CN103735832A - Medicament for treating chicken salpingitis and preparation method thereof - Google Patents
Medicament for treating chicken salpingitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating chicken salpingitis and a preparation method thereof. The medicament comprises the following raw medicinal materials: radix codonopsis, prepared rehmannia root, siberian nitraria fruit, litchi, bornet cowlily rhizome, sichuan lovage rhizome, melia toosendan, gordon euryale, gypsum, medlar, human placenta, radix ophiopogonis, kapok, loofah sponge and liquorice. The medicament disclosed by the invention has the beneficial effects that the main therapeutic principle of the medicament is to consolidatie basis, clear heat, promote dampness and activate blood circulation to stasis and dredge collaterals; the medicament has the advantages of obvious treating effect, short curing time, no toxic or side effect and no medicament residue during treatment of the chicken salpingitis; furthermore, the laying rate of laying hens can be increased, and the physique and the disease resistance of the laying hens are improved.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of Chicken salpingitis and preparation method thereof.
Background technology
Chicken salpingitis is the common reproductive system disease of chicken, and cause of disease is one or several mixed infection of antibacterial, mycoplasma, anaerobe and infusorian etc., and take clinically ovary, fallopian tube, peritoneal inflammation is feature, when serious, follicle distortion, congested, hemorrhage, is bronzing or taupe, even breaks, the egg yolk liquid breaking in abdominal cavity, taste stench, follicle shrinkage sometimes, shape is irregular, be golden yellow or brown, tarnish, when the state of an illness is slightly long, intestinal adhesion, fallopian tube has the cheesy thing of yellow-white.Cause of disease more complicated is to threaten one of poultry husbandry sound development frequently-occurring disease.
Pouity dwelling place sanitary condition is too poor, and cloaca is polluted and intrusion fallopian tube by antibacterial (as Salmonella pullorum, Salmonella paratyphi, escherichia coli etc.); Or feeding animals forage is too much, lay eggs excessive or produce double-yolked egg, eggshell breaks in fallopian tube sometimes, damage fallopian tube; Or lay eggs too much, be deficient in vitamin in feedstuff A, D, E etc. all can cause salpingitis.Poultry suffers from salpingitis, tends to cause prolapse of fallopian tube, difficult labour etc.
Sick fowl main manifestations is that pain is uneasy, on its eggshell of the egg of output often with bloodstain.In fallopian tube, often discharge yellow, white pus sample secretions, pollute anus around and feather below, the difficulty of laying eggs.Along with the development of the state of an illness, sick fowl starts heating, and after heat is moved back, painful uneasy, stands transfixed to the ground, and two wings are sagging, and disorderly, some abdominal paries, by ground or lethargy, can cause peritonitis, or salpingorrhexis cause yolk peritonitis to feather pine when inflammation spreads to abdominal cavity.
Western medical treatment Chicken salpingitis: should isolate immediately inspection after morbidity, rest in cloaca if any egg ovum, pour into lubricant class in cloaca, impel ovum is excreted.Then with potassium permanganate liquid injection cloaca and the fallopian tube bottom of syringe suction warm water or low concentration, rinse the egg drop reduction that unknown cause causes: ovum health (100g is watered 2000 jin) jin drinking-water, many ovum of egg fowl element+Bai Yang egg good fortune spice; The egg drop reduction that virosis causes: ovum health drinking-water, many ovum of egg fowl element+Antiphlogistic Powder of Schizonepetae and Ledebouriellae spice.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine that is used for the treatment of Chicken salpingitis, for treatment Chicken salpingitis, have successful, healing time is short, has no side effect, the advantage of drug residue free, and can improve body constitution and the premunition of laying rate of laying hen, enhancing laying hen.
In order to realize foregoing invention object, the invention provides a kind of medicine that is used for the treatment of Chicken salpingitis, described medicine comprises following raw medicinal material: Radix Codonopsis, Radix Rehmanniae Preparata, Herba Carlinae biebersteinii, Fructus Litchi, Rhizoma Nupharis Bornetii, Rhizoma Chuanxiong, Fructus Toosendan, Semen Euryales, Gypsum Fibrosum, Fructus Lycii, Placenta Hominis, Radix Ophiopogonis, Flos Bombacis Malabarici, Retinervus Luffae Fructus and Radix Glycyrrhizae.
