CN101024062A - Medicine for treating salpingitis tubal obstruction and preparing method - Google Patents
Medicine for treating salpingitis tubal obstruction and preparing method Download PDFInfo
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- CN101024062A CN101024062A CNA2007100141014A CN200710014101A CN101024062A CN 101024062 A CN101024062 A CN 101024062A CN A2007100141014 A CNA2007100141014 A CN A2007100141014A CN 200710014101 A CN200710014101 A CN 200710014101A CN 101024062 A CN101024062 A CN 101024062A
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Abstract
The present invention discloses a Chinese medicine for effectively curing salpingitis with obvious therapeutic effect. Said Chinese medicine is made up by using 8 Chinese medicinal materials of Chinese angelica root, ligusticum root, zedoary, forsythia fruit, prunella spike, liquidambar fruit and others through a certain preparation process.
Description
Affiliated technical field
The present invention relates to a kind of Chinese medicine preparation, is the medicine of treatment salpingitis tubal obstruction specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Salpingitis tubal obstruction is the major reason of infertility, accounts for 36% of infertility.Still lack effective treatment means at present both at home and abroad.Western medical treatment is taked hysteroscope conduit mediation art more, and microsurgery is rebuild under the peritoneoscope, but fallopian tube is had certain destructiveness, easily restenosis.Gamete is transplanted in the application official jargon that has, external fertilization--the treatment of-embryo transfer, and the infertility expense costliness that causes therefrom, success rate is low.And need higher technical conditions and equipment requirements, therefore fail extensively to carry out.Tcm therapy commonly used is to use treatments such as the medicine of activating blood circulation to dissipate blood stasis and dredge the collateral such as Ramulus Cinnamomi Indian buead capsule, but simple activating blood circulation to dissipate blood stasis and dredge the collateral Chinese medicine or Chinese patent medicine clinical effectiveness are unsatisfactory.
Summary of the invention
The objective of the invention is to excavate provides a kind of on the basis of motherland's medical heritage and increases clearing away heat-damp and promoting diuresis on the basis of activating blood circulation to dissipate blood stasis and dredge the collateral, the medicine of the novel therapeutic salpingitis tubal obstruction of hard masses softening and resolving effect.
Another object of the present invention provides the preparation method of this medicine.
Solution of the present invention is
Of the present invention it be the medicament of making by the raw material of following ratio of weight and number:
Radix Angelicae Sinensis 20-50 Rhizoma Chuanxiong 20-50 Rhizoma Curcumae 20---50 Fructus Forsythiae 20-50
Spica Prunellae 20-50 stir-baked SQUAMA MANITIS 10-20 Fructus Liquidambaris 20-50 Fructus Foeniculi 10-20.
The various raw materials in part by weight ratios of optimizing are:
Radix Angelicae Sinensis 20-40 Rhizoma Chuanxiong 20-40 Rhizoma Curcumae 20-40 Fructus Forsythiae 20-40
Spica Prunellae 20-40 stir-baked SQUAMA MANITIS 10-20 Fructus Liquidambaris 20-40 Fructus Foeniculi 10-20.
Preferred various raw material weight umber ratio is:
Radix Angelicae Sinensis 40 Rhizoma Chuanxiongs 40 Rhizoma Curcumae 40 Fructus Forsythiaes 40
Spica Prunellae 40 stir-baked SQUAMA MANITISs 10 Fructus Liquidambaris 40 Fructus Foeniculi 10.
A kind of preparation method for the treatment of the medicine of salpingitis tubal obstruction comprises the steps:
A, system stir-baked SQUAMA MANITIS fine powder: two clean Squama Maniss, size is separately put sand in the pot, adds Squama Manis after intense fire is made popular and constantly stirs, and scalds to heaving jaundice with husky, carries out quench in vinegar with the vinegar of Squama Manis weight 30%, and it is clean to take out drying, dries, and makes 100 order fine powders.
B, decoction, receipts cream: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Curcumae, Fructus Liquidambaris, Fructus Forsythiae, Spica Prunellae, Fructus Foeniculi seven flavor medicine thing are made 50 order coarse powder respectively, mix by described ratio of weight and number, the water logging coarse powder of 3 times of weight of adding medicated powder 24 hours, to boiling 30 minutes, it is standby to leach medicine juice; The water that the coarse powder that boiled is added again 1.5 times of weight carries out decocting the second time, and to boiling 30 minutes, it is standby to leach medicine juice.Twice decocting medicine juice mixed, filter, concentrate, receive cream.
