CN107328950A - It is a kind of to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis - Google Patents
It is a kind of to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis Download PDFInfo
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- CN107328950A CN107328950A CN201710724844.4A CN201710724844A CN107328950A CN 107328950 A CN107328950 A CN 107328950A CN 201710724844 A CN201710724844 A CN 201710724844A CN 107328950 A CN107328950 A CN 107328950A
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- swab
- sample cell
- sample
- sliding block
- cell
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
It is used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis the invention discloses a kind of, including sampling needle and swab, the sampling needle is fixedly installed on sampling needle rack, the sampling needle rack is fixedly connected with substrate, swab sliding equipment and sample cell hoisting mechanism are provided with the substrate, the swab is connected with swab sliding equipment, the sample cell is positioned on sample cell hoisting mechanism, the sample cell hoisting mechanism is lifted up in the presence of drive mechanism, in lifting process, the sample cell upper end opening portion and swab bottom are fitted close to form sealing and by swab jack-up, the sample cell hoisting mechanism and swab sliding equipment are synchronized with the movement, the sample cell remains opposing seal state with swab during tight fit is synchronized with the movement.The present invention can complete the absorption transfer of sample in swab and the relative movement of sampling needle and position control, sample cell simultaneously, can complete sample introduction, cleaning and the disengaging of full automatic sample cell tube.
Description
Technical field
It is more particularly to a kind of to be carried for sample cell in cell analysis the invention belongs to blood cell analysis equipment technical field
The automatic sample handling system for rising and cleaning.
Background technology
In medical science vitro diagnosis assays instrument, such as in blood cell analyzer and stream type cell analyzer, typically make
The cell in sample is constrained to unicellular fluid with flow focusing art, and measure cell successively it is single flow through quartz flow room or
The pulse signal produced during person's micropore（Including optical scattering, fluorescence signal or resistance antinoise signal）, and by electronic system to difference
The pulse signal of amplitude and width carries out Information Statistics and analysis.The diagnostic result of these cytoanalyzes, is that conditions of patients enters
Row diagnosis and the important step of analysis, can directly instruct the development of subsequent medical behavior.
, can be thin based on Coulter principle, streaming according to difference of the variety classes haemocyte in terms of physics and biochemical property
Born of the same parents' art is carried out the differentiation and counting of cell category using modes such as cell dyeing, light scattering, electrical impedance, carried in different system
Each application messages such as blood supply cell five is classified, immunophenotyping, tumour ploidy analysis and cell factor.In these cytoanalyzes
When carrying out diagnostic analysis, it is necessary first to by sample sampling device from heparin tube or test tube, draw after a certain amount of fluorescence labeling
Blood or the sample such as cell, and by sample introduction capillary or sampling needle, the sample of absorption is injected into analysis cell or flow chamber, and
Recognized successively by instrument detection.Therefore how sample cell is placed in user（Including heparin tube or test tube）Afterwards, automatically to sample
Carry out the primary goal that transfer is sample sampling device.
Simultaneously from test tube after the sample such as draw blood, cell, it can be stayed in sampling needle inner and outer surfaces and sample feeding passage
Lower residual, it is necessary to which the blood sample or cell of these residuals are cleaned up and avoided to next before gathering next sample and analyzing
The detection of individual sample causes cross pollution.Current common principle is to be rinsed using cleaning fluid and collection device（Hereinafter referred to as
" swab "）, such as Patent No. US 5,408,891 U.S. patents and applications number for 200610021359.2,
Swab structure disclosed in 201210222699.7 Chinese patent, this three parts of bibliography be described in detail each cavity of swab,
The detailed design of inlet and leakage fluid dram, but do not provide the structure that is relatively moved above and below swab, sampling needle and test tube with
Scheme.
In addition for the clean consideration with safety of medicine equipment, need to ensure during sample loading no liquid splash and on
Sample mechanical structure is to medical personnel's not damaged.In such as Chinese patent of Application No. 201210222699.7, it is proposed that band baffle ring
Loading needle construction be used to avoid in test tube to steep the pollution to swab with vim and vigour；But it is sampling needle during the sample introduction in the document
Quickly move up and down, there is larger puncture potential safety hazard, and have no the disclosure for the structure that gets sample.
Therefore, swab and the relative movement of sampling needle and upper-lower position control how are completed simultaneously, complete sample cell
The absorption of middle sample is shifted and ensures that no liquid is splashed without potential safety hazard, as those skilled in the art's technical problem to be solved.
If full automatic cell sample sample introduction, cleaning and detachment system can be designed, the sample that sampling needle surfaces externally and internally is remained is carried out
Cleaning, and ensure characteristic with low cost and easy to use by rationally setting, flow cytometer and haemocyte point will be caused
The analytical instrument such as analyzer have more the market competitiveness.
The content of the invention
It is an object of the invention to：For above-mentioned problem full automatic cell sample can be completed there is provided one kind
The sample introduction of pipe, cleaning and depart from, and sampling needle surfaces externally and internally residual sample is cleaned for sample cell in cell analysis
Lifting and the automatic sample handling system of cleaning.
