CN1080721C - 1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物 - Google Patents

1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物 Download PDF

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Publication number
CN1080721C
CN1080721C CN96193768A CN96193768A CN1080721C CN 1080721 C CN1080721 C CN 1080721C CN 96193768 A CN96193768 A CN 96193768A CN 96193768 A CN96193768 A CN 96193768A CN 1080721 C CN1080721 C CN 1080721C
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CN
China
Prior art keywords
hydrochloride
isoquinolinesulfonyl
homopiperazine
trihydrate
tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN96193768A
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English (en)
Chinese (zh)
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CN1183782A (zh
Inventor
川久保弘
大野胜
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Asahi Kasei Corp
Original Assignee
Asahi Kasei Corp
Asahi Kasei Kogyo KK
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Publication of CN1183782A publication Critical patent/CN1183782A/zh
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Publication of CN1080721C publication Critical patent/CN1080721C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN96193768A 1995-07-03 1996-06-19 1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物 Expired - Fee Related CN1080721C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16746095 1995-07-03
JP167460/95 1995-07-03

Publications (2)

Publication Number Publication Date
CN1183782A CN1183782A (zh) 1998-06-03
CN1080721C true CN1080721C (zh) 2002-03-13

Family

ID=15850096

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96193768A Expired - Fee Related CN1080721C (zh) 1995-07-03 1996-06-19 1－(5－异喹啉磺酰基)高哌嗪盐酸盐水合物

Country Status (7)

Country Link
US (1) US5942505A (enExample)
EP (1) EP0870767B1 (enExample)
KR (1) KR100236853B1 (enExample)
CN (1) CN1080721C (enExample)
DE (1) DE69606721T2 (enExample)
ES (1) ES2142065T3 (enExample)
WO (1) WO1997002260A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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US5140031A (en) * 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
KR100396171B1 (ko) 1998-08-10 2003-08-27 아사히 가세이 가부시키가이샤 염산 파수딜의 경구 서방성 제제
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
WO2004105757A2 (en) * 2003-05-29 2004-12-09 Schering Aktiengesellschaft Use of rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
US20080242660A1 (en) * 2004-01-29 2008-10-02 Asahi Kasei Pharma Corporation Therapeutic Agent for Vasospasm Accompanying Bypass Operation
WO2005087237A1 (ja) * 2004-03-16 2005-09-22 Asahi Kasei Pharma Corporation ファスジル含有製剤及びその安定性を改善する方法
MY139797A (en) 2004-11-29 2009-10-30 Kowa Co (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate
EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
US7993836B2 (en) * 2006-01-27 2011-08-09 Translational Genomics Research Institute Genes affecting human memory performance
CN101092413B (zh) * 2006-06-23 2011-05-18 山东轩竹医药科技有限公司 法舒地尔的药用盐的水合物
EP2061314A4 (en) * 2006-08-10 2010-08-04 Translational Genomics Res Inst CONNECTIONS TO IMPROVE LEARNING AND MEMORY
CN102002036B (zh) * 2009-08-31 2013-01-30 秦引林 一种法舒地尔的精制方法
CN102020635B (zh) * 2009-09-10 2013-04-17 河北凯盛医药科技有限公司 一种盐酸法舒地尔半水合物的制备方法
EP2332917B1 (en) 2009-11-11 2012-08-01 Sygnis Bioscience GmbH & Co. KG Compounds for PIM kinase inhibition and for treating malignancy
CN101985444B (zh) * 2010-08-20 2013-04-24 天津红日药业股份有限公司 盐酸法舒地尔的v晶型及其制备方法和用途
CN101962379B (zh) * 2010-09-28 2013-02-27 山西普德药业股份有限公司 一种磺酰基异喹啉衍生物的精制方法
CN102020636A (zh) * 2010-11-25 2011-04-20 江苏万邦生化医药股份有限公司 盐酸法舒地尔的合成及提纯方法
CN102060845B (zh) * 2010-12-28 2013-07-03 天津红日药业股份有限公司 一种法舒地尔的晶型ⅲ及其制备方法和用途
CN102229601B (zh) * 2011-05-12 2013-07-03 天津市汉康医药生物技术有限公司 六氢-1-(5-异喹啉磺酰基)-1(h)-1,4-二氮杂卓盐酸盐无定形化合物
CN102225929B (zh) * 2011-05-12 2014-07-16 天津市汉康医药生物技术有限公司 一种稳定的盐酸法舒地尔水合物化合物
WO2013135596A1 (en) 2012-03-12 2013-09-19 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Rho kinase inhibitors for use in treating amyotrophic lateral sclerosis
US8715764B2 (en) 2012-06-21 2014-05-06 Choco Finesse LLC Eutectic mixtures of esterified propoxylated glycerols with digestible fats
CN104327052A (zh) * 2014-10-20 2015-02-04 郑州四环医药用品有限公司 一种高纯度盐酸法舒地尔的制备方法
CN104945381B (zh) * 2015-06-24 2019-05-03 山东罗欣药业集团股份有限公司 一种盐酸法舒地尔化合物、其制备方法及其药物组合物
US11878023B2 (en) 2017-10-25 2024-01-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents
EA202191339A1 (ru) 2018-12-17 2021-08-27 Д. Вестерн Терапьютикс Инститьют, Инк. Новая форма изохинолинсульфонамида
CN109776497A (zh) * 2019-03-07 2019-05-21 山东新华制药股份有限公司 一种盐酸法舒地尔半水合物的制备方法
WO2020193802A1 (en) 2019-03-28 2020-10-01 Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe Polymeric conjugates and uses thereof
CN113968841B (zh) * 2020-07-23 2024-05-14 合肥久诺医药科技有限公司 一种盐酸法舒地尔半水合物的制备方法
CA3236332A1 (en) 2021-10-30 2023-05-04 Ziev B. Moses Treatments for disturbed cerebral homeostasis
JP2025506684A (ja) 2022-02-17 2025-03-13 ウールジー・ファーマシューティカルズ・インコーポレイテッド イオン交換樹脂を含むファスジルの経口製剤
JP2025506686A (ja) 2022-02-17 2025-03-13 ウールジー・ファーマシューティカルズ・インコーポレイテッド ファスジルの味マスキング経口製剤

