CN108619190A - Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
- Publication number
- CN108619190A CN108619190A CN201810733281.XA CN201810733281A CN108619190A CN 108619190 A CN108619190 A CN 108619190A CN 201810733281 A CN201810733281 A CN 201810733281A CN 108619190 A CN108619190 A CN 108619190A
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- China
- Prior art keywords
- rhizoma
- materical crude
- medicine materical
- crude slice
- radix notopterygii
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 25
- 239000008187 granular material Substances 0.000 title claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000012141 concentrate Substances 0.000 claims abstract description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000005469 granulation Methods 0.000 claims abstract description 3
- 230000003179 granulation Effects 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract 2
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- OWTSKJPRWFIYHU-SFHVURJKSA-N (2s)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C(=C3O2)CC=C(C)C)OC)=CC=C(O)C=C1 OWTSKJPRWFIYHU-SFHVURJKSA-N 0.000 claims description 3
- BKIACVAZUKISOR-MKMNVTDBSA-N Notopterol Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC/C=C(C)/CC(O)C=C(C)C BKIACVAZUKISOR-MKMNVTDBSA-N 0.000 claims description 3
- BKIACVAZUKISOR-UHFFFAOYSA-N Notopterol Natural products O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)CC(O)C=C(C)C BKIACVAZUKISOR-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 235000020985 whole grains Nutrition 0.000 abstract description 3
- 238000009461 vacuum packaging Methods 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- YQBNJPACAUPNLV-UHFFFAOYSA-N peucedanin Chemical compound O1C(=O)C=CC2=C1C=C1OC(C(C)C)=C(OC)C1=C2 YQBNJPACAUPNLV-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000008713 qiang-huo Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of " Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：Rhizoma Et Radix Notopterygii harvest after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Rhizoma Et Radix Notopterygii medicine materical crude slice.
Background technology
Chinese Medicine " qianghuo " is samphire Rhizoma Et Radix NotopterygiiNotopterygium inchumTing ex H, T- Chang or width
Leaf Rhizoma Et Radix NotopterygiiNotopterygium franchetii H. the dry rhizome and root of de Boiss. has relieving exterior syndrome and dispelling cold, wind-dispelling
The effect of dehumidifying, analgesic.This product is mainly used for anemofrigid cold, and have a headache Xiang Qiang, arthralgia pain due to rheumatism, the treatment of aching pain in shoulder and back etc., in being
Cure clinically common a herb.The processing method of traditional Rhizoma Et Radix Notopterygii is：Spring, the excavation of two season of autumn, remove fibrous root and silt, shine
It is dry, it is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.The medicine materical crude slice volume so processed is big, health
Standard deviation is learned, is easy to make moist, mildew, is unfavorable for taking care of, storage and transportation cost are high.In addition, such prepared slice quality stability
Difference, clinical efficacy be difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage/transportation
It is at low cost, conducive to keeping, carry and easy to use, rapid-action novel Rhizoma Et Radix Notopterygii medicine materical crude slice, it is imperative.Existing market Rhizoma Et Radix Notopterygii drinks
Piece, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both with traditional medicine materical crude slice
For raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular is only
Water-soluble components can be extracted.
Invention content
The invention discloses a kind of " Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：It is harvested in Rhizoma Et Radix Notopterygii
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare
Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains Notopterol
（C21H22O5）And Isomperatorin（C16H14O4）Total amount be no less than 0.60%.Rhizoma Et Radix Notopterygii granule pieces stable quality, good fluidity,
Clinical general usage amount is 1 ~ 5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, from
And the convenience and compliance of Clinical practice are substantially increased, be conducive to the treatment of clinical acute disease.
The present invention solve traditional Rhizoma Et Radix Notopterygii medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Rhizoma Et Radix Notopterygii medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80
It is 10% DEG C to be dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains Notopterol（C21H22O5）With different Europe
Peucedanin（C16H14O4）Total amount be no less than 0.60%.
Claims (2)
1. a kind of Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：It after Rhizoma Et Radix Notopterygii harvests, cleans, removes in time
The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness
The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 ~ 10 are added in the gained dregs of a decoction
The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, crosses 60 ~ 100
Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；It is standby that gained concentrate leaves and takes 1% ~ 3%
With remaining spray drying；By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10%
Grain is vacuum-packed to get finished product；Finished product medicine materical crude slice contains Notopterol（C21H22O5）And Isomperatorin（C16H14O4）Total amount it is many
In 0.60%.
2. Rhizoma Et Radix Notopterygii according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733281.XA CN108619190A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733281.XA CN108619190A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108619190A true CN108619190A (en) | 2018-10-09 |
Family
ID=63689541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733281.XA Withdrawn CN108619190A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108619190A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114984073A (en) * | 2022-07-20 | 2022-09-02 | 江阴天江药业有限公司 | Preparation method of notopterygium root formula granules |
-
2018
- 2018-07-06 CN CN201810733281.XA patent/CN108619190A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114984073A (en) * | 2022-07-20 | 2022-09-02 | 江阴天江药业有限公司 | Preparation method of notopterygium root formula granules |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181009 |
|
| WW01 | Invention patent application withdrawn after publication |