Described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion and Radix Glycyrrhizae 10-20 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion and Radix Glycyrrhizae 12-19 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portions, Radix Rehmanniae Preparata 15 weight portions, Herba Carlinae biebersteinii 14 weight portions, Fructus Litchi 19 weight portions, Rhizoma Nupharis Bornetii 17 weight portions, Rhizoma Chuanxiong 21 weight portions, Fructus Toosendan 14 weight portions, Semen Euryales 17 weight portions, Gypsum Fibrosum 14 weight portions, Fructus Lycii 25 weight portions, Placenta Hominis 17 weight portions, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portions, Retinervus Luffae Fructus 17 weight portions and Radix Glycyrrhizae 16 weight portions.
Described medicine also comprises: Cortex Hibisci, Flos Moutan, Litsea chenii, Herba Verbenae and Herba Malvastri Coromandeliani.
Described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion, Radix Glycyrrhizae 10-20 weight portion, Cortex Hibisci 10-15 weight portion, Flos Moutan 10-15 weight portion, Litsea chenii 15-20 weight portion, Herba Verbenae 15-20 weight portion and Herba Malvastri Coromandeliani 15-20 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion, Radix Glycyrrhizae 12-19 weight portion, Cortex Hibisci 12-15 weight portion, Flos Moutan 10-13 weight portion, Litsea chenii 15-18 weight portion, Herba Verbenae 15-18 weight portion and Herba Malvastri Coromandeliani 18-20 weight portion.
Described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portions, Radix Rehmanniae Preparata 15 weight portions, Herba Carlinae biebersteinii 14 weight portions, Fructus Litchi 19 weight portions, Rhizoma Nupharis Bornetii 17 weight portions, Rhizoma Chuanxiong 21 weight portions, Fructus Toosendan 14 weight portions, Semen Euryales 17 weight portions, Gypsum Fibrosum 14 weight portions, Fructus Lycii 25 weight portions, Placenta Hominis 17 weight portions, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portions, Retinervus Luffae Fructus 17 weight portions, Radix Glycyrrhizae 16 weight portions, Cortex Hibisci 13 weight portions, Flos Moutan 12 weight portions, Litsea chenii 17 weight portions, Herba Verbenae 16 weight portions and Herba Malvastri Coromandeliani 19 weight portions.
In order better to realize foregoing invention object, the invention provides a kind of preparation method that is used for the treatment of the medicine of Chicken salpingitis, described preparation method comprises:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 2～4 hours, and the amount of the water adding and the mass ratio of mixture are 6～9:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, medicinal residues after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 2～4 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 6～10:1, decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains mixture clear paste, and under 60 ℃ of conditions, the relative density of clear paste is 1.10～1.20;
The 5th step, in mixture clear paste, adding determining alcohol is 95% ethanol, obtains containing alcohol clear paste, the ethanol adding and the mass ratio of clear paste are 2～3:1;
The 6th step, will get supernatant containing alcohol clear paste standing 12～24h at room temperature, and clear paste residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, and is ground into powder, obtains drug powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: it is primary treatment principle that medicine of the present invention be take element culturing fixed folder, clearing away heat-damp and promoting diuresis, activating blood circulation to dissipate blood stasis and dredge the collateral, at treatment Chicken salpingitis, there is therapeutic effect obvious, healing time is short, have no side effect, the advantage of drug residue free, and can improve body constitution and the premunition of laying rate of laying hen, enhancing laying hen.
