CN108066313A - 一种盐酸二甲双胍包合物的制备方法及制备设备 - Google Patents
一种盐酸二甲双胍包合物的制备方法及制备设备 Download PDFInfo
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- CN108066313A CN108066313A CN201711481284.0A CN201711481284A CN108066313A CN 108066313 A CN108066313 A CN 108066313A CN 201711481284 A CN201711481284 A CN 201711481284A CN 108066313 A CN108066313 A CN 108066313A
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- metformin hydrochloride
- fine powder
- suspension
- cylinder
- preparation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
时间(h) | 0.5 | 1 | 2 | 3 | 5 | 7 | 9 | 11 | 12 |
溶出量(mg) | 21.3 | 45.2 | 73.8 | 107.7 | 141.3 | 162.5 | 162.5 | 162.3 | 162.2 |
占比(%) | 13.1 | 27.8 | 45.4 | 66.3 | 87.0 | 100 | 100 | 99.9 | 99.9 |
时间(h) | 0.5 | 1 | 2 | 3 | 5 | 7 | 9 | 11 | 12 |
溶出量(mg) | 48.6 | 69.8 | 119.0 | 139.3 | 158.9 | 178.1 | 178.0 | 177.8 | 177.9 |
占比(%) | 27.3 | 39.2 | 66.8 | 78.2 | 89.2 | 100 | 100 | 99.9 | 99.9 |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201711481284.0A CN108066313B (zh) | 2017-12-29 | 2017-12-29 | 一种盐酸二甲双胍包合物的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201711481284.0A CN108066313B (zh) | 2017-12-29 | 2017-12-29 | 一种盐酸二甲双胍包合物的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108066313A true CN108066313A (zh) | 2018-05-25 |
CN108066313B CN108066313B (zh) | 2021-02-19 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201711481284.0A Active CN108066313B (zh) | 2017-12-29 | 2017-12-29 | 一种盐酸二甲双胍包合物的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN108066313B (zh) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1375507A (zh) * | 2001-03-20 | 2002-10-23 | 清华大学 | 磁性微球的表面包覆和基团功能化修饰方法及所得微球及其应用 |
WO2010113176A2 (en) * | 2009-03-31 | 2010-10-07 | Reliance Life Sciences Pvt. Ltd. | Novel copolymers for controlled release delivery system |
WO2012071452A2 (en) * | 2010-11-23 | 2012-05-31 | Howard University | Stealth polymeric particles for delivery of bioactive or diagnostic agents |
CN104231137A (zh) * | 2014-10-10 | 2014-12-24 | 河北科技大学 | 一种聚合物包埋疏水性抗肿瘤药物纳米复合微球的制备方法 |
CN204583149U (zh) * | 2015-03-28 | 2015-08-26 | 罗定市星光化工有限公司 | 一种萜烯树脂的聚合反应罐 |
CN103816130B (zh) * | 2014-01-22 | 2016-01-20 | 悦康药业集团有限公司 | 一种盐酸二甲双胍缓释片 |
-
2017
- 2017-12-29 CN CN201711481284.0A patent/CN108066313B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1375507A (zh) * | 2001-03-20 | 2002-10-23 | 清华大学 | 磁性微球的表面包覆和基团功能化修饰方法及所得微球及其应用 |
WO2010113176A2 (en) * | 2009-03-31 | 2010-10-07 | Reliance Life Sciences Pvt. Ltd. | Novel copolymers for controlled release delivery system |
WO2012071452A2 (en) * | 2010-11-23 | 2012-05-31 | Howard University | Stealth polymeric particles for delivery of bioactive or diagnostic agents |
CN103816130B (zh) * | 2014-01-22 | 2016-01-20 | 悦康药业集团有限公司 | 一种盐酸二甲双胍缓释片 |
CN104231137A (zh) * | 2014-10-10 | 2014-12-24 | 河北科技大学 | 一种聚合物包埋疏水性抗肿瘤药物纳米复合微球的制备方法 |
CN204583149U (zh) * | 2015-03-28 | 2015-08-26 | 罗定市星光化工有限公司 | 一种萜烯树脂的聚合反应罐 |
Also Published As
Publication number | Publication date |
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CN108066313B (zh) | 2021-02-19 |
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Inventor after: Zhu Deqi Inventor after: Zeng Dan Inventor after: Li Xuemei Inventor after: Xie Yang Inventor after: Zou Yong Inventor after: Wen Lijuan Inventor after: Shen Hua Inventor after: Feng Lu Inventor before: Zhu Deqi Inventor before: Zeng Dan Inventor before: Li Xuemei Inventor before: Xie Yang Inventor before: Zou Yong Inventor before: Wen Lijuan |