CN107530157B - 用于改变悬浮液并将悬浮液输送到个体的具有侧开口的导管 - Google Patents

用于改变悬浮液并将悬浮液输送到个体的具有侧开口的导管 Download PDF

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CN107530157B
CN107530157B CN201680022906.0A CN201680022906A CN107530157B CN 107530157 B CN107530157 B CN 107530157B CN 201680022906 A CN201680022906 A CN 201680022906A CN 107530157 B CN107530157 B CN 107530157B
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suspension
catheter
outlet
proximal
embolic
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CN107530157A (zh
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迈克尔·加布里埃尔·塔尔
埃尔安·米乐
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Accurate Medical Therapeutics Ltd
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Accurate Medical Therapeutics Ltd
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    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
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    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Surgery (AREA)
  • Biomedical Technology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680022906.0A 2015-03-02 2016-03-02 用于改变悬浮液并将悬浮液输送到个体的具有侧开口的导管 Active CN107530157B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562127036P 2015-03-02 2015-03-02
US62/127,036 2015-03-02
PCT/IB2016/051175 WO2016139597A2 (en) 2015-03-02 2016-03-02 Catheters with side openings for modifying and delivering suspensions to a subject

Publications (2)

Publication Number Publication Date
CN107530157A CN107530157A (zh) 2018-01-02
CN107530157B true CN107530157B (zh) 2020-11-10

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CN201680022906.0A Active CN107530157B (zh) 2015-03-02 2016-03-02 用于改变悬浮液并将悬浮液输送到个体的具有侧开口的导管

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US (5) US11344314B2 (enExample)
EP (4) EP3469996B1 (enExample)
JP (4) JP7055021B2 (enExample)
KR (1) KR102579386B1 (enExample)
CN (1) CN107530157B (enExample)
BR (1) BR112017018851B1 (enExample)
CA (1) CA2978394C (enExample)
ES (3) ES2907571T3 (enExample)
HK (1) HK1248500A1 (enExample)
IL (1) IL254240B (enExample)
PL (1) PL3264997T3 (enExample)
WO (3) WO2016139606A1 (enExample)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
ES2975734T3 (es) 2015-01-29 2024-07-12 Becton Dickinson Co Catéter integrado de inserción rápida
CN109414266B (zh) 2016-05-04 2021-07-23 阿克瑞特医学治疗有限公司 具有狭缝状图案的栓塞微导管头部
WO2018067844A1 (en) * 2016-10-06 2018-04-12 Mivi Neuroscience, Inc. Hydraulic displacement and removal of thrombus clots, and catheters for performing hydraulic displacement
WO2018071254A1 (en) * 2016-10-13 2018-04-19 The Cleveland Clinic Foundation Systems and methods for peripheral vascular cannulation
US12102331B2 (en) 2017-02-13 2024-10-01 Daniel Ezra Walzman Single lumen microcatheter for executing plugs near distal terminus of lumen
US12029432B2 (en) 2017-02-13 2024-07-09 Daniel Ezra Walzman Single lumen microcatheter for executing plugs near distal terminus of lumen and method
US12089851B2 (en) 2017-02-13 2024-09-17 Daniel Ezra Walzman Microcatheters for injecting embolic liquid agents into vessels
CN111447882B (zh) * 2017-11-02 2024-05-24 阿克瑞特医学治疗有限公司 具有一体式过滤器的栓塞导管
WO2019195860A2 (en) 2018-04-04 2019-10-10 Vdyne, Llc Devices and methods for anchoring transcatheter heart valve
MX2020010500A (es) * 2018-04-06 2020-11-12 Frank Levy Aparato y metodo para producir una suspension medica enriquecida.
