CN107847481A - 包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂 - Google Patents

包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂 Download PDF

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CN107847481A
CN107847481A CN201680037409.8A CN201680037409A CN107847481A CN 107847481 A CN107847481 A CN 107847481A CN 201680037409 A CN201680037409 A CN 201680037409A CN 107847481 A CN107847481 A CN 107847481A
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cancer
foregoing
cell
compound
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C·J·李
Y·李
高媛
王宇新
J·黄
H·罗戈夫
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Boston Bio Pharmaceutical Co Ltd
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Boston Bio Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Furan Compounds (AREA)
CN201680037409.8A 2015-06-03 2016-06-03 包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂 Pending CN107847481A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562170498P 2015-06-03 2015-06-03
US62/170,498 2015-06-03
US201562233081P 2015-09-25 2015-09-25
US62/233,081 2015-09-25
PCT/US2016/035721 WO2016196935A1 (en) 2015-06-03 2016-06-03 Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer

Publications (1)

Publication Number Publication Date
CN107847481A true CN107847481A (zh) 2018-03-27

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CN201680037409.8A Pending CN107847481A (zh) 2015-06-03 2016-06-03 包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂

Country Status (15)

Country Link
US (1) US20180140572A1 (https=)
EP (1) EP3302462A1 (https=)
JP (2) JP2018521979A (https=)
KR (1) KR20180015195A (https=)
CN (1) CN107847481A (https=)
AU (1) AU2016271475A1 (https=)
BR (1) BR112017026025A2 (https=)
CA (1) CA2988126A1 (https=)
EA (1) EA201792623A1 (https=)
HK (1) HK1245632A1 (https=)
IL (1) IL256052A (https=)
MX (1) MX2017015618A (https=)
PH (1) PH12017502195A1 (https=)
TW (1) TW201717935A (https=)
WO (1) WO2016196935A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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CN109675040A (zh) * 2018-12-31 2019-04-26 清华大学 治疗乳腺癌的组合物及其应用
CN112530581A (zh) * 2020-12-03 2021-03-19 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN113874008A (zh) * 2019-03-25 2021-12-31 Ac生命科学有限公司 β-咔啉化合物及其在癌症的非细胞毒性和免疫治疗中的用途
CN113891709A (zh) * 2019-04-02 2022-01-04 德克萨斯大学系统董事会 用于治疗疾病的转录抑制剂和免疫检验点抑制剂的组合

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CN110072553B (zh) 2016-12-22 2023-09-15 豪夫迈·罗氏有限公司 在抗pd-l1/pd1治疗失败之后抗csf-1r抗体与抗pd-l1抗体组合对肿瘤的治疗
WO2018160887A1 (en) * 2017-03-01 2018-09-07 Boston Biomedical, Inc. Pdl1-specific and beta-catenin-specific asymmetric interfering rna compositions, uses or preparation thereof
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US12150978B2 (en) 2017-06-15 2024-11-26 Cancer Advances Inc. Compositions and methods for preventing tumors and cancer
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109675040A (zh) * 2018-12-31 2019-04-26 清华大学 治疗乳腺癌的组合物及其应用
CN109675040B (zh) * 2018-12-31 2021-07-30 清华大学 治疗乳腺癌的组合物及其应用
CN113874008A (zh) * 2019-03-25 2021-12-31 Ac生命科学有限公司 β-咔啉化合物及其在癌症的非细胞毒性和免疫治疗中的用途
CN113891709A (zh) * 2019-04-02 2022-01-04 德克萨斯大学系统董事会 用于治疗疾病的转录抑制剂和免疫检验点抑制剂的组合
CN112530581A (zh) * 2020-12-03 2021-03-19 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN112530581B (zh) * 2020-12-03 2023-11-21 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用

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US20180140572A1 (en) 2018-05-24
BR112017026025A2 (pt) 2018-08-14
KR20180015195A (ko) 2018-02-12
WO2016196935A1 (en) 2016-12-08
IL256052A (en) 2018-01-31
HK1245632A1 (zh) 2018-08-31
JP2020169223A (ja) 2020-10-15
TW201717935A (zh) 2017-06-01
PH12017502195A1 (en) 2018-06-04
JP2018521979A (ja) 2018-08-09
CA2988126A1 (en) 2016-12-08
MX2017015618A (es) 2018-08-15
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EA201792623A1 (ru) 2018-04-30
EP3302462A1 (en) 2018-04-11

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