CN108450665A - It is a kind of to be used to prevent feed addictive of enteric infection and its preparation method and application - Google Patents
It is a kind of to be used to prevent feed addictive of enteric infection and its preparation method and application Download PDFInfo
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- CN108450665A CN108450665A CN201810273505.3A CN201810273505A CN108450665A CN 108450665 A CN108450665 A CN 108450665A CN 201810273505 A CN201810273505 A CN 201810273505A CN 108450665 A CN108450665 A CN 108450665A
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- feed addictive
- parts
- pericarp
- acidolysis
- shell
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- 206010022678 Intestinal infections Diseases 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 241001070941 Castanea Species 0.000 claims abstract description 16
- 235000014036 Castanea Nutrition 0.000 claims abstract description 15
- 244000105624 Arachis hypogaea Species 0.000 claims abstract description 14
- 235000009496 Juglans regia Nutrition 0.000 claims abstract description 14
- 208000015181 infectious disease Diseases 0.000 claims abstract description 14
- 235000020234 walnut Nutrition 0.000 claims abstract description 14
- 235000017060 Arachis glabrata Nutrition 0.000 claims abstract description 13
- 235000010777 Arachis hypogaea Nutrition 0.000 claims abstract description 13
- 235000018262 Arachis monticola Nutrition 0.000 claims abstract description 13
- 235000020232 peanut Nutrition 0.000 claims abstract description 13
- 241001465754 Metazoa Species 0.000 claims abstract description 12
- 240000003377 Shepherdia canadensis Species 0.000 claims abstract description 12
- 235000018324 Shepherdia canadensis Nutrition 0.000 claims abstract description 12
- 210000000936 intestine Anatomy 0.000 claims abstract description 11
- 239000000835 fiber Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 244000144972 livestock Species 0.000 claims abstract description 7
- 244000144977 poultry Species 0.000 claims abstract description 6
- 208000035240 Disease Resistance Diseases 0.000 claims abstract description 5
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- 238000005904 alkaline hydrolysis reaction Methods 0.000 claims description 27
- 238000000605 extraction Methods 0.000 claims description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
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- 230000000968 intestinal effect Effects 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
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- RDEIXVOBVLKYNT-HDZPSJEVSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1r)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2 Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@@H](C)N)N)[C@@H](N)C[C@H]1N.O1[C@H]([C@@H](C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-HDZPSJEVSA-N 0.000 description 1
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- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/49—Fagaceae (Beech family), e.g. oak or chestnut
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Microbiology (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Fodder In General (AREA)
Abstract
The invention belongs to the technical fields of feed addictive, disclose a kind of for preventing feed addictive of enteric infection and its preparation method and application.The feed addictive is prepared by the following raw material counted in parts by weight：15~40 parts of soapberry pericarp, 10~30 parts of walnut pericarp, 10~30 parts of oil tea pericarp, bitter 5~20 parts of sweet oak shell, 5~20 parts of chestnut shell, 5~20 parts of peanut shell, 5~20 parts of acorn cup.Method is that raw material is used Subcritical Water Extraction by (1), obtains extracting solution and residue；(2) residue is handled, obtains water-insoluble fiber；(3) water-insoluble fiber is mixed with extracting solution, is adsorbed, it is dry, obtain feed addictive.The feed addictive of the present invention is added to the disease resistance that can prevent animal and bird intestines infection in feed and improve livestock and poultry, which can also improve it in the stability of gastrointestinal tract and the dispersibility in feed；The recovery rate of active constituent is high in the method for the present invention.
Description
Technical field
The invention belongs to the technical fields of feed addictive, and in particular to a kind of feed addition for preventing enteric infection
Agent and the preparation method and application thereof.
Background technology
As China's Animal husbandry production scale constantly expands the continuous improvement with intensive degree, various intestines problems are presented
Multiple trend, wherein direct economic loss is up to tens billion of members every year caused by intestines problem.Common livestock and poultry intestinal canal diseases
The mainly enteric infection caused by bacterium, virus and parasite.Currently, main control measure is to use antibiotic, so
And a large amount of antibiotic usage causes pathogenic microorganism to generate a large amount of antibiotic residue in drug resistance and livestock products, seriously
Threaten human health.Therefore, a kind of natural prodcuts substitute antibiotics for preventing enteric infection of searching become very urgent need
It asks.
