CN111789913A - Traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application - Google Patents

Traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application Download PDF

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Publication number
CN111789913A
CN111789913A CN202010800627.0A CN202010800627A CN111789913A CN 111789913 A CN111789913 A CN 111789913A CN 202010800627 A CN202010800627 A CN 202010800627A CN 111789913 A CN111789913 A CN 111789913A
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parts
chinese medicine
traditional chinese
laying hens
compound preparation
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CN111789913B (en
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张作栋
常守海
王永梅
孙庆建
张宪磷
匡米可
黄顺明
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Xinxiang Hexie Animal Pharmaceutical Co ltd
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Xinxiang Hexie Animal Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application thereof, and relates to the technical field of veterinary medicines. The traditional Chinese medicine compound preparation comprises the following traditional Chinese medicine components in parts by weight: 10-20 parts of dandelion, 5-15 parts of nux vomica, 10-20 parts of gypsum, 5-15 parts of safflower, 5-15 parts of motherwort, 5-15 parts of hedysarum polybotrys, 5-15 parts of flastem milkvetch seed, 5-15 parts of rhizoma polygonati and 5-15 parts of rhizoma cyperi. The traditional Chinese medicine components adopted by the invention are reasonable in compatibility, and the traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, expelling toxin and the like by combining the traditional Chinese medicine components. The traditional Chinese medicine compound preparation has a definite curative effect on preventing and treating salpingitis of the laying hens, and can obviously improve the health condition of the laying hens, improve the egg yield, reduce the defective egg rate, improve the egg yield, improve the production performance of the laying hens and increase the production benefit. The invention is prepared from natural traditional Chinese medicines, has strong pertinence, obvious curative effect, no drug resistance, drug residue and no toxic and harmful substances, and is more beneficial to human health.

Description

Traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application
Technical Field
The invention relates to the technical field of veterinary drugs, and in particular relates to a traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application thereof.
Background
With the rapid development of Chinese laying hen intensive breeding industry, diseases caused by bacteria or viruses are increased day by day, laying hen salpingitis caused by bacteria such as escherichia coli is a common disease of chickens, particularly laying hens, and is common in the laying period and the egg laying peak period. Laying hens infected with salpingitis are mainly characterized by pain, rigidity, drooping of two wings, loose feathers, leaning to the ground or lethargy of some abdomens, the produced eggs often have bloodstains on the eggshells, pus-like secretion is often discharged in the fallopian tubes, the feathers around and below the anus are polluted, the egg laying is difficult, the egg laying rate is obviously reduced, and the laying hens are easy to lay soft-shell eggs, thin-shell eggs, malformed eggs, preserved eggs, small-sized eggs and white preserved eggs.
In order to prevent and treat diseases such as salpingitis of laying hens and the like, farmers often add chemosynthetic drugs such as antibiotics and the like into feed or drinking water. The antibiotics are widely used in the breeding of the laying hens, and the production performance, the laying rate and the feed-egg ratio of the laying hens are improved to a certain extent. However, the wide application of antibiotics easily causes the strains to generate drug resistance, which not only affects the quality of eggs, but also remains in eggs and is harmful to human health. Therefore, a green and pollution-free preparation is urgently needed to be found and applied to the production of the laying hens, and the aims of preventing and treating reproductive diseases of the laying hens, improving the production performance, improving the egg quality and the like are fulfilled.
Chinese herbal medicines are concerned with due to the unique advantages of naturalness, multifunctionality, no toxic or side effect, no drug resistance and the like. The Chinese herbal medicine can treat diseases such as salpingitis of the laying hens, can provide a large amount of nutrient substances such as amino acid, vitamin, trace elements and the like for animals, can improve the utilization rate of feed and promote the growth of the laying hens, is rich in natural bioactive substances such as polysaccharide, organic acid, flavonoid, alkaloid and the like, can enhance the immunity of organisms, prevent and treat the diseases and keep the health, and therefore plays an important role in the breeding industry.
