CN108567808A - Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
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- CN108567808A CN108567808A CN201810733167.7A CN201810733167A CN108567808A CN 108567808 A CN108567808 A CN 108567808A CN 201810733167 A CN201810733167 A CN 201810733167A CN 108567808 A CN108567808 A CN 108567808A
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- Prior art keywords
- radix codonopsis
- fresh
- materical crude
- medicine materical
- crude slice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of " Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：Radix Codonopsis harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 12%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical field, the manufacture field for especially belonging to Radix Codonopsis medicine materical crude slice is fallen.
Background technology
Chinese medicine Radix Codonopsis is Campanulaceae Radix Codonopsis, codonopsis pilosula var. modesta or the dry root of radix codonpsis tangshen.Radix Codonopsis has strengthening spleen and tonifying lung, supports
The effect of blood promotes the production of body fluid.It is usually used in spleen-lung Qi deficiency, eat less and tired, false asthma cough, the treatment of insufficiency of vital energy and blood etc., in being common simply
Medicine.The processing method of traditional Radix Codonopsis is：It after medicinal material is excavated, directly dries/dries, bundle and package, storage and transportation.To after medicine materical crude slice factory,
It washs, soften, be sliced, dry, pack again.Thus obtained Radix Codonopsis medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to make moist, grow
It is mould, infested, it is unfavorable for taking care of, storage and transportation cost are high.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to
It ensures, patient takes inconvenience, works slow.Therefore, develop a kind of stable quality is reliable, storage/transportation is at low cost, be conducive to protect
Pipe, carrying and easy to use, rapid-action novel Radix Codonopsis medicine materical crude slice, it is imperative.Existing market Radix Codonopsis medicine materical crude slice, in addition to traditional medicine materical crude slice
Except, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, quality is determined
Due to the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular can only extract water solubility
Composition.
Invention content
The invention discloses a kind of " Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：It is harvested in Radix Codonopsis
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare
Concentrate mixing granulation, dry to be less than 12% to water content, whole grain is vacuum-packed to get finished product.Radix Codonopsis granule pieces quality is steady
Fixed, good fluidity, clinical general usage amount is 1 ~ 5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter capsule
And in tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.
The present invention solve traditional Radix Codonopsis medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after codonopsis pilosula is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80
It is 10% DEG C to be dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.
Claims (2)
1. a kind of Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：It after Radix Codonopsis harvesting, cleans, removes in time
The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness
The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 ~ 10 are added in the gained dregs of a decoction
The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, crosses 60 ~ 100
Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；It is standby that gained concentrate leaves and takes 1% ~ 3%
With remaining spray drying；By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 12%
Grain is vacuum-packed to get finished product.
2. Radix Codonopsis according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733167.7A CN108567808A (en) | 2018-07-06 | 2018-07-06 | Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733167.7A CN108567808A (en) | 2018-07-06 | 2018-07-06 | Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108567808A true CN108567808A (en) | 2018-09-25 |
Family
ID=63573661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733167.7A Pending CN108567808A (en) | 2018-07-06 | 2018-07-06 | Radix Codonopsis is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108567808A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150164971A1 (en) * | 2012-07-03 | 2015-06-18 | Eu Yan Sang International Ltd | Seven-star tea without excipient and method of preparing the same |
| CN106109530A (en) * | 2016-07-23 | 2016-11-16 | 徐漫 | A kind of Folium Isatidis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN107281236A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107281247A (en) * | 2017-08-25 | 2017-10-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eclipta |
| CN107320508A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Chinese trumpet creeper |
| CN107468751A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Longtube Ground Ivy Herb |
-
2018
- 2018-07-06 CN CN201810733167.7A patent/CN108567808A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150164971A1 (en) * | 2012-07-03 | 2015-06-18 | Eu Yan Sang International Ltd | Seven-star tea without excipient and method of preparing the same |
| CN106109530A (en) * | 2016-07-23 | 2016-11-16 | 徐漫 | A kind of Folium Isatidis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN107281236A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107281247A (en) * | 2017-08-25 | 2017-10-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eclipta |
| CN107320508A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Chinese trumpet creeper |
| CN107468751A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Longtube Ground Ivy Herb |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180925 |
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| WD01 | Invention patent application deemed withdrawn after publication |