Agricultural product roughing process will produce more waste, contain a variety of active ingredients in these wastes.If
By these wastes by rationally screening, extracting, it is expected to form the inexpensive preparation or feed for effectively preventing animal and bird intestines infection
Additive.
Invention content
In order to overcome the disadvantages and deficiencies of the prior art, the primary purpose of the present invention is that providing a kind of for preventing enteron aisle
The feed addictive of infection.
Another object of the present invention is to provide the above-mentioned preparation methods for preventing the feed addictive of enteric infection.
It is still another object of the present invention to provide application of the above-mentioned feed addictive in preventing animal and bird intestines infection preparation.
The purpose of the invention is achieved by the following technical solution：
A kind of feed addictive for preventing enteric infection is prepared by the following raw material counted in parts by weight：Nothing
Suffer from 15~40 parts of sub- pericarp, 10~30 parts of walnut pericarp, 10~30 parts of oil tea pericarp, bitter 5~20 parts of sweet oak shell, chestnut shell 5~20
Part, 5~20 parts of peanut shell, 5~20 parts of acorn cup.
The above-mentioned preparation method for preventing the feed addictive of enteric infection includes the following steps：
(1) by soapberry pericarp, walnut pericarp, oil tea pericarp, bitter sweet oak shell, chestnut shell, peanut shell and acorn cup using sub-
Critical is extracted, and extracting solution and residue are obtained；
(2) residue is handled, obtains water-insoluble fiber；
(3) water-insoluble fiber is mixed with extracting solution, is adsorbed, dry, acquisition adds for preventing the feed of enteric infection
Add agent.
The condition of Subcritical Water Extraction described in step (1) is 5~20MPa of pressure, 150~300 DEG C of temperature；The extraction
0.5~3h of time.The subcritical water and the volume mass ratio of raw material total amount are (8~50) mL：1g.
Processing described in step (2) refers to carrying out acidolysis using acid and carrying out alkaline hydrolysis using alkali, can be first acidolysis alkali again
Solution or first alkaline hydrolysis acidolysis again.
The acid of the acidolysis is hydrochloric acid, sulfuric acid or nitric acid；The alkali of the alkaline hydrolysis is that sodium hydroxide solution or potassium hydroxide are molten
Liquid；
The acidolysis condition be acid a concentration of 0.5~2.5mol/L, the acidolysis time be 1~5h, acidolysis temperature be 50~
100℃；When acidolysis, the mass volume ratio of residue and acid is 1g:(3~20) mL；
The alkaline hydrolysis condition be alkali a concentration of 2wt%~5wt%, the alkaline hydrolysis time be 1~5h, alkaline hydrolysis temperature be 50~
100℃；When alkaline hydrolysis, the mass volume ratio of residue and alkali is 1g:(3~20) mL.
Concussion absorption is adsorbed as described in step (3), the condition of absorption is：Adsorption temp is 20~45 DEG C, shakes frequency
For 50~300 times/min, 0.5~2h of time of absorption is shaken.
Dry to be dried in vacuo described in step (3), vacuum drying condition is：Temperature is 50~80 DEG C, and pressure is
0.01~0.1MPa, drying time are 2~8h.In step (3), it can be filtered after absorption.
It needs to mix raw material before extraction in step (1), crush, sieving.The sieving referred to 40~120 mesh sieve.
Above-mentioned feed addictive, the application in preventing animal and bird intestines infection preparation；It is used to prepare and prevents animal and bird intestines sense
The feeding feed of dye and/or the disease resistance of raising livestock and poultry.
The feed addictive by 0.05~1% mass fraction addition (refer to additive be feeding quality 0.05~
1%) in feeding feed, can be used for preventing animal and bird intestines infection and improve the disease resistance of livestock and poultry.