The technical proposal of the invention is realized in this way：It is a kind of be used for cell analysis in sample cell lifting and cleaning it is automatic
Sampling system, including sampling needle and swab, it is characterised in that：The sampling needle is fixedly installed on sampling needle rack, described to adopt
Sample needle rack is fixedly connected with substrate, and swab sliding equipment and sample cell hoisting mechanism are provided with the substrate, described
Swab is connected with swab sliding equipment, and the sample cell is positioned on sample cell hoisting mechanism, the sampling needle through swab and
Stretched in sampling process in sample cell, the sample cell hoisting mechanism is lifted up in the presence of drive mechanism；Carrying
During rising, the sample cell upper end opening portion and swab bottom are fitted close to form sealing and by swab jack-up, the sample
Pipe hoisting mechanism and swab sliding equipment are synchronized with the movement, the sample cell and swab during tight fit is synchronized with the movement all the time
Keep opposing seal state.
Of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, it is in the swab
Extension spring is provided with sliding equipment, described extension spring one end is connected with swab sliding equipment, and its other end is connected with base plate bottom, institute
State extension spring and be in extended state during sample cell and swab are synchronized with the movement.
Of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, it is in the substrate
Above, swab sliding equipment glide direction is provided with stopper slot, be provided with the swab sliding equipment corresponding with stopper slot
The loading baffle plate of cooperation, the extension spring upper end is connected with loading baffle plate, the extension spring pin connection of its lower end and base plate bottom, when described
When swab sliding equipment is in extreme lower position with sample cell hoisting mechanism, the sample cell is in disengaged position with swab, and
Sampling needle lower end needle tip is placed in swab.
Of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, it is in the swab
Fixed connecting rod is provided between sliding equipment and sample cell hoisting mechanism, the fixed connecting rod lower end is consolidated with sample cell hoisting mechanism
Fixed connection, is provided with vertical chute, the vertical chute and the slide protrusion on swab sliding equipment on the fixed connecting rod
Portion's correspondence is slidably matched, and when the sample cell hoisting mechanism is in extreme lower position, the slide protrusion portion is located at fixed connecting rod
The top position of upper vertical chute.
Of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its described swab is slided
Motivation structure includes swab sliding block composition and swab support frame, and the swab support frame and loading baffle plate are respectively fixedly connected with swab
The both ends of sliding block composition, the swab is fixedly connected on the end of swab support frame；The sample cell hoisting mechanism includes sample
QC sliding block is constituted and sample cell lifting arm, and the sample cell sliding block composition is connected by connection component with drive mechanism, described
Sample cell lifting arm and connection component are respectively fixedly connected with the both ends constituted in sample cell sliding block, and the sample cell is positioned over sample
The end of QC lifting arm, the swab sliding block composition and sample cell sliding block composition are slidably arranged in are fixed on substrate respectively
Line slideway module on.
Of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its described swab is slided
Block composition is made up of upper rail sliding block and top shoe, and the upper rail sliding block is slidably disposed on line slideway module, institute
State top shoe to be fixed together with upper rail sliding block, the top shoe upper end is fixedly connected with swab support frame, described
Top shoe bottom is fixedly connected with loading baffle plate, and the slide protrusion portion is fixedly connected on top shoe；The sample cell is slided
Block composition is made up of lower guideway sliding block and sliding block, and the lower guideway sliding block is slidably disposed on line slideway module, institute
State sliding block to be fixed together with lower guideway sliding block, the sliding block upper end is fixedly connected with connection component, it is described under
Sliding block bottom is fixedly connected with sample cell lifting arm, and the fixed connecting rod bottom is fixedly connected on sliding block.
It is of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its described driving machine
Structure includes motor, synchronous cog belt, driving wheel and driven pulley, and the motor is fixedly connected on substrate, described
The clutch end connection of driving wheel and motor, the driven pulley is rotatably arranged on substrate, described synchronizing jugged
Band two ends are around being connected on driving wheel and driven pulley, and the synchronous cog belt passes through the downslide of connection component and sample cell hoisting mechanism
Block links together, and the sample cell hoisting mechanism is synchronized with the movement with synchronous cog belt.
It is of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its described connection group
Part includes loading belt pad and belt locking plate, and the loading belt pad is fixedly connected on the upper end of sliding block, it is described on
Sample belt pad and belt locking plate are oppositely arranged and synchronous cog belt are clamped in into centre, and on the substrate, bottom sets respectively
Photoelectric sensor is equipped with, the belt locking plate coordinates with corresponding photoelectric sensor, the motion for judgement sample pipe hoisting mechanism
Position.
It is of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its described swab bag
The swab body that center is provided with cavity is included, the cavity of the swab body central is in upper chamber, lower cavity and connection
Portion's cavity and the central through hole of lower cavity composition, the diameter of the upper chamber and lower cavity are more than the hole of central through hole
Footpath, i.e., the overall structure of described swab body central cavity is in outside the dumbbell structure of big at both ends and small in middle, the sampling needle
Footpath is less than the aperture of central through hole, and the upper chamber is connected with sewer pipe, and the lower cavity is connected with lotion pipeline, when described
When sampling needle passes through the central cavity of swab body, cleaned for the outer wall to sampling needle, when the needle point of the sampling needle
When in upper chamber, it is used to clean the inwall of sampling needle by back flush mode.
