CN108619267A - The coptis is fresh to carry spray-dried powders medicine materical crude slice - Google Patents
The coptis is fresh to carry spray-dried powders medicine materical crude slice Download PDFInfo
- Publication number
- CN108619267A CN108619267A CN201810733356.4A CN201810733356A CN108619267A CN 108619267 A CN108619267 A CN 108619267A CN 201810733356 A CN201810733356 A CN 201810733356A CN 108619267 A CN108619267 A CN 108619267A
- Authority
- CN
- China
- Prior art keywords
- medicine materical
- materical crude
- crude slice
- fresh
- coptis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of " coptis is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that:Rhizoma Coptidis harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of coptis medicine materical crude slice.
Background technology
Chinese Drug Rhizomes of Coptis is the dry rhizome of the ranunculaceae plant coptis, the triangle leaf coptis or cloud even, has heat-clearing and damp-drying drug, rushes down
The effect of fire removing toxic substances.This product is mainly used for damp and hot feeling of fullness, vomits acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, it is vexed not
It sleeps, palpitation and uneasiness, blood-head tells nosebleed, hot eyes, toothache, the treatment quenched one's thirst etc., is common a herb on tcm clinical practice.It is traditional yellow
Even processing method be:Autumn excavates, and removes fibrous root and silt, dry, hits residual fibrous root, is packaged, storage and transportation.To medicine materical crude slice factory
Afterwards, it then washs, soften, be sliced, dry, pack.Such medicine materical crude slice volume is big, and Hygienic Standard is poor, is not easy to take care of, and stores and transports
It is defeated of high cost.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.
Therefore, develop a kind of stable quality is reliable, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action new
Type coptis medicine materical crude slice, it is imperative.Existing market coptis medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentration
Grain two kinds of forms of medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultra micro is drunk
Piece cannot solve the problems, such as that medicinal material pollutes;Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " coptis is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that:In Rhizoma Coptidis
After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~
The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering,
Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.The concentrate of gained is spray-dried, control dried object water content is to be crushed within 10%, crosses 60
Mesh sieves, and is vacuum-packed to get finished product.Finished product medicine materical crude slice is no less than 6.5% containing jamaicin, and coptisine is no less than 2.5%.This powder is drunk
The clinical general usage amount of piece is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, powder, capsule and tablet
In, to substantially increase the convenience and compliance of Clinical practice, be conducive to the treatment of clinical acute disease.
The present invention solve traditional coptis medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Rhizoma Coptidis is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained is spray-dried, until water content is 10%, is crushed, and is crossed 60 mesh sieve, is vacuum-packed to get finished product.Finished product medicine materical crude slice contains
Jamaicin is 7.0%, coptisine 3.0%.
Claims (2)
1. a kind of coptis is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that:After Rhizoma Coptidis harvesting, clean in time,
Impurity and the dis-medicinal part such as silt are removed, in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness, addition 1 ~
The water of 5 times of 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 are added in the gained dregs of a decoction
The water of ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, cross 60 ~
100 mesh sieve, and are concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;Gained concentrate is spray-dried,
It is to be crushed within 10% to control dried object water content, crosses 60 mesh sieve, is vacuum-packed to get finished product;Finished product medicine materical crude slice contains jamaicin not
Less than 6.5%, coptisine is no less than 2.5%.
2. the coptis according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that:Clinic generally uses
Amount is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810733356.4A CN108619267A (en) | 2018-07-06 | 2018-07-06 | The coptis is fresh to carry spray-dried powders medicine materical crude slice |
Applications Claiming Priority (1)
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CN201810733356.4A CN108619267A (en) | 2018-07-06 | 2018-07-06 | The coptis is fresh to carry spray-dried powders medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
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CN108619267A true CN108619267A (en) | 2018-10-09 |
Family
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CN201810733356.4A Pending CN108619267A (en) | 2018-07-06 | 2018-07-06 | The coptis is fresh to carry spray-dried powders medicine materical crude slice |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107362182A (en) * | 2017-08-25 | 2017-11-21 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of phoenix-tail fern |
CN107412303A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eupatorium |
CN107432883A (en) * | 2017-08-25 | 2017-12-05 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of lopseed |
CN107582624A (en) * | 2017-08-25 | 2018-01-16 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Pogostemon cablin |
CN108186690A (en) * | 2018-03-21 | 2018-06-22 | 山西省医药与生命科学研究院 | A kind of Chinese medicine processing method |
-
2018
- 2018-07-06 CN CN201810733356.4A patent/CN108619267A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107362182A (en) * | 2017-08-25 | 2017-11-21 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of phoenix-tail fern |
CN107412303A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eupatorium |
CN107432883A (en) * | 2017-08-25 | 2017-12-05 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of lopseed |
CN107582624A (en) * | 2017-08-25 | 2018-01-16 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Pogostemon cablin |
CN108186690A (en) * | 2018-03-21 | 2018-06-22 | 山西省医药与生命科学研究院 | A kind of Chinese medicine processing method |
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Application publication date: 20181009 |