The principle of the present invention：Using the desinsection of oil tea pericarp, soapberry pericarp, walnut pericarp and bitter sweet oak shell, anti-inflammatory, resist
Bacterium, antiviral effect coordinate peanut shell and the gastrointestinal tract regulatory function of chestnut shell and the immune enhancing function of acorn cup,
Reasonable formula is carried out, animal and bird intestines infection can be effectively prevented and improves the disease resistance of livestock and poultry.The present invention is extracted using subcritical water
It takes, using the change in polarity of subcritical water, can fully extract the active constituent of the opposed polarity in pericarp or shell.Pericarp or
After active material in shell is extracted, the biodegradable component of shell is removed with acidolysis and alkaline hydrolysis, is left water-insoluble cellulose.
The cellulose has larger porosity and specific surface area, and contains a large amount of hydroxyl, is easy to be formed with polyphenol isoreactivity ingredient
Hydrogen bond has stronger adsorptivity, the active constituent of extraction is supported in shell fiber, can improve active constituent in animal
Stability in enteron aisle and the dispersibility in feed.It is source and effect of prescription raw material below：
Oil tea pericarp：The fruit shell (part in fruit other than seed) of Theaceae Camellia shrub or middle arbor, tool
There are clearing heat and detoxicating, desinsection, antibiotic effect, but is not developed and used；
Soapberry pericarp：The pericarp of Sapindaceae Sapindus arbor fruit, fruit rind (fruit stone (seed) in fruit
Part in addition) in be rich in saponin(e, there is heat-clearing, the effect of eliminating the phlegm, disperse accumulation, desinsection；
Walnut pericarp：The pericarp of Juglandaceae juglans arbor fruit, has effects that desinsection, anti-inflammatory, antibacterial；The present invention's
Use the exocarp and middle pericarp that walnut pericarp is fruit；
Bitter sweet oak shell：Fagaceae cone belongs to the fruit shell of arbor, and bitter sweet oak has the effects that clearing heat and detoxicating, solution productization silt, antidiarrheal,
But its shell is not used；Bitter sweet oak shell is the exocarp (i.e. acorn-cup wraps up the part of seed) of fruit；
Peanut shell：The shell of the annual herb plant seed of pulse family Arachis contains resveratrol, single unsaturated lipid
The ingredients such as fat acid and cupreol have spleen benefiting and stimulating the appetite, benefiting qi and checking blood effect；
Chestnut shell：Fagaceae Castanea arbor, chestnut shell have drop it is inverse promote the production of body fluid, heat-clearing dissipating bind, hemostasis, anti-gastric disorder causing nausea the effect of,
But it is not developed and used；Chestnut shell is the acorn-cup (i.e. the exocarp of Chinese chestnut) of Chinese chestnut；
Acorn cup：The shell of the fruit of Fagaceae oak category arbor, plant adaptability is extremely strong, and seed can control rush down dysentery, increases
Strong immune function.Contain flavone compound in its shell, but is not used.Acorn cup is the exocarp of acorn-cup, that is, acorn nut.
The present invention has the following advantages and effects with respect to the prior art：
(1) present invention is using reactive compound in Subcritical Water Extraction extraction pericarp and shell, and recovery rate is high, and activity is good,
It is environmental-friendly without using organic solvent.
(2) present invention uses the fiber-loaded polyphenol structural compounds of shell, improves it in the stability of gastrointestinal tract and is raising
Dispersibility in material.
(3) preparation process of the present invention is simple, is convenient for industrialized production.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Embodiment 1
(1) by soapberry pericarp 40g, walnut pericarp 20g, oil tea pericarp 20g, bitter sweet oak shell 5g, chestnut shell 5g, peanut shell 5g
With acorn cup 5g mix, crush, cross 40 mesh sieve, be added 1L water extraction, extracting pressure 15MPa, 200 DEG C of extraction temperature, extraction when
Between 1h, obtain extracting solution 820g and residue 230g；
(2) a concentration of 1.5mol/L hydrochloric acid solutions of 1150mL are added in step (1) residue and carry out acidolysis, acidolysis temperature 70
DEG C, after acidolysis 2h, filtering；Filter residue is added the sodium hydrate aqueous solution that 1150mL mass fractions are 2% and carries out alkaline hydrolysis, alkaline hydrolysis 2h
Afterwards, it filters, filter residue is washed to neutrality, obtains product 56g；
(3) product obtained by step (2) is added in the extracting solution of step (1), 20 DEG C of frequency oscillations with 300 times/min
2h, then in temperature 50 C, pressure 0.01MPa, dry 2h must prevent the feed addictive 62g of enteric infection.