Of the present invention to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, it is in the swab
Body two ends, which are separately provided for blocking up on the swab of closing swab central cavity, blocks up son, the swab under son and swab
Upper stifled son is arranged on the swab of swab body upper surface formation on round platform, and son is blocked up on the swab and coordinates shape with round platform on swab
Into for the ring-type Access Division with the swab support frame end fixing hole corresponding matching of swab sliding equipment, son is blocked up under the swab
Swab body lower surface is arranged on, and is formed with indent arcuate structure, the swab on the indent arc and sample cell of stifled son
End opening portion cooperatively forms sealing structure, and being separately provided for sampling needle on stifled son under stifled son and swab on the swab wears
The central through hole crossed.
The present invention is directed to propose a kind of sampling system for being automatically performed sample cell lifting and cleaning in cell analysis, its profit
The mode fixed with sampling needle, by the mutual cooperation of swab, sample cell, swab sliding equipment and sample cell hoisting mechanism with
And the position control of relative movement, full automatic sample cell tube sample introduction, cleaning and detachment function can be completed.Overall knot of the invention
Structure is succinct, and has saved sample pin scavenging period, improves detection efficiency, is only to complete two activities with a drive mechanism
The precision-fit of part, and ensure that characteristic with low cost and easy to use.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention.
Fig. 2 is the fractionation structural representation of the present invention.
Fig. 3 is the structural representation of substrate in the present invention.
Fig. 4 is that line slideway module and the schematic diagram of drive mechanism are provided with substrate in the present invention.
Fig. 5 is the structural representation of swab sliding equipment in the present invention.
Fig. 6 is the structural representation of sample cell hoisting mechanism in the present invention.
Fig. 7 is that swab sliding equipment is not having extension spring and fixed connecting rod limitation time-division with sample cell hoisting mechanism in the present invention
Not Wei Yu high-low limit position structural representation.
Fig. 8 and Fig. 9 are the structural representations of swab in the present invention.
Marked in figure：1 is sampling needle, and 2 be swab, and 3 be sampling needle rack, and 4 be substrate, and 5 be swab sliding equipment, and 6 are
Sample cell hoisting mechanism, 7 be sample cell, and 8 be drive mechanism, and 9 be extension spring, and 10 be loading baffle plate, and 11 be fixed connecting rod, and 12 be cunning
Dynamic lug boss, 13 be line slideway module, and 14 be loading belt pad, and 15 be belt locking plate, and 16 be clamp set, and 21 be swab sheet
Body, 22 be upper chamber, and 23 be through hole centered on lower cavity, 24, and 25 be sewer pipe, and 26 be lotion pipeline, and 27 be to be blocked up on swab
Son, 28 be stifled son under swab, and 29 be round platform on swab, and 41 be stopper slot, and 51 be swab support frame, and 52 be upper rail sliding block, 53
It is sample cell lifting arm for top shoe, 61,62 be lower guideway sliding block, and 63 be sliding block, and 81 be motor, and 82 be synchronizing jugged
Band, 83 be driving wheel, and 84 be driven pulley, and 111 be vertical chute.
Embodiment
Below in conjunction with the accompanying drawings, the present invention is described in detail.
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
As shown in figures 1 to 6, it is a kind of to be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, including sampling
Pin 1 and swab 2, the sampling needle 1 are fixedly installed on sampling needle rack 3, and the sampling needle rack 3 is fixedly connected with substrate 4,
The swab 2 is used for the upper port of sealed sample pipe 7 in the uphill process of sample cell 7, and sampling needle 1 is carried out during decline
The cleaning of inside and outside wall, in the present embodiment, the sampling needle 1 are transferred to flow chamber or analysis cell as solution in sample cell 7
Fluid passage, is provided with the clamp opened or closed the set 16 for controlling sample loading pipeline on sampling needle rack 3, described
Needle rack 3 of sampling is used for the fixation of sampling needle 1 and clamp set 16, and more specifically, the sampling needle 1 can be inverted L-shaped cylinder
Shape hollow structure, comprising vertical section and horizontal segment, wherein vertical section is used to insert the bottom of sample cell 7 progress loading, the sampling
The vertical segment length of pin 1 is slightly longer than the height of sample cell 7, it is ensured that the needle point of sampling needle 1 can touch the bottom of sample cell 7, its level
Section can be connected to pinch valve 16 by rubber tube, opening and closing for controlling sample liquids passage, and the sampling needle 1 is whole
Remained static during individual auto injection, sample cell 7 lifted and the cleaning process of sampling needle 1 in, the sampling needle 1 is used
Fixed mode, effectively prevent the issuable personnel's harm in high-speed motion of sharp sampling needle 1.
