CN100531759C

CN100531759C - Medicine for treating gynecopathy and cypridopathy and its preparing method

Info

Publication number: CN100531759C
Application number: CNB2006100055156A
Authority: CN
Inventors: 杨峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-01-08
Filing date: 2006-01-08
Publication date: 2009-08-26
Anticipated expiration: 2026-01-08
Also published as: CN1839980A

Abstract

The invention discloses a medicament for treating gynaecologic diseases and venereal diseases, as well as its preparing process, which is prepared from dried alum, calamine, mercurous chloride and yellow-corktree bark by a predetermined weight ratio proportion.

Description

A kind of medicine for the treatment of gynaecopathia, sexually transmitted disease (STD) and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of gynaecopathia, sexually transmitted disease (STD) and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Mycotic, trichomonal vaginitis, genital herpes, syphilis temper cervicitis, vagina erosion are one of common gynaecopathia, sexually transmitted disease (STD), clinically mostly are that frequent micturition, urgent micturition, herpes vulvaris, erosion, urethral orifice pyorrhea, vaginal secretions increase, the trachelopanus erosion, stenchly are feature.Part patient has a headache and fever with General Symptoms, the vomiting poor appetite, and oral ulcer, outbreak repeatedly, painful hard to bear.Western medical treatment is many, and bactericidal antiphlogistic carries out remissive treatment to focus with local application, can't solve recurrence and remove old complaint.

Summary of the invention:

For this reason the patient to curative effect preferably Chinese medicine preparation exist and to crave for, also do not find the report of any relevant pharmaceutical composition of the present invention at present.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has made the Chinese medicine external used medicine that the treatment of better curative effect gynaecopathia, sexually transmitted disease (STD) are arranged finally, thereby has finished the present invention.

Purpose of the present invention just provides a kind of Chinese medicine composition of a kind of effective treatment gynaecopathia, sexually transmitted disease (STD).

Another object of the present invention has provided the preparation method of this Chinese medicine composition.

Medicament selection dried Alumen of the present invention, Calamina, Calomelas, Cortex Phellodendri charcoal, Oleum Hydnocapi semen, Radix Sophorae Flavescentis, Borax, Borneolum Syntheticum, camphor, the Radix Angelicae Dahuricae and the Radix Astragali make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of gynaecopathia and sexually transmitted disease (STD).Wherein select for use dried Alumen to be because the dried Alumen nature and flavor are sour and astringent, cold, poisonous, return lung, spleen, stomach, large intestine channel, expectorant, dampness, antidiarrheal, hemostasis, detoxifcation, parasiticidal function are arranged.Cure mainly epilepsy, sore throat, sputum and stop up very hepatitis, jaundice, gastroduodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid, scabies.The Calamina nature and flavor are sweet flat, return liver, stomach warp, and the function of heat clearing away, detoxifcation, dampness, blood stasis dispelling, convergence granulation promoting is arranged, the kind again removing nebula that makes eye bright, removing dampness granulation promoting.Calomelas nature and flavor suffering, cold, scorching poisonous, return the Liver and kidney warp.Parasite killing, counteracting toxic substances, diuretic, relieving constipation.Cure mainly scabies, syphilis, primary sore, be used for skin ulcer, edema, expansion, defecation is closed.The Cortex Phellodendri charcoal, the nature and flavor bitter cold is returned kidney, urinary bladder channel, heat clearing away, pathogenic fire purging, dampness detoxifcation.Cure mainly hematodiarrhoea, hemorrhoid, have blood in stool, aphtha of the mouth and tongue, sore swollen toxin.The Semen Hydnocarpi nature and flavor are hot, and are poisonous, return the liver,spleen,kidney warp, dispeiling pathogenic wind and removing dampness, and detoxicating and killing parasites is controlled leprosy, scabies, syphilitic skin lesion.Radix Sophorae Flavescentis nature and flavor bitter cold is returned Liver and kidney, large intestine, small intestine meridian, heat clearing away, and dampness, parasite killing is controlled the mange malignant boil, erosion of vulva pruritus due to damp pathogen, scrofula, anal fistula is scalded.Borax is the refining crystallization that forms of mineral Borax warp, and nature and flavor are sweet, and are salty, and lung, stomach, warp are returned in cold, heat clearing away, expectorant, and it is anticorrosion to detoxify, and controls laryngopharynx swelling and pain, aphtha of the mouth and tongue, conjunctival congestion cataracta.The Borneolum Syntheticum nature and flavor are arduous, cold, and GUIXIN, lung meridian, the refreshment of having one's ideas straightened out, removing nebula makes eye bright, and reducing swelling and alleviating pain is controlled the apoplexy locked mouth, and the calentura coma is fainted from fear mental confusion due to phlegm, conjunctivitis.Camphor, nature and flavor suffering, heat, the GUIXIN warp, external dehumidifying parasite killing, warming and odynolysis, for oral administration, have one's ideas straightened out that it is dirty to ward off, dissipating blood stasisization is turbid.The Radix Angelicae Dahuricae, nature and flavor suffering, temperature are returned lung, spleen, stomach warp, dispel the wind, dampness, detumescence, leucorrhea with red and white discharge is controlled in pain relieving, ulcer sores, hemorrhoidal hamorrhage anal fistula, cold-damp stomachache.The Radix Astragali, nature and flavor are sweet, warm, return spleen, lung meridian, are used for tonifying Qi and lifting yang, and benefit is defended consolidating superficial resistance, detoxification granulation promoting, inducing diuresis to remove edema.

