CN108567875A - A kind of Chinese medicine composition and its Chinese medicine preparation for treating salpingitis of layer chicken - Google Patents
A kind of Chinese medicine composition and its Chinese medicine preparation for treating salpingitis of layer chicken Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions and its Chinese medicine preparation for treating salpingitis of layer chicken, are made of the raw material of following parts by weight：8 15 parts of Selaginella tamariscina, 8 15 parts of field pennycress, 8 15 parts of gulfweed, 8 15 parts of red-spotted stonecrop, 8 15 parts of scissors grass, 2 10 parts of puncture vine, 2 10 parts of, Bi Collettiis, 8 15 parts of tangerine leaf, 10 20 parts of the rhizome of davallia, 10 20 parts of radix achyranthis bidentatae.The Chinese medicine preparation includes above-mentioned Chinese medicine composition and pharmaceutically acceptable auxiliary material.The Chinese medicine preparation is but is not limited only to：Granule, decoction, powder, oral solution, pill.The present invention has clearing heat and detoxicating, the promoting blood circulation and removing blood stasis, carbuncle that disappears toxin expelling and other effects, can prevent salpingitis of layer chicken, the laying rate and egg that improve laying hen quality, the constitution of poultry can also be enhanced, improve immunity of organisms and premunition.The present invention is made of natural traditional Chinese medicine, have it is with strong points, significant in efficacy, have no drug resistance, noresidue, it is nonirritant, without any harmful toxic matter, toxic side effect will not be generated to animal body, health will not more be had an impact.
Description
Technical field
The invention belongs to veterinary drug technical fields, and in particular to a kind of Chinese medicine composition that treating salpingitis of layer chicken and wherein
Medicine preparation.
Background technology
Caused by the salpingitis of laying hen has plenty of Escherichia coli, salmonella etc., have plenty of due to egg-laying peak, it is defeated
Caused by the mucosal function some lost of oviduct, besides due to strong stress factor, as the variation of temperature, immunity are low
Caused by inferior.In addition, being easiest to that salpingitis tubal occurs in egg-laying peak, produced because the general connect product of high yield chicken group is stopped for 7 days
One day, the secretion of albumen, the formation of eggshell were required for the participation of fallopian tubal, the function excitatory state of high intensity to easily lead to face
The tachytrophism of film layer causes the premature loss of aging and Secretion to also result in the generation of salpingitis tubal.Clinical symptoms
Change with dissection：Diseased chicken is listless, and body temperature increases, and hat is pale, and egg production declines, and some stoppings are laid eggs, and produce soft-shelled egg, breaks
Egg increases, and chicken does not rise with crouching sometimes after arranging egg, and milky egg white sample loose stools is discharged or white green loose stools, cloaca protrude, pain
Uneasiness, often with bloodstain on its eggshell of the egg of output.Yellow, white purulence sample secretion is often discharged in fallopian tubal, pollutes anus
Surrounding and feather below, difficulty of laying eggs.With the development of the state of an illness, sick fowl starts to generate heat, and then heat is moved back, and pain is uneasy, stays
Vertical motionless, two wings are sagging, loose random, and some abdomens can cause peritonitis when inflammation spreads to abdominal cavity by ground or lethargic sleep, or
Salpingorrhexis causes yolk peritonitis.Dissect can be seen fallopian tubal and lesion occur：Fallopian tube mucosa is congested, bleeding, oedema,
Inside there are a large amount of mucus white secretion, inner product to have special-shaped egg sample exudate, there is 1 to 2 to form intact chicken at cloaca
Egg fails output, and some suffers from intestinal adhesions at chicken abdominal cavity.
Currently, in terms for the treatment of and preventing diseases of bird and livestock, mostly use chemical synthetic drug, although chemical synthetic drug dosage it is small,
It is quick but often palliative, there is the halfway drawback for the treatment of, and chemical synthetic drug side effect is larger, in the flesh of chicken
There is chemicals residues, hazard residue in meat and egg may do harm to huamn body；The especially use of antibiotic is held
Easily make bacterial strain develop immunity to drugs and to no effect；And meat drug residue is serious, is directly detrimental to health.Viral infection exists
On animal body it occur frequently that, once occurring, heavy losses can be caused to aquaculture, can also be caused damages to the mankind.
