CN107847430B - 一种具有抗病毒活性的鼻塞疏通组合物 - Google Patents

一种具有抗病毒活性的鼻塞疏通组合物 Download PDF

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Publication number
CN107847430B
CN107847430B CN201680039448.1A CN201680039448A CN107847430B CN 107847430 B CN107847430 B CN 107847430B CN 201680039448 A CN201680039448 A CN 201680039448A CN 107847430 B CN107847430 B CN 107847430B
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composition
carrageenan
concentration
osmotic pressure
hypertonic
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Chinese (zh)
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CN107847430A (zh
Inventor
A·格拉索尔
E·普里斯赫-格拉索尔
A·博登泰希
C·科勒
M·莫罗库蒂-库尔兹
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Marinomed Biotech AG
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Marinomed Biotech AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/731—Carrageenans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201680039448.1A 2015-07-14 2016-07-12 一种具有抗病毒活性的鼻塞疏通组合物 Active CN107847430B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15176670 2015-07-14
EP15176670.6 2015-07-14
PCT/EP2016/066565 WO2017009351A1 (en) 2015-07-14 2016-07-12 Stuffy nose deblocking composition having antiviral activity

Publications (2)

Publication Number Publication Date
CN107847430A CN107847430A (zh) 2018-03-27
CN107847430B true CN107847430B (zh) 2021-02-02

Family

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CN201680039448.1A Active CN107847430B (zh) 2015-07-14 2016-07-12 一种具有抗病毒活性的鼻塞疏通组合物

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Country Link
US (1) US10660914B2 (enExample)
EP (1) EP3370692B1 (enExample)
JP (1) JP6774435B2 (enExample)
KR (1) KR102628781B1 (enExample)
CN (1) CN107847430B (enExample)
AU (1) AU2016293004B2 (enExample)
BR (1) BR112018000592B1 (enExample)
CA (1) CA2992352C (enExample)
CL (1) CL2018000033A1 (enExample)
DK (1) DK3370692T3 (enExample)
EA (1) EA037085B1 (enExample)
ES (1) ES2949139T3 (enExample)
FI (1) FI3370692T3 (enExample)
HU (1) HUE062108T2 (enExample)
IL (1) IL256883B (enExample)
LT (1) LT3370692T (enExample)
MA (1) MA43155A (enExample)
MX (1) MX372625B (enExample)
MY (1) MY194870A (enExample)
NZ (1) NZ738597A (enExample)
PH (1) PH12018500044B1 (enExample)
PL (1) PL3370692T3 (enExample)
PT (1) PT3370692T (enExample)
SA (1) SA518390689B1 (enExample)
WO (1) WO2017009351A1 (enExample)
ZA (1) ZA201708595B (enExample)

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JP2019505538A (ja) * 2016-02-17 2019-02-28 エント テクノロジーズ ピーティーワイ リミテッド 副鼻腔疾患および障害の治療のための組成物と方法
GB2567285A (en) * 2017-08-07 2019-04-10 Suprapharm Cc Preparation for nasal-nasopharyngeal treatment
US12268707B2 (en) 2020-03-12 2025-04-08 Sydney David Cullis-Hill Treatment for coronavirus infection and associated cytokine toxicity
CN111437270A (zh) * 2020-04-24 2020-07-24 瑞希(重庆)生物科技有限公司 一种卡拉胶鼻用即型凝胶喷雾剂及其制备方法
US11013687B1 (en) * 2020-06-08 2021-05-25 Amcyte Pharma, Inc. Preventive and therapeutic treatment for COVID 19 and any other disease caused by SARS CoV 2
WO2021253643A1 (zh) 2020-06-18 2021-12-23 大连工业大学 硫酸化多糖在抗新型冠状病毒中的应用
CN111686125A (zh) * 2020-06-18 2020-09-22 大连工业大学 卡拉胶在抗新型冠状病毒中的应用
CN115942941A (zh) * 2020-06-22 2023-04-07 马里奥·埃尔门·特伦布莱 包含λ-卡拉胶的个人润滑剂
EP3939597A1 (en) * 2020-07-16 2022-01-19 Marinomed Biotech AG Antiviral pharmaceutical composition comprising a carrageenan component
CN116249515A (zh) * 2020-08-04 2023-06-09 科斯莫索弗特公司 用于通过鼻腔途径治疗covid-19疾病的呼吸道症状的包含甘油和卡波姆的水凝胶
FR3113237B1 (fr) 2020-08-04 2023-06-09 Biopass Produit pour le traitement de maladies virales par voie nasale
DE202020004186U1 (de) * 2020-10-05 2020-10-21 Christian Fleischhammel Antiinfektive Arzneiform zur Herstellung einer Nasenspülung gegen COVID-19
EP3991561A1 (en) * 2020-10-28 2022-05-04 Vepidan ApS Antimicrobial disinfectant gel
GB202109888D0 (en) 2021-07-08 2021-08-25 Pollinner Ltd Nasal spray
KR102720037B1 (ko) * 2021-12-21 2024-10-22 (주)메디코어 비강 세정제 조성물 및 그 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424043A1 (en) * 1989-10-17 1991-04-24 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Liquid aqueous ophthalmic composition undergoing liquid-gel phase transition
CN101784272A (zh) * 2007-08-24 2010-07-21 玛丽诺姆德生物技术公司 包含硫酸多糖的抗病毒组合物
WO2013049538A1 (en) * 2011-09-30 2013-04-04 Mcneil-Ppc, Inc. Allergen nasal compositions

