CN108619266A

CN108619266A - The coptis is fresh to carry spray-dried granules medicine materical crude slice

Info

Publication number: CN108619266A
Application number: CN201810733285.8A
Authority: CN
Inventors: 徐自升
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-07-06
Filing date: 2018-07-06
Publication date: 2018-10-09

Abstract

The invention discloses a kind of " coptis is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：The coptis harvest after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.

Description

The coptis is fresh to carry spray-dried granules medicine materical crude slice

Technical field

The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of coptis medicine materical crude slice.

Background technology

Chinese Drug Rhizomes of Coptis is the dry rhizome of the ranunculaceae plant coptis, the triangle leaf coptis or cloud even, has heat-clearing and damp-drying drug, rushes down The effect of fire removing toxic substances.This product is mainly used for damp and hot feeling of fullness, vomits acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, it is vexed not It sleeps, palpitation and uneasiness, blood-head tells nosebleed, hot eyes, toothache, the treatment quenched one's thirst etc., is common a herb on tcm clinical practice.It is traditional yellow Even processing method be：Autumn excavates, and removes fibrous root and silt, dry, hits residual fibrous root, is packaged, storage and transportation.To medicine materical crude slice factory Afterwards, it then washs, soften, be sliced, dry, pack.Such medicine materical crude slice volume is big, and Hygienic Standard is poor, is not easy to take care of, and stores and transports It is defeated of high cost.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow. Therefore, develop a kind of stable quality is reliable, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action new Type coptis medicine materical crude slice, it is imperative.Existing market coptis medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentration Grain two kinds of forms of medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultra micro is drunk Piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular can only extract water-soluble components.

Invention content

The invention discloses a kind of " coptis is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：It is harvested in the coptis Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains jamaicin not Less than 6.5%, coptisine is no less than 2.5%.Coptis granule pieces stable quality, good fluidity, clinical general usage amount is 1 ~ 5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, make to substantially increase clinic Convenience and compliance are conducive to the treatment of clinical acute disease.

The present invention solve traditional coptis medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular Piece is more preferable.

Specific embodiment

It after Rhizoma Coptidis is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80 It is 10% DEG C to be dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice Berberine content is 7.0%, yellow Even alkali content is 3.0%.

Claims

1. a kind of coptis is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：It after the coptis harvests, cleans, removes in time The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 ~ 10 are added in the gained dregs of a decoction The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, crosses 60 ~ 100 Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；It is standby that gained concentrate leaves and takes 1% ~ 3% With remaining spray drying；By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10% Grain is vacuum-packed to get finished product；Finished product medicine materical crude slice is no less than 6.5% containing jamaicin, and coptisine is no less than 2.5%.

2. the coptis according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：Clinic generally uses Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.