Chinese herbal medicine have the characteristics that it is nontoxic, do not remain, do not develop immunity to drugs, be gradually valued by people.Chinese herbal medicine is not
The diseases such as the salpingitis of laying hen can be only treated, a large amount of amino acid, vitamin, trace element etc. can also be provided for animal
Nutriment can improve the utilization rate of feed, promote laying hen growth, and rich in polysaccharide, organic acid, flavonoids, biology
The natural bioactive substance such as bases, can enhance the immunity of body, and disease preventing and treating is kept fit, therefore in aquaculture
It plays an important role.
Invention content
It is an object of the invention to overcome the above problem, provide a kind of raw material be easy to get, be formulated rationally, preparation method it is simple,
Safety and environmental protection does not generate drug resistance, the Chinese medicine composition and its Chinese medicine preparation for treating salpingitis of layer chicken curative for effect.
To achieve the above object, the technical solution adopted in the present invention is specific as follows：
A kind of Chinese medicine composition for treating salpingitis of layer chicken, is made of the raw material of following parts by weight：8-15 parts of Selaginella tamariscina, field pennycress
8-15 parts, 8-15 parts of gulfweed, 8-15 parts of red-spotted stonecrop, 8-15 parts of scissors grass, 2-10 parts of, Bi Collettiis of 2-10 parts of puncture vine, 8-15 parts of tangerine leaf,
10-20 parts of the rhizome of davallia, 10-20 parts of radix achyranthis bidentatae.
Preferably, the Chinese medicine composition of the treatment salpingitis of layer chicken is made of the raw material of following parts by weight：Selaginella tamariscina 10
Part, 10 parts of field pennycress, 10 parts of gulfweed, 10 parts of red-spotted stonecrop, 10 parts of scissors grass, 5 parts of puncture vine, 5 parts of, Bi Collettiis, 10 parts of tangerine leaf, the rhizome of davallia
15 parts, 15 parts of radix achyranthis bidentatae.
The preparation method of the Chinese medicine composition of above-mentioned treatment salpingitis of layer chicken is：Above-mentioned raw materials are dried at 55-70 DEG C
60-100 mesh sieve is crossed in 3-5h, cooling, crushing, is mixed in proportion.
A kind of Chinese medicine preparation for treating salpingitis of layer chicken, including above-mentioned Chinese medicine composition and pharmaceutically acceptable auxiliary
Material.
Preferably, the Chinese medicine preparation is but is not limited only to：Granule, decoction, powder, oral solution, pill.
Herbal pharmacology effect of the present invention is as follows：
Selaginella tamariscina：It is pungent, flat, Return liver, the heart channel of Hang-Shaoyin.Has effects that invigorate blood circulation, for treating closed dysmenorrhea, wei lumps in the abdomen lump in the abdomen, bruise damage
The diseases such as wound.
Field pennycress：It is pungent, bitter, cool, return stomach, large intestine, Liver Channel.Have effects that the clearing heat and detoxicating, carbuncle that disappears apocenosis, blood circulation promoting competent silt,
For treating the diseases such as acute appendicitis, lung carbuncle and sore and toxic, the stagnant caused chest and abdomen pain of the real heat stasis of blood, postpartum stasis of blood.
Gulfweed：It is sweet, light, cool, converge to heart and liver channels.Have effects that clearing heat and promoting diuresis, dispelling pathogenic wind for improving eyesight, removing toxic substances, desinsection, is used for
Treat anemopyretic cold, jaundice, infantile malnutrition, dysentery, difficulty and pain in micturition, the puckery pain of hot eyes, red eye, swell pain, carbuncle swells, verruca vulgaris, sore tinea etc.
Disease.
Red-spotted stonecrop：Bitter, acid, cold, the thoughts of returning home, liver, kidney, large intestine channel.Has effects that clearing heat and detoxicating, hemostasis, for treating red trip
Erysipelas, furunculosis carbuncle furuncle, pinkeye mesh screen, dysphoria with smothery sensation shy mad, rubella, dermatitis rhus, burn and scald, snakebite and bugbite, haematemesis, spitting of blood, hyper-menorrhea,
The diseases such as traumatic hemorrhage.