Embodiment 2
(1) by soapberry pericarp 20g, walnut pericarp 30g, oil tea pericarp 15g, bitter sweet oak shell 10g, chestnut shell 10g, peanut shell
10g and acorn cup 5g mixing, crush, cross 120 mesh sieve, and the extraction of 2L water, extracting pressure 20MPa, 300 DEG C of extraction temperature, extraction is added
It takes time 0.5h, obtain extracting solution 1850g and residue 210g；
(2) a concentration of 0.5mol/L aqueous hydrochloric acid solutions of 4.2L are added in step (1) residue and carry out acidolysis, acidolysis temperature is
100 DEG C, after acidolysis 3h, filtering；Filter residue is added the sodium hydrate aqueous solution that 2.1L mass fractions are 2% and carries out alkaline hydrolysis, alkaline hydrolysis 3h
Afterwards, it filters, filter residue is washed to neutrality, obtains product 47g；
(3) product obtained by step (2) is added in the extracting solution of step (1), 45 DEG C of frequency oscillations with 50 times/min
0.5h；Then in 80 DEG C, pressure 0.05MPa of temperature, dry 4h must prevent the feed addictive 53g of enteric infection.
Embodiment 3
(1) by soapberry pericarp 30g, walnut pericarp 15g, oil tea pericarp 15g, bitter sweet oak shell 5g, chestnut shell 5g, peanut shell
20g and acorn cup 10g mixing, crush, cross 60 mesh sieve, and the extraction of 0.8L water, extracting pressure 5MPa, 150 DEG C of extraction temperature, extraction is added
Time 3h is taken, extracting solution 590g and residue 270g is obtained；
(2) a concentration of 2.5mol/L aqueous hydrochloric acid solutions of 810mL are added in step (1) residue and carry out acidolysis, acidolysis temperature is
50 DEG C, after acidolysis 1.5h, filtering；Filter residue is added the sodium hydrate aqueous solution that 1080mL mass fractions are 2.5% and carries out alkaline hydrolysis, alkali
After solving 1.5h, filtering, filter residue is washed to neutrality, obtains product 63g；
(3) product obtained by step (2) is added in the extracting solution of step (1), 35 DEG C of frequency oscillations with 100 times/min
1h；Filtering, then in 80 DEG C, pressure 0.1MPa of temperature, dry 3h must prevent the feed addictive 68g of enteric infection.
Embodiment 4
(1) by soapberry pericarp 15g, walnut pericarp 15g, oil tea pericarp 30g, bitter sweet oak shell 15g, chestnut shell 5g, peanut shell
5g and acorn cup 15g mixing, crush, cross 80 mesh sieve, and the extraction of 5L water, extracting pressure 10MPa, 250 DEG C of extraction temperature, extraction is added
Time 1.5h obtains extracting solution 4850g and residue 240g；
(2) a concentration of 2mol/L aqueous hydrochloric acid solutions of 2.4L are added in step (1) residue and carry out acidolysis, acidolysis temperature 80
DEG C, after acidolysis 1h, filtering；Filter residue is added the sodium hydrate aqueous solution that 1.2L mass fractions are 5% and carries out alkaline hydrolysis, after alkaline hydrolysis 1h,
Filtering, filter residue are washed to neutrality, obtain product 44g；
(3) product obtained by step (2) is added in the extracting solution of step (1), 25 DEG C of frequency oscillations with 200 times/min
1.5h；Then in temperature 70 C, pressure 0.03MPa, dry 8h must prevent the feed addictive 50g of enteric infection.
