CN108524578A

CN108524578A - Radix Isatidis is fresh to carry spray-dried granules medicine materical crude slice

Info

Publication number: CN108524578A
Application number: CN201810732925.3A
Authority: CN
Inventors: 徐自升
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-07-06
Filing date: 2018-07-06
Publication date: 2018-09-14

Abstract

The invention discloses a kind of " Radix Isatidis is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：Radix Isatidis harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.

Description

Radix Isatidis is fresh to carry spray-dried granules medicine materical crude slice

Technical field

The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Radix Isatidis medicine materical crude slice.

Background technology

Radix Isatidis is cruciferae isatisIsatis indigotica Fort. dry root has heat-clearing The effect of removing toxic substances, cool blood relieving sore-throat.This product is mainly used for poison when warm epidemic disease, pharyngalgia of generating heat, febrile virulent maculae, mumps, scarlet fever, major part Pestilence, erysipelas, the treatment of carbuncle swells etc. are a herbs common on tcm clinical practice.The processing method of traditional Radix Isatidis is：Autumn Excavation removes silt, dries, and is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.It is thus obtained Radix Isatidis medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high. In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, it develops A kind of stable quality is reliable, storage/transportation is at low cost, conducive to keeping, carrying and easy to use, rapid-action novel Radix Isatidis drink Piece, it is imperative.Existing market Radix Isatidis medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice Two kinds of forms, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot Solve the problems, such as that medicinal material pollutes；Concentrated granular can only extract water-soluble components.

Invention content

The invention discloses a kind of " Radix Isatidis is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：In Radix Isatidis After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~ The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice is accused containing (R, S)- It must not be less than 0.040% according to the spring.Banlangen granules, banlangen keli prepared slice quality is stablized, good fluidity, and clinical general usage amount is 1 ~ 5g.It is such Medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, to substantially increase the convenient of Clinical practice Property and compliance, are conducive to the treatment of clinical acute disease.

The present invention solve traditional Radix Isatidis medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, The shortcomings such as the poor, unstable quality of hygiene condition, due to being to take advantage of fresh extraction, quality is than ultramicro grinding medicine materical crude slice and concentrated granular Medicine materical crude slice is more preferable.

Specific embodiment

It after chromatogram of Radix Isatidis is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours certainly Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density. The concentrate of gained is left and taken into 3% spare, remaining spray drying.Spray powder is collected, pelleting is mixed with spare concentrate, It is 10% that 80 DEG C, which are dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice must not lack containing (R, S)-announcement according to the spring In 0.040%.

Claims

1. a kind of Radix Isatidis is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：After Radix Isatidis harvesting, clean in time, Impurity and the dis-medicinal part such as silt are removed, in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness, addition 1 ~ The water of 5 times of 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 are added in the gained dregs of a decoction The water of ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, and are concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；Gained concentrate leaves and takes 1% ~ 3% It is spare, remaining spray drying；By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10% Grain is vacuum-packed to get finished product；Finished product medicine materical crude slice is accused containing (R, S)-must not be less than 0.040% according to the spring.

2. Radix Isatidis according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：Clinic generally makes Dosage is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.