CN107635979A - 溴结构域抑制剂 - Google Patents
溴结构域抑制剂 Download PDFInfo
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- CN107635979A CN107635979A CN201580070259.6A CN201580070259A CN107635979A CN 107635979 A CN107635979 A CN 107635979A CN 201580070259 A CN201580070259 A CN 201580070259A CN 107635979 A CN107635979 A CN 107635979A
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| DK2571503T3 (en) | 2010-05-14 | 2015-04-20 | Dana Farber Cancer Inst Inc | COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS |
| CN103154246B (zh) | 2010-05-14 | 2015-11-25 | 达那-法伯癌症研究所 | 用于治疗白血病的组合物和方法 |
| KR102438072B1 (ko) | 2012-01-12 | 2022-08-31 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
| LT3057586T (lt) | 2013-10-18 | 2020-03-10 | Celgene Quanticel Research, Inc. | Bromodomeno inhibitoriai |
| RU2016122654A (ru) | 2013-11-08 | 2017-12-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка |
| US10925881B2 (en) | 2014-02-28 | 2021-02-23 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CR20170219A (es) | 2014-10-27 | 2017-08-14 | Tensha Therapeutics Inc | Inhibidores del bromodominio |
| EP4414369A3 (en) | 2015-03-18 | 2024-10-16 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
| WO2017030814A1 (en) | 2015-08-19 | 2017-02-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| WO2018075908A1 (en) * | 2016-10-21 | 2018-04-26 | University Of Miami | Materials and methods for treating ophthalmic inflammation |
| CN109503618A (zh) * | 2017-09-14 | 2019-03-22 | 成都海创药业有限公司 | 一种brd4抑制剂 |
| EP3743066A4 (en) | 2018-01-26 | 2021-09-08 | Yale University | IMIDE-BASED PROTEOLYSIS MODULATORS AND RELATED METHODS OF USE |
| MX2020010571A (es) | 2018-04-13 | 2021-01-08 | Arvinas Operations Inc | Ligandos de cereblon y compuestos bifuncionales que los comprenden. |
| EA202092635A1 (ru) | 2018-06-13 | 2021-03-23 | Дибли Аг | Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet |
| EP4342543A3 (en) | 2018-09-11 | 2024-06-19 | F. Hoffmann-La Roche AG | Tert-butyl (s)-2-(4-(phenyl)-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain brd4 inhibitors for treating cancer |
| CA3165168A1 (en) | 2019-12-19 | 2021-06-24 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| WO2024123929A1 (en) * | 2022-12-06 | 2024-06-13 | Bioventures, Llc | Development of potent dual hdac/brd4 inhibitors |
| WO2025049555A1 (en) | 2023-08-31 | 2025-03-06 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
| WO2025053994A1 (en) * | 2023-09-08 | 2025-03-13 | The Regents Of The University Of California | Small molecule enhancers of secreted clusterin (sclu) |
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| EP1887008A1 (en) * | 2005-05-30 | 2008-02-13 | Mitsubishi Tanabe Pharma Corporation | Thienotriazolodiazepine compound and a medicinal use thereof |
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| WO2011143657A1 (en) * | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Male contraceptive compositions and methods of use |
| WO2013030150A1 (de) * | 2011-09-01 | 2013-03-07 | Bayer Intellectual Property Gmbh | 6H-THIENO[3,2-f][1,2,4]TRIAZOLO[4,3-a][1,4]DIAZEPINE |
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| UA122130C2 (uk) | 2020-09-25 |
| PH12017500745A1 (en) | 2017-10-30 |
| KR20170068597A (ko) | 2017-06-19 |
| IL251784A0 (en) | 2017-06-29 |
| MX376748B (es) | 2025-03-07 |
| HK1243415A1 (en) | 2018-07-13 |
| SG11201703414VA (en) | 2017-05-30 |
| US10124009B2 (en) | 2018-11-13 |
| CR20170219A (es) | 2017-08-14 |
| EA201790922A1 (ru) | 2017-08-31 |
| EA033325B1 (ru) | 2019-09-30 |
| EP3212654B1 (en) | 2020-04-08 |
| BR112017008714A2 (pt) | 2017-12-19 |
| WO2016069578A1 (en) | 2016-05-06 |
| CA2965330A1 (en) | 2016-05-06 |
| AU2015339511A1 (en) | 2017-05-18 |
| AU2015339511B2 (en) | 2020-05-14 |
| CO2017004898A2 (es) | 2017-10-31 |
| MX2017005555A (es) | 2018-02-09 |
| JP2017531688A (ja) | 2017-10-26 |
| EP3212654A1 (en) | 2017-09-06 |
| US20170333444A1 (en) | 2017-11-23 |
| PE20171042A1 (es) | 2017-07-19 |
| JP6715243B2 (ja) | 2020-07-01 |
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