The specific embodiment
Theoretical according to Chinese veterinarian, along with the development of poultry husbandry, fowl disease becomes increasingly complex.In laying hen production process, often there is take laying hen and produce the class epidemic disease that soft-preserved egg, shell egg, husky shell egg etc. are feature, be commonly called as hens salpingitis.In doctor trained in Western medicine etiology, cause fallopian tube pathological changes to be mainly the infection such as weak malicious bird flu, atypical newcastle disease, infectious bronchitis, chlamydiosis and colibacillosis, the rule for the treatment of mainly be take anti-inflammation as main.And the traditional Chinese medical science think pathogenic factor mostly be take good care of oneself while laying eggs improper, the evil poison of diseases caused by exogenous pathogenic factor or the overwork etc. of laying eggs, the heresy of turbid damp is flooded to twine and is difficult to resolve, blood stasis is difficult for suddenly removing, damp and hot bridle of a specified duration is accumulated uterus, causes QI-blood circulation not smooth.Based on above-mentioned theory, it is primary treatment principle that element culturing fixed folder, clearing away heat-damp and promoting diuresis, activating blood circulation to dissipate blood stasis and dredge the collateral are take in the present invention, a kind of medicine that is used for the treatment of Chicken salpingitis is provided, has comprised following raw medicinal material: Radix Codonopsis, Radix Rehmanniae Preparata, Herba Carlinae biebersteinii, Fructus Litchi, Rhizoma Nupharis Bornetii, Rhizoma Chuanxiong, Fructus Toosendan, Semen Euryales, Gypsum Fibrosum, Fructus Lycii, Placenta Hominis, Radix Ophiopogonis, Flos Bombacis Malabarici, Retinervus Luffae Fructus and Radix Glycyrrhizae.
Wherein, the pharmacological property of each raw medicinal material is as follows:
Radix Codonopsis: property is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.The just > > of < < book on Chinese herbal medicine carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry, grows stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in vibration, and without just dry fraud.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can lung benefiting consolidating superficial resistance.Radix Codonopsis QI invigorating, can only spleen invigorating QI invigorating, and without the power of consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali is without the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis is without diuretic effect.This two tastes medicine share can invigorating the spleen and replenishing QI, improves resistance.
Radix Rehmanniae Preparata: sweet in the mouth, warm in nature; Return liver, kidney channel.Enrich blood moist; It is sallow that benefit essence is filled out marrow blood tiger; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.< < herbal classic is met former > >: " Radix Rehmanniae Preparata, false firepower steams and shines, and turning bitter is the yang aspect of yin for sweet, therefore vigour in energy the kidney invigorating." generation research, the contained Dihuang polysaccharide of Radix Rehmanniae Preparata has obvious immune antitumor activity, also has significant heart tonifying, diuresis, protects the liver, the effect such as blood sugar lowering, anti-hypertrophy, exudation, antiinflammatory, antifungal, anti-radiation.
Herba Carlinae biebersteinii: sweet acid; Micro-salty; Temperature.Return spleen; Liver; Kidney channel.Function cures mainly: strengthening the spleen and stomach; Replenishing QI and blood; Tune have through.Main insufficiency of the spleen lack of appetite; Dyspepsia; Deficiency of both QI and blood; Asthenic body; Have through uncomfortable.
Fructus Litchi: sweet; Acid; Temperature.Return spleen; Liver Channel.Function cures mainly: the spleen invigorating of nourishing blood; Promoting the circulation of QI for relieving swelling.Main body is after being ill empty, and Tianjin wound is thirsty; Diarrhea due to hypofunction of the spleen; Singultus; Lack of appetite; Scrofula; Furuncle is swollen; Traumatic hemorrhage.
Rhizoma Nupharis Bornetii: sweet; Bitter; Be slightly cold.Return spleen channel.Function cures mainly: nourishing YIN and clearing away heat.Main impairment caused by overstrain is deficient; Fever due to yin deficiency; Night sweat; External application
Rhizoma Chuanxiong: ligustrazine energy coronary artery dilator, increase coronary artery blood flow, improve myocardium blood oxygen supply, and reduce myocardium oxygen consumption; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can reduce surface activity of blood platelet, suppress platelet aggregation, the formation of pre-preventing thrombosis; The low dose of promotion of neutral compound of contained ferulic acid, heavy dose of uterine smooth muscle that suppresses; Water decoction has sedation to animal central nervous system, and has obvious and lasting hypotensive effect; Can accelerate the to fracture absorption of local hematoma, promotes callus formation; There is the effect of vitamin antagonist E shortage; Can suppress multiple bacillus; There are antihistaminic and choleretic effect.
