CN108653627A - Smilax is fresh to carry spray-dried powders medicine materical crude slice - Google Patents
Smilax is fresh to carry spray-dried powders medicine materical crude slice Download PDFInfo
- Publication number
- CN108653627A CN108653627A CN201810733357.9A CN201810733357A CN108653627A CN 108653627 A CN108653627 A CN 108653627A CN 201810733357 A CN201810733357 A CN 201810733357A CN 108653627 A CN108653627 A CN 108653627A
- Authority
- CN
- China
- Prior art keywords
- materical crude
- medicine materical
- crude slice
- fresh
- smilax
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 23
- 239000000843 powder Substances 0.000 title claims abstract description 13
- 241000362909 Smilax <beetle> Species 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 241000605422 Asparagus asparagoides Species 0.000 claims abstract description 11
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000012141 concentrate Substances 0.000 claims abstract description 5
- 239000003826 tablet Substances 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 238000003860 storage Methods 0.000 description 3
- ZROGCCBNZBKLEL-FHXNIQKESA-N Astilbin Natural products O([C@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O)[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 ZROGCCBNZBKLEL-FHXNIQKESA-N 0.000 description 2
- ZROGCCBNZBKLEL-MPRHSVQHSA-N astilbin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1C(=O)C2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1 ZROGCCBNZBKLEL-MPRHSVQHSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000366676 Justicia pectoralis Species 0.000 description 1
- 208000008763 Mercury poisoning Diseases 0.000 description 1
- 206010027439 Metal poisoning Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 201000002266 mite infestation Diseases 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of " smilax is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：Rhizoma smilacis glabrae medicinal material harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of smilax medicine materical crude slice.
Background technology
Chinese medicine smilax is liliaceous plant smilacis glabraSmilax glabra Roxb. dry rhizome has removing toxic substances,
Dehumidifying, easing joint movement effect.This product is mainly used for the limbs contraction caused by syphilis and mercury poisoning, arthralgia and myalgia；Damp and hot stranguria with turbid discharge,
Under band, carbuncle swells, scrofula, the treatment of mange etc. is a herb common on tcm clinical practice.The processing method of traditional smilax
For：After medicinal material is excavated, fibrous root, cleaning, drying are removed；Or fresh-cut flakiness is taken advantage of, and it is dry, it is packaged, storage and transportation.The drink of this method processing
Piece volume is big, and hygiene condition is poor, is easy to make moist, mildew, is unfavorable for taking care of, and storage and transportation cost are high.In addition, such drink
Tablet quality stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, developing a kind of stable quality can
Lean on, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action novel smilax medicine materical crude slice, it is imperative.Mesh
Preceding market smilax medicine materical crude slice, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but the two
All it is using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve medicinal material pollution
Problem；Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " smilax is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：In smilax
It after medicinal material harvesting, cleans in time, removal impurity and the dis-medicinal part such as silt, cleans and cut in taking advantage of using fresh herb tap water in 24 hours
At the piece of 2 ~ 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes,
Filtering, dregs pressing take juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction
It squeezes the juice again, collects concoction.Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, is concentrated into opposite
The concentrate that density is 1.02 ~ 1.10.The concentrate of gained is spray-dried, control dried object water content is powder within 10%
It is broken, 60 mesh sieve is crossed, is vacuum-packed to get finished product.Finished product medicine materical crude slice contains astilbin（C21H22O11）No less than 0.60%.This powder is drunk
The clinical general usage amount of piece is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, powder, capsule and tablet
In, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.
The present invention solve traditional smilax medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested,
The shortcomings such as the poor, unstable quality of hygiene condition, due to being to take advantage of fresh extraction, quality is than ultramicro grinding medicine materical crude slice and concentrated granular
Medicine materical crude slice is more preferable.
Specific embodiment
It after rhizoma smilacis glabrae medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours certainly
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction
Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.
The concentrate of gained is spray-dried, until water content is 10%, is crushed, 60 mesh sieve is crossed, is vacuum-packed to get finished product.Finished product medicine materical crude slice
Middle astilbin（C21H22O11）Content be 0.65%.
Claims (2)
1. a kind of smilax is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：It is net in time after rhizoma smilacis glabrae medicinal material harvesting
Choosing, removal impurity and the dis-medicinal part such as silt add in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness
Enter the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and constantly stir 5 ~ 30 minutes, filtering, dregs pressing takes juice；In the gained dregs of a decoction again
The water of 5 ~ 10 times of weight is added, boils 10 ~ 30 minutes, filters while hot, the dregs of a decoction are squeezed the juice again, collect concoction；Merge above-mentioned concoction,
60 ~ 100 mesh sieve is crossed, is concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；Gained concentrate is sprayed
Dry, control dried object water content is to be crushed within 10%, crosses 60 mesh sieve, is vacuum-packed to get finished product；Finished product medicine materical crude slice is new containing falling
Woman's glycosides（C21H22O11）No less than 0.60%.
2. smilax according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：Clinic generally makes
Dosage is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733357.9A CN108653627A (en) | 2018-07-06 | 2018-07-06 | Smilax is fresh to carry spray-dried powders medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733357.9A CN108653627A (en) | 2018-07-06 | 2018-07-06 | Smilax is fresh to carry spray-dried powders medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108653627A true CN108653627A (en) | 2018-10-16 |
Family
ID=63773505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733357.9A Withdrawn CN108653627A (en) | 2018-07-06 | 2018-07-06 | Smilax is fresh to carry spray-dried powders medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108653627A (en) |
-
2018
- 2018-07-06 CN CN201810733357.9A patent/CN108653627A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181016 |
|
| WW01 | Invention patent application withdrawn after publication |