US10595994B1 (en) 2018-09-20 2020-03-24 Vdyne, Llc Side-delivered transcatheter heart valve replacement
US12186187B2 (en) 2018-09-20 2025-01-07 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US11071627B2 (en) 2018-10-18 2021-07-27 Vdyne, Inc. Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis
US11344413B2 (en) 2018-09-20 2022-05-31 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US11278437B2 (en) 2018-12-08 2022-03-22 Vdyne, Inc. Compression capable annular frames for side delivery of transcatheter heart valve replacement
US10321995B1 (en) 2018-09-20 2019-06-18 Vdyne, Llc Orthogonally delivered transcatheter heart valve replacement
US11109969B2 (en) 2018-10-22 2021-09-07 Vdyne, Inc. Guidewire delivery of transcatheter heart valve
US11253359B2 (en) 2018-12-20 2022-02-22 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valves and methods of delivery
WO2020146842A1 (en) 2019-01-10 2020-07-16 Vdyne, Llc Anchor hook for side-delivery transcatheter heart valve prosthesis
US11185409B2 (en) 2019-01-26 2021-11-30 Vdyne, Inc. Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis
US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
CN113395988B (zh) * 2019-02-08 2023-03-31 科洛普拉斯特公司 导尿管
EP4364706B1 (en) 2019-03-05 2025-12-03 VDyne, Inc. Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
US11076956B2 (en) 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
CN120827457A (zh) 2019-05-04 2025-10-24 维迪内股份有限公司 用于在自体瓣环中部署侧面递送的假体心脏瓣膜的束紧装置和方法
BR112021023510A2 (pt) * 2019-05-23 2022-01-18 Accurate Medical Therapeutics Ltd Cateter de embolização para distribuição livre de refluxo de microesferas.
AU2020334080B2 (en) 2019-08-20 2025-11-27 Vdyne, Inc. Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
CN120531525A (zh) 2019-08-26 2025-08-26 维迪内股份有限公司 可侧面输送的经导管假体瓣膜及其输送和锚定方法
KR20220060550A (ko) 2019-09-10 2022-05-11 바드 액세스 시스템즈, 인크. 신속 삽입 중앙 카테터 및 그 방법(rapidly inserted central catheter and methods thereof)
CA3153525A1 (en) 2019-09-24 2021-04-01 Bard Access Systems, Inc. An integrated acute central venous catheter and peripherally inserted venous catheter
WO2021081434A1 (en) 2019-10-25 2021-04-29 Bard Access Systems, Inc. Guidewire-management devices and methods thereof
US11234813B2 (en) 2020-01-17 2022-02-01 Vdyne, Inc. Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery
CA3168492A1 (en) 2020-01-23 2021-07-29 Bard Access Systems, Inc. Splitable catheter docking station system
EP4096533A4 (en) * 2020-01-31 2024-02-28 Daniel Ezra Walzmann Microcatheers for injecting embolic liquid agents into vessels
CA3172383A1 (en) 2020-03-13 2021-09-16 Bard Access Systems, Inc. Guidewire-management devices and methods thereof
WO2021183952A1 (en) 2020-03-13 2021-09-16 Bard Access Systems, Inc. Guidewire-management devices and methods thereof
AU2021259483B2 (en) 2020-04-23 2025-10-02 Bard Access Systems, Inc. Rapidly insertable central catheters including catheter assemblies
KR20230013131A (ko) 2020-05-21 2023-01-26 바드 액세스 시스템즈, 인크. 카테터 어셈블리를 포함하는 신속 삽입 가능 중심 카테터 및 그 방법(rapidly insertable central catheters including catheter assemblies and methods thereof)
WO2021247850A2 (en) 2020-06-05 2021-12-09 Cook Medical Technologies Llc Medical scopes for delivering therapeutic agents
US12274836B2 (en) 2020-06-29 2025-04-15 Bard Access Systems, Inc. Rapidly insertable central catheters including assemblies and methods thereof
US12161820B2 (en) 2020-06-29 2024-12-10 Bard Access Systems, Inc. Rapidly insertable central catheters including catheter assemblies and methods thereof