Scissors grass：It is bitter, pungent, cool.Have effects that expelling wind and clearing away heat, the promoting flow of qi and blood circulation, removing toxicity for detumescence, for treating flu hair
Heat, dyspeptic abdominalgia, vomiting, diarrhea, dysentery, diphtheria, abscess of throat, carbuncle swells erysipelas, nettle rash, insect-bite, bruise hinder bleeding
Equal diseases.
Puncture vine：Pungent, bitter, tepor, return liver warp.With flat liver solution strongly fragrant, promoting blood circulation by removing wind, improving eyesight, antipruritic effect, for treating
Dizziness of having a headache, distending pain in the chest and hypochondrium, breast close the diseases such as acute mastitis, cataract, rubella itch.
Bi Collettii：It is bitter, flat, Return liver, stomach, bladder warp.Have effects that wind-dispelling, dampness removing, for treating rheumatoid arthritis stubborn, waist and knee pain
Bitterly, the diseases such as difficult urination, stranguria with turbid discharge, seminal emission, damp and hot sore.
Tangerine leaf：It is bitter, pungent, flat, Liver Channel.Have effects that soothing the liver promoting the circulation of qi, reducing phlegm and resolving masses, for treat acute mastitis, breast caking,
The diseases such as distending pain in the chest and hypochondrium, hernia.
The rhizome of davallia：Bitter, temperature, returns kidney, Liver Channel.Have effects that The strong bone of kidney tonifying, continues and hinders pain relieving, for treat lumbago due to the kidney deficiency,
Hiccough and deaf, tooth mobility, falling winks frustrates, injured bone, the diseases such as Control outward alopecia areata, leucoderma.Radix achyranthis bidentatae：It is bitter, sour, flat, Return liver,
Kidney channel.Have effects that filling liver kidney, strengthening the bones and muscles, dispelling stasis of blood and stimulating the menstrual flow, ensuring proper downward flow of the blood, for treating soreness of waist and knee joint, muscles and bones inability, Amenorrhea
The diseases such as abdominal mass, dizziness due to hyperactivity of liver-YANG.
The beneficial effects of the invention are as follows：
The Chinese medicine composition and its Chinese medicine preparation of the present invention has clearing heat and detoxicating, promoting blood circulation dedicated for treating salpingitis of layer chicken
Stagnation resolvation, the carbuncle that disappears toxin expelling and other effects, can effectively prevent salpingitis of layer chicken, improve the laying rate of laying hen and the quality of egg,
The constitution of poultry can also be enhanced, improve immunity of organisms and premunition.The present invention is made of natural traditional Chinese medicine, has specific aim
By force, significant in efficacy, have no drug resistance, drug noresidue, it is nonirritant, without any harmful toxic matter, poison will not be generated to animal body
Side effect will not more have an impact health.
Specific implementation mode
Below by specific embodiment, the invention will be further described.
Embodiment 1
A kind of Chinese medicine composition for treating salpingitis of layer chicken, is made of the raw material of following parts by weight：8 parts of Selaginella tamariscina, field pennycress 8
Part, 8 parts of gulfweed, 8 parts of red-spotted stonecrop, 8 parts of scissors grass, 2 parts of puncture vine, 2 parts of, Bi Collettiis, 8 parts of tangerine leaf, 10 parts of the rhizome of davallia, 10 parts of radix achyranthis bidentatae.
The preparation method of the Chinese medicine composition of above-mentioned treatment salpingitis of layer chicken is：Above-mentioned raw materials are dried into 5h at 55 DEG C,
60 mesh sieve is crossed in cooling, crushing, is mixed in proportion.
Embodiment 2
A kind of Chinese medicine composition for treating salpingitis of layer chicken, is made of the raw material of following parts by weight：15 parts of Selaginella tamariscina, field pennycress 15
Part, 15 parts of gulfweed, 15 parts of red-spotted stonecrop, 15 parts of scissors grass, 10 parts of puncture vine, 10 parts of, Bi Collettiis, 15 parts of tangerine leaf, 20 parts of the rhizome of davallia, bosom ox
20 parts of knee.
The preparation method of the Chinese medicine composition of above-mentioned treatment salpingitis of layer chicken is：Above-mentioned raw materials are dried into 3h at 70 DEG C,
It cools down, crush, sieve with 100 mesh sieve, mix in proportion.