C, will receive cream and stir-baked SQUAMA MANITIS fine powder by the proportioning mix homogeneously, oven dry, granulation incapsulates, the 0.25g/ grain.
Based on understanding and the Therapeutic Principle of motherland's medical science to salpingitis tubal obstruction.Fallopian tube belongs to conception vessel, the collaterals of the uterus category of the traditional Chinese medical science.Salpingemphraxis is generally caused by reasons such as chronic pelvic inflammatory disease, the adhesion of operation on pelvis rear attachment, endometriosis adhesions, and long-term salpingitis tubal shows effect repeatedly, make Mucous Epithelium of Fallopian Tube damage or destruction, and then the tube chamber adhesion is blocked.The traditional Chinese medical science thinks that this genus is damp and hot, blood stasis retardance conception vessel, collaterals of the uterus, finally cause smart ovum can not in conjunction with and infertile.Treatment is based on blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, hard masses softening and resolving.Medicine of the present invention is a pure Chinese medicinal preparation, and it is made up of eight herbal medicines such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Curcumae, stir-baked SQUAMA MANITIS, Fructus Forsythiae, Fructus Liquidambaris, Spica Prunellae, Fructus Foeniculi, has the effect of blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, hard masses softening and resolving.The merit that Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Curcumae have a blood circulation promoting and blood stasis dispelling in the side is monarch drug altogether.The Zhang Xichun cloud: " Rhizoma Curcumae is peace closely, and to control woman's blood stasis, though heavily fortified point also can dissipate slowly as ferrum ".Fructus Forsythiae, Spica Prunellae clearing away heat-damp and promoting diuresis, hard masses softening and resolving are ministerial drug.Fructus Forsythiae can heat-clearing and toxic substances removing again can the eliminating carbuncle eliminating stagnation, be called persons particularly liable to develop skin infection's panacea by forefathers.Li Shicai calls its " it is all through blood agglomeration to loose ".Spica Prunellae can eliminating stagnation, purge heat, dampness removing.Stir-baked SQUAMA MANITIS, Fructus Liquidambaris assistant principal drug assistance promoting blood circulation to restore menstrual flow." Records of Tradition Chinese and Western Medicine in Combination " cloud: " Squama Manis a surname purging FU-organs is dirty, runs through meridians, reaches the pass key thoroughly, and all blood clotting blood is poly-all can open it for disease ".Before the person its " walk to scurry meridians, nowhere less than, reach disease institute ".Fructus Liquidambaris can be promoted blood circulation in promoting the circulation of blood.But the two share the extremely sick institute of priming and blood circulation promoting and blood stasis dispelling, sensible meridians.The hot temperature of Fructus Foeniculi is regulated the flow of vital energy, and the capable then blood of gas is capable.The bitter cold that can make the medicine of a cold nature injures one's stomach and can strengthen the power of disperse blood stasis and dredge collateral.All medicines share and gather blood circulation promoting and blood stasis dispelling altogether, clearing away heat-damp and promoting diuresis, the effect of hard masses softening and resolving.Thereby play the merit of mediation conception vessel, collaterals of the uterus.
This medicine instructions of taking: every day three times, each 4-6 grain, one after each meal, eliminating cold for resuscitation water send down.
Be to determine the curative effect of medicine of the present invention, according among the Luo Lilan chief editor " sterility and infertility " about salpingitis tubal obstruction infertile diagnostic criteria carry out clinical research.Get rid of the patient of other diseases such as tuberculosis of fallopian tube through Salpingography, be divided into 2 groups by randomization.Aspects such as its age, the state of an illness, the course of disease constitute there was no significant difference, P＞0.05 for two groups.The treatment group is taken capsule of the present invention, and 3 times on the 1st, each 5, matched group gives GUIZHI FULING JIAONANG, and takes by explanation, is for 8 weeks per course of treatment.
Observation index: 1. Salpingography (HSG), 2. hydrotubation pressure, adverse effect and side effect are 4. observed in 3. blood fat, liver function, kidney merit, hematuria routine examination, observe pregnancy rate after 5.6 months.
Efficacy assessment standard:
1. cure: Salpingography shows the fallopian tube clear display, and is good to the pelvic cavity disperse; Pressure
＜15Kpa, logical liquid measure＞30ml; Gestation in 6 months.
