CN108619278A - Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice - Google Patents
Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice Download PDFInfo
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- CN108619278A CN108619278A CN201810733308.5A CN201810733308A CN108619278A CN 108619278 A CN108619278 A CN 108619278A CN 201810733308 A CN201810733308 A CN 201810733308A CN 108619278 A CN108619278 A CN 108619278A
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- China
- Prior art keywords
- materical crude
- medicine materical
- crude slice
- morinda officinalis
- fresh
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- 239000003814 drug Substances 0.000 title claims abstract description 24
- 241000096284 Gynochthodes officinalis Species 0.000 title claims abstract description 15
- 239000000843 powder Substances 0.000 title claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000012141 concentrate Substances 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- FLDFNEBHEXLZRX-DLQNOBSRSA-N Nystose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(O[C@@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FLDFNEBHEXLZRX-DLQNOBSRSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 238000003860 storage Methods 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241000157491 Morinda Species 0.000 description 1
- 241000123069 Ocyurus chrysurus Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000017524 noni Nutrition 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of " Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：Morinda officinalis medicinal material harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Morinda officinalis medicine materical crude slice.
Background technology
Chinese medicine is madder wort Morinda officinalisMorinda officinalisThe dry root of How has kidney-replenishing, strengthening tendons
The effect of bone, wind-damp dispelling.It is mainly used for impotence and seminal emission, uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscles and bones impotence
The treatment of equal cards is a herb common on tcm clinical practice.The processing method of traditional Morinda officinalis is：After medicinal material is excavated, wash
Only, fibrous root is removed, is shone to 6 seventy percent dry, gently beats flat, dries, is packaged, storage and transportation.Thus obtained medicine materical crude slice volume is big, is unfavorable for
It adjusts, Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.In addition, such
Prepared slice quality stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, a kind of stable quality is developed
Reliably, storage/transportation it is at low cost, conducive to keeping, carry and easy to use, rapid-action novel Morinda officinalis medicine materical crude slice, it is imperative.
Existing market Morinda officinalis medicine materical crude slice, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but two
Person is using traditional medicine materical crude slice as raw material, and quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve medicinal material pollution
The problem of；Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：In Morinda officinalis
It after medicinal material harvesting, cleans in time, removal impurity and the dis-medicinal part such as silt, cleans and cut in taking advantage of using fresh herb tap water in 24 hours
At the piece of 2 ~ 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes,
Filtering, dregs pressing take juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction
It squeezes the juice again, collects concoction.Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, is concentrated into opposite
The concentrate that density is 1.02 ~ 1.10.The concentrate of gained is spray-dried, control dried object water content is powder within 10%
It is broken, 60 mesh sieve is crossed, is vacuum-packed to get finished product.This resistance to sugar in finished product medicine materical crude slice（C24H42O21）Content is no less than 3.0%.
The clinical general usage amount of this powder decoction pieces is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, dissipate
In agent, capsule and tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to controlling for clinical acute disease
It treats.
The present invention solve traditional Morinda officinalis medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested,
The shortcomings such as the poor, unstable quality of hygiene condition, due to being to take advantage of fresh extraction, quality is than ultramicro grinding medicine materical crude slice and concentrated granular
Medicine materical crude slice is more preferable.
Specific embodiment
It after Morinda officinalis medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours certainly
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction
Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.
The concentrate of gained is spray-dried, until water content is 10%, is crushed, 60 mesh sieve is crossed, is vacuum-packed to get finished product.Finished product medicine materical crude slice
In it is resistance to this sugar（C24H42O21）Content is 3.0%.
Claims (2)
1. a kind of Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：It is net in time after the harvesting of Morinda officinalis medicinal material
Choosing, removal impurity and the dis-medicinal part such as silt add in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness
Enter the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and constantly stir 5 ~ 30 minutes, filtering, dregs pressing takes juice；In the gained dregs of a decoction again
The water of 5 ~ 10 times of weight is added, boils 10 ~ 30 minutes, filters while hot, the dregs of a decoction are squeezed the juice again, collect concoction；Merge above-mentioned concoction,
60 ~ 100 mesh sieve is crossed, is concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；Gained concentrate is sprayed
Dry, control dried object water content is to be crushed within 10%, crosses 60 mesh sieve, is vacuum-packed to get finished product；In finished product medicine materical crude slice it is resistance to this
Sugar（C24H42O21）Content is no less than 3.0%.
2. Morinda officinalis according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：Clinic generally makes
Dosage is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733308.5A CN108619278A (en) | 2018-07-06 | 2018-07-06 | Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733308.5A CN108619278A (en) | 2018-07-06 | 2018-07-06 | Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108619278A true CN108619278A (en) | 2018-10-09 |
Family
ID=63689726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733308.5A Withdrawn CN108619278A (en) | 2018-07-06 | 2018-07-06 | Morinda officinalis is fresh to carry spray-dried powders medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108619278A (en) |
-
2018
- 2018-07-06 CN CN201810733308.5A patent/CN108619278A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181009 |
|
| WW01 | Invention patent application withdrawn after publication |