The consumption of drug component of the present invention carries out a large amount of practice summaries through the inventor and draws, and each amounts of components all has better curative effect at following weight range:

Dried Alumen 450-550 gram Calaminas 450-550 gram Calomelass 450-550 grams

Cortex Phellodendri charcoal 450-550 gram Oleum Hydnocapi semen 25-35 gram Radix Sophorae Flavescentiss 250-350 grams

Borax 180-250 cron brains 25-35 gram camphors 25-35 grams

The Radix Angelicae Dahuricae 900-1100 gram Radixs Astragali 2800-3200 grams

Be preferably: dried Alumen 500 grams, Calamina 500 grams, Calomelas 500 grams, Cortex Phellodendri charcoal 500 grams, Oleum Hydnocapi semen 30 grams, Radix Sophorae Flavescentis 300 grams, Borax 200 grams, Borneolum Syntheticum 30 grams, camphor 30 grams, the Radix Angelicae Dahuricae 1000 grams, the Radix Astragali 3000 grams.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the external preparation of any routine, for example these crude drug pulverize mix homogeneously can be made capsule, powder or water preparation and use.

The preparation method of drug component of the present invention is as follows:

1, Calamina(processed) is respectively got Rhizoma Coptidis, Radix Et Rhizoma Rhei 100 grams in advance, adds water 2000 gram, decocts into concentrated solution, gets to purify Calamina 5000 grams and forge to 6 hours with slow fire again, with the concentrated solution Calamina of quenching, quenches and puts shady and cool place after broken and cooled in 48 hours.

2, system dried Alumen is got the Alumen of choosing clean and is put the fusing of marmite internal heating, and forges to dried-up, takes out and cuts piece.

3, Cortex Phellodendri charcoal decocts with water 30 minutes with Rhizoma Atractylodis 100 grams and gets the decocting in water dope, and water boiling down liquid soaked Cortex Phellodendri after 60 minutes, took out and fried to coke black with slow fire.

4, Calomelas mixes and stirs with cooking stove and fires the mercury compound that forms for Chalcanthitum, Sal, hydrargyrum, laterite add water.

5, be monarch drug with above-mentioned four kinds of medicine porphyrizes.

6, the system Oleum Hydnocapi semen is got the clean core of Semen Hydnocarpi, pulverizes and steams thoroughly, and oil is got in squeezing.

7, Radix Sophorae Flavescentis is ground be smalls, immersing in the Radix Sophorae Flavescentis end with Oleum Hydnocapi semen is ministerial drug.