Embodiment 3
A kind of Chinese medicine composition for treating salpingitis of layer chicken, is made of the raw material of following parts by weight：10 parts of Selaginella tamariscina, field pennycress 10
Part, 10 parts of gulfweed, 10 parts of red-spotted stonecrop, 10 parts of scissors grass, 5 parts of puncture vine, 5 parts of, Bi Collettiis, 10 parts of tangerine leaf, 15 parts of the rhizome of davallia, radix achyranthis bidentatae
15 parts.
The preparation method of the Chinese medicine composition of above-mentioned treatment salpingitis of layer chicken is：Above-mentioned raw materials are dried into 4h at 60 DEG C,
80 mesh sieve is crossed in cooling, crushing, is mixed in proportion.
Embodiment 4
Chinese medicine composition made from Example 1-3 adds customary adjuvant, according to a conventional method, granule is made.
Embodiment 5
Chinese medicine composition made from Example 1-3 adds customary adjuvant, according to a conventional method, decoction is made.
Embodiment 6
Chinese medicine composition made from Example 1-3 adds customary adjuvant, according to a conventional method, powder is made.
Embodiment 7
Chinese medicine composition made from Example 1-3 adds customary adjuvant, according to a conventional method, oral solution is made.
Embodiment 8
Chinese medicine composition made from Example 1-3 adds customary adjuvant, according to a conventional method, pill is made.
9 clinical test 1 of embodiment
1. test material：
1.1 experimental animal
Test chicken group is 360 ages in days sea, 2650 plumage of blue grey laying hen, and by Zhengzhou, individual raiser provides.
1.2 test drug
Chinese medicine composition obtained by trial drug embodiment of the present invention 1-3.
10% amoxicillin soluble powder of control drug, is purchased from Qingdao LiuHe Pharmacy Co., Ltd.
2. test method
2.1 experiment groupings
By 360 ages in days of purchase sea, 2500 plumage of blue grey laying hen, be randomly divided into 5 groups, i.e., blank control group, test group 1, test group 2,
Test group 3 and drug control group, every group of 500 plumages.Chicken is presented with production soft-preserved egg, shell egg, blood egg, husky shell egg before on-test
The features such as salpingitis disease, it is 3% or so that daily bad egg, which leads (production soft-preserved egg, shell egg, blood egg, husky shell egg),.
2.2 therapeutic scheme
In addition to blank control group, test group 1-3 is respectively by Chinese medicine composition obtained by embodiment 1-3 according to the weight percent of feed 1%
Than being mixed into feed, fed according to conventional feed mode；Amoxicillin is mixed into feeding by drug control group by 5 ‰ weight percent
In material, is fed according to conventional feed mode, be used in conjunction 7 days, be discontinued after 7 days.It is all experiment under identical feeding and management condition into
Row.7d starts to lay eggs to testing full group to weigh and count 360 age in days chickens before the test, to trying in half a month after on-test
It tests full group and lays eggs and weigh and count.
2.3 Observe and measure projects
Daily observation chicken group variation, health status, record feed intake, egg production, egg size, soft broken egg number calculate feedstuff-egg ratio, lay eggs
Rate.
3. result and analysis
The influence of 3.1 performance in layers
As it can be seen from table 1 2.4% is improved than laying rate before experiment after the experiment of 1 chicken of test group, than experiment after the experiment of 2 chicken of test group
Preceding laying rate improves 2.7%, improves 2.9% than laying rate before experiment after the experiment of 3 chicken of test group, has a competition after the experiment of drug control group chicken
Laying rate improves 1.5% before testing, and blank control group reduces by 0.8%.
1 performance in layers of table
Note：It tests during number of days one arranges " -7 " and indicates 7d before the test；" 15 " indicate in the 15d of on-test, similarly hereinafter.