Wherein, be provided with swab sliding equipment 5 and sample cell hoisting mechanism 6 on the substrate 4, the swab 2 with
Swab sliding equipment 5 is connected, and the sample cell 7 is positioned on sample cell hoisting mechanism 6, is set on the swab sliding equipment 5
Extension spring 9 is equipped with, described one end of extension spring 9 is connected with swab sliding equipment 5, and its other end is connected with the bottom of substrate 4, the sampling needle
1 passes through swab 2 and is stretched in sampling process in sample cell 7, preferably extends into the inner bottom part of sample cell 7, the sample cell is carried
Mechanism 6 is risen to be lifted up in the presence of drive mechanism 8, in lifting process, the upper end opening portion of sample cell 7 and swab 2
Bottom is fitted close to form sealing and by the jack-up of swab 2, and the sample cell hoisting mechanism 6 and swab sliding equipment 5 are synchronized with the movement,
The sample cell 7 remains opposing seal state with swab 2 during close-fitting be synchronized with the movement, and the extension spring 9 exists
Sample cell 7 is in extended state during being synchronized with the movement with swab 2, to ensure the sealing reliability of sample cell and swab, simultaneously
The active force resetted downwards can also be provided for swab, and swab also can move to lower position under extension spring effect when power is off.Its
In, sample cell is the containment device of cell analysis testing sample, is often the cylindrical tube structure of bottom hemispherical, it is included but not
It is limited to medical vacuum heparin tube, flow cytometer showed 5mL sample cells and Bioexperiment 1~5mL centrifuge tubes etc..
In the present embodiment, the drive mechanism 8 includes motor 81, synchronous cog belt 82, the driving wheel of high torque
83 and driven pulley 84, the motor uses stepper motor, and the motor 81 is fixedly connected on substrate 4, described
Driving wheel 83 is connected with the clutch end of motor 81, and the driven pulley 84 is rotatably arranged on substrate 4, described same
The two ends of cog belt 82 are walked around being connected on driving wheel 83 and driven pulley 84, the synchronous cog belt 82 passes through connection component and sample cell
The sliding block 63 of hoisting mechanism 6 links together, and the sample cell hoisting mechanism 6 is synchronized with the movement with synchronous cog belt 82.It is described
Electric impulse signal is changed into angular displacement by stepper motor, and drives driving wheel to rotate, and the wheel face of driving wheel is starlike lobe structure,
Cooperation can be engaged with synchronous cog belt formation, and then synchronous cog belt is moved up and down, and drive is fixed to synchronous cog belt
Sample cell hoisting mechanism be synchronized with the movement.Wherein, driven pulley is more specifically driven on substrate, the underface of driven pulley
Wheel may include follower shaft, driven pulley sleeve column, plain washer and fixed screw.The line slideway module is parallel with synchronous cog belt
Set, and be fixed to substrate-side panel, the linear slide for sample cell hoisting mechanism and swab sliding equipment.
As shown in figure 3, the overall L-shaped vertical page structure of substrate 4, its front panel is narrower to be used to consolidate automatic sample handling system
Determine to instrument, and square region is stretched out provided with connecting portion for fixed sample needle rack 3 at top, its side panel is wider, if
There is mounting hole to be used for the stretching of the output shaft of motor 81 and the fixation of motor 81, and provided with being fixed for photoelectric sensor
Square hole, be additionally provided with the connecting hole installed for line slideway module 13, wherein, on the substrate 4, along swab sliding equipment
5 glide directions are provided with stopper slot 41, and the motion that the stopper slot 41 is used to limit swab is interval, in the swab sliding equipment
The loading baffle plate 10 with the corresponding matching of stopper slot 41 is provided with 5, the upper end of extension spring 9 is connected with loading baffle plate 10, its lower end
With the extension spring pin connection of the bottom of substrate 4, when loading baffle plate is moved to the bottom of ceiling substrate position groove, the swab skate machine
Structure is in extreme lower position；Fixed connecting rod 11 is provided between the swab sliding equipment 5 and sample cell hoisting mechanism 6, it is described solid
Determine the lower end of connecting rod 11 to be fixedly connected with sample cell hoisting mechanism 6, vertical chute 111, institute are provided with the fixed connecting rod 11
State that vertical chute 111 is corresponding with the slide protrusion portion 12 on swab sliding equipment 5 to be slidably matched, when the sample cell hoisting mechanism
6 when being in extreme lower position, and the slide protrusion portion 12 is located at the top position of vertical chute 111 on fixed connecting rod 11, i.e., this
When sample cell hoisting mechanism be the equal of to be articulated in by fixed connecting rod on swab sliding equipment.When the swab sliding equipment 5
When being in extreme lower position with sample cell hoisting mechanism 6, the sample cell 7 is in disengaged position with swab 2, in order to sample
Pipe is changed, and now the lower end needle tip of sampling needle 1 is placed in swab 2, i.e., sampling needle uses fixed form and sampling
Pin needle point whole process effectively prevent potential hazard of the sampling needle to operating personnel without exposure.
Wherein, the highest distance position that fixed connecting rod 11 is used to limit between swab sliding equipment 5 and sample cell hoisting mechanism 6 is closed
System, when n.s pipe 7 is put into, fixed connecting rod 11 is in stretching stress, and sample cell hoisting mechanism 6 is in lowest order；When
When sample cell 7 is put into and starts lifting, fixed connecting rod 11 is not stressed state in contraction, and swab sliding equipment 5 is carried with sample cell
The distance between mechanism 6 is risen to reduce.As shown in fig. 7, during in the system without extension spring 9 and fixed connecting rod 11, swab is slided
Highest distance position and mutual position relationship that mechanism 5 and sample cell hoisting mechanism 6 are moveable to.