Veterinary common diarrhea-stopping granule, Chinese pulsatilla root oral liquid, white dragon granule and the like, and researches find that the preparation has poor effect and is easy to repeat when being used for treating salpingitis of laying hens; the Chinese medicinal powder for treating the salpingitis of the laying hens, which is prepared from the egg activating powder and the egg increasing powder, has the advantages of low cure rate, slow effect, low cost performance and the like in clinic, so that the development of the Chinese medicinal preparation for treating the salpingitis of the laying hens, which has a definite curative effect, is green and economic, has no resistance and toxic or side effect, is urgently needed.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a Chinese herbal compound preparation for treating laying hen salpingitis, which has the advantages of definite curative effect, no resistance, no toxic or side effect and no pollution, and an application thereof.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme:
on one hand, the invention provides a traditional Chinese medicine compound preparation for treating salpingitis of laying hens, which comprises the following traditional Chinese medicine components in parts by weight: 10-20 parts of dandelion, 5-15 parts of nux vomica, 10-20 parts of gypsum, 5-15 parts of safflower, 5-15 parts of motherwort, 5-15 parts of hedysarum polybotrys, 5-15 parts of flastem milkvetch seed, 5-15 parts of rhizoma polygonati and 5-15 parts of rhizoma cyperi.
Further, as a further optimization of the traditional Chinese medicine compound preparation for treating salpingitis of the laying hens, the traditional Chinese medicine compound preparation comprises the following traditional Chinese medicine components in parts by weight: 14-18 parts of dandelion, 8-12 parts of nux vomica, 13-18 parts of gypsum, 8-12 parts of safflower, 8-12 parts of motherwort, 8-12 parts of hedysarum polybotrys, 8-12 parts of flastem milkvetch seed, 8-12 parts of rhizoma polygonati and 8-12 parts of rhizoma cyperi.
Further, as a further optimization of the traditional Chinese medicine compound preparation for treating salpingitis of the laying hens, the traditional Chinese medicine compound preparation comprises the following traditional Chinese medicine components in parts by weight: 15 parts of dandelion, 10 parts of nux vomica, 15 parts of gypsum, 10 parts of safflower, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flastem milkvetch seed, 10 parts of rhizoma polygonati and 10 parts of rhizoma cyperi.
Further, as a further optimization of the traditional Chinese medicine compound preparation for treating salpingitis of the laying hens, the dosage form of the traditional Chinese medicine compound preparation is powder or granules.
On the other hand, the invention provides a preparation method of a traditional Chinese medicine compound preparation for treating salpingitis of laying hens, which comprises the following steps:
(1) weighing the following traditional Chinese medicine components in parts by weight: 10-20 parts of dandelion, 5-15 parts of nux vomica, 10-20 parts of gypsum, 5-15 parts of safflower, 5-15 parts of motherwort, 5-15 parts of hedysarum polybotrys, 5-15 parts of flastem milkvetch seed, 5-15 parts of rhizoma polygonati and 5-15 parts of rhizoma cyperi; cleaning the raw materials, drying and crushing, and uniformly mixing to obtain traditional Chinese medicine coarse powder;
(2) decocting the coarse powder of the traditional Chinese medicine obtained in the step (1) with water for three times, each time lasting for 3 hours, then combining the decoctions, standing for 24 hours, filtering, concentrating the filtrate to a relative density of 1.24-1.26, and cooling to room temperature for later use;
(3) adding 65% ethanol into the concentrated filtrate obtained in the step (2), wherein the amount of the ethanol is 2.5-3 times of the weight of the filtrate, standing overnight, filtering, recovering ethanol from the filtrate, and concentrating to relative density of 1.42-1.44 to obtain Chinese medicinal fluid extract;
(4) and (4) spray-drying the traditional Chinese medicine clear paste obtained in the step (3), preparing into granules, sterilizing and packaging to obtain the traditional Chinese medicine compound preparation.
The invention also provides application of the traditional Chinese medicine compound preparation for treating salpingitis of the laying hens, and the traditional Chinese medicine compound preparation is used for treating the salpingitis of the laying hens, and the specific dosage is as follows: (1) the dosage form of the Chinese medicinal compound preparation is powder, and 1500 jin of the material is mixed every 1000 g; (2) the Chinese medicine compound preparation is granules, and 150 liters of mixed water is used for every 100 g.
The traditional Chinese medicine compound preparation of the invention has the following pharmacological actions of the traditional Chinese medicine components:
dandelion: bitter and sweet in taste, cold in nature, entering liver and stomach meridians; has effects in clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, and inducing diuresis for treating stranguria; can be used for treating furuncle, swelling, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, stranguria with heat, and pain; the composition contains effective components such as flavonoids, coumarins, phenolic acids, terpenes, sterols, polysaccharides and the like, and clinical researches show that the composition has pharmacological effects of bacteriostasis, antioxidation, anti-inflammation, anti-tumor gastrointestinal protection and the like.