AU2021371314B2 (en) 2020-10-28 2025-09-25 Bard Access Systems, Inc. Catheter placement system with stiffening system
KR102516178B1 (ko) * 2020-10-29 2023-03-30 최돈경 도뇨장치
WO2022115554A1 (en) * 2020-11-25 2022-06-02 Endobar Solutions Llc System for delivering a therapeutic radioactive substance into a subject
CN114602038A (zh) 2020-12-03 2022-06-10 巴德阿克塞斯系统股份有限公司 导丝
US12220540B2 (en) * 2020-12-04 2025-02-11 Phoenix Children's Hospital, Inc. Anti-reflux plug forming detachable tip microcatheter
KR20230121775A (ko) 2020-12-17 2023-08-21 바드 액세스 시스템즈, 인크. 신속 삽입 가능 중심 카테터, 조립체, 및 그 방법(rapidlyinsertable central catheters, assemblies, and methods thereof)
WO2022140429A1 (en) 2020-12-21 2022-06-30 Bard Access Systems, Inc. Optimized structural support in catheter insertion systems
AU2021409944B2 (en) 2020-12-21 2025-10-02 Bard Access Systems, Inc. Fluid path optimization in catheter insertion systems
KR102593281B1 (ko) * 2021-07-05 2023-10-24 주식회사 바이오솔루션 스페로이드형 세포치료제 이식용 주입장치
CN115999013A (zh) * 2021-10-22 2023-04-25 上海拓脉医疗科技有限公司 一种医用导管和医用套件
CN114081568B (zh) * 2021-11-19 2022-08-30 心凯诺医疗科技(上海)有限公司 一种包含栓塞材料及其输送系统的组合件
US20240165294A1 (en) * 2022-11-23 2024-05-23 Case Western Reserve University Tunable, stable sclerosing foam for vascular interventions
WO2025122700A1 (en) * 2023-12-05 2025-06-12 The Regents Of The University Of California System and method for minimally invasive tubal sterilization

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021455A1 (en) * 1995-12-14 1997-06-19 Medtronic, Inc. Device and method for selectively delivering fluid into an anatomical lumen
US5833671A (en) * 1996-06-17 1998-11-10 Cardeon Corporation Triple lumen catheter with controllable antegrade and retrograde fluid flow
US5964223A (en) * 1994-06-17 1999-10-12 Trudell Medical Limited Nebulizing catheter system and methods of use and manufacture
WO2001032240A1 (en) * 1999-10-29 2001-05-10 Bard Access Systems, Inc., A Subsidiary Of C.R. Bard, Inc. Bolus tip design for a multi-lumen catheter
WO2008067362A2 (en) * 2006-11-28 2008-06-05 Medrad, Inc. Multiple lumen diffusion catheter
WO2010026578A1 (en) * 2008-09-02 2010-03-11 By-Pass, Inc. Microporous balloon catheter
WO2010125159A1 (en) * 2009-04-29 2010-11-04 Cardio3 Biosciences S.A. Device for delivering a therapeutic agent
CN102065945A (zh) * 2008-04-22 2011-05-18 贝克顿·迪金森公司 用来改进导管孔阵列效率的系统和方法
WO2011091275A1 (en) * 2010-01-23 2011-07-28 Duke University Jetless intravenous catheters and mechanical assist devices for hand-injection of contrast media during dynamic computer tomography and methods of using same
CN102186526A (zh) * 2008-08-19 2011-09-14 微治疗公司 可分离末端的微型导液管
CN102596304A (zh) * 2009-04-29 2012-07-18 卡迪欧参生物科技 用于将治疗剂递送到基质中的注射导管
WO2014047179A1 (en) * 2012-09-19 2014-03-27 University Of Virginia Patent Foundation Method and system for enhanced imaging visualization of deep brain anatomy using infusion
CN104043187A (zh) * 2013-03-11 2014-09-17 柯惠有限合伙公司 控制导管流动

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888249A (en) * 1973-11-02 1975-06-10 David L Spencer Arterial infusion catheter
US5178611A (en) 1991-05-01 1993-01-12 Paul Rosenberg Device and method for inhibiting intravascular device associated infection
CA2117088A1 (en) 1991-09-05 1993-03-18 David R. Holmes Flexible tubular device for use in medical applications
US5318032A (en) 1992-02-05 1994-06-07 Devices For Vascular Intervention Guiding catheter having soft tip