As shown in figure 5, the swab sliding equipment 5 includes swab sliding block composition and swab support frame 51, the swab branch
Support 51 is used for the fixation of swab 2, and specially square arm structure, its larger one end is provided with swab fixing hole, and hole is integrally approached
Circle, and the clamp in distalmost end provided with a semicircle, lower edge and provided with standing shape, swab 2 can proximally be pushed into distal end and will wipe
Son 2 is fixed on swab support frame 51, and the swab support frame 51 and loading baffle plate 10 are respectively fixedly connected with swab sliding block group
Into both ends, the swab 2 is fixedly connected on the end of swab support frame 51, wherein, the swab sliding block composition is led from above
Rail sliding block 52 and top shoe 53 are constituted, and are rectangular-shape structure, and the upper rail sliding block 52 is slidably disposed on straight line and led
On rail module 13, the top shoe 53 is fixed together with upper rail sliding block 52, the upper end of top shoe 53 and swab
Support frame 51 is fixedly connected, and the bottom of top shoe 53 is fixedly connected with loading baffle plate 10, and the slide protrusion portion 12 is fixed
It is connected on top shoe 53, in the present embodiment, the loading baffle plate 10 is L-shaped structure, and its is long-armed to be fixed under top shoe 53
End, its galianconism length is longer than the height of swab sliding block composition, the galianconism of loading baffle plate during auto injection above and below sample
In the stopper slot 41 of substrate.
As shown in fig. 6, the sample cell hoisting mechanism 6 directly acts on the bottom of sample cell 7, it is whole automatic lifting and clear
The motor unit of journey is washed, it includes sample cell sliding block composition and sample cell lifting arm 61, the sample cell lifting arm 61 is used for
The lifting of sample cell 7, is square arm structure, its smaller one end is provided with lifting annulus, its circular ring structure and the bottom of sample cell 7 half
Spherical to coordinate, for the carrying and fixation of sample cell 7, the sample cell sliding block composition is connected by connection component with drive mechanism 8
Connect, the sample cell lifting arm 61 and connection component are respectively fixedly connected with the both ends constituted in sample cell sliding block, the sample
Pipe 7 is positioned over the end of sample cell lifting arm 61, wherein, the sample cell sliding block composition is by lower guideway sliding block 62 and sliding block 63
Composition, is rectangular-shape structure, the lower guideway sliding block 62 is slidably disposed on line slideway module 13, described to glide
Block 63 is fixed together with lower guideway sliding block 62, and the upper end of sliding block 63 is fixedly connected with connection component, it is described under
The bottom of sliding block 63 is fixedly connected with sample cell lifting arm 61, and the fixed bottom of connecting rod 11 is fixedly connected on sliding block 63
On.
Wherein, the connection component includes loading belt pad 14 and belt locking plate 15, and the loading belt pad 14 is in L
Shape square body structure, its is long-armed to be fixed to the vertical upper end of sliding block, and its galianconism interfixes with belt locking plate 15, the belt
The T-shaped flake structure of locking plate 15, the loading belt pad 14 is oppositely arranged with belt locking plate 15 and presss from both sides synchronous cog belt 82
Tightly in centre, and then sample cell hoisting mechanism 6 is fixed on synchronous cog belt 82, in sample cell auto injection process about 7
In, synchronous cog belt 82 drives sample cell hoisting mechanism 6 to move, and U-shaped photoelectric transfer is provided with respectively in the upper and lower part of substrate 4
Sensor, the galianconism of the belt locking plate 15 coordinates with corresponding photoelectric sensor, the motion bit for judgement sample pipe hoisting mechanism 6
Put, the photoelectric sensor is attached in the square hole of substrate.
As shown in figure 8, the swab 2 is used for the cleaning of the inner and outer wall of sampling needle 1, and to sample cell during loading
7 motion path plays guiding and restriction effect, and the swab 2 includes the swab body 21 that center is provided with cavity, and its entirety is in
Cylindrical structure, the cavity at the center of swab body 21 is by upper chamber 22, lower cavity 23 and connection upper chamber 22
Constituted with the central through hole 24 of lower cavity 23, the diameter of the upper chamber 22 and lower cavity 23 is more than central through hole 24
Aperture, i.e., the overall structure of the described central cavity of swab body 21 is in the dumbbell structure of big at both ends and small in middle, the sampling needle 1
External diameter be slightly less than the aperture of central through hole 24, in the present embodiment, the diameter of the upper chamber and lower cavity is much larger than
The external diameter of sampling needle, such as 3~7 times, and the diameter of central through hole is slightly larger than the external diameter of sampling needle, such as 0.25 mm；The upper chambers
Body 22 is connected with sewer pipe 25, and the lower cavity 23 is connected with lotion pipeline 26, and the sewer pipe 25 and lotion pipeline 26 can
For steel pipe, and waste liquid bore is more than the internal diameter of lotion pipeline.