2. produce effects: Salpingography shows the fallopian tube clear display, and is good to the pelvic cavity disperse; The fallopian tube blood pressure
＜15Kpa, logical liquid measure＞30ml person, but do not have gestation.
3. effective: Salpingography improves but unfavorable above-mentioned standard person before showing treatment.
4. invalid: defeated Guan Xuanying fallopian tube does not develop, contrast-agent-free disperse in the pelvic cavity.
Clinical test results: this statistics is through X
2Check and T check (table 1, table 2)
Clinical efficacy (table 1)
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Total effectively (%) |
| The treatment group | 70 | 18 | 22 | 16 | 14 | 80 ※ |
| Matched group | 50 | 6 | 7 | 9 | 28 | 44 |
※P＜0.01, clinical efficacy comparison shows that two groups of cure rates and total effective rate all there were significant differences, illustrate that Drug therapy salpingitis tubal of the present invention is better than matched group.
Fallopian tube pressure decline situation (table 2)
| Group | Before the treatment (Kpa) | Treatment back (Kpa) | Rate of descent (%) |
| The treatment group | 30.52±4.67 | 14.51±1.95 ※※ | 52.2 ※ |
| Matched group | 29.36±4.49 | 19.89±2.08 | 32.3 |
※P＜0.05,
※ ※Relatively there is highly significant difference P＜0.01 before and after the visible Drug therapy of the present invention and with the matched group rate of descent.Illustrate that medicine of the present invention can obviously reduce the hydrotubation resistance, and be better than matched group.
Observe treatment back clothes medicine group patient of the present invention, find that 3 routine patient's mild nausea are arranged, stomach discomfort is outer, do not have other untoward reaction.All case is not seen allergy sufferers, contrast before and after the treatment, patient's hematuria routine, hepatic and renal function, blood glucose, the equal no significant difference of blood fat.
This clinical research result shows Drug therapy salpingitis tubal obstruction total effective rate 80% of the present invention, pregnancy rate 25.74%, fallopian tube pressure descends 52.2%, and above-mentioned each index and the contrast of GUIZHI FULING JIAONANG group all have significant difference, show that Drug therapy salpingitis tubal curative effect of the present invention is reliable.Obviously be better than GUIZHI FULING JIAONANG.Analyzing drug main of the present invention wants the pharmacological action Radix Angelicae Sinensis of Chinese medicine can suppress smooth muscle, antiplatelet aggregation, antiinflammatory.Rhizoma Chuanxiong has antithrombotic, vasodilative effect.Rhizoma Curcumae Main Ingredients and Appearance curcumenol and B one elemene have obvious inhibition to destroy the tumor cell effect, blood viscosity lowering simultaneously, and anticoagulant improves hemorheological property, microcirculation improvement and have antiinflammatory, antibiotic, antivirus action.And that Fructus Forsythiae, Spica Prunellae all have is antibiotic, antiinflammatory, antiallergic, antivirus action, and especially Fructus Forsythiae can reduce inflammatory lesions blood capillary fragility.Squama Manis energy blood vessel dilating reduces Peripheral resistance, improves hypoxia-bearing capability.Fructus Liquidambaris reduces vascular permeability, and Fructus Foeniculi has the inhibition platelet aggregation, the expansion microcirculation, and anticoagulant, anti-fibrinolytic effect, and sex hormone function is arranged, and fallopian tube weight is increased, eliminate the phlegm.This shows that medicine of the present invention can improve patient's fallopian tube diseased region blood fortune and hemorheology, promote inflammation to absorb, thus adhesion loosen and the softening absorption of proliferative lesion makes the logical again reproductive function that recovers of fallopian tube tube chamber.
According to the specification requirement of new drug pharmacological research, the acute toxicity result who adopts acute toxicity test in mice to estimate medicine of the present invention shows: medicine 10g/Kg of the present invention observed 28 days, and mice does not see death and obvious adverse reaction.So its LD
50(mice)＞10g/kg.It is generally acknowledged, during oral administration, a kind of LD of chemical substance
50Value represents that this material reality is nontoxic during greater than 5g/kg.Therefore by mice LD
50Classification, medicine of the present invention belongs to non-toxic type.
