresh to carry spray-dried powders medicine materical crude slice

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810733335.2A CN108524839A (en) 2018-07-06 2018-07-06 Trigone is fresh to carry spray-dried powders medicine materical crude slice

Publications (1)

Publication Number Publication Date
CN108524839A true CN108524839A (en) 2018-09-14

Family

ID=63487637

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810733335.2A Withdrawn CN108524839A (en) 2018-07-06 2018-07-06 Trigone is fresh to carry spray-dried powders medicine materical crude slice

Country Status (1)

Country Link
CN (1) CN108524839A (en)

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Application publication date: 20180914