When the sampling needle 1 passes through the central cavity of swab body 21, cleaned for the outer wall to sampling needle 1,
Now cleaning fluid is ejected into sampling needle outer surface via lotion pipeline 26 under positive pressure effect with certain speed, and under
Circulation is formed in portion's cavity 23, at the same time, sewer pipe 25 is connected to negative pressure, the waste liquid after being cleaned under pressure differential effect is preferential
Through central through hole 24 and into upper chamber 22, and waste liquid barrel is sucked by sewer pipe；When the needle point of the sampling needle 1 is positioned at upper
When in portion's cavity 22, it is used to clean the inwall of sampling needle 1 by back flush mode, now cleaning fluid is acted in positive pressure
Under, via the recoil of the inside of sampling needle 1 to upper chamber 22, sewer pipe 25 is connected to negative pressure, and waste liquid is preferential under pressure differential effect
Waste liquid barrel is sucked by sewer pipe 25.
As shown in figure 9, being separately provided for what swab central cavity was closed at the two ends of swab body 21
Blocked up on swab stifled sub 28 under son 27 and swab, blocking up son 27 on the swab is arranged on the swab of the upper surface of swab body 21 formation
Blocking up son 27 on round platform 29, on the swab and cooperatively formed with round platform 29 on swab is used for and the end fixing hole pair of swab support frame 51
Son 28 is blocked up under the ring-type Access Division that should coordinate, the swab and is arranged on the lower surface of swab body 21, and is formed with indent arc knot
The indent arc of son 28 is blocked up under structure, the swab and the upper end opening portion of sample cell 7 cooperatively forms sealing structure, on the swab
Blocked up under stifled son 27 and swab and be separately provided for blocking up son on the central through hole that sampling needle 1 is passed through, the swab on son 28 and wipe
The central through hole aperture set on the lower stifled son of son is identical and coaxial with the aperture of central through hole in swab body, and the sampling needle can
Sequentially pass through to block up on swab and subcenter through hole is blocked up under subcenter through hole, swab central through hole and swab, and moved up and down.
The operation principle of the present invention：
Sample cell is lifted and sampling needle cleaning can be specifically divided into sample cell uphill process and the step of decline process two, wherein declining process
Two sections can be further divided into, is specially：
Moved upwards by sample cell hoisting mechanism 6 in uphill process, and lift sample cell 7 and complete sealing to the bottom of swab 2,
And then jack-up swab 2, now swab sliding block composition and sample cell sliding block are constituted and not in contact with sample cell lifting arm 61, sample cell 7
Formed and be fitted close with the three of swab 2.Swab 2 moves to a high position with sample cell hoisting mechanism 6, until sampling needle 1 is inserted
The bottom of sample cell 7, and sample transfer is completed by sampling needle 1.
In decline process first paragraph, sample cell hoisting mechanism 6 is moved downward under the effect of stepper motor 81, and swab is slided
Mechanism 5 is in extended state due to extension spring 9, by downward tensile force so that swab sliding equipment 5, which is followed, to be moved downward.
Swab 2 can start to clean the outer wall of sample pin 1 during downwards, as previously described.First paragraph declines to be transported in loading baffle plate 10
Terminate when moving to 41 bottom of stopper slot, now swab sliding equipment 5 moves to stop position, and now the needle point of sampling needle 1 is still located at
In the upper chamber 22 of swab 2, can now recoil cleaning be carried out to the inwall of sampling needle 1.
In decline process second segment, swab sliding equipment 5 has moved to its stop position, and sample cell hoisting mechanism 6 is in step
Stepper motor 81 continues to move downward under acting on, the slip being moved to fixed connecting rod 11 on maximum position, i.e. swab sliding equipment 5
Boss 12 is on fixed connecting rod at the top position of vertical chute 111.Now sample cell hoisting mechanism 6 moves to minimum
Position, distance is maximum between swab sliding equipment 5 and sample cell hoisting mechanism 6, and sample cell 7 departs from the bottom of swab 2, user or instrument
Device can freely take out sample cell.
During the uphill process of sample cell 7 and decline, sampling needle 1 is at least across a central through hole of swab 2 so that
Sampling needle 1 and the central through hole automatic aligning of swab 2, it is ensured that the accuracy of the direction of motion, it is ensured that sampling needle 1 is smooth from test tube 7
Draw liquid；On the other hand, 28 less bottom end openings of son are blocked up under swab can avoid the band vim and vigour bubble in test tube 7 from entering swab
Swab 2 is polluted in 2 lower cavity 23, meanwhile, during swab loading, the effect of sample tube cover is also acts as, effectively
Avoid liquid splash.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (10)
1. a kind of be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, including sampling needle（1）And swab
（2）, it is characterised in that：The sampling needle（1）It is fixedly installed on sampling needle rack（3）On, the sampling needle rack（3）With substrate
（4）It is fixedly connected, in the substrate（4）On be provided with swab sliding equipment（5）And sample cell hoisting mechanism（6）, it is described to wipe
Son（2）With swab sliding equipment（5）Connection, the sample cell（7）It is positioned over sample cell hoisting mechanism（6）On, the sampling needle
（1）Through swab（2）And sample cell is stretched in sampling process（7）It is interior, the sample cell hoisting mechanism（6）In drive mechanism
（8）In the presence of be lifted up, in lifting process, the sample cell（7）Upper end opening portion and swab（2）Bottom is fitted close
Form sealing and by swab（2）Jack-up, the sample cell hoisting mechanism（6）With swab sliding equipment（5）It is synchronized with the movement, the sample
QC（7）With swab（2）Opposing seal state is remained during tight fit is synchronized with the movement.