4. discussing
The embodiment of the present invention can prevent salpingitis of layer chicken well, and traditional Chinese medicinal components of the present invention, compatibility is reasonable,
All medicines share has clearing heat and detoxicating, the promoting blood circulation and removing blood stasis, carbuncle that disappears toxin expelling and other effects, can effectively prevent salpingitis of layer chicken, improves
The laying rate of laying hen and the quality of egg can also enhance the constitution of poultry, improve immunity of organisms and premunition.The present invention by
Natural traditional Chinese medicine is made, have it is with strong points, significant in efficacy, have no drug resistance, drug noresidue, it is nonirritant, without any murder by poisoning object
Matter will not generate toxic side effect to animal body, will not more be had an impact to health.
The treatment of salpingitis of layer chicken is imitated in addition, also demonstrating different Chinese medicine preparations prepared by 5-8 of the embodiment of the present invention
Fruit, it is as a result more satisfactory.
10 clinical test 2 of embodiment
1. experimental animal and grouping
Test chicken group is the laying hen 60 of egg-laying peak, wherein suffering from salpingitis laying hen 50, healthy laying hen 10 is all from
Zhengzhou individual raiser, grouping are shown in Table 2 with processing.
2 animal packet of table and processing
2. test method
The clinical manifestation of 2.1 laying hens
Mental status, feeding drinking-water situation, egg number, the egg number inferior etc. of laying hen are observed during administration.
2.2 ELISA are detected
Medication the 8th day, every group takes 3 laying hens, wing venous blood collection 2mL to detach serum at random, detects the content of IL-2 in serum.
2.3 fluorescence quantitative PCR detection
Its IL-2 expression detects in medication the 8th day, every group of oviduct tissue for taking 3 laying hens at random.IL-2 and β-actin
Primer sequence be shown in Table 3.
3 primer sequence of table
3. result
3.1 laying hen clinical manifestations
After treatment phase, the laying hen mental restoration of test group and western medicine group is preferable, and feeding drinking-water is normal, and egg production has
Increased, egg number inferior is declined, and the laying hen spirit of blank control group is more depressed, and laying rate is not high, and egg number inferior is not
Once declined（It is shown in Table 4）.
4 Egg Production of Laying Hens situation of table
IL-2 content detections in 3.2 Laying-hen Serums
It is shown in Table 5.As shown in Table 5, IL-2 levels in I, II, III group of Laying-hen Serum are tested and are substantially less than blank control group（P<
0.05）, there is statistical significance, and western medicine group is compared with blank control group, though IL-2 levels are declined without notable
Sex differernce can make laying hen due to fallopian tubal after illustrating experiment I, II, III group of traditional Chinese medicine composition for treating obtained by the embodiment of the present invention
The horizontal of IL-2 significantly reduces in scorching and raised serum, and then to reduce amplitude little for western medicine group.
IL-2 levels change in 5 Laying-hen Serum of table
Note：* it indicates and blank control group significant difference（P<0.05）.
IL-2 gene expression doses detect in 3.3 laying hen oviduct tissues
It is shown in Table 6.As shown in Table 6, test III group it is extremely notable with blank control group difference, experiment I, II group and western medicine group with sky
White control group significant difference, illustrates after traditional Chinese medicine composition for treating obtained by the embodiment of the present invention, can make IL-2 in oviduct tissue
The expression quantity of gene reduces, the most apparent with 3 gained Chinese medicine composition of embodiment.
The expression of IL-2 genes in 6 laying hen oviduct tissue of table
Note：* it indicates and blank control group significant difference（P<0.05）, * * indicate extremely notable with blank control group difference（P<
0.01）.
4. discussing
The embodiment of the present invention can treat salpingitis of layer chicken well, and traditional Chinese medicinal components of the present invention, compatibility is reasonable,
All medicines share has clearing heat and detoxicating, the promoting blood circulation and removing blood stasis, carbuncle that disappears toxin expelling and other effects, can effectively treat salpingitis of layer chicken, improves
The laying rate of laying hen and the quality of egg reduce the amount with IL-2 in oviduct tissue in Laying-hen Serum, can also enhance poultry
Constitution, improve immunity of organisms and premunition.The present invention is made of natural traditional Chinese medicine, have it is with strong points, significant in efficacy, without resistance to
Pharmacological property, drug noresidue, it is nonirritant, without any harmful toxic matter, toxic side effect will not be generated to animal body, more will not be to people
Body health has an impact.
The treatment of salpingitis of layer chicken is imitated in addition, also demonstrating different Chinese medicine preparations prepared by 5-8 of the embodiment of the present invention
Fruit, it is as a result more satisfactory.
