CN108524588A - Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
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- CN108524588A CN108524588A CN201810733194.4A CN201810733194A CN108524588A CN 108524588 A CN108524588 A CN 108524588A CN 201810733194 A CN201810733194 A CN 201810733194A CN 108524588 A CN108524588 A CN 108524588A
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- Prior art keywords
- cortex eucommiae
- fresh
- materical crude
- medicine materical
- crude slice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
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- Microbiology (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：Cortex Eucommiae harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%, and finished product is no less than 0.20% containing Pinoresinol diglucoside.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Cortex Eucommiae medicine materical crude slice.
Background technology
Traditional Chinese medicine eucommia bark is Eucommiaceae plant Cortex EucommiaeEucommia u1moidesOliv. dry bark has filling liver kidney,
The effect of strengthening the bones and muscles, tocolysis.This product can be used for kidney deficiency and liver, and soreness of waist and knee joint, muscles and bones is powerless, has a dizzy spell, blood leaking in gestation, movement of the foetus
The treatment of the diseases such as uneasiness is a herb common on tcm clinical practice.The processing method of traditional Cortex Eucommiae is：After stripping bark, scrape
Tertia is removed, it is in puce to bank up " sweating " to endothelium, is dried, and is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, does
Dry, packaging.Thus obtained Cortex Eucommiae medicine materical crude slice volume is big, and hygiene condition is poor, vulnerable to pollution, is unfavorable for taking care of, and stores and transports
It is of high cost.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Cause
This, develop a kind of stable quality is reliable, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action novel
Cortex Eucommiae medicine materical crude slice, it is imperative.Existing market Cortex Eucommiae medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentrated granular
Two kinds of forms of medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece
It cannot solve the problems, such as that medicinal material pollutes；Concentrated granular can only extract water-soluble components.
Invention content
The invention discloses a kind of " Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：It is harvested in Cortex Eucommiae
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare
Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product two grape containing rosin spirit
Glucosides is no less than 0.20%.Duzhong prepared slice quality is stablized, good fluidity, and clinical general usage amount is 1 ~ 5g.Such medicine materical crude slice was both
Decoction decoction can be entered, taken after mixing it with water, also can directly be entered in capsule and tablet, to substantially increase the convenience of Clinical practice and suitable
Ying Xing is conducive to the treatment of clinical acute disease.
The present invention solve traditional Cortex Eucommiae medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Eucommia ulmoides are harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80
It is 10% DEG C to be dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Pinoresinol diglucoside content in finished product medicine materical crude slice
It is 0.25%.
Claims (2)
1. a kind of Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：It after Cortex Eucommiae harvesting, cleans, removes in time
The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness
The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 ~ 10 are added in the gained dregs of a decoction
The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, crosses 60 ~ 100
Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；It is standby that gained concentrate leaves and takes 1% ~ 3%
With remaining spray drying；By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10%
Grain is vacuum-packed to get finished product；Finished product is no less than 0.20% containing Pinoresinol diglucoside.
2. Cortex Eucommiae according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733194.4A CN108524588A (en) | 2018-07-06 | 2018-07-06 | Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733194.4A CN108524588A (en) | 2018-07-06 | 2018-07-06 | Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108524588A true CN108524588A (en) | 2018-09-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733194.4A Withdrawn CN108524588A (en) | 2018-07-06 | 2018-07-06 | Cortex Eucommiae is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108524588A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568378A (en) * | 2018-11-19 | 2019-04-05 | 广东方制药有限公司 | A method of Cortex Eucommiae or stir-baked CORTEX EUCOMMIAE with salt solution granule are prepared using continuous dynamic countercurrent extraction process |
-
2018
- 2018-07-06 CN CN201810733194.4A patent/CN108524588A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568378A (en) * | 2018-11-19 | 2019-04-05 | 广东方制药有限公司 | A method of Cortex Eucommiae or stir-baked CORTEX EUCOMMIAE with salt solution granule are prepared using continuous dynamic countercurrent extraction process |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180914 |