CN108524613A - Rheum officinale is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Rheum officinale is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
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- CN108524613A CN108524613A CN201810733185.5A CN201810733185A CN108524613A CN 108524613 A CN108524613 A CN 108524613A CN 201810733185 A CN201810733185 A CN 201810733185A CN 108524613 A CN108524613 A CN 108524613A
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- Prior art keywords
- fresh
- rheum officinale
- materical crude
- medicine materical
- crude slice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " rheum officinale is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:Rheum officinale harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of rhubarb decoction pieces.
Background technology
Chinese herb rhubarb is polygonum rheum palmatumRheum palmatumL., Rheum tanguticum MaximRheum tanguticumMaxim.ex Balf. or Rheum officinaleRheum officinale Baill. dry root and rhizome, have
The effect of heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.It is mainly used for the stagnant constipation of real heat, blood-head
Hematemesis, hot eyes pharynx swelling, carbuncle swells furunculosis, abdominalgia with intestinal abscess, blood stasis closed, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice,
The treatment of stranguria, oedema and externally treating burns and scalds etc. is a herb common on tcm clinical practice.The processing method of traditional rheum officinale
For:Autumn end cauline leaf is withered or the preceding excavation of secondary spring germination, removes radicula, scrapes off crust, valve cutting or section, and restricting, it is dry or direct to wear bunchiness
It is dry, it is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Such medicine materical crude slice volume is big, hygiene mark
It is accurate poor, it is easy to make moist, mildew, is unfavorable for taking care of, storage and transportation cost height.In addition, such prepared slice quality stability is poor, face
Bed curative effect is difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage/transportation cost
It is low, conducive to keeping, carry and easy to use, rapid-action novel rhubarb decoction pieces, it is imperative.Existing market rhubarb decoction pieces, are removed
Except traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice two kinds of forms, but be both original with traditional medicine materical crude slice
Material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes;Concentrated granular can only carry
Take out water-soluble components.
Invention content
The invention discloses a kind of " rheum officinale is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:It is harvested in rheum officinale
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection with it is spare
Concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product is containing general anthraquinone with aloe
Rheum emodin(C15H10O5), Rhein(C15H8O6), rheum emodin(C15H10O5), Chrysophanol(C15H10O4)And Physcion
(C16H12O5)Total amount meter, no less than 3.0%.Rheum officinale granule pieces stable quality, good fluidity, clinical general usage amount is 1 ~
5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, make to substantially increase clinic
Convenience and compliance are conducive to the treatment of clinical acute disease.
The present invention solve traditional rhubarb decoction pieces are bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after rhubarb medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained leaves and takes 3% spare, remaining spray drying.Spray powder is collected, mixes pelleting with spare concentrate, 80
It is 10% DEG C to be dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Finished product is containing general anthraquinone with aloe-emodin
(C15H10O5), Rhein(C15H8O6), rheum emodin(C15H10O5), Chrysophanol(C15H10O4)And Physcion(C16H12O5)'s
Total amount meter, no less than 3.0%.
Claims (2)
1. a kind of rheum officinale is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:It after rheum officinale harvesting, cleans, removes in time
The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness
The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 ~ 10 are added in the gained dregs of a decoction
The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, crosses 60 ~ 100
Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;It is standby that gained concentrate leaves and takes 1% ~ 3%
With remaining spray drying;By the spray powder of collection and spare concentrate mixing granulation, drying to water content is whole less than 10%
Grain is vacuum-packed to get finished product;Finished product is containing general anthraquinone with aloe-emodin(C15H10O5), Rhein(C15H8O6), rheum emodin
(C15H10O5), Chrysophanol(C15H10O4)And Physcion(C16H12O5)Total amount meter, no less than 3.0%.
2. rheum officinale according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733185.5A CN108524613A (en) | 2018-07-06 | 2018-07-06 | Rheum officinale is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733185.5A CN108524613A (en) | 2018-07-06 | 2018-07-06 | Rheum officinale is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108524613A true CN108524613A (en) | 2018-09-14 |
Family
ID=63487974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201810733185.5A Withdrawn CN108524613A (en) | 2018-07-06 | 2018-07-06 | Rheum officinale is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
Country | Link |
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CN (1) | CN108524613A (en) |
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2018
- 2018-07-06 CN CN201810733185.5A patent/CN108524613A/en not_active Withdrawn
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WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180914 |
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