Embodiment 5
(1) by soapberry pericarp 20g, walnut pericarp 15g, oil tea pericarp 15g, bitter sweet oak shell 20g, chestnut shell 20g, peanut shell
5g and acorn cup 5g mixing, crushes, and crosses 60 mesh sieve, is added the extraction of 3L water, when extracting pressure 8MPa, 180 DEG C of extraction temperature, extraction
Between 1.5h, obtain extracting solution 2750g and residue 280g；
(2) a concentration of 1.5mol/L aqueous hydrochloric acid solutions of 1.4L are added in step (1) residue and carry out acidolysis, acidolysis temperature 60
DEG C, after acidolysis 4h, filtering；Filter residue is added the sodium hydrate aqueous solution that 1.4L mass fractions are 3% and carries out alkaline hydrolysis, after alkaline hydrolysis 4h,
Filtering, filter residue are washed to neutrality, obtain product 62g；
(3) product obtained by step (2) is added in the extracting solution of step (1), 35 DEG C of frequency oscillations with 250 times/min
1h；Then in temperature 60 C, pressure 0.01MPa, dry 5h must prevent the feed addictive 70g of enteric infection.
Embodiment 6
(1) by soapberry pericarp 25g, walnut pericarp 10g, oil tea pericarp 10g, bitter sweet oak shell 10g, chestnut shell (Chinese chestnut it is outer
Pericarp) 10g, peanut shell 15g and acorn cup 20g mixing, it crushes, sieves with 100 mesh sieve, be added the extraction of 4L water, extracting pressure 12MPa,
250 DEG C of extraction temperature, extraction time 2.5h obtain extracting solution 3700g and residue 310g；
(2) a concentration of 2.5mol/L aqueous hydrochloric acid solutions of 3.1L are added in step (1) residue and carry out acidolysis, acidolysis temperature 70
DEG C, after acidolysis 3.5h, filtering；Filter residue is added the sodium hydrate aqueous solution that 5L mass fractions are 5% and carries out alkaline hydrolysis, alkaline hydrolysis 3.5h
Afterwards, it filters, filter residue is washed to neutrality, obtains product 65g.
(3) product obtained by step (2) is added in the extracting solution of step (1), 40 DEG C of frequency oscillations with 150 times/min
1.5h；Then in temperature 70 C, pressure 0.05MPa, dry 6h must prevent the feed addictive 73g of enteric infection.
Embodiment 7
The feed addictive for preventing enteric infection infects chicken the therapeutic effect experiment of salmonella
Method：1 age in days Qingyuan Chicken 300 is taken, is randomly divided into 10 groups, every group 30.Be divided into control group, antibiotic group,
The high, medium and low dosage group of 1 additive of embodiment, 2~6 additive middle dose group of embodiment.It is infected with chicken source salmonella C79-1
1 time (feeding 0.1mL, about 108Viable bacteria), additive in feed additive amount be 1% (high dose), 0.5% (middle dosage) and
0.1% (low dosage), antibiotic are amikacin sulfate, and additive amount is 30mg/kg in feed.It is continuous to feed 30 days.Statistics
Chicken death number takes out spleen and thymus gland after being put to death to not dead chicken, calculates index and spleen index and thymus index.
As a result：The additive of the present invention has good control action, no death to occur the infection of chicken caused by salmonella,
Its Thymus and spleen index is significantly improved compared with control.Illustrate that they have the therapeutic effect of antibiotic and improve chicken immunity
Effect.It the results are shown in Table 1.
Therapeutic effect of 1 additive of table to salmonella infection chicken
Embodiment 8
The feed addictive for preventing enteric infection tests the therapeutic effect of pig ehec infection
Method：Ternary pigs 200 in 10~20 days are taken, are randomly divided into 10 groups, every group 20.It is grouped into control group, implements
The high, medium and low dosage group of 1 additive of example, 2~6 additive middle dose group of embodiment, antibiotic group.With Escherichia coli O301Infection
(feeding 5mL/ days, about 109Viable bacteria) 5 days, additive additive amount in feed be 0.2% (high dose), 0.1% (middle dosage) and
0.05% (low dosage), antibiotic are gentamicin sulphate, and additive amount is 10mg/kg in feed.Continuous use 3 days.Observation
Pig situation：Symptom disappears, diet and mental status are well to cure；It is effective that diarrhoea status, which mitigates, appetite improves；Diarrhoea status
Do not mitigate or aggravate, appetite does not improve is invalid.