Fructus Toosendan: hardship, cold; Return liver, small intestinal, urinary bladder channel.Function cures mainly: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Semen Euryales: sweet in the mouth, puckery, property is flat.Cure mainly rheumatic arthritis, back gonalgia.Invigorating the spleen and replenishing QI, the strong will of refreshing oneself, makes people's normal hearing and eyesight.It is not hungry that clothes of a specified duration are made light of one's life by commiting suicide people.Can also whet the appetite and help gas and the kidney invigorating, control frequency of micturition, seminal emission, purulent leukorrhea.Make powder edible, beneficial people.But the unsuitable polyphagia of children's, strengthening the spleen stomach, is not difficult to digestion.
Gypsum Fibrosum: natural dihydrate gypsum (CaSO42H2O) is called again Gypsum Fibrosum, through calcining, the levigate Gypsum Fibrosum preparata that obtains.Clearing away heat-fire, relieving restlessness is quenched the thirst, convergence granulation promoting (with Gypsum Fibrosum Preparatum).Gypsum Fibrosum is mainly used in apoplexy cold and heat, and heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.Except seasonal epidemic pathogens headache fever of the body, the large heat of three warmers, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, the restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, the pharynx heat of panting, also can do bath soup.Cure the wound cold headache as split.Simmer tea with Herba Alii fistulosi, the pain of decaptitating.Control day row fanatic, wind syndrome of head revolves, and stimulating milk secretion is wiped tooth benefit tooth.Except gastric heat lung-heat, loose YIN pathogen, slow spleen QI invigorating.Stop Yangming Channel headache, fever with chills, day food in one's mouth hectic fever, drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.From < < Compendium of Materia Medica > > 1, for the syndrome of epidemic febrile disease edema caused by disorder of QI excess-heat.Normal and Rhizoma Anemarrhenae mutual reinforcement between is use, as Baihu Tang.For epidemic febrile disease intense heat in both QI and blood systems, Gao Refa speckle, the removing pathogenic heat from blood and toxic substance from the body medicine compatibility such as normal and Cornu rhinocerotis, Radix Scrophulariae, with heat clearing away speckle removing, as Huaban Tang.2, for dyspnea and cough due to lung-heat, restlessness and thirst.Normal and Semen Armeniacae Amarum, Herba Ephedrae adapted, with clearing away and dispersing lung-heat, relieving cough and asthma, as MAXINGSHIGAN TANG.3, for the high Sheng of stomach-fire, headache, toothache, gingival swelling and pain.The compatibilities such as normal and the Rhizoma Anemarrhenae, Radix Achyranthis Bidentatae, bitterly slow with pathogenic fire purging, as yunü decoction.4,, for eczema, skin infection is not held back after bursting, burn due to hot liquid or fire.The compatibilities such as normal and Cortex Phellodendri, Indigo Naturalis, outward in order to heat clearing away sore, granulation promoting.
Fructus Lycii: the liver and the kidney tonifying Chinese medicine, its color is scarlet, and its taste is fragrant and sweet.Modern medicine study confirms that it contains the nutritional labelings such as betanin, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamin C, vitamin B1, vitamin B2 and calcium, phosphorus, ferrum, zinc, manganese, linoleic acid, hemopoietic function is had to facilitation, can also defying age, the effect such as mutation, antitumor, anti-fatty liver and blood sugar lowering.The traditional Chinese medical science usually with it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission.
Placenta Hominis: sweet salty, warm.The effect of there is QI invigorating, nourish blood, benefit is smart.Cure mainly: the disease such as deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency, seminal emission.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, be slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.< < Mingyi Bielu > > records: treat heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, asthenia exopathogenic heat, xerostomia excessive thirst, preventing or arresting vomiting is told, and more flaccidity falls, and reinforcing YIN-essence benefit essence, during rapid digestion of food is adjusted, protect god, determine lung qi, settling five organs, makes us fertile strong.The newly organized > > of < < book on Chinese herbal medicine records: Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often use less and can not be successfully for unfortunately also.Do not know that Radix Ophiopogonis is necessary multiplex, strength begins large, and Gai Huofu, in lung, sparkles dry interior liquid, and more than Radix Ophiopogonis, fire can not be made; Heat is vehement in stomach, endures its moon to the greatest extent, and more than Radix Ophiopogonis, fire can not cease.The fire that more has bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to the heat of bladder also, with the medicine of water flowing, do not imitate, with the agent of pathogenic fire reducing, do not imitate, how does this use again? the gas of lid bladder, must the clear respectful order of the part of the body cavity above the diaphragm housing the heart and lungs go, and fire is to decline, and water is lower logical.The clear respectful order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, heat of the lung, and making that lung is respectful is clearly not all right, and bladder fire closes, water also closes.Therefore wish is led to bladder person, gas that must lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpfully, if do not have benefit in clear Radix Ophiopogonis eventually, can rush down the fire of bladder, and don't damage the gas of bladder, yet use less it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and begin have Ji also.