Medicine of the present invention is taken " dredging capsule " according to its curative effect, and " failing " is the defeated logical meaning of transportation, and the fallopian tube implication is also arranged.Logical promptly unobstructed, the meaning of logical conception vessel and collaterals of the uterus is arranged.
Beneficial effect of the present invention is:
1, this product is a pure Chinese medicinal preparation, and human body is not had wound.
2, determined curative effect.Clinical efficacy and pharmacology confirm that this medical instrument has antibiotic, antiinflammatory action, have the platelet aggregation of improvement, expand blood vessel, and microcirculation improvement promotes the effect that salpingitis tubal absorbs and hypertrophy disappears.
3, experimental results show that this medicine does not have obvious adverse reaction and toxic and side effects.
4, dosage form is a capsule, and taking convenience is easy to carry, and patient takes like a shot.
The specific embodiment
Realization the specific embodiment of the present invention is:
Embodiment 1: a kind of medicine for the treatment of salpingitis tubal obstruction, it is the medicament of being made by following materials of weight proportions.
Radix Angelicae Sinensis 20-50 Rhizoma Chuanxiong 20-50 Rhizoma Curcumae 20---50 Fructus Forsythiae 20-50
Spica Prunellae 20-50 stir-baked SQUAMA MANITIS 10-20 Fructus Liquidambaris 20-50 Fructus Foeniculi 10-20.
A kind of preparation method for the treatment of the medicine of salpingitis tubal obstruction is:
A, system stir-baked SQUAMA MANITIS fine powder: get clean Squama Manis, size is separately put sand in the pot, add Squama Manis after intense fire is made popular and constantly stir, scald to heaving jaundice, carry out quench in vinegar with the vinegar of Squama Manis weight 30% with husky, taking-up, dry, clean is dried, and makes 100 order fine powders.
B, decoction, receipts cream: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Curcumae, Fructus Liquidambaris, Fructus Forsythiae, Spica Prunellae, Fructus Foeniculi seven flavor medicine thing are made 50 order coarse powder respectively, mix by described ratio of weight and number, the water logging coarse powder of 3 times of weight of adding medicated powder 24 hours, to boiling 30 minutes, it is standby to leach medicine juice; The water that the coarse powder that boiled is added again 1.5 times of weight carries out decocting the second time, and to boiling 30 minutes, it is standby to leach medicine juice.Twice decocting medicine juice mixed, filter, concentrate, receive cream.
C, will receive cream and stir-baked SQUAMA MANITIS fine powder by the proportioning mix homogeneously, oven dry, granulation incapsulates, the 0.25g/ grain.
Embodiment 2: it is heavier to be used for salpingitis tubal adhesion obstruction, the sturdy person of body constitution.Get Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 50g, Rhizoma Curcumae 50g, Fructus Forsythiae 50g, Spica Prunellae 50g, Fructus Liquidambaris 50g, stir-baked SQUAMA MANITIS 10g, Fructus Foeniculi 20g.Make medicament of the present invention according to the preparation method of embodiment 1.
Embodiment 3: be used for the salpingitis tubal adhesion and block the weakness of the spleen and stomach person.Get Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 50g, Rhizoma Curcumae 30g, Fructus Forsythiae 50g, Spica Prunellae 50g, Fructus Liquidambaris 50g, stir-baked SQUAMA MANITIS 10g, Fructus Foeniculi 20g.Make medicament of the present invention according to embodiment 1 preparation method.
Embodiment 4: be used for the salpingitis tubal adhesion and block than the lighter.Get Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 50g, Rhizoma Curcumae 30g, Fructus Forsythiae 30g, Spica Prunellae 30g, Fructus Liquidambaris 30g, stir-baked SQUAMA MANITIS 10g, Fructus Foeniculi 10g.Make medicament of the present invention according to embodiment 1 preparation method.
Claims (5)
1, a kind of medicine for the treatment of salpingitis tubal obstruction is characterized in that: it is the medicament of being made by the raw material of following ratio of weight and number:
Radix Angelicae Sinensis 20-50 Rhizoma Chuanxiong 20-50 Rhizoma Curcumae 20---50 Fructus Forsythiae 20-50
Spica Prunellae 20-50 stir-baked SQUAMA MANITIS 10-20 Fructus Liquidambaris 20-50 Fructus Foeniculi 10-20.
