PE20180217A1 - Anticuerpos anti-transtiretina - Google Patents

Anticuerpos anti-transtiretina

Info

Publication number
PE20180217A1
PE20180217A1 PE2017001287A PE2017001287A PE20180217A1 PE 20180217 A1 PE20180217 A1 PE 20180217A1 PE 2017001287 A PE2017001287 A PE 2017001287A PE 2017001287 A PE2017001287 A PE 2017001287A PE 20180217 A1 PE20180217 A1 PE 20180217A1
Authority
PE
Peru
Prior art keywords
ttr
antibodies
transtiretin
accumulation
amyloidosis
Prior art date
Application number
PE2017001287A
Other languages
English (en)
Spanish (es)
Inventor
Avijit Chakrabartty
Tarlochan S Nijjar
Jeffrey N Higaki
Yue Liu
Original Assignee
Prothena Biosciences Ltd
Univ Health Network
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prothena Biosciences Ltd, Univ Health Network filed Critical Prothena Biosciences Ltd
Publication of PE20180217A1 publication Critical patent/PE20180217A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PE2017001287A 2015-01-28 2016-01-28 Anticuerpos anti-transtiretina PE20180217A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562109002P 2015-01-28 2015-01-28
US201562266556P 2015-12-11 2015-12-11

Publications (1)

Publication Number Publication Date
PE20180217A1 true PE20180217A1 (es) 2018-01-31

Family

ID=55299694

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017001287A PE20180217A1 (es) 2015-01-28 2016-01-28 Anticuerpos anti-transtiretina

Country Status (31)

Country Link
US (1) US20160251418A1 (OSRAM)
EP (2) EP3250592B1 (OSRAM)
JP (2) JP6748086B2 (OSRAM)
KR (2) KR102598180B1 (OSRAM)
CN (1) CN107406499B (OSRAM)
AU (1) AU2016210888C1 (OSRAM)
CA (1) CA2974912A1 (OSRAM)
CL (2) CL2017001924A1 (OSRAM)
CO (1) CO2017008476A2 (OSRAM)
CU (1) CU24480B1 (OSRAM)
DK (1) DK3250592T3 (OSRAM)
EA (1) EA036080B1 (OSRAM)
ES (1) ES2934656T3 (OSRAM)
FI (1) FI3250592T3 (OSRAM)
HR (1) HRP20221538T1 (OSRAM)
HU (1) HUE060878T2 (OSRAM)
IL (1) IL253633B (OSRAM)
LT (1) LT3250592T (OSRAM)
MX (1) MX394170B (OSRAM)
PE (1) PE20180217A1 (OSRAM)
PH (1) PH12017501318B1 (OSRAM)
PL (1) PL3250592T3 (OSRAM)
PT (1) PT3250592T (OSRAM)
RS (1) RS63906B1 (OSRAM)
SA (1) SA517382002B1 (OSRAM)
SG (2) SG10202101763VA (OSRAM)
SI (1) SI3250592T1 (OSRAM)
TW (2) TWI786505B (OSRAM)
UA (1) UA122142C2 (OSRAM)
WO (1) WO2016120810A1 (OSRAM)
ZA (1) ZA201705663B (OSRAM)

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US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
EP3478714A2 (en) * 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
MX2020003043A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Métodos para detectar transtiretina.
MX2020003041A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Anticuerpos anti-transtiretina.
CN111433223B (zh) * 2017-11-29 2024-08-27 诺和诺德A/S(股份有限公司) 抗甲状腺素运载蛋白单克隆抗体的冻干制剂
WO2020094883A1 (en) 2018-11-09 2020-05-14 Neurimmune Ag Patient-derived amyloid xenograft non-human animal model
WO2021185961A1 (en) 2020-03-18 2021-09-23 Al-S Pharma Ag Misfolded sod1 assay
JP2023525790A (ja) 2020-05-12 2023-06-19 ニューリミューン エイジー Ttrアミロイドーシスに対する併用療法
WO2021231982A1 (en) * 2020-05-14 2021-11-18 City Of Hope Smc1a antibodies and uses thereof
JP2023548005A (ja) * 2020-10-28 2023-11-15 ノヴォ ノルディスク アー/エス 抗トランスサイレチン抗体およびその使用方法
CN113845593B (zh) * 2021-10-27 2023-03-10 福州迈新生物技术开发有限公司 抗α-SMA蛋白单克隆抗体、细胞系及其应用
WO2023099788A1 (en) 2021-12-03 2023-06-08 Neurimmune Ag Novel potency assay for antibody-based drugs and useful means therefor
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WO2024240562A1 (en) 2023-05-19 2024-11-28 Neurimmune Ag Novel immunotherapy for musculoskeletal disorders and conditions
TW202528347A (zh) 2023-11-15 2025-07-16 瑞士商紐立慕公司 抗運甲狀腺素蛋白抗體、包含所述抗體之組成物及用於治療或預防運甲狀腺素蛋白介導之澱粉樣變性的方法
TW202525341A (zh) 2023-12-15 2025-07-01 丹麥商諾佛 儂迪克股份有限公司 穩定的液體調配物
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Also Published As

Publication number Publication date
SI3250592T1 (sl) 2023-03-31
LT3250592T (lt) 2023-02-10
CN107406499B (zh) 2021-10-22
KR102598180B1 (ko) 2023-11-03
SG11201706124VA (en) 2017-08-30
EA036080B1 (ru) 2020-09-23
ES2934656T3 (es) 2023-02-23
AU2016210888C1 (en) 2022-06-02
FI3250592T3 (fi) 2023-01-13
SG10202101763VA (en) 2021-04-29
CL2022003027A1 (es) 2023-06-09
CU24480B1 (es) 2020-03-04
KR102677203B1 (ko) 2024-06-20
JP6748086B2 (ja) 2020-09-02
HUE060878T2 (hu) 2023-04-28
SA517382002B1 (ar) 2021-11-25
EP4134379A1 (en) 2023-02-15
HRP20221538T1 (hr) 2023-03-03
JP2018506277A (ja) 2018-03-08
TWI786505B (zh) 2022-12-11
WO2016120810A1 (en) 2016-08-04
NZ733896A (en) 2024-11-29
JP2020185009A (ja) 2020-11-19
EP3250592A1 (en) 2017-12-06
TW201632554A (zh) 2016-09-16
DK3250592T3 (en) 2023-01-09
TW202124436A (zh) 2021-07-01
CN107406499A (zh) 2017-11-28
BR112017016330A2 (pt) 2018-04-03
PH12017501318A1 (en) 2018-02-05
JP7028923B2 (ja) 2022-03-02
PL3250592T3 (pl) 2023-06-19
CL2017001924A1 (es) 2018-04-27
PT3250592T (pt) 2022-12-28
EP3250592B1 (en) 2022-10-05
AU2016210888B2 (en) 2021-11-04
US20160251418A1 (en) 2016-09-01
IL253633B (en) 2021-06-30
CA2974912A1 (en) 2016-08-04
AU2016210888A1 (en) 2017-08-10
KR20230156164A (ko) 2023-11-13
RS63906B1 (sr) 2023-02-28
IL253633A0 (en) 2017-09-28
TWI718122B (zh) 2021-02-11
MX394170B (es) 2025-03-24
PH12017501318B1 (en) 2018-02-05
KR20170106469A (ko) 2017-09-20
ZA201705663B (en) 2018-08-29
EA201791712A1 (ru) 2017-12-29
CU20170097A7 (es) 2018-03-13
UA122142C2 (uk) 2020-09-25
MX2017009806A (es) 2018-08-15
CO2017008476A2 (es) 2018-01-16

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