2. according to claim 1 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：In the swab sliding equipment（5）On be provided with extension spring（9）, the extension spring（9）One end and swab sliding equipment（5）Even
Connect, its other end and substrate（4）Bottom is connected, the extension spring（9）In sample cell（7）With swab（2）Locate during being synchronized with the movement
In extended state.
3. according to claim 2 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：In the substrate（4）Above, along swab sliding equipment（5）Glide direction is provided with stopper slot（41）, slided in the swab
Mechanism（5）On be provided with and stopper slot（41）The loading baffle plate of corresponding matching（10）, the extension spring（9）Upper end and loading baffle plate
（10）Connection, its lower end and substrate（4）The extension spring pin connection of bottom, when the swab sliding equipment（5）With sample cell elevator
Structure（6）When being in extreme lower position, the sample cell（7）With swab（2）In disengaged position, and the sampling needle（1）Lower end
Needle tip is placed in swab（2）It is interior.
4. according to claim 3 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：In the swab sliding equipment（5）With sample cell hoisting mechanism（6）Between be provided with fixed connecting rod（11）, the fixation
Connecting rod（11）Lower end and sample cell hoisting mechanism（6）It is fixedly connected, in the fixed connecting rod（11）On be provided with vertical chute
（111）, the vertical chute（111）With swab sliding equipment（5）On slide protrusion portion（12）Correspondence is slidably matched, when described
Sample cell hoisting mechanism（6）During in extreme lower position, the slide protrusion portion（12）Positioned at fixed connecting rod（11）Upper vertical chute
（111）The top position.
5. according to claim 4 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：The swab sliding equipment（5）Including swab sliding block composition and swab support frame（51）, the swab support frame（51）With
Loading baffle plate（10）It is respectively fixedly connected with the both ends constituted in swab sliding block, the swab（2）It is fixedly connected on swab support
Frame（51）End；The sample cell hoisting mechanism（6）Including sample cell sliding block composition and sample cell lifting arm（61）, the sample
QC sliding block composition passes through connection component and drive mechanism（8）Connection, the sample cell lifting arm（61）With connection component difference
It is fixedly connected on the both ends of sample cell sliding block composition, the sample cell（7）It is positioned over sample cell lifting arm（61）End, institute
State swab sliding block composition and sample cell sliding block composition is slidably arranged in is fixed on substrate respectively（4）On line slideway module
（13）On.
6. according to claim 5 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：The swab sliding block composition is by upper rail sliding block（52）And top shoe（53）Composition, the upper rail sliding block（52）It can slide
Line slideway module is arranged on dynamicly（13）On, the top shoe（53）With upper rail sliding block（52）It is fixed together, institute
State top shoe（53）Upper end and swab support frame（51）It is fixedly connected, the top shoe（53）Bottom and loading baffle plate（10）
It is fixedly connected, the slide protrusion portion（12）It is fixedly connected on top shoe（53）On；The sample cell sliding block composition is by lower guideway
Sliding block（62）And sliding block（63）Composition, the lower guideway sliding block（62）It is slidably disposed on line slideway module（13）On,
The sliding block（63）With lower guideway sliding block（62）It is fixed together, the sliding block（63）Upper end is consolidated with connection component
Fixed connection, the sliding block（63）Bottom and sample cell lifting arm（61）It is fixedly connected, the fixed connecting rod（11）Bottom
It is fixedly connected on sliding block（63）On.
7. according to claim 6 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：The drive mechanism（8）Including motor（81）, synchronous cog belt（82）, driving wheel（83）And driven pulley（84）,
The motor（81）It is fixedly connected on substrate（4）On, the driving wheel（83）With motor（81）Clutch end
Connection, the driven pulley（84）It is rotatably arranged in substrate（4）On, the synchronous cog belt（82）Two ends are around being connected on driving wheel
（83）And driven pulley（84）On, the synchronous cog belt（82）Pass through connection component and sample cell hoisting mechanism（6）Sliding block
（63）Link together, the sample cell hoisting mechanism（6）With synchronous cog belt（82）It is synchronized with the movement.
8. according to claim 7 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：The connection component includes loading belt pad（14）With belt locking plate（15）, the loading belt pad（14）It is fixed
It is connected to sliding block（63）Upper end, the loading belt pad（14）With belt locking plate（15）It is oppositely arranged and by synchronous gear
Shape band（82）Centre is clamped in, in the substrate（4）Upper and lower part is provided with photoelectric sensor, the belt locking plate respectively（15）
Coordinate with corresponding photoelectric sensor, for judgement sample pipe hoisting mechanism（6）Movement position.