Flos Bombacis Malabarici: sweet; Light; Cool in nature.Return spleen; Liver; Large intestine channel.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances; Hemostasis.Main having loose bowels; Dysentery; Hemoptysis; Spit blood; Metrorrhagia; Incised wound is hemorrhage; Sore; Eczema.
Retinervus Luffae Fructus: sweet, flat.Return lung, stomach, Liver Channel.Function cures mainly: dredging collateral, invigorate blood circulation, and dispel the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.
Radix Glycyrrhizae: property is flat, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Medicine of the present invention also comprises: Cortex Hibisci, Flos Moutan, Litsea chenii, Herba Verbenae and Herba Malvastri Coromandeliani.
Cortex Hibisci: sweet, tepor.Function cures mainly: clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.For dysentery, leucorrhea; Eczema scrotum tinea corporis, tinea pedis are controlled in external.
Flos Moutan: hardship; Light; Flat.Return Liver Channel, function cures mainly: promoting blood flow to regulate menstruation.Main menoxenia; Abdominal pain during menstruation.
Litsea chenii: pungent; Bitter; Temperature.Return spleen; Stomach warp.Function cures mainly: circulation of qi promoting; Invigorating the stomach and promoting digestion.Main dyspepsia; Abdominal distention.
Herba Verbenae: the medicine that is originally removing heat from blood removing blood stasis.Bottom abscess person, the utmost point of heat in blood, furthermore damp and hot, thus the turbid skin ulcer that forms of blood stains, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi is called its removing blood stasis parasite killing, also this meaning ear.2. < < does not record > >: main bottom abscess.3. < < Bencao Shiyi > >: primary symptom addiction blood addiction, chronic malaria, removing blood stasis.Decoct as sugar wine clothes.4. < < Japan hanako materia medica > >: logical menstruation, control married woman's vim and vigour tripe swollen, month wait irregular.5. < < Amplification on Materia Medica addendum > >: control incised wound, promoting the circulation of blood, 6. < < detailed outline > > invigorate blood circulation: smash and be coated with carbuncle and earwig urine skin ulcer, man's swelling of the vulva.7. the < < SHENGCAO property of medicine is for wanting > >: promoting blood circulation to restore menstrual flow.Can remove septicopyemia, wash hemorrhoid poison, move back top fire, reason traumatic injury.8. < < classification medical herbs > >: go urine stranguria with blood to swell and ache.9. < < Tian Bao book on Chinese herbal medicine > >: diuresis, suppressing the hyperactive liver pathogenic fire purging.Control red skin ulcer, acute catarrhal conjunctivitis.10. the modern Practical Chinese medicinal > of < < >: root is for dysentery, chronic malaria, edema, tympanites etc.And there is a discharge function.
Herba Malvastri Coromandeliani: sweet, light, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances dissipating blood stasis.Be used for the enteritis of catching a cold, dysentery, icterohepatitis, rheumatic arthritis; Traumatic injury is controlled in external, furuncle, carbuncle.
Embodiment 1 medicine 1
The embodiment of the present invention 1 provides a kind of medicine that is used for the treatment of Chicken salpingitis, and medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portions, Radix Rehmanniae Preparata 15 weight portions, Herba Carlinae biebersteinii 14 weight portions, Fructus Litchi 19 weight portions, Rhizoma Nupharis Bornetii 17 weight portions, Rhizoma Chuanxiong 21 weight portions, Fructus Toosendan 14 weight portions, Semen Euryales 17 weight portions, Gypsum Fibrosum 14 weight portions, Fructus Lycii 25 weight portions, Placenta Hominis 17 weight portions, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portions, Retinervus Luffae Fructus 17 weight portions and Radix Glycyrrhizae 16 weight portions.
