CN108619265A - The coptis is fresh to carry freeze-dried powder medicine materical crude slice - Google Patents
The coptis is fresh to carry freeze-dried powder medicine materical crude slice Download PDFInfo
- Publication number
- CN108619265A CN108619265A CN201810733224.1A CN201810733224A CN108619265A CN 108619265 A CN108619265 A CN 108619265A CN 201810733224 A CN201810733224 A CN 201810733224A CN 108619265 A CN108619265 A CN 108619265A
- Authority
- CN
- China
- Prior art keywords
- coptis
- materical crude
- medicine materical
- fresh
- crude slice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of " coptis is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that:The coptis harvest after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution is freeze-dried after being condensed into clear cream, then is vacuum-packed after crushing, being sieved.The water content of powder decoction pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of coptis medicine materical crude slice.
Background technology
Chinese Drug Rhizomes of Coptis is the dry rhizome of the ranunculaceae plant coptis, the triangle leaf coptis or cloud even, has heat-clearing and damp-drying drug, rushes down
The effect of fire removing toxic substances.This product is mainly used for damp and hot feeling of fullness, vomits acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, it is vexed not
It sleeps, palpitation and uneasiness, blood-head tells nosebleed, hot eyes, toothache, the treatment quenched one's thirst etc., is common a herb on tcm clinical practice.It is traditional yellow
Even processing method be:Autumn excavates, and removes fibrous root and silt, dry, hits residual fibrous root, is packaged, storage and transportation.To medicine materical crude slice factory
Afterwards, it then washs, soften, be sliced, dry, pack.Such medicine materical crude slice volume is big, and Hygienic Standard is poor, is not easy to take care of, and stores and transports
It is defeated of high cost.In addition, such prepared slice quality stability is poor, clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.
Therefore, develop a kind of stable quality is reliable, storage/transportation is at low cost, conducive to keeping, carry and easy to use, rapid-action new
Type coptis medicine materical crude slice, it is imperative.Existing market coptis medicine materical crude slice, other than traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentration
Grain two kinds of forms of medicine materical crude slice, but both using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultra micro is drunk
Piece cannot solve the problems, such as that medicinal material pollutes;Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " coptis is fresh to carry freeze-dried powder medicine materical crude slice ", are primarily characterized in that:It is harvested in the coptis
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.15 ~ 1.25 clear cream.It is cold in -20 ~ -40 DEG C of vacuum after gained clear cream is freezed 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators
It is lyophilized dry.Lyophilized products be dried under vacuum to again at 60 ~ 80 DEG C water content be less than 10%, crush, cross 60 mesh sieve, vacuum packaging to get at
Product.Finished product medicine materical crude slice is no less than 6.5% containing jamaicin, and coptisine is no less than 2.5%.The clinical general usage amount of this medicine materical crude slice is 1 ~ 5g,
Both it can enter decoction decoction, take after mixing it with water, also can directly enter in pill, powder, capsule and tablet, to substantially increase Clinical practice
Convenience and compliance, be conducive to the treatment of clinical acute disease.
The present invention solve traditional coptis medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Rhizoma Coptidis is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature be set as 70 DEG C, be concentrated into relative density be 1.20 it is clear
Cream.By the clear cream of gained after -80 DEG C are freezed 12 hours, in -40 DEG C of vacuum freeze dryings.Dried object is dried in vacuo with 60 DEG C again
It is 8% to water content, crushes, crosses 60 mesh sieve, be vacuum-packed to get finished product.Finished product medicine materical crude slice is no less than 6.5% containing jamaicin, the coptis
Alkali is no less than 2.5%.
Claims (2)
1. a kind of coptis is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that:After Rhizoma Coptidis harvesting, clean in time,
Impurity and the dis-medicinal part such as silt are removed, medicinal material surface wettability is kept, cleans in taking advantage of using fresh herb tap water in 24 hours and is cut into 2
The water of 1 ~ 5 times of 50 ~ 70 DEG C of weight is added in the piece of ~ 5mm thickness, impregnates and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes juice;
The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;
Merge above-mentioned concoction, cross 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.15 ~ 1.25 to be concentrated into relative density
Clear cream;After gained clear cream freezes 12 ~ 24 hours in -20 ~ -80 DEG C of refrigerators, in -20 ~ -40 DEG C of vacuum freeze dryings;Lyophilized products
Water content is dried under vacuum at 60 ~ 80 DEG C again and is less than 12%, is crushed, 60 mesh sieve is crossed, is vacuum-packed to get finished product;Finished product medicine materical crude slice contains
Jamaicin is no less than 6.5%, and coptisine is no less than 2.5%.
2. the coptis according to claim 1 is fresh to carry freeze-dried powder medicine materical crude slice, it is primarily characterized in that:Clinic generally uses
Amount is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733224.1A CN108619265A (en) | 2018-07-06 | 2018-07-06 | The coptis is fresh to carry freeze-dried powder medicine materical crude slice |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733224.1A CN108619265A (en) | 2018-07-06 | 2018-07-06 | The coptis is fresh to carry freeze-dried powder medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108619265A true CN108619265A (en) | 2018-10-09 |
Family
ID=63688794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810733224.1A Withdrawn CN108619265A (en) | 2018-07-06 | 2018-07-06 | The coptis is fresh to carry freeze-dried powder medicine materical crude slice |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108619265A (en) |
-
2018
- 2018-07-06 CN CN201810733224.1A patent/CN108619265A/en not_active Withdrawn
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108524787A (en) | Rhizoma Gastrodiae is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108524562A (en) | Rhizoma Et Radix Notopterygii is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108671008A (en) | Radix pseudostellariae is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108619305A (en) | Glutinous rehmannia is fresh to carry freeze-drying granule pieces | |
CN108619265A (en) | The coptis is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108671036A (en) | Radix Paeoniae Alba is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108553491A (en) | The root of Dahurain angelica is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108619195A (en) | Red ginseng is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108670996A (en) | Ginseng is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108619208A (en) | Radix Isatidis is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108567832A (en) | The coptis is fresh to carry freeze-drying granule pieces | |
CN108671042A (en) | The coptis is fresh to carry vacuum drying powder decoction pieces | |
CN108619306A (en) | Glutinous rehmannia is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108671131A (en) | Rhizoma anemarrhenae is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108619267A (en) | The coptis is fresh to carry spray-dried powders medicine materical crude slice | |
CN108578453A (en) | Rhizoma Chuanxiong is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108524582A (en) | Campanulaceae is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108721366A (en) | Root of Chinese trichosanthes is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108619194A (en) | American ginseng fresh carries freeze-dried powder medicine materical crude slice | |
CN108619205A (en) | Rhizoma Atractylodis Macrocephalae is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108619266A (en) | The coptis is fresh to carry spray-dried granules medicine materical crude slice | |
CN108671005A (en) | Radix Codonopsis is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108671017A (en) | Root and ratio of rhizome medicinal material is fresh carries freeze-dried powder medicine materical crude slice | |
CN108653406A (en) | Cimicifugae foetidae is fresh to carry freeze-dried powder medicine materical crude slice | |
CN108578486A (en) | The Chinese bulbul is fresh to carry freeze-dried powder medicine materical crude slice |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181009 |
|
WW01 | Invention patent application withdrawn after publication |