CN108619238A - The root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
The root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
- Publication number
- CN108619238A CN108619238A CN201810733301.3A CN201810733301A CN108619238A CN 108619238 A CN108619238 A CN 108619238A CN 201810733301 A CN201810733301 A CN 201810733301A CN 108619238 A CN108619238 A CN 108619238A
- Authority
- CN
- China
- Prior art keywords
- root
- materical crude
- medicine materical
- crude slice
- fresh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:The root of three-nerved spicebush harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%, linderane in root tuber of Lindera in finished product medicine materical crude slice(C15H16O4)Content is no less than 0.040%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of root of three-nerved spicebush medicine materical crude slice.
Background technology
The Chinese medicine root of three-nerved spicebush is the canella root of three-nerved spicebushLindera aggregata(Sims)Kos-term. dried root, has
The effect of promoting qi circulation and relieving pain, warming kidney for dispelling cold.This product is mainly used for cold obstruction causing qi stagnation, and chest and abdomen swelling and pain, circulation of vital energy in the wrong direction asthma is anxious, deficiency-cold in the urinary bladder, the enuresis
Frequent micturition, hernia pain, the treatment through the diseases such as abdominal pain of trembling with fear are a herbs common on tcm clinical practice.The processing side of traditional root of three-nerved spicebush
Method is:After medicinal material is excavated, radicula is removed, is cleaned, is taken advantage of fresh slices, dry, or directly dry, is packaged, storage and transportation.It is thus obtained
Root of three-nerved spicebush medicine materical crude slice volume is big, and Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.This
Outside, such prepared slice quality stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, one is developed
Kind of quality is reliable and stable, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action novel root of three-nerved spicebush medicine materical crude slice,
It is imperative.Existing market root of three-nerved spicebush medicine materical crude slice, other than traditional medicine materical crude slice, also two kinds of shapes of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice
Formula, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve medicine
The problem of material pollutes;Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:It is harvested in the root of three-nerved spicebush
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare
Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.In finished product medicine materical crude slice in linderoxide
Ester(C15H16O4)Content is no less than 0.040%.Root of three-nerved spicebush granule pieces stable quality, good fluidity, clinical general usage amount is 1 ~
5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, make to substantially increase clinic
Convenience and compliance are conducive to the treatment of clinical acute disease.
The present invention solve traditional root of three-nerved spicebush medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after root of three-nerved spicebush medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80
It is 10% DEG C to be dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Linderane in root tuber of Lindera in finished product medicine materical crude slice(C15H16O4)Contain
Amount no less than 0.045%.
Claims (2)
1. a kind of root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:It after root of three-nerved spicebush harvesting, cleans, removes in time
The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness
The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 ~ 10 are added in the gained dregs of a decoction
The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, crosses 60 ~ 100
Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;It is standby that gained concentrate leaves and takes 1% ~ 3%
With remaining spray drying;By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10%
Grain is vacuum-packed to get finished product;Linderane in root tuber of Lindera in finished product medicine materical crude slice(C15H16O4)Content is no less than 0.040%.
2. the root of three-nerved spicebush according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733301.3A CN108619238A (en) | 2018-07-06 | 2018-07-06 | The root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733301.3A CN108619238A (en) | 2018-07-06 | 2018-07-06 | The root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108619238A true CN108619238A (en) | 2018-10-09 |
Family
ID=63688773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810733301.3A Withdrawn CN108619238A (en) | 2018-07-06 | 2018-07-06 | The root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108619238A (en) |
-
2018
- 2018-07-06 CN CN201810733301.3A patent/CN108619238A/en not_active Withdrawn
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108671030A (en) | Herba Cistanches are fresh to carry spray-dried granules medicine materical crude slice | |
CN108524557A (en) | Teasel root is fresh to carry spray-dried granules medicine materical crude slice | |
CN108524560A (en) | Radix Angelicae Pubescentis is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619190A (en) | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried granules medicine materical crude slice | |
CN108524838A (en) | Trigone is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619238A (en) | The root of three-nerved spicebush is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619186A (en) | Radix bupleuri is fresh to carry spray-dried granules medicine materical crude slice | |
CN108771692A (en) | Rhizoma Et Radix Notopterygii is fresh to carry spray-dried powders medicine materical crude slice | |
CN108635533A (en) | The tuber of stemona is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619250A (en) | Cymose buckwheat rhizome is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619304A (en) | Glutinous rehmannia is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619249A (en) | Radix Polygalae is fresh to carry spray-dried granules medicine materical crude slice | |
CN108635382A (en) | Rhizoma cibotii is fresh to carry spray-dried granules medicine materical crude slice | |
CN108567806A (en) | Root of Aucklandia lappa Decne is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619413A (en) | Reed root is fresh to carry spray-dried granules medicine materical crude slice | |
CN108771724A (en) | Rhizoma cyperi is fresh to carry spray-dried granules medicine materical crude slice | |
CN108635436A (en) | Morinda officinalis is fresh to carry spray-dried granules medicine materical crude slice | |
CN108635384A (en) | The root of Dahurain angelica is fresh to carry spray-dried granules medicine materical crude slice | |
CN108635386A (en) | Rhizoma Chuanxiong is fresh to carry spray-dried granules medicine materical crude slice | |
CN108578451A (en) | The root of bidentate achyranthes is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619181A (en) | Radix cyathulae is fresh to carry spray-dried granules medicine materical crude slice | |
CN108619180A (en) | Cynomorium songaricum is fresh to carry spray-dried granules medicine materical crude slice | |
CN108653363A (en) | Rhizoma atractylodis are fresh to carry spray-dried granules medicine materical crude slice | |
CN108671196A (en) | Radix Curcumae is fresh to carry spray-dried granules medicine materical crude slice | |
CN108771698A (en) | Root of Aucklandia lappa Decne is fresh to carry spray-dried powders medicine materical crude slice |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181009 |