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US6080783A (en) * 1998-09-01 2000-06-27 Gum Tech International, Inc. Method and composition for delivering zinc to the nasal membrane
EP2522365B1 (en) * 2004-11-24 2016-10-26 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20080241271A1 (en) * 2006-11-08 2008-10-02 Roman Stephen B Foaming anti-adhesion composition
MX2009005838A (es) 2006-12-05 2009-06-16 Marinomed Biotechnologie Gmbh Uso de carrageninas para el tratamiento de infecciones por rinovirus.
JP4941977B2 (ja) * 2007-04-11 2012-05-30 大蔵製薬株式会社 ベンズイソキサゾール誘導体の経口ゼリー状医薬組成物
JP5634066B2 (ja) * 2007-11-06 2014-12-03 三栄源エフ・エフ・アイ株式会社 唾液分泌促進剤
FR2926218B1 (fr) * 2008-01-10 2010-08-13 Galderma Res & Dev Composition comprenant un retinoide et du peroxyde de benzoyle disperse.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424043A1 (en) * 1989-10-17 1991-04-24 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Liquid aqueous ophthalmic composition undergoing liquid-gel phase transition
CN101784272A (zh) * 2007-08-24 2010-07-21 玛丽诺姆德生物技术公司 包含硫酸多糖的抗病毒组合物
WO2013049538A1 (en) * 2011-09-30 2013-04-04 Mcneil-Ppc, Inc. Allergen nasal compositions

Non-Patent Citations (4)

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Behavior of k-carrageenan in glycerol and sorbitol solutions;S. Ramakrishnan;《Carbohydrate Polymers》;20001231;第43卷;第327-332页 *
Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold;Eccles et al.;《Respiratory Research》;20101231;第11卷;第1-10页 *
the Influence of Stabilizer and Bioadhesive Polymer on the PermeationEnhancing Effect of AT1002 in the Nasal Delivery of a Paracellular Marker;Keon-Hyoung Song et al.;《Arch Pharm Res》;20121231;第35卷(第2期);第359-366页 *
Valerio Damiani et al..Long-term Efficacy of Narivent ® in the Treatment of Nasal Congestion.《The Open Medical Devices Journal》.2012,第4卷第73-79页. *

Also Published As

Publication number Publication date
HUE062108T2 (hu) 2023-09-28
CA2992352C (en) 2023-06-27
MX372625B (es) 2020-05-12
WO2017009351A1 (en) 2017-01-19
EP3370692A1 (en) 2018-09-12
MX2018000285A (es) 2018-02-19
HK1253038A1 (zh) 2019-06-06
IL256883B (en) 2021-07-29
LT3370692T (lt) 2023-07-10
PL3370692T3 (pl) 2023-08-14
AU2016293004B2 (en) 2021-05-06
PH12018500044B1 (en) 2022-04-27
US10660914B2 (en) 2020-05-26
NZ738597A (en) 2021-12-24
CA2992352A1 (en) 2017-01-19
PT3370692T (pt) 2023-07-18
MY194870A (en) 2022-12-21
BR112018000592B1 (pt) 2024-02-06
JP6774435B2 (ja) 2020-10-21
CN107847430A (zh) 2018-03-27
ZA201708595B (en) 2021-06-30
KR102628781B1 (ko) 2024-01-24
CL2018000033A1 (es) 2018-08-10
IL256883A (en) 2018-03-29
MA43155A (fr) 2018-09-12
EA201890196A1 (ru) 2018-06-29
ES2949139T3 (es) 2023-09-25
JP2018523635A (ja) 2018-08-23
SA518390689B1 (ar) 2021-07-17
FI3370692T3 (fi) 2023-06-16
BR112018000592A2 (pt) 2018-09-11
KR20180054570A (ko) 2018-05-24
AU2016293004A1 (en) 2018-01-18
DK3370692T3 (da) 2023-06-26
US20190060358A1 (en) 2019-02-28
PH12018500044A1 (en) 2018-07-23
EP3370692B1 (en) 2023-04-12
EA037085B1 (ru) 2021-02-04

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