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152658A (ja) * 1984-12-27 1986-07-11 Asahi Chem Ind Co Ltd 置換されたイソキノリンスルホンアミド誘導体
JPS6293643A (ja) * 1985-10-19 1987-04-30 Fuji Photo Film Co Ltd 核酸の塩基配列決定のための信号処理方法
JPH02256617A (ja) * 1989-03-30 1990-10-17 Asahi Chem Ind Co Ltd 脳細胞機能障害改善剤
JPH04278094A (ja) * 1991-03-07 1992-10-02 Asahi Chem Ind Co Ltd １−ヒドロキシ−イソキノリンスルホンアミド誘導体の製造方法
JPH05569A (ja) * 1991-06-25 1993-01-08 Kanzaki Paper Mfg Co Ltd 感熱記録体
JPH0741424A (ja) * 1993-07-28 1995-02-10 Asahi Chem Ind Co Ltd 抗炎症剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678783B1 (en) * 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
JPH0680569A (ja) * 1992-09-03 1994-03-22 Asahi Chem Ind Co Ltd 血小板凝集阻害剤
JP3464012B2 (ja) * 1993-04-05 2003-11-05 旭化成株式会社 精神症候治療剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61152658A (ja) * 1984-12-27 1986-07-11 Asahi Chem Ind Co Ltd 置換されたイソキノリンスルホンアミド誘導体
JPS6293643A (ja) * 1985-10-19 1987-04-30 Fuji Photo Film Co Ltd 核酸の塩基配列決定のための信号処理方法
JPH02256617A (ja) * 1989-03-30 1990-10-17 Asahi Chem Ind Co Ltd 脳細胞機能障害改善剤
JPH04278094A (ja) * 1991-03-07 1992-10-02 Asahi Chem Ind Co Ltd １−ヒドロキシ−イソキノリンスルホンアミド誘導体の製造方法
JPH05569A (ja) * 1991-06-25 1993-01-08 Kanzaki Paper Mfg Co Ltd 感熱記録体
JPH0741424A (ja) * 1993-07-28 1995-02-10 Asahi Chem Ind Co Ltd 抗炎症剤

Also Published As

Publication number Publication date
KR19990008278A (ko) 1999-01-25
DE69606721T2 (de) 2000-06-21
HK1013598A1 (en) 1999-09-03
EP0870767A4 (enExample) 1998-10-14
EP0870767B1 (en) 2000-02-16
DE69606721D1 (de) 2000-03-23
WO1997002260A1 (en) 1997-01-23
EP0870767A1 (en) 1998-10-14
CN1183782A (zh) 1998-06-03
ES2142065T3 (es) 2000-04-01
KR100236853B1 (ko) 2000-02-01
US5942505A (en) 1999-08-24

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