CN107441487B - 通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法 - Google Patents

通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法 Download PDF

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CN107441487B
CN107441487B CN201710732211.8A CN201710732211A CN107441487B CN 107441487 B CN107441487 B CN 107441487B CN 201710732211 A CN201710732211 A CN 201710732211A CN 107441487 B CN107441487 B CN 107441487B
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antibody
cgrp
visceral pain
seq
pain
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CN107441487A (zh
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A·A·皮奥斯
K·T·波尔森
D·L·谢尔顿
J·泽勒
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Teva Pharmaceuticals International GmbH
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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CN201710732211.8A 2009-08-28 2010-08-23 通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法 Active CN107441487B (zh)

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US23790109P 2009-08-28 2009-08-28
US61/237,901 2009-08-28
CN2010800385860A CN102740884A (zh) 2009-08-28 2010-08-23 通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法

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CN2010800385860A Pending CN102740884A (zh) 2009-08-28 2010-08-23 通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法

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US (6) US8623366B2 (https=)
EP (2) EP3165236B1 (https=)
JP (5) JP2011046710A (https=)
KR (1) KR101519192B1 (https=)
CN (2) CN107441487B (https=)
AU (1) AU2010288194B2 (https=)
BR (1) BR112012004464B8 (https=)
CA (1) CA2771186C (https=)
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IL (1) IL218228B (https=)
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