The preparation method of the medicine of the embodiment of the present invention comprises the following steps:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 3 hours, and the amount of the water adding and the mass ratio of mixture are 7:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, the medicinal residues after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 2 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 6:1, and decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains mixture clear paste, and under 60 ℃ of conditions, the relative density of clear paste is 1.20;
The 5th step, in mixture clear paste, adding determining alcohol is 95% ethanol, obtains containing alcohol clear paste, the ethanol adding and the mass ratio of clear paste are 3:1;
The 6th step, will get supernatant containing alcohol clear paste standing 12h at room temperature, and clear paste residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, and is ground into powder, obtains drug powder.
The using method of embodiment of the present invention medicine: medicine is sneaked in feedstuff according to the percentage by weight of feedstuff 2-5%, feed according to the routine mode of feeding.
Embodiment 2 medicines 2
The embodiment of the present invention 2 provides a kind of medicine that is used for the treatment of Chicken salpingitis, medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portions, Radix Rehmanniae Preparata 15 weight portions, Herba Carlinae biebersteinii 14 weight portions, Fructus Litchi 19 weight portions, Rhizoma Nupharis Bornetii 17 weight portions, Rhizoma Chuanxiong 21 weight portions, Fructus Toosendan 14 weight portions, Semen Euryales 17 weight portions, Gypsum Fibrosum 14 weight portions, Fructus Lycii 25 weight portions, Placenta Hominis 17 weight portions, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portions, Retinervus Luffae Fructus 17 weight portions, Radix Glycyrrhizae 16 weight portions, Cortex Hibisci 13 weight portions, Flos Moutan 12 weight portions, Litsea chenii 17 weight portions, Herba Verbenae 16 weight portions and Herba Malvastri Coromandeliani 19 weight portions.
The preparation method of the medicine of the embodiment of the present invention comprises the following steps:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 4 hours, and the amount of the water adding and the mass ratio of mixture are 8:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, the medicinal residues after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 4 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 7:1, and decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains mixture clear paste, and under 60 ℃ of conditions, the relative density of clear paste is 1.10;
The 5th step, in mixture clear paste, adding determining alcohol is 95% ethanol, obtains containing alcohol clear paste, the ethanol adding and the mass ratio of clear paste are 2:1;
The 6th step, will get supernatant containing alcohol clear paste standing 18h at room temperature, and clear paste residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, and is ground into powder, obtains drug powder.
The using method of embodiment of the present invention medicine: medicine is sneaked in feedstuff according to the percentage by weight of feedstuff 2-5%, feed according to the routine mode of feeding.
Toxicity test
1, acute toxicity test
According to acute toxicity test, require to carry out prerun, find that tested medicine cannot measure LD50.Therefore carry out maximum dosage-feeding test in a day.Get 40 of above-mentioned mices, fasting be can't help water after 12 hours, by body weight, be divided at random administration group and water matched group, every group 20, administration group is given the medicinal liquid 0.4ml/10g containing the crude drug amount 2.4g/ml concentration of the medicine of embodiment 1 preparation, gavage one day 2 times, makes dosage in a day reach symphysis dose 192.0g/kg, and water matched group is to the water of equal volume.After each treated animal administration, 5, every box, normal raising, close observation, all Continuous Observation is seven days, the toxic reaction that record may occur and death condition, after administration, mice outward appearance hair color light, behavioral activity is normal, without abnormal pathologic neural reflex, occur, in seven days, well, other Novel presentation is seen at end in feed, and body weight change is compared no significant difference and none animal dead with water matched group, the main organs such as the perusal heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.Use the medicine of the embodiment of the present invention 2 to carry out above-mentioned test to mice, result is as identical in the test result of embodiment 1 medicine.
2, long term toxicity test
The medicine of the embodiment of the present invention 1 to mice by 10.78,20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: medicine of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.Use the medicine of the embodiment of the present invention 2 to carry out above-mentioned test to mice, result is as identical in the test result of embodiment 1 medicine.
