CN108771692A - Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice - Google Patents
Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice Download PDFInfo
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- CN108771692A CN108771692A CN201810733321.0A CN201810733321A CN108771692A CN 108771692 A CN108771692 A CN 108771692A CN 201810733321 A CN201810733321 A CN 201810733321A CN 108771692 A CN108771692 A CN 108771692A
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- China
- Prior art keywords
- rhizoma
- materical crude
- medicine materical
- crude slice
- radix notopterygii
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that:Rhizoma Et Radix Notopterygii medicinal material harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Rhizoma Et Radix Notopterygii medicine materical crude slice.
Background technology
Chinese Medicine " qianghuo " is samphire Rhizoma Et Radix NotopterygiiNotopterygium inchumTing ex H, T- Chang or width
Leaf Rhizoma Et Radix NotopterygiiNotopterygium franchetii H. the dry rhizome and root of de Boiss. has relieving exterior syndrome and dispelling cold, wind-dispelling
The effect of dehumidifying, analgesic.This product is mainly used for anemofrigid cold, and have a headache Xiang Qiang, arthralgia pain due to rheumatism, the treatment of aching pain in shoulder and back etc., in being
Cure clinically common a herb.The processing method of traditional Rhizoma Et Radix Notopterygii is:Spring, the excavation of two season of autumn, remove fibrous root and silt, shine
It is dry, it is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.The medicine materical crude slice volume so processed is big, health
Standard deviation is learned, is easy to make moist, mildew, is unfavorable for taking care of, storage and transportation cost are high.In addition, such prepared slice quality stability
Difference, clinical efficacy be difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage/transportation
It is at low cost, conducive to keeping, carry and easy to use, rapid-action novel Rhizoma Et Radix Notopterygii medicine materical crude slice, it is imperative.Existing market Rhizoma Et Radix Notopterygii drinks
Piece, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both with traditional medicine materical crude slice
For raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes;Concentrated granular is only
Water soluble ingredient can be extracted.
Invention content
The invention discloses a kind of " Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that:In Rhizoma Et Radix Notopterygii medicinal material
After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~
The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering,
Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.The concentrate of gained is spray-dried, control dried object water content is to be crushed within 10%, crosses 60
Mesh sieves, and is vacuum-packed to get finished product.Finished product medicine materical crude slice contains Notopterol(C21H22O5)And Isomperatorin(C16H14O4)Total amount not
Less than 0.60%.The clinical general usage amount of this powder decoction pieces is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, also can directly enter pill,
In powder, capsule and tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to controlling for clinical acute disease
It treats.
The present invention solve traditional Rhizoma Et Radix Notopterygii medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Rhizoma Et Radix Notopterygii medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained is spray-dried, until water content is 10%, is crushed, and is crossed 60 mesh sieve, is vacuum-packed to get finished product.Finished product medicine materical crude slice contains
Notopterol(C21H22O5)And Isomperatorin(C16H14O4)Total amount be 0.65%.
Claims (2)
1. a kind of Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that:After the harvesting of Rhizoma Et Radix Notopterygii medicinal material, clean in time,
Impurity and the dis-medicinal part such as silt are removed, in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness, addition 1 ~
The water of 5 times of 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 are added in the gained dregs of a decoction
The water of ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, cross 60 ~
100 mesh sieve, and are concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;Gained concentrate is spray-dried,
It is to be crushed within 10% to control dried object water content, crosses 60 mesh sieve, is vacuum-packed to get finished product;Finished product medicine materical crude slice contains Notopterol
(C21H22O5)And Isomperatorin(C16H14O4)Total amount be no less than 0.60%.
2. Rhizoma Et Radix Notopterygii according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that:Clinic generally uses
Amount is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810733321.0A CN108771692A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice |
Applications Claiming Priority (1)
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CN201810733321.0A CN108771692A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
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CN108771692A true CN108771692A (en) | 2018-11-09 |
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CN201810733321.0A Withdrawn CN108771692A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice |
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CN (1) | CN108771692A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113759045A (en) * | 2021-09-13 | 2021-12-07 | 北京康仁堂药业有限公司 | Characteristic spectrum of notopterygium root decoction pieces or formula granules, construction method of characteristic spectrum, notopterygium root formula granules, preparation method of notopterygium root formula granules and quality control method of notopterygium root formula granules |
-
2018
- 2018-07-06 CN CN201810733321.0A patent/CN108771692A/en not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113759045A (en) * | 2021-09-13 | 2021-12-07 | 北京康仁堂药业有限公司 | Characteristic spectrum of notopterygium root decoction pieces or formula granules, construction method of characteristic spectrum, notopterygium root formula granules, preparation method of notopterygium root formula granules and quality control method of notopterygium root formula granules |
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PB01 | Publication | ||
PB01 | Publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181109 |
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WW01 | Invention patent application withdrawn after publication |