8, getting the Radix Angelicae Dahuricae, the Radix Astragali adds 10 kg of water and decocts, when frying in shallow oil to 1500 milliliters of medicinal liquids, squeeze and remove slag only, the reuse slow fire boiling is concentrated into 60 milliliters, 60 milliliters concentrated solution is admixed mix homogeneously in the monarch drug, mixed monarch drug being placed on clean cloth watt last firing with slow fire drying, is monarch drug, ministerial drug mixing and stirring adjuvant drug then.Bu Wa, for earth burns to the fish scale shape small black tile that forms, old times Anhui Yangze river and Huai river one band this watt commonly used builds a house.

9, Borax is pounded in bulk with Borax, puts a pot internal heating, fries to heaving vesicle or snowy white caking, and taking-up cools.

10, with Borax, Borneolum Syntheticum, camphor by measuring foot, mix to grind and be to be messenger drug by smalls.

11, with monarch, minister, help, make four medicine mixed together to stir, grind superfine end and cross 200 order dusting covers, be made as superfine medicated powder and incapsulate, every 0.4 gram or be prepared into tablet, powder and water preparation.

Medicine of the present invention has the detoxifcation parasite killing, the sterilization antiinflammatory, the row of drawing out pus by applying a plaster to the affected part is dense, restrain antipruritic, the function of hemostasia and promoting granulation.Can treat diseases such as vagina uterine herpes that mycotic, trichomonal vaginitis, fungal infection cause, genital herpes, condyloma acuminatum, syphilis vaginitis, metritis, vagina erosion.

The specific embodiment:

Below further sets forth the beneficial effect of medicine of the present invention by testing example, test the test of pesticide effectiveness and the clinical observation on the therapeutic effect that example comprises medicine of the present invention (the abbreviation woman uses capsule) and test.

The therapeutic test of rabbit vagina ulcer due to [test example 1] medicine Dichlorodiphenyl Acetate of the present invention.

Test material: anthology invention medicine woman uses capsule, and every content is 0.4 gram.

Test method: get 30 of New Zealand's Female rabbits, body weight 2.0-2.5kg, put into rabbit vagina and made film in about 15 seconds with being immersed in cotton swab in the acetic acid, diameter 8-the 10mm of mucosa ulcer, after making film rabbit is divided into 3 groups, every group 10, wherein 2 groups are the treatment group of use woman of the present invention with capsule various dose medicine, and 1 group for using the treatment comparable group of Western medicine Pianomide.

The woman with the treatment group usefulness that capsule 5mg and 10mg supply rabbit, with Western medicine antiinflammatory 10mg porphyrize, is used for rabbit treatment comparable group.The dosage woman is 5mg and 10mg with capsule, and the Western medicine Pianomide is 10mg.

Press above-mentioned dosage to treatment group and the administration of treatment comparable group, administering mode is secondary every day, medicine is put into intravaginal, continuous 15 days is a course of treatment, observe local red and swollen symptom every day, exudate what, ulcer healing time, put to death rabbit after 15 days and dissect, detect by an unaided eye earlier, carry out pathology section examination then.

The result shows that rabbit forms white ulcer after making film, white secretions occurs in second day, viewing duration, and matched group rabbit vagina mouth secretions is unnecessary other groups obviously, and the beginning in the 3rd day of administration group secretions obviously reduces, and the ulcer situation is clearly better.Administration finishes the back anatomic observation and the results are shown in Table 1 and table 2:

The therapeutical effect (perusal) of rabbit vagina ulcer due to the table 1 woman usefulness capsule Dichlorodiphenyl Acetate

Group	Dosage (mg)	Mortality rate (only)	Survival rate (%)	Ulcer area (mm2)	Cure number (only)	Cure rate (%)
Group	Dosage (mg)	Mortality rate (only)	Survival rate (%)	Ulcer area (mm2)	Cure number (only)	Cure rate (%)	Western medicine Pianomide woman uses capsule with the capsule woman	10 5 10	1 0 0	90 100 100	19.1±7.2 8.6±3.5 0±0	7 8 10	70 80 100

Table 2 woman uses (pathologic finding) with the treatment of rabbit vagina ulcer due to the capsule Dichlorodiphenyl Acetate

The result shows, perusal and check pathological section as seen, the woman is with capsule administration group and matched group and the comparison of treatment comparable group, ulcer of vagina has the obvious treatment effect due to the Dichlorodiphenyl Acetate.