Clinical trial
(1) laboratory animal
During in January, 2012-October, in Shandong, Mou Ji plant tests, and selects to suffer from 2200 of the laying hens of Chicken salpingitis as subjects.The symptom of ill chicken is: pain is uneasy, on its eggshell of the egg of output, often with bloodstain, in fallopian tube, often discharge yellow, white pus sample secretions, pollute anus around and feather below, the difficulty of laying eggs, egg production declines, and good egg rate reduces, and the person of being in a bad way also there will be heating, stand transfixed to the ground, two wings are sagging, and disorderly, some abdominal paries are by the symptom of ground or lethargy for feather pine.
(2) test method
Using 900 ill chickens wherein as this experiment for examination animal, be divided at random three groups, 300 every group, adopt respectively the medicine (embodiment group 1) of the embodiment of the present invention 1, medicine (embodiment group 2) and the conventional medicament of embodiment 2 are treated.Wherein, embodiment group 1 is sneaked into medicine in feedstuff according to the percentage by weight of feedstuff 3%, according to the routine mode of feeding, feeds; Embodiment group 2 is sneaked into medicine in feedstuff according to the percentage by weight of feedstuff 3%, according to the routine mode of feeding, feeds; Conventional medicament is selected: ovum health (100g is watered 2000 jin) jin drinking-water, many ovum of egg fowl element+Bai Yang egg good fortune is mixed rear spice, according to the routine mode of feeding, feeds.Test period is 5 days, tests before and record respectively after treatment the day egg production of every group of ill chicken.
(3) efficacy determination
Egg production is become reconciled the recovery of egg rate normally, and mental status is good, and feather is normal, and fallopian tube, without pussy discharge, is judged to be healing; The egg production egg rate of becoming reconciled takes a turn for the better, and mental status is good, and fallopian tube, without pussy discharge, is judged to be effectively; The egg production egg rate of becoming reconciled does not have to change substantially, and fallopian tube still has pussy discharge, and it is invalid to be judged to be.Wherein, effective percentage accounts for total percentage ratio for curing number and significant figure.
(4) therapeutic outcome
Therapeutic effect is as shown in table 1, and from therapeutic effect, adopting medicine of the present invention is more than 91% to the treated effect of Chicken salpingitis, higher than matched group.Experiment before and after every group of laying hen every day egg production and good egg rate synopsis as shown in table 2.
Table 1 therapeutic effect synopsis
From the data of table 1, compare with matched group, use the Drug therapy Chicken salpingitis of the embodiment of the present invention 1 and embodiment 2, have advantages of evident in efficacy, cure rate is high; In long-term observation subsequently, find, the laying hen that embodiment group 1 and embodiment group 2 cured again sickness rate is starkly lower than the chicken of matched group.
The synopsis of egg production and good egg rate before and after table 2 treatment
From the data of table 2, the medicine of the embodiment of the present invention 1 and embodiment 2 has improved the laying rate of ill chicken, aspect treatment Chicken salpingitis, has advantages of that cure rate is high.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (9)
1. the medicine that is used for the treatment of Chicken salpingitis, it is characterized in that, described medicine comprises following raw medicinal material: Radix Codonopsis, Radix Rehmanniae Preparata, Herba Carlinae biebersteinii, Fructus Litchi, Rhizoma Nupharis Bornetii, Rhizoma Chuanxiong, Fructus Toosendan, Semen Euryales, Gypsum Fibrosum, Fructus Lycii, Placenta Hominis, Radix Ophiopogonis, Flos Bombacis Malabarici, Retinervus Luffae Fructus and Radix Glycyrrhizae.
2. the medicine that is used for the treatment of Chicken salpingitis according to claim 1, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion and Radix Glycyrrhizae 10-20 weight portion.
3. the medicine that is used for the treatment of Chicken salpingitis according to claim 1 and 2, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion and Radix Glycyrrhizae 12-19 weight portion.
4. according to the medicine that is used for the treatment of Chicken salpingitis described in claim 1-3 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portions, Radix Rehmanniae Preparata 15 weight portions, Herba Carlinae biebersteinii 14 weight portions, Fructus Litchi 19 weight portions, Rhizoma Nupharis Bornetii 17 weight portions, Rhizoma Chuanxiong 21 weight portions, Fructus Toosendan 14 weight portions, Semen Euryales 17 weight portions, Gypsum Fibrosum 14 weight portions, Fructus Lycii 25 weight portions, Placenta Hominis 17 weight portions, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portions, Retinervus Luffae Fructus 17 weight portions and Radix Glycyrrhizae 16 weight portions.
