CN107635990A - 新型3‑吲哚取代的衍生物、药物组合物及使用方法 - Google Patents

新型3‑吲哚取代的衍生物、药物组合物及使用方法 Download PDF

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Publication number
CN107635990A
CN107635990A CN201680028408.7A CN201680028408A CN107635990A CN 107635990 A CN107635990 A CN 107635990A CN 201680028408 A CN201680028408 A CN 201680028408A CN 107635990 A CN107635990 A CN 107635990A
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Prior art keywords
fluoro
indol
isothiazole
methyl
yls
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Pending
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CN201680028408.7A
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English (en)
Chinese (zh)
Inventor
S·宁科维奇
S·克罗西尼亚尼
S·A·斯凯尔斯
I·J·麦卡尔平
M·R·柯林斯
A·马代尔纳
M·威思
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Kuyt Medical Oswald
Pfizer Inc
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Kuyt Medical Oswald
Pfizer Inc
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Priority claimed from PCT/IB2015/051957 external-priority patent/WO2015140717A1/en
Application filed by Kuyt Medical Oswald, Pfizer Inc filed Critical Kuyt Medical Oswald
Publication of CN107635990A publication Critical patent/CN107635990A/zh
Pending legal-status Critical Current

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61P31/14—Antivirals for RNA viruses
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680028408.7A 2015-03-17 2016-03-17 新型3‑吲哚取代的衍生物、药物组合物及使用方法 Pending CN107635990A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IBPCT/IB2015/051957 2015-03-17
PCT/IB2015/051957 WO2015140717A1 (en) 2014-03-18 2015-03-17 Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use
US201562203032P 2015-08-10 2015-08-10
US62/203,032 2015-08-10
PCT/IB2016/051509 WO2016147144A1 (en) 2015-03-17 2016-03-17 Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use

Publications (1)

Publication Number Publication Date
CN107635990A true CN107635990A (zh) 2018-01-26

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CN201680028408.7A Pending CN107635990A (zh) 2015-03-17 2016-03-17 新型3‑吲哚取代的衍生物、药物组合物及使用方法

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US (1) US9873690B2 (enExample)
EP (1) EP3271354A1 (enExample)
JP (1) JP6775516B2 (enExample)
KR (1) KR102013512B1 (enExample)
CN (1) CN107635990A (enExample)
AU (1) AU2016231832B2 (enExample)
BR (1) BR112017019699A2 (enExample)
CA (1) CA2979616C (enExample)
HK (1) HK1243999A1 (enExample)
IL (1) IL254124A0 (enExample)
MX (1) MX2017011951A (enExample)
RU (1) RU2672252C1 (enExample)
SG (1) SG11201706992TA (enExample)
WO (1) WO2016147144A1 (enExample)

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CN111166735A (zh) * 2020-01-15 2020-05-19 延边大学 邻苯二甲酸-双-(2-乙基庚基)酯在抑制脂肪蓄积中的应用
CN111499592A (zh) * 2020-03-14 2020-08-07 江苏省农用激素工程技术研究中心有限公司 5-氨甲基糖精的合成方法
CN111777557A (zh) * 2020-07-28 2020-10-16 中国科学院上海有机化学研究所 以芳香联苯烯为骨架的新型抗肿瘤先导化合物及其应用
WO2021218912A1 (zh) * 2020-04-30 2021-11-04 南京明德新药研发有限公司 含苯基并内磺酰胺的化合物
CN119707855A (zh) * 2024-12-20 2025-03-28 西南大学 一种光学活性胺类衍生物及其不对称烷基化合成方法和应用

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JP2025508076A (ja) 2022-03-08 2025-03-21 アレンティス・セラピューティクス・アクチェンゲゼルシャフト Ｔ細胞の利用能を向上させるための抗クローディン－１抗体の使用
JP2026501506A (ja) 2022-12-14 2026-01-16 アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法
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TW202541837A (zh) 2023-12-08 2025-11-01 日商安斯泰來製藥公司 含有結合至cldn18.2和cd3之雙特異性結合劑和穩定或增加cldn18.2表現之藥劑之組合療法
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