2, a kind of medicine for the treatment of salpingitis tubal obstruction according to claim 1, its feature
Be: its various raw materials in part by weight ratios are:
Radix Angelicae Sinensis 20-40 Rhizoma Chuanxiong 20-40 Rhizoma Curcumae 20-40 Fructus Forsythiae 20-40
Spica Prunellae 20-40 stir-baked SQUAMA MANITIS 10-20 Fructus Liquidambaris 20-40 Fructus Foeniculi 10-20.
3, a kind of medicine for the treatment of salpingitis tubal obstruction according to claim 1 is characterized in that: its various raw material weight umber ratios are:
Radix Angelicae Sinensis 40 Rhizoma Chuanxiongs 40 Rhizoma Curcumae 40 Fructus Forsythiaes 40
Spica Prunellae 40 stir-baked SQUAMA MANITISs 10 Fructus Liquidambaris 40 Fructus Foeniculi 10.
4, according to claim 1,2, one of 3 described a kind of medicines for the treatment of salpingitis tubal obstruction, it is characterized in that: described medicament is capsule, tablet or sublimed preparation.
5, the described a kind of preparation method for the treatment of the medicine of salpingitis tubal obstruction of claim 4 is characterized in that: comprise the steps:
A, system stir-baked SQUAMA MANITIS fine powder: get clean Squama Manis, size is separately put sand in the pot, add Squama Manis after intense fire is made popular and constantly stir, scald to heaving jaundice, carry out quench in vinegar with the vinegar of Squama Manis weight 30% with husky, taking-up, dry, clean is dried, and makes 100 order fine powders.
B, decoction, receipts cream: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Curcumae, Fructus Liquidambaris, Fructus Forsythiae, Spica Prunellae, Fructus Foeniculi seven flavor medicine thing are made 50 order coarse powder respectively, mix by described ratio of weight and number, the water logging coarse powder of 3 times of weight of adding medicated powder 24 hours, to boiling 30 minutes, it is standby to leach medicine juice; The water that the coarse powder that boiled is added again 1.5 times of weight carries out decocting the second time, and to boiling 30 minutes, it is standby to leach medicine juice.Twice decocting medicine juice mixed, filter, concentrate, receive cream.
C, the receipts cream that step B is made and stir-baked SQUAMA MANITIS fine powder be by the proportioning mix homogeneously, oven dry, and granulation incapsulates, the 0.25g/ grain.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100141014A CN100548365C (en) | 2007-03-29 | 2007-03-29 | A kind of medicine for the treatment of salpingitis tubal obstruction and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100141014A CN100548365C (en) | 2007-03-29 | 2007-03-29 | A kind of medicine for the treatment of salpingitis tubal obstruction and preparation method thereof |
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|---|---|
| CN101024062A true CN101024062A (en) | 2007-08-29 |
| CN100548365C CN100548365C (en) | 2009-10-14 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949664A (en) * | 2012-11-13 | 2013-03-06 | 刘晓燕 | Traditional Chinese medicinal composite for treating fallopian-tube obstructive infertility |
| CN103735832A (en) * | 2014-01-27 | 2014-04-23 | 山东新希望六和集团有限公司 | Medicament for treating chicken salpingitis and preparation method thereof |
| CN105853959A (en) * | 2016-04-11 | 2016-08-17 | 广州暨南生物医药研究开发基地有限公司 | Traditional Chinese medicine composition containing folium artemisiae argyi for treating salpingitis and preparation method of traditional Chinese medicine composition |
-
2007
- 2007-03-29 CN CNB2007100141014A patent/CN100548365C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949664A (en) * | 2012-11-13 | 2013-03-06 | 刘晓燕 | Traditional Chinese medicinal composite for treating fallopian-tube obstructive infertility |
| CN103735832A (en) * | 2014-01-27 | 2014-04-23 | 山东新希望六和集团有限公司 | Medicament for treating chicken salpingitis and preparation method thereof |
| CN103735832B (en) * | 2014-01-27 | 2015-12-02 | 山东新希望六和集团有限公司 | Medicine being used for the treatment of Chicken salpingitis and preparation method thereof |
| CN105853959A (en) * | 2016-04-11 | 2016-08-17 | 广州暨南生物医药研究开发基地有限公司 | Traditional Chinese medicine composition containing folium artemisiae argyi for treating salpingitis and preparation method of traditional Chinese medicine composition |
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| Publication number | Publication date |
|---|---|
| CN100548365C (en) | 2009-10-14 |
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