CN108619181A - Radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
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- CN108619181A CN108619181A CN201810733201.0A CN201810733201A CN108619181A CN 108619181 A CN108619181 A CN 108619181A CN 201810733201 A CN201810733201 A CN 201810733201A CN 108619181 A CN108619181 A CN 108619181A
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- China
- Prior art keywords
- materical crude
- medicine materical
- crude slice
- radix cyathulae
- fresh
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:Radix cyathulae harvest after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%, cyasterone in finished product medicine materical crude slice(C29H44O8)Content is no less than 0.040%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of radix cyathulae medicine materical crude slice.
Background technology
Chinese medicine radix cyathulae is amaranthaceous plant radix cyathulaeCyathula officinalis The dry root of Kuan has by the stasis of blood
Promoting menstruation, it is easing joint movement, the effect of inducing diuresis for treating strangurtia.This product is mainly used for Amenorrhea abnormal pigmentary deposit on the skin lump in the abdomen, placenta retension, injury from falling down, arthralgia pain due to rheumatism,
Sufficient impotence muscle contraction, the treatment of the diseases such as cards such as hematuria blood drenches are a herbs common on tcm clinical practice.The processing method of traditional radix cyathulae
For:After medicinal material is excavated, removing LU, fibrous root and silt are removed, dries or shines to half-dried, stacking backwash, then dry or dry, be packaged,
Storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Thus obtained radix cyathulae medicine materical crude slice volume is big, hygiene
Condition is poor, is easy to make moist, mildew, is unfavorable for taking care of, and storage and transportation cost are high.In addition, such prepared slice quality stability is poor,
Clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, develop a kind of stable quality is reliable, storage/transportation at
This is low, conducive to keeping, carry and easy to use, rapid-action novel radix cyathulae medicine materical crude slice, it is imperative.Existing market radix cyathulae drinks
Piece, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both with traditional medicine materical crude slice
For raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes;Concentrated granular is only
Water-soluble components can be extracted.
Invention content
The invention discloses a kind of " radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:In radix cyathulae
After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~
The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering,
Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare
Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains cyasterone
(C29H44O8)No less than 0.030%.Radix cyathulae granule pieces stable quality, good fluidity, clinical general usage amount is 1 ~ 5g.This
Class medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, to substantially increase Clinical practice just
Victory and compliance are conducive to the treatment of clinical acute disease.
The present invention solve traditional radix cyathulae medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested,
The shortcomings such as the poor, unstable quality of hygiene condition, due to being to take advantage of fresh extraction, quality is than ultramicro grinding medicine materical crude slice and concentrated granular
Medicine materical crude slice is more preferable.
Specific embodiment
It after radix cyathulae medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours certainly
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction
Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.
The concentrate of gained is left and taken into 3% spare, remaining spray drying.Spray powder is collected, pelleting is mixed with spare concentrate,
It is 10% that 80 DEG C, which are dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains cyasterone(C29H44O8)Amount
It is 0.035%.
Claims (2)
1. a kind of radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:After radix cyathulae harvests, clean in time,
Impurity and the dis-medicinal part such as silt are removed, in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness, addition 1 ~
The water of 5 times of 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 are added in the gained dregs of a decoction
The water of ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, cross 60 ~
100 mesh sieve, and are concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;Gained concentrate leaves and takes 1% ~ 3%
It is spare, remaining spray drying;By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10%
Grain is vacuum-packed to get finished product;Finished product medicine materical crude slice contains cyasterone(C29H44O8)0.030% must not be less than.
2. radix cyathulae according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:Clinic generally makes
Dosage is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733201.0A CN108619181A (en) | 2018-07-06 | 2018-07-06 | Radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733201.0A CN108619181A (en) | 2018-07-06 | 2018-07-06 | Radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108619181A true CN108619181A (en) | 2018-10-09 |
Family
ID=63689630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201810733201.0A Withdrawn CN108619181A (en) | 2018-07-06 | 2018-07-06 | Radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
Country | Link |
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CN (1) | CN108619181A (en) |
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2018
- 2018-07-06 CN CN201810733201.0A patent/CN108619181A/en not_active Withdrawn
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Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181009 |