CN107406499B - 抗甲状腺素运载蛋白抗体 - Google Patents

抗甲状腺素运载蛋白抗体 Download PDF

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Publication number
CN107406499B
CN107406499B CN201680010882.7A CN201680010882A CN107406499B CN 107406499 B CN107406499 B CN 107406499B CN 201680010882 A CN201680010882 A CN 201680010882A CN 107406499 B CN107406499 B CN 107406499B
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antibody
seq
ttr
variable region
chain variable
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Chinese (zh)
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CN107406499A (zh
Inventor
刘跃
塔洛陈·S.·尼扎
A·恰克拉布阿缇
J·N·海加凯
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Neoto Neuroscience Ltd
University Health Network
Novo Nordisk AS
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University Health Network
Prothena Biosciences Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680010882.7A 2015-01-28 2016-01-28 抗甲状腺素运载蛋白抗体 Active CN107406499B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562109002P 2015-01-28 2015-01-28
US62/109,002 2015-01-28
US201562266556P 2015-12-11 2015-12-11
US62/266,556 2015-12-11
PCT/IB2016/050415 WO2016120810A1 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Publications (2)

Publication Number Publication Date
CN107406499A CN107406499A (zh) 2017-11-28
CN107406499B true CN107406499B (zh) 2021-10-22

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CN201680010882.7A Active CN107406499B (zh) 2015-01-28 2016-01-28 抗甲状腺素运载蛋白抗体

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EP (2) EP3250592B1 (OSRAM)
JP (2) JP6748086B2 (OSRAM)
KR (2) KR102598180B1 (OSRAM)
CN (1) CN107406499B (OSRAM)
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CA (1) CA2974912A1 (OSRAM)
CL (2) CL2017001924A1 (OSRAM)
CO (1) CO2017008476A2 (OSRAM)
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DK (1) DK3250592T3 (OSRAM)
EA (1) EA036080B1 (OSRAM)
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LT (1) LT3250592T (OSRAM)
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SA (1) SA517382002B1 (OSRAM)
SG (2) SG10202101763VA (OSRAM)
SI (1) SI3250592T1 (OSRAM)
TW (2) TWI786505B (OSRAM)
UA (1) UA122142C2 (OSRAM)
WO (1) WO2016120810A1 (OSRAM)
ZA (1) ZA201705663B (OSRAM)

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US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
EP3478714A2 (en) * 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
MX2020003043A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Métodos para detectar transtiretina.
MX2020003041A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anticuerpos anti-transtiretina.
CN111433223B (zh) * 2017-11-29 2024-08-27 诺和诺德A/S（股份有限公司） 抗甲状腺素运载蛋白单克隆抗体的冻干制剂
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TW202528347A (zh) 2023-11-15 2025-07-16 瑞士商紐立慕公司 抗運甲狀腺素蛋白抗體、包含所述抗體之組成物及用於治療或預防運甲狀腺素蛋白介導之澱粉樣變性的方法
TW202525341A (zh) 2023-12-15 2025-07-01 丹麥商諾佛 儂迪克股份有限公司 穩定的液體調配物
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SI3250592T1 (sl) 2023-03-31
LT3250592T (lt) 2023-02-10
KR102598180B1 (ko) 2023-11-03
SG11201706124VA (en) 2017-08-30
EA036080B1 (ru) 2020-09-23
ES2934656T3 (es) 2023-02-23
PE20180217A1 (es) 2018-01-31
AU2016210888C1 (en) 2022-06-02
FI3250592T3 (fi) 2023-01-13
SG10202101763VA (en) 2021-04-29
CL2022003027A1 (es) 2023-06-09
CU24480B1 (es) 2020-03-04
KR102677203B1 (ko) 2024-06-20
JP6748086B2 (ja) 2020-09-02
HUE060878T2 (hu) 2023-04-28
SA517382002B1 (ar) 2021-11-25
EP4134379A1 (en) 2023-02-15
HRP20221538T1 (hr) 2023-03-03
JP2018506277A (ja) 2018-03-08
TWI786505B (zh) 2022-12-11
WO2016120810A1 (en) 2016-08-04
NZ733896A (en) 2024-11-29
JP2020185009A (ja) 2020-11-19
EP3250592A1 (en) 2017-12-06
TW201632554A (zh) 2016-09-16
DK3250592T3 (en) 2023-01-09
TW202124436A (zh) 2021-07-01
CN107406499A (zh) 2017-11-28
BR112017016330A2 (pt) 2018-04-03
PH12017501318A1 (en) 2018-02-05
JP7028923B2 (ja) 2022-03-02
PL3250592T3 (pl) 2023-06-19
CL2017001924A1 (es) 2018-04-27
PT3250592T (pt) 2022-12-28
EP3250592B1 (en) 2022-10-05
AU2016210888B2 (en) 2021-11-04
US20160251418A1 (en) 2016-09-01
IL253633B (en) 2021-06-30
CA2974912A1 (en) 2016-08-04
AU2016210888A1 (en) 2017-08-10
KR20230156164A (ko) 2023-11-13
RS63906B1 (sr) 2023-02-28
IL253633A0 (en) 2017-09-28
TWI718122B (zh) 2021-02-11
MX394170B (es) 2025-03-24
PH12017501318B1 (en) 2018-02-05
KR20170106469A (ko) 2017-09-20
ZA201705663B (en) 2018-08-29
EA201791712A1 (ru) 2017-12-29
CU20170097A7 (es) 2018-03-13
UA122142C2 (uk) 2020-09-25
MX2017009806A (es) 2018-08-15
CO2017008476A2 (es) 2018-01-16

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