CN108567865A - Blackberry lily is fresh to carry spray-dried granules medicine materical crude slice - Google Patents

Blackberry lily is fresh to carry spray-dried granules medicine materical crude slice Download PDF

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Publication number
CN108567865A
CN108567865A CN201810733296.6A CN201810733296A CN108567865A CN 108567865 A CN108567865 A CN 108567865A CN 201810733296 A CN201810733296 A CN 201810733296A CN 108567865 A CN108567865 A CN 108567865A
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China
Prior art keywords
materical crude
medicine materical
crude slice
fresh
blackberry lily
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Withdrawn
Application number
CN201810733296.6A
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Chinese (zh)
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徐自升
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Individual
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Individual
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Priority to CN201810733296.6A priority Critical patent/CN108567865A/en
Publication of CN108567865A publication Critical patent/CN108567865A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/13Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of " blackberry lily is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:Blackberry lily harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%, and finished product medicine materical crude slice contains irisflorentin(C20H18O8)0.20% must not be less than.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.

Description

Blackberry lily is fresh to carry spray-dried granules medicine materical crude slice
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of blackberry lily medicine materical crude slice.
Background technology
Chinese medicine blackberry lily is irides blackberry lilyBelamcanda chinensis (L.)DC. dry rhizome has clear The effect of thermal detoxification, dissolving phlegm, relieving sore-throat.It can be used for heat toxin convulsive seizure due to phlegm-fire pent-up, abscess of throat, accumulation and obstruction of sputum, the diseases such as cough and asthma control It treats, is a herb common on tcm clinical practice.The processing method of traditional blackberry lily is:After medicinal material is excavated, fibrous root is removed, is washed Only, dry, or fresh slices are taken advantage of, it is dry, it is packaged, storage and transportation.Thus obtained blackberry lily medicine materical crude slice volume is big, and hygiene condition is poor, unfavorable In keeping, storage and transportation cost are high.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes Inconvenience works slow.Therefore, develop a kind of stable quality is reliable, storage/transportation is at low cost, be conducive to keeping, carry and user Just, rapid-action novel blackberry lily medicine materical crude slice, it is imperative.Existing market blackberry lily medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder Two kinds of forms of medicine materical crude slice and concentrated granular medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, quality is decided by traditional medicine materical crude slice Quality, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes;Concentrated granular can only extract water-soluble components.
Invention content
The invention discloses a kind of " blackberry lily is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:It is harvested in blackberry lily Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains time wild flag Flavine(C20H18O8)No less than 0.20%.Blackberry lily granule pieces stable quality, good fluidity, clinical general usage amount is 1 ~ 5g.This Class medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, to substantially increase Clinical practice just Victory and compliance are conducive to the treatment of clinical acute disease.
The present invention solve traditional blackberry lily medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular Piece is more preferable.
Specific embodiment
It after blackberry lily medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80 DEG C vacuum drying content be 0.25%.

Claims (2)

1. a kind of blackberry lily is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:It after blackberry lily harvesting, cleans, removes in time The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 ~ 10 are added in the gained dregs of a decoction The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, crosses 60 ~ 100 Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;It is standby that gained concentrate leaves and takes 1% ~ 3% With remaining spray drying;By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10% Grain is vacuum-packed to get finished product;Finished product medicine materical crude slice contains irisflorentin(C20H18O8)0.20%1 must not be less than.
2. blackberry lily according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:Clinic generally uses Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
CN201810733296.6A 2018-07-06 2018-07-06 Blackberry lily is fresh to carry spray-dried granules medicine materical crude slice Withdrawn CN108567865A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810733296.6A CN108567865A (en) 2018-07-06 2018-07-06 Blackberry lily is fresh to carry spray-dried granules medicine materical crude slice

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810733296.6A CN108567865A (en) 2018-07-06 2018-07-06 Blackberry lily is fresh to carry spray-dried granules medicine materical crude slice

Publications (1)

Publication Number Publication Date
CN108567865A true CN108567865A (en) 2018-09-25

Family

ID=63573692

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810733296.6A Withdrawn CN108567865A (en) 2018-07-06 2018-07-06 Blackberry lily is fresh to carry spray-dried granules medicine materical crude slice

Country Status (1)

Country Link
CN (1) CN108567865A (en)

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PB01 Publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20180925

WW01 Invention patent application withdrawn after publication