CN108771699A

CN108771699A - Radix Isatidis is fresh to carry spray-dried powders medicine materical crude slice

Info

Publication number: CN108771699A
Application number: CN201810733318.9A
Authority: CN
Inventors: 徐漫
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-07-06
Filing date: 2018-07-06
Publication date: 2018-11-09

Abstract

The invention discloses a kind of " Radix Isatidis is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：Chromatogram of Radix Isatidis harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.

Description

Radix Isatidis is fresh to carry spray-dried powders medicine materical crude slice

Technical field

The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Radix Isatidis medicine materical crude slice.

Background technology

Radix Isatidis is cruciferae isatisIsatis indigotica Fort. dry root has heat-clearing The effect of removing toxic substances, cool blood relieving sore-throat.This product is mainly used for poison when warm epidemic disease, pharyngalgia of generating heat, febrile virulent maculae, mumps, scarlet fever, major part Pestilence, erysipelas, the treatment of carbuncle swells etc. are a herbs common on tcm clinical practice.The processing method of traditional Radix Isatidis is：Autumn Excavation removes silt, dries, and is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Such medicine materical crude slice body Product is big, and hygiene condition is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.In addition, such Prepared slice quality stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, a kind of stable quality is developed Reliably, storage/transportation it is at low cost, conducive to keeping, carry and easy to use, rapid-action novel Radix Isatidis medicine materical crude slice, it is imperative. Existing market Radix Isatidis medicine materical crude slice, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but two Person is using traditional medicine materical crude slice as raw material, and quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve medicinal material pollution The problem of；Concentrated granular can only extract water soluble ingredient.

Invention content

The invention discloses a kind of " Radix Isatidis is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：In Radix Isatidis It after medicinal material harvesting, cleans in time, removal impurity and the dis-medicinal part such as silt, cleans and cut in taking advantage of using fresh herb tap water in 24 hours At the piece of 2 ~ 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, Filtering, dregs pressing take juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction It squeezes the juice again, collects concoction.Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, is concentrated into opposite The concentrate that density is 1.02 ~ 1.10.The concentrate of gained is spray-dried, control dried object water content is powder within 10% It is broken, 60 mesh sieve is crossed, is vacuum-packed to get finished product.Finished product medicine materical crude slice is accused containing (R, S)-must not be less than 0.040% according to the spring.This powder is drunk The clinical general usage amount of piece is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, powder, capsule and tablet In, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.

The present invention solve traditional Radix Isatidis medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, The shortcomings such as the poor, unstable quality of hygiene condition, due to being to take advantage of fresh extraction, quality is than ultramicro grinding medicine materical crude slice and concentrated granular Medicine materical crude slice is more preferable.

Specific embodiment

It after chromatogram of Radix Isatidis is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours certainly Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density. The concentrate of gained is spray-dried, until water content is 10%, is crushed, 60 mesh sieve is crossed, is vacuum-packed to get finished product.Finished product medicine materical crude slice In (R, S)-accuse according to the spring content be 0.045%.

Claims

1. a kind of Radix Isatidis is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：It is net in time after chromatogram of Radix Isatidis harvesting Choosing, removal impurity and the dis-medicinal part such as silt add in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness Enter the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and constantly stir 5 ~ 30 minutes, filtering, dregs pressing takes juice；In the gained dregs of a decoction again The water of 5 ~ 10 times of weight is added, boils 10 ~ 30 minutes, filters while hot, the dregs of a decoction are squeezed the juice again, collect concoction；Merge above-mentioned concoction, 60 ~ 100 mesh sieve is crossed, is concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；Gained concentrate is sprayed Dry, control dried object water content is to be crushed within 10%, crosses 60 mesh sieve, is vacuum-packed to get finished product；Finished product medicine materical crude slice containing (R, S)-announcement must not be less than 0.040% according to the spring.

2. Radix Isatidis according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：Clinic generally makes Dosage is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.