CN1084623C - 特定的α－半乳糖基神经酰胺、药物组合物及其用途 - Google Patents

特定的α－半乳糖基神经酰胺、药物组合物及其用途 Download PDF

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Publication number
CN1084623C
CN1084623C CN93116586A CN93116586A CN1084623C CN 1084623 C CN1084623 C CN 1084623C CN 93116586 A CN93116586 A CN 93116586A CN 93116586 A CN93116586 A CN 93116586A CN 1084623 C CN1084623 C CN 1084623C
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CN
China
Prior art keywords
integer
galactosylceramide
compound
formula
galactopyranosyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN93116586A
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English (en)
Chinese (zh)
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CN1088093A (zh
Inventor
肥塚靖彦
蒲谷浩司
元木一宏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Pharma KK
Kirin Holdings Co Ltd
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Kirin Brewery Co Ltd
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Publication of CN1088093A publication Critical patent/CN1088093A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN93116586A 1992-07-16 1993-07-16 特定的α－半乳糖基神经酰胺、药物组合物及其用途 Expired - Lifetime CN1084623C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP212015/92 1992-07-16
JP21201592 1992-07-16
JP85219/93 1993-03-19
JP8521993 1993-03-19

Publications (2)

Publication Number Publication Date
CN1088093A CN1088093A (zh) 1994-06-22
CN1084623C true CN1084623C (zh) 2002-05-15

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ID=26426239

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93116586A Expired - Lifetime CN1084623C (zh) 1992-07-16 1993-07-16 特定的α－半乳糖基神经酰胺、药物组合物及其用途

Country Status (12)

Country Link
US (3) US5767092A (enExample)
EP (1) EP0650732B1 (enExample)
JP (1) JP3088461B2 (enExample)
KR (1) KR100277621B1 (enExample)
CN (1) CN1084623C (enExample)
AT (1) ATE200224T1 (enExample)
AU (1) AU684466B2 (enExample)
CA (1) CA2140013C (enExample)
DE (1) DE69330096T2 (enExample)
FI (1) FI950166A7 (enExample)
TW (1) TW261533B (enExample)
WO (1) WO1994002168A1 (enExample)

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TW555562B (en) * 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
AU739673B2 (en) * 1997-02-05 2001-10-18 Kirin Pharma Kabushiki Kaisha Lyophilized compositions containing sphingoglycolipid and process for preparing them
US6417167B1 (en) 1997-02-05 2002-07-09 Kirin Beer Kabushiki Kaisha Lyophilized compositions containing shingoglycolipid and process for preparing them
CN1222293C (zh) 1997-04-10 2005-10-12 麒麟麦酒株式会社 含有α－糖基神经酰胺的NKT细胞活化剂
TW575420B (en) * 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
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CA2453880A1 (en) * 2001-07-25 2003-02-06 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
WO2003016326A1 (fr) * 2001-08-16 2003-02-27 Daiichi Suntory Pharma Co., Ltd. Glycolipide et agent therapeutique pour maladies auto-immunes le contenant en tant qu'ingredient actif
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WO2004026318A1 (ja) * 2002-09-20 2004-04-01 Kirin Beer Kabushiki Kaisha α-グリコシルセラミドを有効成分とするＣ型肝炎ウイルス抑制剤
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US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
CA2591232C (en) * 2004-12-28 2014-10-21 The Rockefeller University Glycolipids and analogues thereof as antigens for nk t cells
US7923013B2 (en) * 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
DK1848813T3 (da) 2005-01-28 2013-07-15 Univ Brigham Young Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler
US20090036658A1 (en) * 2005-03-04 2009-02-05 The Regents Of The University Of California Highly efficient synthesis of alpha-O-galactosyl ceramides
CA2613350A1 (en) * 2005-07-01 2007-01-11 Japan As Represented By President Of National Center Of Neurology And Ps Ychiatry Glycolipid derivative and drug containing the same as active component
EP1776963A1 (en) 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
BRPI0710668A2 (pt) * 2006-04-07 2011-08-16 Scripps Res Insittute alfa-galactosil ceramidas modificadas para marcar e estimular células t matadoras naturais
US7794722B2 (en) * 2006-06-30 2010-09-14 The Scripps Research Institute Adjuvants and methods of use
US8263576B2 (en) * 2006-08-15 2012-09-11 Mayo Foundation For Medical Education And Research Non-natural sphingolipid analogs and uses thereof
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
JP5416125B2 (ja) * 2007-10-12 2014-02-12 ルイジ パンツァ， 免疫アジュバントとして有用な糖脂質の類似体
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
KR101566847B1 (ko) * 2007-12-05 2015-11-06 아비박스 항원에 대한 면역 반응 증강을 위한 글리코실세라마이드의 용도
RU2571267C2 (ru) * 2008-10-08 2015-12-20 Абивакс Вакцинная композиция против гриппа
HRP20150998T1 (hr) 2009-02-16 2015-11-20 Cerenis Therapeutics Holding Sa Mimetici apolipoproteina a-i
RS56529B1 (sr) 2010-10-18 2018-02-28 Cerenis Therapeutics Holding Sa Jedinjenja, kompozicije i postupci pogodni za mobilizaciju holesterola
JPWO2012074116A1 (ja) 2010-12-02 2014-05-19 独立行政法人理化学研究所 アロＮＫＴ細胞を用いた免疫療法およびそのためのＴ細胞抗原受容体（ＴＣＲ）遺伝子のα鎖領域が均一なＶα−Ｊαに再構成されている細胞および該細胞由来ＮＫＴ細胞のバンキング
WO2013119857A1 (en) 2012-02-07 2013-08-15 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
JP6283809B2 (ja) 2012-08-22 2018-02-28 株式会社レグイミューン Ｉ型糖尿病の予防又は治療のための製剤
EP2906576B1 (en) 2012-10-12 2019-09-11 The Brigham and Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
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JP2015205835A (ja) * 2014-04-21 2015-11-19 国立大学法人福井大学 中性子線障害防護剤
KR20230117371A (ko) 2020-12-04 2023-08-08 가부시키가이샤 레그이뮨 체내 동태가 개선된 CD1d 리간드 화합물 함유 리포솜 제제

Citations (1)

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Also Published As

Publication number Publication date
TW261533B (enExample) 1995-11-01
CA2140013C (en) 2002-08-27
EP0650732A1 (en) 1995-05-03
EP0650732B1 (en) 2001-04-04
WO1994002168A1 (fr) 1994-02-03
FI950166A7 (fi) 1995-01-31
EP0650732A4 (en) 1998-04-01
CN1088093A (zh) 1994-06-22
CA2140013A1 (en) 1994-02-03
DE69330096T2 (de) 2001-10-18
ATE200224T1 (de) 2001-04-15
AU4583593A (en) 1994-02-14
KR100277621B1 (ko) 2001-02-01
FI950166A0 (fi) 1995-01-13
US5767092A (en) 1998-06-16
US6071884A (en) 2000-06-06
HK1009937A1 (en) 1999-09-17
KR950702431A (ko) 1995-07-29
AU684466B2 (en) 1997-12-18
JP3088461B2 (ja) 2000-09-18
US6017892A (en) 2000-01-25
DE69330096D1 (de) 2001-05-10

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