As a result：The additive of the present invention has good control action, obvious effective rate 80 to the infection of pig caused by Escherichia coli
~100%, cure rate is 50~90%.Illustrate that they have pig ehec infection the substitution effect of antibiotic.As a result see
Table 2.
Therapeutic effect of 2 additive of table to coli-infection pig
| Extract | Number of animals/only | Effective number/only | Healing number/only | Invalid number/only | Obvious effective rate/% | Cure rate/% |
| Control group | 20 | 0 | 0 | 20 | 0 | 0 |
| 1 low dosage of embodiment | 20 | 16 | 10 | 4 | 80 | 50 |
| 1 middle dosage of embodiment | 20 | 19 | 16 | 1 | 95 | 80 |
| 1 high dose of embodiment | 20 | 20 | 18 | 0 | 100 | 90 |
| 2 middle dosage of embodiment | 20 | 18 | 14 | 2 | 90 | 70 |
| 3 middle dosage of embodiment | 20 | 19 | 16 | 1 | 95 | 80 |
| 4 middle dosage of embodiment | 20 | 20 | 17 | 0 | 100 | 85 |
| 5 middle dosage of embodiment | 20 | 18 | 15 | 2 | 90 | 75 |
| 6 middle dosage of embodiment | 20 | 19 | 17 | 1 | 95 | 85 |
| Gentamicin | 20 | 20 | 17 | 0 | 100 | 85 |
Embodiment 9
The Examples 1 to 6 feed addictive obtained for preventing enteric infection is added separately in chicken feed, and additive amount is
5%, using 14 days, chicken upgrowth situation was good, and catching without chicken intestinal in two months occurs.
Embodiment 10
The Examples 1 to 6 feed addictive obtained for preventing enteric infection is added separately in ox feed, and additive amount is
0.1%, using 7 days, Niu Shengchang and milk production in order, occurred in two months without enteric infection disease.
The above embodiment is a preferred embodiment of the present invention and is not restricted to the described embodiments, and others are any not to carry on the back
Change made by under Spirit Essence and principle from the present invention, modification, substitute.Combination simplifies, and should be equivalent displacement side
Formula is included within the scope of the present invention.
Claims (10)
1. a kind of feed addictive for preventing enteric infection, it is characterised in that：By the following raw material system counted in parts by weight
It is standby to form：15~40 parts of soapberry pericarp, 10~30 parts of walnut pericarp, 10~30 parts of oil tea pericarp, bitter 5~20 parts of sweet oak shell, plate
5~20 parts of chestnut shell, 5~20 parts of peanut shell, 5~20 parts of acorn cup.
2. being used to prevent the preparation method of the feed addictive of enteric infection according to claim 1, it is characterised in that：Including
Following steps：
(1) by soapberry pericarp, walnut pericarp, oil tea pericarp, bitter sweet oak shell, chestnut shell, peanut shell and acorn cup using subcritical
Water is extracted, and extracting solution and residue are obtained；
(2) residue is handled, obtains water-insoluble fiber；
(3) water-insoluble fiber is mixed with extracting solution, is adsorbed, it is dry, obtain the feed addictive for preventing enteric infection.
3. being used to prevent the preparation method of the feed addictive of enteric infection according to claim 2, it is characterised in that：Step
(1) condition of Subcritical Water Extraction described in is 5~20MPa of pressure, 150~300 DEG C of temperature；The time 0.5 of the extraction~
3h。
4. being used to prevent the preparation method of the feed addictive of enteric infection according to claim 2, it is characterised in that：It is described
Subcritical water and the volume mass ratio of raw material total amount are (8~50) mL：1g.
5. being used to prevent the preparation method of the feed addictive of enteric infection according to claim 2, it is characterised in that：Step
(2) processing described in refers to carrying out acidolysis using acid and carrying out alkaline hydrolysis using alkali, for first acidolysis alkaline hydrolysis or first alkaline hydrolysis acidolysis again again.