5. according to the medicine that is used for the treatment of Chicken salpingitis described in claim 1-4 any one, it is characterized in that, described medicine also comprises: Cortex Hibisci, Flos Moutan, Litsea chenii, Herba Verbenae and Herba Malvastri Coromandeliani.
6. according to the medicine that is used for the treatment of Chicken salpingitis described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion, Radix Glycyrrhizae 10-20 weight portion, Cortex Hibisci 10-15 weight portion, Flos Moutan 10-15 weight portion, Litsea chenii 15-20 weight portion, Herba Verbenae 15-20 weight portion and Herba Malvastri Coromandeliani 15-20 weight portion.
7. according to the medicine that is used for the treatment of Chicken salpingitis described in claim 1-6 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion, Radix Glycyrrhizae 12-19 weight portion, Cortex Hibisci 12-15 weight portion, Flos Moutan 10-13 weight portion, Litsea chenii 15-18 weight portion, Herba Verbenae 15-18 weight portion and Herba Malvastri Coromandeliani 18-20 weight portion.
8. according to the medicine that is used for the treatment of Chicken salpingitis described in claim 1-7 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portions, Radix Rehmanniae Preparata 15 weight portions, Herba Carlinae biebersteinii 14 weight portions, Fructus Litchi 19 weight portions, Rhizoma Nupharis Bornetii 17 weight portions, Rhizoma Chuanxiong 21 weight portions, Fructus Toosendan 14 weight portions, Semen Euryales 17 weight portions, Gypsum Fibrosum 14 weight portions, Fructus Lycii 25 weight portions, Placenta Hominis 17 weight portions, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portions, Retinervus Luffae Fructus 17 weight portions, Radix Glycyrrhizae 16 weight portions, Cortex Hibisci 13 weight portions, Flos Moutan 12 weight portions, Litsea chenii 17 weight portions, Herba Verbenae 16 weight portions and Herba Malvastri Coromandeliani 19 weight portions.
9. a preparation method for the medicine that is used for the treatment of Chicken salpingitis as described in claim 1-8 any one, is characterized in that, described preparation method comprises:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 2～4 hours, and the amount of the water adding and the mass ratio of mixture are 6～9:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, medicinal residues after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 2～4 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 6～10:1, decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains mixture clear paste, and under 60 ℃ of conditions, the relative density of clear paste is 1.10～1.20;
The 5th step, in mixture clear paste, adding determining alcohol is 95% ethanol, obtains containing alcohol clear paste, the ethanol adding and the mass ratio of clear paste are 2～3:1;
The 6th step, will get supernatant containing alcohol clear paste standing 12～24h at room temperature, and clear paste residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, and is ground into powder, obtains drug powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039137A (en) * | 2016-05-30 | 2016-10-26 | 宿州天雨养殖（集团）有限公司 | Medicine for treating salpingitis in egg-laying poultry |
| CN108567875A (en) * | 2018-07-16 | 2018-09-25 | 李焱焱 | A kind of Chinese medicine composition and its Chinese medicine preparation for treating salpingitis of layer chicken |
| CN108771754A (en) * | 2018-08-02 | 2018-11-09 | 河南牧翔动物药业有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating laying hen middle and later periods salpingitis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039137A (en) * | 2016-05-30 | 2016-10-26 | 宿州天雨养殖（集团）有限公司 | Medicine for treating salpingitis in egg-laying poultry |
| CN108567875A (en) * | 2018-07-16 | 2018-09-25 | 李焱焱 | A kind of Chinese medicine composition and its Chinese medicine preparation for treating salpingitis of layer chicken |
| CN108771754A (en) * | 2018-08-02 | 2018-11-09 | 河南牧翔动物药业有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating laying hen middle and later periods salpingitis |
| CN108771754B (en) * | 2018-08-02 | 2021-03-02 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for treating salpingitis of laying hens in middle and later periods and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103735832B (en) | 2015-12-02 |
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