Nux vomica: bitter taste, warm nature, entering liver and spleen meridians; has the effects of dredging collaterals, relieving pain, resolving hard mass and relieving swelling; can be used for treating traumatic injury, rheumatism, numbness, paralysis, and sore throat; the nux vomica extract contains alkaloids, terpenoids, steroids and glycosides thereof, organic acids and other effective components, and researches show that the nux vomica has the pharmacological effects of resisting tumors, regulating immunity, resisting inflammation and easing pain, regulating small intestine movement and the like.
Gypsum: sweet and pungent in flavor and cold in nature, entering lung and stomach meridians; has effects in expelling pathogenic factors from the exterior, expelling pathogenic factors from the muscles, clearing away heat, purging pathogenic water, relieving restlessness, and quenching thirst; can be used for treating common cold, fever, polydipsia, lung heat, cough, asthma, excessive stomach fire, headache, and toothache; gypsum Fibrosum contains various microelements such as calcium, ferrum, zinc, manganese, copper, etc., and has effects of enhancing organism immunity and resisting virus.
Safflower: pungent taste and warm nature, entering heart and liver meridians; has the effects of promoting blood circulation, dredging channels, removing blood stasis and relieving pain; can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, and pyocutaneous disease with swelling and pain; it comprises chemical components such as flavonoids, steroids, phenolic acids, diols, lignans, chalcones, alkynes and volatile oil, wherein carthamin is used as a main active component.
Motherwort: bitter and pungent in flavor, slightly cold in nature, entering liver, pericardium and bladder meridians; has effects in promoting blood circulation, regulating menstruation, promoting urination, relieving swelling, and clearing away heat and toxic materials; can be used for treating menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema, oliguria, pyocutaneous disease, and toxic swelling; it contains chemical components such as alkaloid, diterpene, flavone, phenylethanoid glycoside, phenylpropanoid, coumarin, triterpene, organic acid, volatile oil, etc.; the study shows that the motherwort can obviously improve the production performance of the laying hens in the initial stage and enhance the immunity of the organism.
Radix hedysari: sweet in taste, slightly cold in nature, entering lung and spleen meridians; has effects in invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, removing toxic materials, expelling pus, healing sore, and promoting granulation; can be used for treating deficiency of qi, asthenia, anorexia, loose stool, metrorrhagia, sallow complexion due to blood deficiency, and edema due to qi deficiency; modern pharmacological research shows that the astragalus polysaccharide has the effects of strengthening heart, promoting urination, reducing blood pressure, protecting liver, resisting inflammation, improving immunity and the like, and the main component of the astragalus is the astragalus polysaccharide, so that nonspecific and specific immunity can be obviously improved.
Flatstem milkvetch seed: sweet in flavor and warm in nature, and enters liver and kidney meridians; has effects of warming and invigorating liver and kidney, arresting spontaneous emission, arresting polyuria, and improving eyesight; can be used for treating lumbago due to kidney deficiency, spermatorrhea, premature ejaculation, leukorrhagia due to turbid urine, vertigo, and blurred vision; it mainly contains triterpene glycoside, flavone and many kinds of glycoside, isoflavone glycoside, amino acid and many kinds of fatty acid compounds and a large amount of trace elements; modern pharmacological research shows that the traditional Chinese medicine composition has the effects of contracting uterus and reducing urination, reducing blood pressure, resisting inflammation, protecting liver, resisting oxidation, improving blood rheological property, inhibiting platelet aggregation, regulating blood fat and the like.
Rhizoma polygonati: sweet in taste and neutral in nature, and has the effects of tonifying qi and yin, invigorating spleen, moistening lung and tonifying kidney, and the spleen, lung and kidney meridians are entered; can be used for treating deficiency of spleen-stomach qi, asthenia, essence and blood deficiency, xerostomia, anorexia, internal heat, and diabetes; rhizoma polygonati contains various chemical components such as polysaccharide, oligosaccharide, flavone, steroidal saponins, alkaloid, lignan, amino acid, inorganic elements, volatile oil and the like, and modern pharmacological research shows that the rhizoma polygonati has the effects of resisting oxidation, reducing blood sugar, regulating immunity, resisting bacteria, resisting inflammation and the like.