Claims (5)
1. a kind of Chinese medicine composition for treating salpingitis of layer chicken, which is characterized in that be made of the raw material of following parts by weight：Selaginella tamariscina
8-15 parts, 8-15 parts of field pennycress, 8-15 parts of gulfweed, 8-15 parts of red-spotted stonecrop, 8-15 parts of scissors grass, 2-10 parts of, Bi Collettiis 2-10 of puncture vine
Part, 8-15 parts of tangerine leaf, 10-20 parts of the rhizome of davallia, 10-20 parts of radix achyranthis bidentatae.
2. treating the Chinese medicine composition of salpingitis of layer chicken according to claim 1, which is characterized in that by following parts by weight
Raw material is made：10 parts of Selaginella tamariscina, 10 parts of field pennycress, 10 parts of gulfweed, 10 parts of red-spotted stonecrop, scissors grass 10 parts, 5 parts of puncture vine, 5 parts of, Bi Collettiis,
10 parts of tangerine leaf, 15 parts of the rhizome of davallia, 15 parts of radix achyranthis bidentatae.
3. the method for preparing the Chinese medicine composition for the treatment of salpingitis of layer chicken described in claims 1 or 2, which is characterized in that will be upper
It states raw material and dries 3-5h at 55-70 DEG C, 60-100 mesh sieve is crossed in cooling, crushing, is mixed in proportion.
4. a kind of Chinese medicine preparation for treating salpingitis of layer chicken, which is characterized in that including above-mentioned Chinese medicine composition and pharmaceutically may be used
The auxiliary material of receiving.
5. according to claim 4 treat salpingitis of layer chicken Chinese medicine preparation, which is characterized in that the Chinese medicine preparation be but
It is not limited only to：Granule, decoction, powder, oral solution, pill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111789913A (en) * | 2020-08-11 | 2020-10-20 | 新乡市和协动物药业有限公司 | Traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application |
| CN111990533A (en) * | 2020-09-21 | 2020-11-27 | 天津纳尔生物科技有限公司 | Fermented eucommia ulmoides leaf extract and application thereof in preparation of chicken feed |
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| CN101658245A (en) * | 2009-08-26 | 2010-03-03 | 王直军 | Chinese medicinal feed additive for preventing and treating hen salpingitis |
| CN103735832A (en) * | 2014-01-27 | 2014-04-23 | 山东新希望六和集团有限公司 | Medicament for treating chicken salpingitis and preparation method thereof |
| CN105535379A (en) * | 2016-01-12 | 2016-05-04 | 北京康华远景科技股份有限公司 | Medicinal composition for preventing and treating laying hen salpingitis and preparation method of medicinal composition |
| CN105560828A (en) * | 2015-12-30 | 2016-05-11 | 广西普大动物保健品有限公司 | Preparation method of traditional Chinese medicine powder for preventing and treating laying hen salpingitis |
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Patent Citations (4)
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| CN101658245A (en) * | 2009-08-26 | 2010-03-03 | 王直军 | Chinese medicinal feed additive for preventing and treating hen salpingitis |
| CN103735832A (en) * | 2014-01-27 | 2014-04-23 | 山东新希望六和集团有限公司 | Medicament for treating chicken salpingitis and preparation method thereof |
| CN105560828A (en) * | 2015-12-30 | 2016-05-11 | 广西普大动物保健品有限公司 | Preparation method of traditional Chinese medicine powder for preventing and treating laying hen salpingitis |
| CN105535379A (en) * | 2016-01-12 | 2016-05-04 | 北京康华远景科技股份有限公司 | Medicinal composition for preventing and treating laying hen salpingitis and preparation method of medicinal composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111789913A (en) * | 2020-08-11 | 2020-10-20 | 新乡市和协动物药业有限公司 | Traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application |
| CN111789913B (en) * | 2020-08-11 | 2022-02-01 | 新乡市和协动物药业有限公司 | Traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application |
| CN111990533A (en) * | 2020-09-21 | 2020-11-27 | 天津纳尔生物科技有限公司 | Fermented eucommia ulmoides leaf extract and application thereof in preparation of chicken feed |
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