US5601539A (en) 1993-11-03 1997-02-11 Cordis Corporation Microbore catheter having kink-resistant metallic tubing
JPH07178176A (ja) * 1993-12-24 1995-07-18 Terumo Corp カテーテル
SE505125C2 (sv) 1995-10-10 1997-06-30 Gambro Ab Kateter, särskilt för peritonealdialys
US5749894A (en) 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
AU737754B2 (en) * 1996-06-17 2001-08-30 Cardeon Corporation Externally valved catheter for controlled antegrade and retrograde fluid flow
US5735289A (en) * 1996-08-08 1998-04-07 Pfeffer; Herbert G. Method and apparatus for organic specimen retrieval
US5817057A (en) 1996-09-13 1998-10-06 Micro Interventional Systems, Inc. Fluid propulsion steerable catheter and method
JP3527378B2 (ja) * 1997-01-31 2004-05-17 テルモ株式会社 造影用カテーテル
US5911734A (en) * 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6676682B1 (en) * 1997-05-08 2004-01-13 Scimed Life Systems, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US5848964A (en) * 1997-06-06 1998-12-15 Samuels; Shaun Lawrence Wilkie Temporary inflatable filter device and method of use
US5941896A (en) * 1997-09-08 1999-08-24 Montefiore Hospital And Medical Center Filter and method for trapping emboli during endovascular procedures
US5957901A (en) * 1997-10-14 1999-09-28 Merit Medical Systems, Inc. Catheter with improved spray pattern for pharmaco-mechanical thrombolysis therapy
US6146373A (en) 1997-10-17 2000-11-14 Micro Therapeutics, Inc. Catheter system and method for injection of a liquid embolic composition and a solidification agent
JPH11276592A (ja) * 1998-03-30 1999-10-12 Terumo Corp カテーテルおよび医療用チューブ
JP3685617B2 (ja) * 1998-03-31 2005-08-24 テルモ株式会社 カテーテル
EP1207931A2 (en) 1999-08-24 2002-05-29 Neuron Therapeutics, Inc. Lumbar drainage catheter
US6695809B1 (en) 1999-09-13 2004-02-24 Advanced Cardiovascular Systems, Inc. Catheter balloon with a discontinuous elastomeric outer layer
US7033776B2 (en) 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
AU2001245660B2 (en) 2000-03-13 2006-06-15 Biocompatibles Uk Limited Embolic compositions
US6936059B2 (en) * 2001-01-16 2005-08-30 Scimed Life Systems, Inc. Endovascular guidewire filter and methods of use
US8979801B2 (en) 2001-01-17 2015-03-17 Medtronic Vascular, Inc. Microcatheter devices and methods for targeted substance delivery
US6610077B1 (en) * 2001-01-23 2003-08-26 Endovascular Technologies, Inc. Expandable emboli filter and thrombectomy device
US6602269B2 (en) 2001-03-30 2003-08-05 Scimed Life Systems Embolic devices capable of in-situ reinforcement
US6887257B2 (en) * 2001-10-19 2005-05-03 Incept Llc Vascular embolic filter exchange devices and methods of use thereof
US7153320B2 (en) * 2001-12-13 2006-12-26 Scimed Life Systems, Inc. Hydraulic controlled retractable tip filter retrieval catheter
US6958074B2 (en) * 2002-01-07 2005-10-25 Cordis Corporation Releasable and retrievable vascular filter system
US8647359B2 (en) 2002-01-10 2014-02-11 Boston Scientific Scimed, Inc. Distal protection filter
US20030176884A1 (en) * 2002-03-12 2003-09-18 Marwane Berrada Everted filter device
US7399307B2 (en) 2002-05-14 2008-07-15 Bacchus Vascular, Inc. Apparatus and method for removing occlusive material within blood vessels
US20040122362A1 (en) 2002-09-10 2004-06-24 Houser Russell A. Pseudo aneurysm repair system
US7220271B2 (en) * 2003-01-30 2007-05-22 Ev3 Inc. Embolic filters having multiple layers and controlled pore size
ES2308149T3 (es) 2003-02-12 2008-12-01 Biocompatibles Uk Limited Composicion para la quimioemboloterapia de tumores solidos.