Rhizoma cyperi: pungent, slightly bitter, slightly sweet, neutral in nature, entering liver, spleen and triple energizer meridians; has effects in dispersing stagnated liver qi, relieving qi stagnation, regulating qi-flowing, relieving epigastric distention, regulating menstruation, and relieving pain; it is clinically used for treating liver qi stagnation, distending pain in chest and hypochondrium, qi stagnation in spleen and stomach, abdominal distention and fullness, distention and pain, menoxenia, amenorrhea and dysmenorrhea; the rhizoma cyperi contains volatile oil, flavone, alkaloid, triterpene, sterol, anthraquinone and other chemical components; modern pharmacological research shows that the rhizoma cyperi can act on a central nervous system, a cardiovascular system, a cerebrovascular system and a digestive system, can relax uterine smooth muscle, and has estrogen-like effects, depression resistance, blood sugar and blood fat reduction, anti-inflammatory, antibacterial, anti-tumor and other effects.
(III) advantageous effects
The invention provides a traditional Chinese medicine compound preparation for treating salpingitis of laying hens and application thereof. The Chinese medicinal compound preparation is prepared by reasonably mixing nine Chinese medicinal herbs such as dandelion, nux vomica, gypsum, safflower and the like according to the traditional Chinese medicine syndrome differentiation treatment principle, fully exerts the functions of the medicaments, has the effects of coordinating the medicaments and increasing the medicament effect, and has the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, expelling toxin and the like. Animal experiments and clinical experiments show that the traditional Chinese medicine compound preparation has a definite curative effect on preventing and treating salpingitis of the laying hens, and can obviously improve the health condition of the laying hens, improve the egg yield, reduce the defective egg rate, improve the egg yield, improve the production performance of the laying hens and increase the production benefit. The invention is prepared from natural traditional Chinese medicines, has strong pertinence, obvious curative effect, no drug resistance, drug residue and no toxic and harmful substances, and is more beneficial to human health.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A traditional Chinese medicine compound preparation for treating salpingitis of laying hens is prepared according to the following steps:
(1) weighing the following traditional Chinese medicine components in parts by weight: 10 parts of dandelion, 5 parts of nux vomica, 10 parts of gypsum, 5 parts of safflower, 5 parts of motherwort, 5 parts of radix hedysari, 5 parts of flatstem milkvetch seed, 5 parts of rhizoma polygonati and 5 parts of rhizoma cyperi; cleaning the raw materials, drying and crushing, and uniformly mixing to obtain traditional Chinese medicine coarse powder;
(2) decocting the coarse powder of the traditional Chinese medicine obtained in the step (1) with water for three times, each time lasting for 3 hours, then combining the decoctions, standing for 24 hours, filtering, concentrating the filtrate to a relative density of 1.24-1.26, and cooling to room temperature for later use;
(3) adding 65% ethanol into the concentrated filtrate obtained in the step (2), wherein the amount of the ethanol is 2.5-3 times of the weight of the filtrate, standing overnight, filtering, recovering ethanol from the filtrate, and concentrating to relative density of 1.42-1.44 to obtain Chinese medicinal fluid extract;
(4) and (4) spray-drying the traditional Chinese medicine clear paste obtained in the step (3), preparing into granules, sterilizing and packaging to obtain the traditional Chinese medicine compound preparation.
The prepared traditional Chinese medicine compound preparation is used for treating salpingitis of laying hens, and the specific dosage is as follows: 150 liters per 100g of mixed water.
Example 2
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 20 parts of dandelion, 15 parts of nux vomica, 20 parts of gypsum, 15 parts of safflower, 15 parts of motherwort, 15 parts of radix hedysari, 15 parts of flastem milkvetch seed, 15 parts of rhizoma polygonati and 15 parts of rhizoma cyperi.
Example 3
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 18 parts of dandelion, 12 parts of nux vomica, 18 parts of gypsum, 12 parts of safflower, 12 parts of motherwort, 12 parts of radix hedysari, 12 parts of flastem milkvetch seed, 12 parts of rhizoma polygonati and 12 parts of rhizoma cyperi.
