CN108239059B - 一种利用模拟移动床从银杏叶提取物中分离黄酮类化合物的方法 - Google Patents
一种利用模拟移动床从银杏叶提取物中分离黄酮类化合物的方法 Download PDFInfo
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- CN108239059B CN108239059B CN201810086539.1A CN201810086539A CN108239059B CN 108239059 B CN108239059 B CN 108239059B CN 201810086539 A CN201810086539 A CN 201810086539A CN 108239059 B CN108239059 B CN 108239059B
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- -1 flavonoid compounds Chemical class 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims abstract description 11
- 229930003935 flavonoid Natural products 0.000 title claims description 10
- 235000017173 flavonoids Nutrition 0.000 title claims description 10
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 42
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- 241000218628 Ginkgo Species 0.000 claims description 21
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
化合物 | CH<sub>50</sub>(mg/mL) |
式I | 0.106±0.012 |
式II | 0.182±0.019 |
产品A | 0.203±0.023 |
产品B | 0.218±0.025 |
肝素钠 | 0.053±0.008 |
Claims (2)
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CN201810086539.1A CN108239059B (zh) | 2018-01-29 | 2018-01-29 | 一种利用模拟移动床从银杏叶提取物中分离黄酮类化合物的方法 |
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CN108239059A CN108239059A (zh) | 2018-07-03 |
CN108239059B true CN108239059B (zh) | 2020-01-03 |
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CN1288438C (zh) * | 2003-10-30 | 2006-12-06 | 鞍山科技大学 | 模拟移动床色谱分离提纯银杏内酯b的方法 |
CN100545157C (zh) * | 2007-05-24 | 2009-09-30 | 江苏汉邦科技有限公司 | 模拟移动床色谱法从芦蒿中分离纯化黄酮的方法 |
CN100528857C (zh) * | 2007-05-24 | 2009-08-19 | 江苏汉邦科技有限公司 | 四区模拟移动床色谱法分离纯化芦荟黄酮的方法 |
CN101347424A (zh) * | 2007-07-20 | 2009-01-21 | 复旦大学 | 木犀草素在制备抗补体药物中的用途 |
CN102304158B (zh) * | 2011-05-20 | 2014-07-30 | 中国人民解放军第二军医大学 | 酰化黄酮苷化合物及其在制备补体抑制剂药物中的应用 |
CN102285951A (zh) * | 2011-09-13 | 2011-12-21 | 辽宁亿灵科创生物医药科技有限公司 | 木犀草素衍生物及其预防和治疗心血管疾病的用途 |
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Effective date of registration: 20200720 Address after: 710400 Jixian Industrial Park, Zhouzhi County, Shaanxi, Xi'an Patentee after: Zhouzhi County Tianyi biological science and Technology Co.,Ltd. Address before: 518000 Oriental times square b1912, 2009 Huaqiang North Road, Huahang community, Huaqiang North Street, Futian District, Shenzhen City, Guangdong Province Patentee before: Shenzhen Zhongyu Intellectual Property Service Co.,Ltd. Effective date of registration: 20200720 Address after: 518000 Oriental times square b1912, 2009 Huaqiang North Road, Huahang community, Huaqiang North Street, Futian District, Shenzhen City, Guangdong Province Patentee after: Shenzhen Zhongyu Intellectual Property Service Co.,Ltd. Address before: 225127 No. 199, Yang Hua Xi Road, Yangzhou, Jiangsu Patentee before: YANGZHOU POLYTECHNIC INSTITUTE |
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Denomination of invention: A Method for Separating Flavonoids from Ginkgo biloba Leaf Extract Using Simulated Moving Bed Effective date of registration: 20231227 Granted publication date: 20200103 Pledgee: Bank of China Limited Xi'an Chang'an District Branch Pledgor: Zhouzhi County Tianyi biological science and Technology Co.,Ltd. Registration number: Y2023610000775 |
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