CN1073878A - 用病毒抗原表达特异性免疫原 - Google Patents

用病毒抗原表达特异性免疫原 Download PDF

Info

Publication number
CN1073878A
CN1073878A CN92113703A CN92113703A CN1073878A CN 1073878 A CN1073878 A CN 1073878A CN 92113703 A CN92113703 A CN 92113703A CN 92113703 A CN92113703 A CN 92113703A CN 1073878 A CN1073878 A CN 1073878A
Authority
CN
China
Prior art keywords
determinant
antigenic
virus
peptide
site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN92113703A
Other languages
English (en)
Chinese (zh)
Inventor
洪伯文
林少光
N·K·卡利扬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of CN1073878A publication Critical patent/CN1073878A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN92113703A 1991-12-11 1992-12-10 用病毒抗原表达特异性免疫原 Pending CN1073878A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80510591A 1991-12-11 1991-12-11
US805,105 1991-12-11

Publications (1)

Publication Number Publication Date
CN1073878A true CN1073878A (zh) 1993-07-07

Family

ID=25190685

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92113703A Pending CN1073878A (zh) 1991-12-11 1992-12-10 用病毒抗原表达特异性免疫原

Country Status (17)

Country Link
US (1) US5591823A (enExample)
EP (1) EP0546787A3 (enExample)
JP (1) JPH05262667A (enExample)
KR (1) KR930013112A (enExample)
CN (1) CN1073878A (enExample)
AU (1) AU2981992A (enExample)
BR (1) BR9204978A (enExample)
CA (1) CA2084180A1 (enExample)
CZ (1) CZ362692A3 (enExample)
FI (1) FI925590A7 (enExample)
HU (2) HUT65366A (enExample)
IL (1) IL103928A0 (enExample)
MX (1) MX9207113A (enExample)
NO (1) NO924780L (enExample)
SK (1) SK362692A3 (enExample)
TW (1) TW239162B (enExample)
ZA (1) ZA929355B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100390289C (zh) * 1993-09-13 2008-05-28 Mg-Pmc有限公司 生产流感血凝素多价疫苗的方法
CN101663315A (zh) * 2007-02-21 2010-03-03 肿瘤疗法科学股份有限公司 用于表达肿瘤相关抗原的癌症的肽疫苗
CN101708442B (zh) * 2009-09-04 2011-08-24 山东中惠仪器有限公司 全自动标准气体配制装置
US8623829B2 (en) 2007-02-21 2014-01-07 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
US8883966B2 (en) 2008-10-22 2014-11-11 Oncotherapy Science, Inc. RAB6KIFL/KIF20A epitope peptide and vaccines containing the same
CN109073639A (zh) * 2016-02-03 2018-12-21 Cg探索股份有限公司 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633929B1 (en) * 1992-04-01 2004-03-03 The Rockefeller University METHOD FOR $i(IN VITRO) PROLIFERATION OF DENDRITIC CELL PRECURSORS AND THEIR USE TO PRODUCE IMMUNOGENS
DE69332485T2 (de) * 1992-08-11 2003-11-13 The President And Fellows Of Harvard College, Cambridge Immunmodulierende peptide
WO1995007099A1 (en) * 1993-09-09 1995-03-16 The Nisshin Oil Mills, Ltd. Vaccine and process for producing the same
EP2374894B1 (en) * 1993-09-13 2014-09-17 Protein Sciences Corporation A method for producing influenza hemagglutinin multivalent vaccines
ES2370937T3 (es) 1993-09-13 2011-12-23 Protein Sciences Corporation Un método para producir vacunas antigripales polivalentes a base de hemaglutinina.
US6300090B1 (en) 1994-07-29 2001-10-09 The Rockefeller University Methods of use of viral vectors to deliver antigen to dendritic cells
EP1275726B1 (en) * 1995-05-26 2008-02-20 Mg-Pmc, L.L.C. A method for producing influenza hemagglutinin multivalent vaccines
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
WO1998048834A1 (en) * 1997-04-30 1998-11-05 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents
DE69840739D1 (de) 1997-10-27 2009-05-28 Merix Bioscience Inc Methode und Zusammensetzung zur Herstellung von reifen dendritischen Zellen
JP2002504322A (ja) 1998-02-20 2002-02-12 ザ ロックフェラー ユニバーシティー 樹状細胞に対するアポトーシス細胞介在抗原提示
WO2002026252A1 (en) * 2000-08-10 2002-04-04 Tsinghua University A vaccine for influenza virus and its preparation
KR100836520B1 (ko) 2000-09-11 2008-06-12 다우 글로벌 테크놀로지스 인크. 무공압 주행 타이어 지지부
US20040203084A1 (en) * 2003-04-10 2004-10-14 Doug Levinson Profiling conformational variants, antibody compositions and methods of using the same
CA2610667A1 (en) * 2005-06-01 2006-12-07 Variation Biotechnologies Inc. Peptide-based influenza vaccine formulation
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
EP2012122A1 (en) * 2007-07-06 2009-01-07 Medigene AG Mutated parvovirus structural proteins as vaccines
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
CA2976814C (en) * 2007-08-27 2022-12-13 Longhorn Vaccines & Diagnostics, Llc Immunogenic compositions and methods for treating influenza
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
DK2691530T3 (en) 2011-06-10 2018-05-22 Univ Oregon Health & Science CMV GLYCOPROTEIN AND RECOMBINANT VECTORS
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
EP2679596B1 (en) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 env glycoprotein variant
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
US10063211B2 (en) 2016-02-03 2018-08-28 Qualcomm Incorporated Compact bypass and decoupling structure for millimeter-wave circuits