Example 4
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 14 parts of dandelion, 8 parts of nux vomica, 13 parts of gypsum, 8 parts of safflower, 8 parts of motherwort, 8 parts of radix hedysari, 8 parts of flastem milkvetch seed, 8 parts of rhizoma polygonati and 8 parts of rhizoma cyperi.
Example 5
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 15 parts of dandelion, 10 parts of nux vomica, 15 parts of gypsum, 10 parts of safflower, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flastem milkvetch seed, 10 parts of rhizoma polygonati and 10 parts of rhizoma cyperi.
Example 6
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 12 parts of dandelion, 6 parts of nux vomica, 12 parts of gypsum, 6 parts of safflower, 14 parts of motherwort, 6 parts of radix hedysari, 6 parts of flastem milkvetch seed, 14 parts of rhizoma polygonati and 8 parts of rhizoma cyperi.
Example 7
(1) Weighing the following traditional Chinese medicine components in parts by weight: 15 parts of dandelion, 10 parts of nux vomica, 15 parts of gypsum, 10 parts of safflower, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flastem milkvetch seed, 10 parts of rhizoma polygonati and 10 parts of rhizoma cyperi; cleaning the raw materials, drying and crushing, and uniformly mixing to obtain traditional Chinese medicine coarse powder;
(2) and (2) crushing the Chinese medicinal coarse powder obtained in the step (1) again to obtain Chinese medicinal superfine powder with the particle size of 300-.
The prepared traditional Chinese medicine compound preparation is used for treating salpingitis of laying hens, and the specific dosage is as follows: 1500 jin per 1000g of the material.
The invention adopts the theory of traditional Chinese medicine, selects medicinal materials and makes the prescription of the medicinal materials, and because the experimental data is more, the prescription is adjusted and tested for many times, only a plurality of groups of prescriptions with higher curative effect are listed and compared with the prescription of the invention.
Formula 1: 10 parts of nux vomica, 15 parts of gypsum, 10 parts of safflower, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flatstem milkvetch seed and 10 parts of rhizoma polygonati.
And (2) formula: 15 parts of dandelion, 10 parts of safflower, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flatstem milkvetch seed, 10 parts of rhizoma polygonati and 10 parts of rhizoma cyperi.
And (3) formula: 15 parts of dandelion, 10 parts of nux vomica, 15 parts of gypsum, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flatstem milkvetch seed and 10 parts of rhizoma cyperi.
And (4) formula: 15 parts of dandelion, 10 parts of nux vomica, 15 parts of gypsum, 10 parts of safflower, 10 parts of rhizoma polygonati and 10 parts of rhizoma cyperi.
The formula of the invention is as follows: 15 parts of dandelion, 10 parts of nux vomica, 15 parts of gypsum, 10 parts of safflower, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flastem milkvetch seed, 10 parts of rhizoma polygonati and 10 parts of rhizoma cyperi.
The Chinese medicinal preparations are respectively prepared according to the formulas, the preparation steps are prepared according to the steps of example 1, and the Chinese medicinal granules under each formula are respectively obtained.
The test method comprises the following steps:
selecting SPF SD rats, female rats, 80 rats and body mass (185 +/-15 g); the method of the reference literature (Zhanghouxiang, Qiuhao, Chengjing, etc. an experimental study on the treatment of chronic salpingitis by an anti-inflammatory and vein-relaxing enema method [ J ] Chinese traditional medicine, 2013, 31 (6): 1378-1381.) adopts a mixed strain inoculation method to prepare a rat model of chronic salpingitis. The 10% chloral hydrate is used for performing intraperitoneal injection anesthesia according to the dose of 3mL/kg, the abdominal cavity is opened, the rats in other groups except the blank group are respectively injected with 20 mu L of mixed bacterial liquid to the two oviducts at the position of the uterus close to the oviducts, 20 mu L of physiological saline is injected into the blank group, and then the wound is sutured.
Rats are divided into a blank group, a model group, a positive control group, a formula 1-4 group and a traditional Chinese medicine granule group according to weight layering at random, and each group comprises 10 rats. The model is built for 7 groups except the blank group, the administration by gastric gavage is started 11 days after the model is built, 2mL of water for injection by gastric gavage is taken for rats in the blank group and the model group every day, 0.4g/kg of Jingangteng capsule is taken for the positive control group by gastric gavage, the traditional Chinese medicine particles obtained by the formulas 1 to 4 and the traditional Chinese medicine particles of the invention are respectively taken for oral gavage for the formulas 1 to 4 and the traditional Chinese medicine particles of the invention, the dose is 0.5g/kg, and the continuous administration is carried out for.
After 25 days of administration, rats are anesthetized with 10% chloral hydrate, blood is taken from abdominal aorta, serum is obtained by centrifugation, and indicators of proinflammatory factors IL-2, IL-6 and TNF-alpha related to salpingitis of the serum of the rats are detected by an enzyme-linked immunosorbent assay (ELISA). The results are shown in Table 1.
The experimental data are statistically analyzed by SPSS19.0 statistical software, and the results are expressed asxS, and comparisons between groups were tested using analysis of variance.
TABLE 1 detection results of inflammation-related indices in rat serum (' sx±s)
Group of n IL-2(pg/mL) IL-6(pg/mL) TNF-α(pg/mL)
Blank group 10 1.56±0.03 123.65±11.36 192.36±5.12
Model set 10 1.87±0.07a 181.97±15.44a 298.10±4.99 a
Positive control group 10 1.73±0.11ab 157.22±9.71 ab 255.42±9.70 ab
Formulation 1 group 10 1.69±0.14ab 150.78±13.74 ab 248.09±9.33 ab
Formulation 2 group 10 1.71±0.02ab 156.03±11.00 ab 253.03±4.61 ab
Formulation 3 group 10 1.70±0.05ab 154.69±14.52 ab 250.85±7.16 ab
Formulation 4 group 10 1.74±0.13ab 162.40±8.91 ab 258.31±5.49 ab
The invention relates to a traditional Chinese medicine granule group 10 1.61±0.20bc 139.16±12.03 abc 238.45±7.36 abc
Note: a <0.05 compared to blank; b <0.05 compared to model group; c P <0.05 compared to positive control group.
Compared with the blank group, the indexes of the serum IL-6 and TNF-alpha of the model group, the positive control group, the formula 1-4 groups and the traditional Chinese medicine granule group are obviously improved and have significant difference (P is less than 0.05); compared with the model group, the serum IL-6 and TNF-alpha indexes of the positive control group, the formula 1-4 groups and the traditional Chinese medicine granule group are obviously reduced and have significant difference (P is less than 0.05); the serum IL-6 and TNF-alpha indexes of the traditional Chinese medicine granule group are obviously reduced compared with those of a positive control group and a formula 1-4 group, and the obvious difference (P < 0.05) exists, and the results are detailed in a table 1.
Compared with the blank group, the serum IL-2 indexes of the model group, the positive control group and the formula 1-4 groups are obviously increased and have significant difference (P is less than 0.05); compared with the model group, the serum IL-2 indexes of the positive control group, the formula 1-4 groups and the traditional Chinese medicine granule group are obviously reduced and have significant difference (P is less than 0.05); the serum IL-2 index of the traditional Chinese medicine granule group is obviously reduced and has obvious difference (P is less than 0.05) compared with the positive control group and the formula 1-4 groups, and the result of the serum IL-2 index of the traditional Chinese medicine granule group has no obvious difference (P is more than 0.05) compared with the blank group is detailed in table 1.
The test results show that the traditional Chinese medicine granules can obviously relieve salpingitis of a rat salpingitis model caused by mixed bacteria, can more obviously reduce the contents of IL-2, IL-6 and TNF-alpha in serum compared with the formula 1-4 groups, and have more effective anti-inflammatory action. The Chinese medicinal compound preparation is prepared from nine Chinese medicinal herbs such as dandelion, nux vomica, gypsum, safflower and the like by reasonable compatibility according to the traditional Chinese medicine syndrome differentiation treatment principle, the effects of all the medicaments are fully exerted, all the medicaments coordinate to enhance the medicinal effect, and all the ingredients in the formula are absent.
To further illustrate the therapeutic effect of the present invention's dispersed granules on salpingitis of laying hens, animal experiments are provided below as an illustration. The following Chinese medicinal granules are prepared according to example 5, and the powder is prepared according to example 7.