The clinical observation material of [test example 2] Drug therapy gynaecopathia of the present invention, sexually transmitted disease (STD).

1, physical data

Accept out-patient's totally 75 examples for medical treatment, wherein 17-30 years old, 25 examples; 31-40 years old, 27 examples; 41-50 years old, 16 examples; 51-60 years old, 7 examples.

2, diagnostic criteria

1. infusorian, colpitis mycotica: external genital is congested red and swollen, and secretions increase is with dysurea urgent micturition, diseases such as leucorrhea.

2. vagina uterine neck ulcer: vulvar erosions, urethral orifice flow dense vaginal secretions and increase.

3. uterine erosion, syphilis: trachelopanus, the vaginal orifice dense secretions stench that overflows, part patient is with General Symptomies such as heating dizzinesses.

4. Squamous Cell Carcinoma, cervical cancer: vaginal orifice hyperemia, secretions increase, individual patient xerostomia, pharyngalgia and oral ulcer etc.

3, Therapeutic Method

Every day secondary, each one, send into intravaginal, 15 days is a course of treatment.

4, efficacy assessment standard

Produce effects: behind drug treatment, various transference cures, the patient recovers normally, observes 3 months no recidivists.

Take a turn for the better: healing time is accelerated, and ulcer fades away, pain relief.

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above one month treatment, with the woman with capsule for treating infusorian, colpitis mycotica 29 examples, produce effects 26 examples as a result, 2 examples that take a turn for the better, invalid 1 example, obvious effective rate is 89.65%, improvement rate is 6.89%, total effective rate is 96.54%.

In two months treatment, with the woman with capsule for treating vagina uterine neck ulcer 26 examples, produce effects 21 examples as a result, 3 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 80.76%, improvement rate is 11.53%, total effective rate is 92.29%.

In trimestral treatment, with the woman with capsule for treating uterine erosion syphilis 12 examples, produce effects 9 examples as a result, 1 example that takes a turn for the better, invalid 2 examples, obvious effective rate is 75%, improvement rate is 8.33%, total effective rate is 83.33%.

In trimestral treatment, with the woman with capsule for treating Squamous Cell Carcinoma, cervical cancer 8 examples, produce effects 5 examples as a result, 2 examples that take a turn for the better, invalid 1 example, obvious effective rate is 62.5%, improvement rate is 25%, total effective rate is 87.5%.

Claims

1, a kind of medicine for the treatment of gynaecopathia, sexually transmitted disease (STD) is characterized in that: it is to be made by following bulk drugs:

Dried Alumen 450-550 gram Calaminas 450-550 gram Calomelass 450-550 grams

Borax 180-250 cron brains 25-35 gram Camphoras 25-35 grams

The Radix Angelicae Dahuricae 900-1100 gram Radixs Astragali 2800-3200 grams;

Described Cortex Phellodendri charcoal decocts with water 30 minutes with Rhizoma Atractylodis 100 grams and gets the decocting in water dope, and water boiling down liquid soaked Cortex Phellodendri after 60 minutes, took out and fried to coke black with slow fire.

2, medicine according to claim 1, wherein the consumption of each crude drug is: dried Alumen 500 grams, Calamina 500 grams, Calomelas 500 grams, Cortex Phellodendri charcoal 500 grams, Oleum Hydnocapi semen 30 grams, Radix Sophorae Flavescentis 300 grams, Borax 200 grams, Borneolum Syntheticum 30 grams, Camphora 30 grams, the Radix Angelicae Dahuricae 1000 grams, the Radix Astragali 3000 grams.