9. it is as claimed in any of claims 1 to 8 be used for cell analysis in sample cell lifting and cleaning automatically enter
Sample system, it is characterised in that：The swab（2）The swab body of cavity is provided with including center（21）, the swab body（21）
The cavity at center is by upper chamber（22）, lower cavity（23）And connection upper chamber（22）And lower cavity（23）Center
Through hole（24）Composition, the upper chamber（22）And lower cavity（23）Diameter be more than central through hole（24）Aperture, i.e. institute
State swab body（21）The overall structure of central cavity is in the dumbbell structure of big at both ends and small in middle, the sampling needle（1）It is outer
Footpath is less than central through hole（24）Aperture, the upper chamber（22）With sewer pipe（25）Connection, the lower cavity（23）With
Lotion pipeline（26）Connection, when the sampling needle（1）Through swab body（21）Central cavity when, for sampling needle（1）'s
Outer wall is cleaned, when the sampling needle（1）Needle point be located at upper chamber（22）When interior, it is used for by back flush mode to sampling
Pin（1）Inwall cleaned.
10. according to claim 9 be used for the automatic sample handling system of sample cell lifting and cleaning in cell analysis, its feature
It is：In the swab body（21）Two ends are separately provided on the swab of closing swab central cavity blocking up son
（27）With stifled son under swab（28）, son is blocked up on the swab（27）It is arranged on swab body（21）Circle on the swab that upper surface is formed
Platform（29）On, son is blocked up on the swab（27）With round platform on swab（29）Cooperatively forming is used for and swab sliding equipment（5）Wipe
Sub- support frame（51）Son is blocked up under the ring-type Access Division of end fixing hole corresponding matching, the swab（28）It is arranged on swab body
（21）Lower surface, and stifled son is formed with indent arcuate structure, the swab（28）Indent arc and sample cell（7）Open upper end
Oral area cooperatively forms sealing structure, and son is blocked up on the swab（27）With stifled son under swab（28）On be separately provided for sampling
Pin（1）The central through hole passed through.
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| CN201710724844.4A CN107328950B (en) | 2017-08-22 | 2017-08-22 | Automatic sample injection system for lifting and cleaning sample tube in cell analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710724844.4A CN107328950B (en) | 2017-08-22 | 2017-08-22 | Automatic sample injection system for lifting and cleaning sample tube in cell analysis |
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|---|---|
| CN107328950A true CN107328950A (en) | 2017-11-07 |
| CN107328950B CN107328950B (en) | 2023-06-27 |
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|---|---|---|---|
| CN201710724844.4A Active CN107328950B (en) | 2017-08-22 | 2017-08-22 | Automatic sample injection system for lifting and cleaning sample tube in cell analysis |
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| CN109358203A (en) * | 2018-08-27 | 2019-02-19 | 中国科学院苏州生物医学工程技术研究所 | Test tube hoisting mechanism |
| CN110106072A (en) * | 2019-04-25 | 2019-08-09 | 珠海迪尔生物工程有限公司 | Sample adding device and method for microbial sample test card |
| CN110118671A (en) * | 2018-02-06 | 2019-08-13 | 深圳市帝迈生物技术有限公司 | A kind of sampler |
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| CN110106072A (en) * | 2019-04-25 | 2019-08-09 | 珠海迪尔生物工程有限公司 | Sample adding device and method for microbial sample test card |
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| CN110187137A (en) * | 2019-06-06 | 2019-08-30 | 杭州迦楠生物科技有限公司 | Automatic sampling equipment for biological medicine |
| CN111337329A (en) * | 2020-04-22 | 2020-06-26 | 睿科集团(厦门)股份有限公司 | Automatic salt adding device for salt powder tube sample pretreatment |
| CN111879955A (en) * | 2020-07-30 | 2020-11-03 | 中国科学院植物研究所 | Automatic sample injector |
| CN111812342A (en) * | 2020-08-14 | 2020-10-23 | 爱威科技股份有限公司 | Sample processing device |
| CN111812342B (en) * | 2020-08-14 | 2023-08-15 | 爱威科技股份有限公司 | Sample processing device |
| CN113063780A (en) * | 2021-03-17 | 2021-07-02 | 长春长光辰英生物科学仪器有限公司 | Swab sample fluid system for optical detection and use method thereof |
| CN113063780B (en) * | 2021-03-17 | 2023-11-03 | 长春长光辰英生物科学仪器有限公司 | Swab sample fluid system for optical detection and application method thereof |
| CN113188879A (en) * | 2021-04-26 | 2021-07-30 | 苏州德运康瑞生物科技有限公司 | Automatic sampling device of blood cell capture staining instrument |
| CN113406256B (en) * | 2021-06-04 | 2024-03-15 | 北京莱伯泰科仪器股份有限公司 | Multifunctional sample processing lifting platform device |
| CN113406256A (en) * | 2021-06-04 | 2021-09-17 | 北京莱伯泰科仪器股份有限公司 | Multifunctional sample treatment lifting platform device |
| CN114410426A (en) * | 2022-01-13 | 2022-04-29 | 济南国科医工科技发展有限公司 | Magnetic type self-positioning manual sample loading device |
| CN114410426B (en) * | 2022-01-13 | 2023-11-07 | 济南国科医工科技发展有限公司 | Magnetic self-positioning manual sample loading device |
| CN115386476A (en) * | 2022-10-11 | 2022-11-25 | 天津海河标测技术检测有限公司 | Microbial colony counter |
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