1 materials and methods
1.1 test drugs
The traditional Chinese medicine granule, the traditional Chinese medicine powder, the amoxicillin soluble powder with the concentration of 10 percent and the egg activating powder
1.2 test animals
2000 feathers of 360-day-old laying hens are randomly divided into five groups, namely a blank group, a test group 1, a test group 2, a drug control group 1 and a drug control group 2. Each group has 500 feathers. Before the test is started, the chickens have the characteristics of salpingitis symptoms such as turbid egg white, soft eggs, blood spot eggs, preserved eggs, low laying rate and the like, and the defective egg rate is 3-4% every day.
1.3 test methods
1.3.1 the drugs are dosed (mixed or mixed with water) in the feed according to the dosage shown in the table 2, the drugs are continuously dosed for 7 days, and the drugs are stopped after 7 days.
TABLE 2 test groups and drug administration dose
1.3.2 Each group experiment was carried out under the same feeding conditions. The 360 day old chickens began weighing and counting the eggs laid by the entire experimental group 7 days before the experiment, and the eggs laid by the entire experimental group were weighed and counted within half a month from the beginning of the experiment.
1.3.3 items of observation measurement: observing the change and health condition of chicken group every day, recording feed intake, egg yield, egg weight, and number of eggs (including soft egg, egg with blood spot, preserved egg, broken egg, etc.), and calculating feed-egg ratio and laying rate.
Treatment effect judgment standard: (1) the method has the following advantages: the disease chicken recovers the normal spirit and appetite, the disease chicken gradually recovers, the laying rate is increased, the number of inferior eggs is reduced, and the disease chicken recurs in the observation period; (2) and (3) curing: the spirit and the appetite of the sick chicken are recovered to be normal, the laying rate is increased to some extent, the number of inferior eggs is reduced, and the bad eggs do not relapse; (3) and (4) invalidation: after the medicine is taken, the symptoms of the sick chicken are not relieved, even aggravated or dead, the laying rate is continuously reduced, and the number of inferior eggs is increased.
2 results and analysis
2.1 clinical manifestations of egg-laying hens
After the treatment period is finished, the hens in the test groups 1 and 2 and the hens in the drug control groups 1 and 2 have better mental recovery, the drinking water and the eating are normal, the laying rate is increased, the number of the inferior eggs is obviously reduced, and the results in the table 3 show that the cure rate and the effective number of the test groups 1 and 2 are both higher than those of the drug control groups 1 and 2, and the ineffective number is far lower than those of the drug control groups 1 and 2.
TABLE 3 therapeutic Effect of the groups of layers
Group of Quantity (only) Cure (only) Effective (only) Invalid (only) Cure rate (%)
Blank group 500
Test group 1 500 481 490 10 96.2
Test group 2 500 483 492 8 96.6
Control drug group 1 500 445 476 23 89.0
Control drug group 2 500 461 482 18 92.2
2.2 laying hen Productivity
As can be seen from the results in table 4, comparing the laying performance of the laying hens 7 days before and after the treatment period, firstly, the egg laying rates of the test groups 1 and 2 and the control drug groups 1 and 2 are obviously increased, the egg laying rates are respectively increased by 3.0%, 5%, 1.8% and 2.2%, and the egg laying rate of the blank group is reduced; the egg weight of the blank group is reduced, the egg ratio is increased, the feed-egg ratio is increased, the egg weight of the test groups 1 and 2 and the egg weight of the drug control groups 1 and 2 are increased, the egg ratio is also reduced, and the feed-egg ratio is obviously reduced; compared with the drug control groups 1 and 2, the test groups 1 and 2 show more excellent production performance, and from the result, the laying rate of the test groups 1 and 2 is about 0.8-3.2% higher than that of the drug control groups 1 and 2, the egg laying rate of the test groups 1 and 2 is kept below 1%, and the feed-egg ratio is obviously reduced. The results are consistent with the clinical manifestations of the laying hens, which shows that the traditional Chinese medicine compound preparation disclosed by the invention has more advantages and more obvious curative effects on the treatment of salpingitis of the laying hens, and is expected to replace the traditional veterinary medicines and avoid the use of antibiotics. The dosage form of the traditional Chinese medicine compound preparation has no influence on the drug effect, and test results show that the powder and the granules both have excellent prevention and treatment effects on the salpingitis of the laying hens.
TABLE 4 egg-laying hen production Performance
Discussion of 3
The Chinese medicinal compound preparation is prepared by reasonably mixing nine Chinese medicinal herbs such as dandelion, nux vomica, gypsum, safflower and the like according to the traditional Chinese medicine syndrome differentiation treatment principle, fully exerts the functions of the medicaments, has the effects of coordinating the medicaments and increasing the medicament effect, and has the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, expelling toxin and the like. The tests can prove that the traditional Chinese medicine compound preparation has a definite curative effect on preventing and treating salpingitis of the laying hens, and the laying rate can be obviously improved, the health condition of the laying hens is improved, the defective egg rate is reduced, the laying rate is improved, the production performance of the laying hens is improved, and the production benefit is increased. The invention is prepared from natural traditional Chinese medicines, has strong pertinence, obvious curative effect, no drug resistance, drug residue and no toxic and harmful substances, and is more beneficial to human health.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (6)

1. The traditional Chinese medicine compound preparation for treating salpingitis of the laying hens is characterized by comprising the following traditional Chinese medicine components in parts by weight: 10-20 parts of dandelion, 5-15 parts of nux vomica, 10-20 parts of gypsum, 5-15 parts of safflower, 5-15 parts of motherwort, 5-15 parts of hedysarum polybotrys, 5-15 parts of flastem milkvetch seed, 5-15 parts of rhizoma polygonati and 5-15 parts of rhizoma cyperi.
2. The compound traditional Chinese medicine preparation for treating salpingitis of laying hens according to claim 1, which is prepared from the following traditional Chinese medicine components in parts by weight: 14-18 parts of dandelion, 8-12 parts of nux vomica, 13-18 parts of gypsum, 8-12 parts of safflower, 8-12 parts of motherwort, 8-12 parts of hedysarum polybotrys, 8-12 parts of flastem milkvetch seed, 8-12 parts of rhizoma polygonati and 8-12 parts of rhizoma cyperi.
3. The compound traditional Chinese medicine preparation for treating salpingitis of laying hens according to claim 1, which is prepared from the following traditional Chinese medicine components in parts by weight: 15 parts of dandelion, 10 parts of nux vomica, 15 parts of gypsum, 10 parts of safflower, 10 parts of motherwort, 10 parts of radix hedysari, 10 parts of flastem milkvetch seed, 10 parts of rhizoma polygonati and 10 parts of rhizoma cyperi.
4. The compound traditional Chinese medicine preparation for treating salpingitis of laying hens according to claim 1, wherein the dosage form of the compound traditional Chinese medicine preparation is powder or granules.
5. The preparation method of the traditional Chinese medicine compound preparation for treating salpingitis of laying hens, which is disclosed by claim 1, is characterized by comprising the following steps of:
(1) weighing the following traditional Chinese medicine components in parts by weight: 10-20 parts of dandelion, 5-15 parts of nux vomica, 10-20 parts of gypsum, 5-15 parts of safflower, 5-15 parts of motherwort, 5-15 parts of hedysarum polybotrys, 5-15 parts of flastem milkvetch seed, 5-15 parts of rhizoma polygonati and 5-15 parts of rhizoma cyperi; cleaning the raw materials, drying and crushing, and uniformly mixing to obtain traditional Chinese medicine coarse powder;
(2) decocting the coarse powder of the traditional Chinese medicine obtained in the step (1) with water for three times, each time lasting for 3 hours, then combining the decoctions, standing for 24 hours, filtering, concentrating the filtrate to a relative density of 1.24-1.26, and cooling to room temperature for later use;
(3) adding 65% ethanol into the concentrated filtrate obtained in the step (2), wherein the amount of the ethanol is 2.5-3 times of the weight of the filtrate, standing overnight, filtering, recovering ethanol from the filtrate, and concentrating to relative density of 1.42-1.44 to obtain Chinese medicinal fluid extract;
(4) and (4) spray-drying the traditional Chinese medicine clear paste obtained in the step (3), preparing into granules, sterilizing and packaging to obtain the traditional Chinese medicine compound preparation.
6. The application of the traditional Chinese medicine compound preparation for treating salpingitis of laying hens, which is disclosed by claim 1, is characterized in that the traditional Chinese medicine compound preparation is a medicine for treating salpingitis of laying hens, and the specific dosage is as follows: (1) the dosage form of the Chinese medicinal compound preparation is powder, and 1500 jin of the material is mixed every 1000 g; (2) the Chinese medicine compound preparation is granules, and 150 liters of mixed water is used for every 100 g.
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