CN1084623C - 特定的α－半乳糖基神经酰胺、药物组合物及其用途 - Google Patents

特定的α－半乳糖基神经酰胺、药物组合物及其用途 Download PDF

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Publication number
CN1084623C
CN1084623C CN93116586A CN93116586A CN1084623C CN 1084623 C CN1084623 C CN 1084623C CN 93116586 A CN93116586 A CN 93116586A CN 93116586 A CN93116586 A CN 93116586A CN 1084623 C CN1084623 C CN 1084623C
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CN
China
Prior art keywords
integer
galactosylceramide
compound
formula
galactopyranosyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN93116586A
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English (en)
Chinese (zh)
Other versions
CN1088093A (zh
Inventor
肥塚靖彦
蒲谷浩司
元木一宏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Pharma KK
Kirin Holdings Co Ltd
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Kirin Brewery Co Ltd
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Publication of CN1088093A publication Critical patent/CN1088093A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN93116586A 1992-07-16 1993-07-16 特定的α－半乳糖基神经酰胺、药物组合物及其用途 Expired - Lifetime CN1084623C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP212015/92 1992-07-16
JP21201592 1992-07-16
JP85219/93 1993-03-19
JP8521993 1993-03-19

Publications (2)

Publication Number Publication Date
CN1088093A CN1088093A (zh) 1994-06-22
CN1084623C true CN1084623C (zh) 2002-05-15

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ID=26426239

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93116586A Expired - Lifetime CN1084623C (zh) 1992-07-16 1993-07-16 特定的α－半乳糖基神经酰胺、药物组合物及其用途

Country Status (12)

Country Link
US (3) US5767092A (enExample)
EP (1) EP0650732B1 (enExample)
JP (1) JP3088461B2 (enExample)
KR (1) KR100277621B1 (enExample)
CN (1) CN1084623C (enExample)
AT (1) ATE200224T1 (enExample)
AU (1) AU684466B2 (enExample)
CA (1) CA2140013C (enExample)
DE (1) DE69330096T2 (enExample)
FI (1) FI950166A7 (enExample)
TW (1) TW261533B (enExample)
WO (1) WO1994002168A1 (enExample)

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SI2056842T1 (sl) 2006-04-07 2013-02-28 The Scripps Research Institute Modificiran galaktosil-ceramid za zdravljenje kancerogenih obolenj
JP5564672B2 (ja) * 2006-06-30 2014-07-30 ザ スクリプス リサーチ インスティテュート アジュバント及びその使用方法
US8263576B2 (en) * 2006-08-15 2012-09-11 Mayo Foundation For Medical Education And Research Non-natural sphingolipid analogs and uses thereof
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
ES2574825T3 (es) * 2007-10-12 2016-06-22 Luigi Panza Análogos de glicolípidos útiles como inmunoadyuvantes
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
AU2008350531B2 (en) * 2007-12-05 2014-01-23 Abivax Use of glycosylceramides for enhancing the immune response to antigens
CN102215864A (zh) * 2008-10-08 2011-10-12 威蒂赛尔公司 用于抗流感的疫苗组合物
DK2396017T3 (en) 2009-02-16 2015-09-14 Cerenis Therapeutics Holding Sa Apolipoprotein A-I-mimetika
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ES2675582T3 (es) 2010-12-02 2018-07-11 Riken Inmunoterapia utilizando células alo-NKT, células para inmunoterapia en las que la cadena alfa del gen del receptor de las células T (TCR) ha sido redistribuida a V alfa-J alfa uniforme, y banco de células NKT derivadas de dichas células
EP2811831B1 (en) 2012-02-07 2018-04-11 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
EP2889039B1 (en) 2012-08-22 2017-11-08 Regimmune Corporation Preparation for preventing or treating type i diabetes
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JP2015205835A (ja) * 2014-04-21 2015-11-19 国立大学法人福井大学 中性子線障害防護剤
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Citations (1)

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
KR100277621B1 (ko) 2001-02-01
WO1994002168A1 (fr) 1994-02-03
KR950702431A (ko) 1995-07-29
US6071884A (en) 2000-06-06
TW261533B (enExample) 1995-11-01
CN1088093A (zh) 1994-06-22
AU4583593A (en) 1994-02-14
AU684466B2 (en) 1997-12-18
HK1009937A1 (en) 1999-09-17
DE69330096D1 (de) 2001-05-10
EP0650732A1 (en) 1995-05-03
EP0650732B1 (en) 2001-04-04
FI950166A0 (fi) 1995-01-13
DE69330096T2 (de) 2001-10-18
FI950166A7 (fi) 1995-01-31
JP3088461B2 (ja) 2000-09-18
EP0650732A4 (en) 1998-04-01
US6017892A (en) 2000-01-25
CA2140013A1 (en) 1994-02-03
CA2140013C (en) 2002-08-27
US5767092A (en) 1998-06-16
ATE200224T1 (de) 2001-04-15

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