CN108653362A - Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
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- CN108653362A CN108653362A CN201810733176.6A CN201810733176A CN108653362A CN 108653362 A CN108653362 A CN 108653362A CN 201810733176 A CN201810733176 A CN 201810733176A CN 108653362 A CN108653362 A CN 108653362A
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- CN
- China
- Prior art keywords
- rhizoma atractylodis
- atractylodis macrocephalae
- fresh
- materical crude
- medicine materical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 17
- 239000008187 granular material Substances 0.000 title claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000012141 concentrate Substances 0.000 claims abstract description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000005469 granulation Methods 0.000 claims abstract description 3
- 230000003179 granulation Effects 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract 2
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 235000020985 whole grains Nutrition 0.000 abstract description 3
- 238000009461 vacuum packaging Methods 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 description 4
- 239000000463 material Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 240000004460 Tanacetum coccineum Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：Rhizoma Atractylodis Macrocephalae harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of atractylodes slice.
Background technology
Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae, has strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, the work(of tocolysis
Effect.It is usually used in spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, the treatment of fetal irritability etc. is normal on tcm clinical practice
A herb.The processing method of traditional Rhizoma Atractylodis Macrocephalae is：It after medicinal material is excavated, directly dries or dries, then remove fibrous root, store up
Fortune.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Thus obtained atractylodes slice volume is big, Hygienic Standard
Difference is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.In addition, such prepared slice quality stability
Difference, clinical efficacy be difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage/transportation
It is at low cost, conducive to keeping, carry and easy to use, rapid-action novel atractylodes slice, it is imperative.Existing market Rhizoma Atractylodis Macrocephalae is drunk
Piece, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both with traditional medicine materical crude slice
For raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular is only
Water-soluble components can be extracted.
Invention content
The invention discloses a kind of " Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：It is harvested in Rhizoma Atractylodis Macrocephalae
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare
Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Rhizoma Atractylodis Macrocephalae granule pieces quality is steady
Fixed, good fluidity, clinical general usage amount is 1 ~ 5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter capsule
And in tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.
The present invention solve traditional atractylodes slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Rhizoma Atractylodis Macrocephalae is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80
It is 10% DEG C to be dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.
Claims (2)
1. a kind of Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：It after Rhizoma Atractylodis Macrocephalae harvesting, cleans, removes in time
The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness
The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 ~ 10 are added in the gained dregs of a decoction
The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, crosses 60 ~ 100
Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；It is standby that gained concentrate leaves and takes 1% ~ 3%
With remaining spray drying；By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10%
Grain is vacuum-packed to get finished product.
2. Rhizoma Atractylodis Macrocephalae according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733176.6A CN108653362A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733176.6A CN108653362A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108653362A true CN108653362A (en) | 2018-10-16 |
Family
ID=63773565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733176.6A Withdrawn CN108653362A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Atractylodis Macrocephalae is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108653362A (en) |
-
2018
- 2018-07-06 CN CN201810733176.6A patent/CN108653362A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181016 |