6. being used to prevent the preparation method of the feed addictive of enteric infection according to claim 5, it is characterised in that：It is described
The acid of acidolysis is hydrochloric acid, sulfuric acid or nitric acid；
The alkali of the alkaline hydrolysis is sodium hydroxide solution or potassium hydroxide solution；
The acidolysis condition is a concentration of 0.5~2.5mol/L of acid, and the acidolysis time is 1~5h, and acidolysis temperature is 50~100
℃；
The alkaline hydrolysis condition is a concentration of 2wt%~5wt% of alkali, and the alkaline hydrolysis time is 1~5h, and alkaline hydrolysis temperature is 50~100 DEG C.
7. being used to prevent the preparation method of the feed addictive of enteric infection according to claim 5, it is characterised in that：Acidolysis
When, the mass volume ratio of residue and acid is 1g:(3~20) mL；When alkaline hydrolysis, the mass volume ratio of residue and alkali is 1g:(3~20)
mL。
8. being used to prevent the preparation method of the feed addictive of enteric infection according to claim 2, it is characterised in that：Step
(3) concussion absorption is adsorbed as described in, the condition of absorption is：Adsorption temp be 20~45 DEG C, concussion frequency be 50~300 times/
Min shakes 0.5~2h of time of absorption；
It is dry for vacuum drying described in step (3).
9. application of the feed addictive according to claim 1 in preventing animal and bird intestines infection preparation.
10. being used to prevent the application of the feed addictive of enteric infection according to claim 1, it is characterised in that：The feeding
Feed additives are used to prepare the feeding feed for the disease resistance for preventing animal and bird intestines infection and/or raising livestock and poultry.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810273505.3A CN108450665B (en) | 2018-03-29 | 2018-03-29 | Feed additive for preventing intestinal infection and preparation method and application thereof |
| PCT/CN2018/110823 WO2019184307A1 (en) | 2018-03-29 | 2018-10-18 | Feed additive for preventing intestinal infection, preparation method therefor and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810273505.3A CN108450665B (en) | 2018-03-29 | 2018-03-29 | Feed additive for preventing intestinal infection and preparation method and application thereof |
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| WO2019184307A1 (en) * | 2018-03-29 | 2019-10-03 | 华南理工大学 | Feed additive for preventing intestinal infection, preparation method therefor and use thereof |
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| KR101273426B1 (en) * | 2013-02-08 | 2013-06-12 | 유니크바이오텍 주식회사 | Manufacturing method of polyphenols fortified feed additives using grape by-product and propolis extract |
| CN104054898A (en) * | 2014-05-19 | 2014-09-24 | 华南理工大学 | Shell extract capable of replacing antibiotics as well as preparation method and application of shell extract |
| CN105311248A (en) * | 2015-11-25 | 2016-02-10 | 华南理工大学 | Tea fruit shell tannin and preparation method thereof |
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|---|---|---|---|---|
| CN103976187B (en) * | 2014-05-16 | 2016-03-23 | 温州中普知识产权有限公司 | Chicken feed |
| CN108450665B (en) * | 2018-03-29 | 2021-07-20 | 华南理工大学 | Feed additive for preventing intestinal infection and preparation method and application thereof |
-
2018
- 2018-03-29 CN CN201810273505.3A patent/CN108450665B/en not_active Expired - Fee Related
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| KR101273426B1 (en) * | 2013-02-08 | 2013-06-12 | 유니크바이오텍 주식회사 | Manufacturing method of polyphenols fortified feed additives using grape by-product and propolis extract |
| CN104054898A (en) * | 2014-05-19 | 2014-09-24 | 华南理工大学 | Shell extract capable of replacing antibiotics as well as preparation method and application of shell extract |
| CN105311248A (en) * | 2015-11-25 | 2016-02-10 | 华南理工大学 | Tea fruit shell tannin and preparation method thereof |
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| WO2019184307A1 (en) * | 2018-03-29 | 2019-10-03 | 华南理工大学 | Feed additive for preventing intestinal infection, preparation method therefor and use thereof |
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