US7413564B2 (en) 2003-03-06 2008-08-19 Medtronic, Inc. Slit valve catheters
CN1802184A (zh) * 2003-03-18 2006-07-12 凯瑟罗斯医疗系统公司 用于从生理上传出的流体收集位置收回医用试剂的方法和装置
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US20070073271A1 (en) * 2003-11-15 2007-03-29 Brucker Gregory G Catheter for diagnostic imaging and therapeutic procedures
US20050175709A1 (en) * 2003-12-11 2005-08-11 Baty Ace M.Iii Therapeutic microparticles
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US20060004316A1 (en) 2004-07-02 2006-01-05 Difiore Attilio E Reduction of recirculation in catheters
JP2008509781A (ja) 2004-08-19 2008-04-03 ベインアールエックス，インコーポレイティド 薬物送達用の閉塞可能な血管内カテーテル及びこれを使用する方法
US8221446B2 (en) * 2005-03-15 2012-07-17 Cook Medical Technologies Embolic protection device
US20080188928A1 (en) * 2005-09-16 2008-08-07 Amr Salahieh Medical device delivery sheath
US8012117B2 (en) * 2007-02-06 2011-09-06 Medrad, Inc. Miniature flexible thrombectomy catheter
ATE536140T1 (de) * 2005-09-30 2011-12-15 Cook Medical Technologies Llc Beschichtete gefässverschlussvorrichtung
US8251963B2 (en) 2005-12-08 2012-08-28 Boston Scientific Scimed, Inc. Flexible needle
CN101415450A (zh) * 2006-02-14 2009-04-22 国立大学法人东京大学 骨填补剂的制造方法、骨填补剂以及三维细胞培养载体、色谱法用分离载体
EP1857134A1 (en) 2006-05-15 2007-11-21 JOANNEUM RESEARCH Forschungsgesellschaft mbH Catheter having an oblong slit
US7938799B2 (en) 2006-08-10 2011-05-10 Boston Scientific Scimed, Inc. Medical device for vessel compatibility during high pressure infusion
US9149610B2 (en) 2007-05-31 2015-10-06 Abbott Cardiovascular Systems Inc. Method and apparatus for improving delivery of an agent to a kidney
US20090068279A1 (en) * 2007-09-12 2009-03-12 Boston Scientific Scimed, Inc. Microspheres with surface projections
US8066757B2 (en) * 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
WO2009134337A1 (en) * 2008-05-01 2009-11-05 Aneuclose Llc Aneurysm occlusion device
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
US20100131002A1 (en) 2008-11-24 2010-05-27 Connor Robert A Stent with a net layer to embolize and aneurysm
DE102010009017A1 (de) * 2009-08-31 2011-03-10 Siemens Aktiengesellschaft Verfahren zur Bildung eines endovaskulären Behandlungshilfsmittels mit Hilfe von selbstorganisierenden, aus Catomen (Cat) bestehenden Nanoroboter und dazu gehöriges System
WO2011044236A1 (en) 2009-10-06 2011-04-14 Regents Of The University Of Minnesota Bioresorbable embolization microspheres
US9539081B2 (en) 2009-12-02 2017-01-10 Surefire Medical, Inc. Method of operating a microvalve protection device
US8696698B2 (en) * 2009-12-02 2014-04-15 Surefire Medical, Inc. Microvalve protection device and method of use for protection against embolization agent reflux
US20110152741A1 (en) 2009-12-21 2011-06-23 Michael Banchieri Cannula system
EP2351779B1 (en) 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres
JP5808792B2 (ja) 2010-04-13 2015-11-10 ミビ・ニューロサイエンス・リミテッド・ライアビリティ・カンパニーＭｉｖｉ Ｎｅｕｒｏｓｃｉｅｎｃｅ ＬＬＣ 急性脳卒中治療装置およびシステム
KR101910207B1 (ko) * 2010-08-12 2018-10-19 씨. 알. 바드, 인크. 원위 부분 안정화 특징부를 포함하는 변형 가능한 카테터
US9445819B2 (en) * 2010-12-30 2016-09-20 Cook Medical Technologies Llc Venous nitinol embolization inserts
US8936581B2 (en) 2011-03-22 2015-01-20 Becton, Dickinson And Company Catheter having a spiral slit
WO2014066811A1 (en) * 2012-10-25 2014-05-01 The Johns Hopkins University Bioreducible poly (b-amino ester)s for sirna delivery
WO2013126456A1 (en) 2012-02-21 2013-08-29 Hospi Corporation A method and apparatus for a clog resistant orifice
US10124087B2 (en) * 2012-06-19 2018-11-13 Covidien Lp Detachable coupling for catheter
WO2014182959A2 (en) * 2013-05-08 2014-11-13 Embolx, Inc. Device and methods for transvascular tumor embolization with integrated flow regulation
ITCT20130016A1 (it) * 2013-07-04 2015-01-05 Stefano Riccardo De Cannula per catetere endovenoso e metodo per la sua realizzazione
EP3154618B1 (en) 2014-06-16 2024-08-14 Edwards Lifesciences Corporation Spring cannulae
US10780246B2 (en) 2014-09-12 2020-09-22 Callisyn Biomedical, Inc. Vascular microcatheter
KR102557862B1 (ko) 2015-01-09 2023-07-20 애커러트 메디컬 테라퓨틱스 엘티디. 색전술 마이크로카테터

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5964223A (en) * 1994-06-17 1999-10-12 Trudell Medical Limited Nebulizing catheter system and methods of use and manufacture
WO1997021455A1 (en) * 1995-12-14 1997-06-19 Medtronic, Inc. Device and method for selectively delivering fluid into an anatomical lumen
US5833671A (en) * 1996-06-17 1998-11-10 Cardeon Corporation Triple lumen catheter with controllable antegrade and retrograde fluid flow
WO2001032240A1 (en) * 1999-10-29 2001-05-10 Bard Access Systems, Inc., A Subsidiary Of C.R. Bard, Inc. Bolus tip design for a multi-lumen catheter
WO2008067362A2 (en) * 2006-11-28 2008-06-05 Medrad, Inc. Multiple lumen diffusion catheter
CN102065945A (zh) * 2008-04-22 2011-05-18 贝克顿·迪金森公司 用来改进导管孔阵列效率的系统和方法
CN102186526A (zh) * 2008-08-19 2011-09-14 微治疗公司 可分离末端的微型导液管
WO2010026578A1 (en) * 2008-09-02 2010-03-11 By-Pass, Inc. Microporous balloon catheter
WO2010125159A1 (en) * 2009-04-29 2010-11-04 Cardio3 Biosciences S.A. Device for delivering a therapeutic agent
CN102596304A (zh) * 2009-04-29 2012-07-18 卡迪欧参生物科技 用于将治疗剂递送到基质中的注射导管
WO2011091275A1 (en) * 2010-01-23 2011-07-28 Duke University Jetless intravenous catheters and mechanical assist devices for hand-injection of contrast media during dynamic computer tomography and methods of using same
WO2014047179A1 (en) * 2012-09-19 2014-03-27 University Of Virginia Patent Foundation Method and system for enhanced imaging visualization of deep brain anatomy using infusion
CN104043187A (zh) * 2013-03-11 2014-09-17 柯惠有限合伙公司 控制导管流动

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