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339504A3 (en) * 1988-04-26 1990-09-12 The Du Pont Merck Pharmaceutical Company Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals
US5166057A (en) * 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
EP0492920A1 (en) * 1990-12-24 1992-07-01 Merck & Co. Inc. Chimaeric influenza-HIV vaccine

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100390289C (zh) * 1993-09-13 2008-05-28 Mg-Pmc有限公司 生产流感血凝素多价疫苗的方法
CN101663315A (zh) * 2007-02-21 2010-03-03 肿瘤疗法科学股份有限公司 用于表达肿瘤相关抗原的癌症的肽疫苗
US8623829B2 (en) 2007-02-21 2014-01-07 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
US8759481B2 (en) 2007-02-21 2014-06-24 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
CN101663315B (zh) * 2007-02-21 2014-10-15 肿瘤疗法科学股份有限公司 用于表达肿瘤相关抗原的癌症的肽疫苗
US9067973B2 (en) 2007-02-21 2015-06-30 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
US9284349B2 (en) 2007-02-21 2016-03-15 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
US8883966B2 (en) 2008-10-22 2014-11-11 Oncotherapy Science, Inc. RAB6KIFL/KIF20A epitope peptide and vaccines containing the same
US9132176B2 (en) 2008-10-22 2015-09-15 Oncotherapy Science, Inc. RAB6KIFL/KIF20A epitope peptide and vaccines containing the same
CN101708442B (zh) * 2009-09-04 2011-08-24 山东中惠仪器有限公司 全自动标准气体配制装置
CN109073639A (zh) * 2016-02-03 2018-12-21 Cg探索股份有限公司 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物
CN109073639B (zh) * 2016-02-03 2022-04-01 Cg探索股份有限公司 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物

Also Published As

Publication number Publication date
CZ362692A3 (en) 1994-02-16
NO924780D0 (no) 1992-12-10
NO924780L (no) 1993-06-14
JPH05262667A (ja) 1993-10-12
ZA929355B (en) 1994-06-02
EP0546787A3 (en) 1994-06-01
FI925590L (fi) 1993-06-12
MX9207113A (es) 1994-05-31
SK362692A3 (en) 1995-11-08
HU211548A9 (en) 1995-12-28
AU2981992A (en) 1993-06-17
HUT65366A (en) 1994-05-02
BR9204978A (pt) 1993-06-15
FI925590A0 (fi) 1992-12-09
TW239162B (enExample) 1995-01-21
EP0546787A2 (en) 1993-06-16
IL103928A0 (en) 1993-04-04
FI925590A7 (fi) 1993-06-12
US5591823A (en) 1997-01-07
HU9203931D0 (en) 1993-04-28
CA2084180A1 (en) 1993-06-12
KR930013112A (ko) 1993-07-21

Similar Documents

Publication Publication Date Title
CN1073878A (zh) 用病毒抗原表达特异性免疫原
JP7250878B2 (ja) 新規多価ナノ粒子に基づくワクチン
US12144857B2 (en) Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein
AU592258B2 (en) Synthetic peptides which induce cellular immunity to the aids virus and aids viral proteins
Mena et al. Insect cell technology is a versatile and robust vaccine manufacturing platform
CN1111540C (zh) 串联的合成hiv-1肽类
CN1064891A (zh) 疫苗
JPH07505412A (ja) Ctl応答の誘導
Ogrina et al. Bacterial expression systems based on Tymovirus-like particles for the presentation of vaccine antigens
CN1903363A (zh) 一种嵌合型病毒样颗粒dna疫苗
CN1047531A (zh) 猪瘟病毒疫苗和诊断
CN1245217C (zh) 一种包含dna疫苗和灭活狂犬病毒的疫苗制剂
JPH06510910A (ja) ネコ白血病ウイルスワクチン
CN1185254C (zh) 丙型肝炎病毒第一高变区抗原及其融合抗原
CN1625409A (zh) 含可变肽表位的免疫原制剂及其制备方法
EP1171454B1 (en) Chimeric lyssavirus nucleic acids and polypeptides
CN111803626A (zh) 猪口蹄疫o型和a型二价合成肽疫苗及其制备方法与应用
Kelker et al. Immunogenic and antigenic properties of an HIV-1 gp120-derived multiple chain peptide.
WO2002026254A2 (en) Non-replicative particulate vaccine delivery system and methods of making and using same
JPH07170982A (ja) ワクチンおよびその製造方法
JP2003310271A (ja) エイズワクチン
RU2451027C2 (ru) Рекомбинантная вакцина против вируса "свиного" гриппа h1n1 и спсоб ее получения
EP1721982B1 (en) Chimeric lyssavirus nucleic acids and polypeptides
CN1663616A (zh) 基于nsp4基因的轮状病毒基因疫苗
CN1243751A (zh) 用于诱导对病毒免疫性的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication