CN208888258U - A kind of immune quantitative analyzer - Google Patents

Abstract

The utility model provides a kind of immune quantitative analyzer, it is mainly made of such as lower component: reagent card mobile mechanism, sample adding device, detection structure, liquid channel system, the storehouse Fei Ka mechanism and rack construction, it can be realized high-throughput detection using the immune quantitative analyzer in the utility model, the effect that detection accuracy is high and detection data is reliable and stable, and detecting instrument overall structure is simple, and equipment instrument is small.

Description

A kind of immune quantitative analyzer

Technical field

The utility model relates to detection fields, and in particular to a kind of detecting instrument.

Background technique

Most of immunochromatographiassays assays instrument is divided into two classes currently on the market, and one kind is semi-automated instrument, be loaded, dilute, Chromatography reaction process is completed outside machine, and the flux of this quasi-instrument is low, and detection speed is slow, and manual operation is complicated, needs operator Professional degree it is high, dilution, the consistency of sample-adding and precision are difficult to ensure that result error is big, and be easy to cause pollution, such as Ten thousand inspire confidence in the winged survey II, the GP1100 etc. of base egg biology of biology；In addition a kind of full-automatic instrument often uses batch sample introduction and into card Mode completes sample-adding in machine and reaction test, existing automatic lmunoassays analyzer has the following problems: 1, wanting in batches into card It asks and multiple reagent cards is placed in fixed container in advance, it, can shadow after second day reagent card dampness if the same day is not finished Ring reaction result；2, since the fixation number of containers for accommodating reagent card is limited, instrument single only supports 3 to 4 project testings, Flux is lower；3, in addition many instruments use tip sample loading alternatives, trace sample can not be supported to be loaded, and operation and maintenance at This height, manual operation are complicated；4, when the conveying stroke of reagent card is larger, conveying mechanism is generally used belt transmission structure, When being manually inserted into reagent card, it is desirable that the holding torque (statical moment) of motor is larger, can make reagent card when being otherwise inserted into reagent card Deck moves, and leads to that the transmission accuracy of reagent card is poor, stability is poor, easily clamping stagnation occurs.On occurring Problem is stated, the motor size of partial immunity analyzer is done bigger, to allow motor to have biggish holding torque, but can be made The volume of immunity analysis instrument is larger, occupied space；5, mostly by artificially collecting the useless card of reagent card, operating process is comparatively laborious, Also have to be provided in partial immunity analyzer and kick mechanism for card, kick card principle are as follows: kick card position when reagent card moves to a certain preset When, it kicks mechanism for card and starts to intervene, by motor drive mode, mechanism for card component movement is kicked in drive, so that reagent card is kicked out of Deck.Mechanism for card is kicked due to being additionally arranged one in immunity analysis instrument, instrument overall structure can be made to become complicated too fat to move, volume It is larger, increase assembly difficulty, high production cost；6, immunochromatographiassays assays technology is very high to detection speed and stability requirement, Immunochromatographiassays assays instrument currently on the market generallys use monochromatic light exposure test strips colour developing window, then uses linear CCD Colouring information in acquisition window, then discriminance analysis is carried out to image, which single can only acquire a test strips information, also have It uses CIS detector test strip and carries out data analysis, which single energy to draw tracer intensity curves Multiple test strips are detected, but the speed for obtaining signal is slow, the image effective pixel points of generation are few, edge blurry；There are also a kind of sides Case provides illumination and shot detection by light source for the test strips that multiple parallel intervals are arranged, but is in the test paper of medium position The intensity of illumination that item is subject to is higher, and middle part is toward marginal position, and the intensity of illumination being then subject to closer to marginal position gradually weakens, together Also there can be the case where interfering with each other between Shi Butong light source, cause the precision of test strips information analysis low；7, existing general to exempt from It is too high in the concentration of sample although epidemic disease quantitative analysis instrument is all to use automatic sample, when being diluted to sample all It is not only to extend detection time in this way using manually diluting, when at once the patient of burst disease needs to carry out certain index When detection, manually to the dilution of sample be obviously prolonged detection time, caused by result may be exactly patient cannot be i.e. What is made suits the remedy to the case, and manually dilution be easy to cause the error of testing result, and the diagnosis to disease is also unfavorable.

Summary of the invention

In order to overcome the above technical problems, the utility model provides stablizes when a kind of detection flux is high, reagent card is mobile Property it is good, transmission accuracy is good, be not easy clamping stagnation and equipment instrument is small, production cost is low, detection accuracy is high, detection speed is fast, detection Information is complete, automatic dilution can be carried out to sample and ensure sample dilution rate of precision, sampling safety and stability, structure simply with And immune quantitative analyzer at low cost.

The utility model provides a kind of immune quantitative analyzer, mainly by being formed with lower component:

Reagent card mobile mechanism: can be according to the mobile reagent card that detection sample is added dropwise of motion track；The motion track Including the reagent card plug-in card position being arranged successively, detection reagent card position and kick except reagent card position, the reagent card moving machine Structure includes the deck for carrying reagent card；

Sample adding device: including sample needle mechanism and sample needle mechanism mobile device, the sample needle mechanism and sample-adding Needle mechanism mobile device completes the suction sample of detection sample, spits sample and movement；

Detection structure: for the information above detection reagent card, including camera bellows mechanism and optical facilities, the camera bellows machine Structure includes at least two cabinets being adjacently positioned, and the optical facilities are set in the camera bellows mechanism；

Liquid channel system: for controlling the flowing of liquid in immune quantitative analyzer and completing the automatic dilution of detection sample With the automatic cleaning of the pipeline in liquid channel system.

Further, the immune quantitative analyzer further includes the storehouse Fei Ka mechanism and frame structure, the storehouse the Fei Ka mechanism For accommodating having completed to test and being kicked the reagent card removed, the frame structure is for fixing in immune quantitative analyzer All moving parts.

Further, the storehouse the Fei Ka mechanism is located at the lower section of the reagent card mobile mechanism.

Further, the volume of detection structure described in the volumetric ratio of the storehouse the Fei Ka mechanism is big.

Further, the reagent card mobile mechanism further include include mounting rack, first motor, lead screw, sliding block, reflection With opposite type sensor integrated circuit board and guiding slide bar, the first motor and guiding slide bar are installed on mounting rack, described One end of lead screw is fixedly connected with the power output shaft of first motor, and the deck is fixedly mounted on sliding block, the sliding block and Lead screw is connected through a screw thread, and sliding block is equipped with through-hole, and reflection is set to reagent card plug-in card position with opposite type sensor integrated circuit board This end set；Preferably, the number of the through-hole is three, and guiding slide bar passes through slider throughbores, the guiding slide bar setting two Root, the through-hole that lead screw passes through, it is preferred that the lead screw and two guiding slide bars are in vertical face composition triangle；It is excellent Choosing, the mounting rack includes bottom plate and the starting stave being fixedly mounted on bottom plate and the second riser；Described first Motor is mounted on the outside of starting stave, and lead screw one end passes through starting stave and is fixedly connected with the power output shaft of first motor, silk The thick stick other end is installed on the second riser；The both ends of the guiding slide bar are separately mounted on starting stave and the second riser.

Further, the deck of the reagent card has 6.

Further, the reagent card mobile mechanism further includes kicking card structure, and the card structure of kicking is set to the inspection In geodesic structure in the back plate of cabinet, the rear side opposite for the deck card inserting mouth of reagent card, it is preferred that in the deck The opposite other side of card inserting mouth is equipped with an opening, and card is kicked in the cooperation realization by kicking card structure and deck opening.

Further, the card structure of kicking is screw, and the screw has 6, and kicking card structure may be other structures, It can be some other widget.

Further, the device that moves up and down stated in sample needle mechanism mobile device is filled by synchronous belt wheel device and sliding block It sets realization and moves up and down function；

Further, the sample adding device includes cleaning swab, sampling needle, position sensor, sample adding device rack, and second Motor, two synchronous pulleys, synchronous belt, sliding block, linear guide and linear bearing, it is preferred that linear guide and linear axis Respectively 2 are held, two synchronous pulleys are separately fixed on the output shaft of second motor and the sample adding device rack Lower section, synchronous belt is wound on two synchronous pulleys, and sliding block is fixed on synchronous belt side by tabletting, and sampling needle one end is fixed on On sliding block, the sampling needle other end passes through cleaning swab, and position sensor is set to the electric close to second of the sample adding device rack This end of machine, two linear guides are each passed through two linear bearings, and the linear bearing is set in sample adding device rack；

Further, optics camera bellows is isolated by N block partition for the cabinet being adjacently positioned, and N block partition is vertical etc. It is located in optics camera bellows away from ground, optics camera bellows is isolated into N+1 cabinet, four side of partition is bonded with Optical Dark Solitary Pulse box inner wall；

Further, the partition is arranged two pieces, and optics camera bellows is isolated into three cabinets；

Further, the optical facilities include light source and camera, and the camera is located at box cover lower surface Middle position；

Further, a reagent card is set under each cabinet, and the light source is located at Optical Dark Solitary Pulse box cover lower surface and position In the surface of the deck of test card；

Further, two reagent cards are set under each cabinet, and the light source is located at Optical Dark Solitary Pulse box cover lower surface and position In the surface of two test strips deck line medium positions, the illumination for being subject to two test strips decks is consistent；

Further, the cabinet surfaces externally and internally uses dumb light coating, and the light source is LED light, halogen lamp or xenon lamp；

Further, the liquid channel system includes the first three-way magnetic valve, the second three-way magnetic valve, third threeway electromagnetism Valve, the 4th three-way magnetic valve, the 5th three-way magnetic valve, vacuum pump, duplex pump one pump, another pump of duplex pump, micro-injection Pump, cleans swab, automatic dilution mechanism, dilution bucket, cleaning solution bucket, waste liquid barrel at foregoing sampling needle as previously described, The dilution bucket, the first three-way magnetic valve, duplex pump one pump be sequentially communicated with automatic dilution mechanism by dilution pipeline, Realize the dilution of detection sample；

Further, described to state cleaning solution bucket, the second three-way magnetic valve, another pump of duplex pump, third three-way magnetic valve With automatic dilution mechanism by cleaning solution pipeline connection, the cleaning of automatic dilution mechanism is realized；The automatic dilution mechanism, the 5th Three-way magnetic valve, vacuum pump and waste liquid barrel are sequentially communicated by pipeline, realize the discharge of automatic dilution mechanism cleaning waste liquid；

Further, the cleaning solution bucket, the second three-way magnetic valve, another pump of duplex pump, third three-way magnetic valve, Four three-way magnetic valves, micro-injection pump and sampling needle are sequentially communicated by pipeline, realize the cleaning of the inner wall of sampling needle；It is described clear Washing lotion bucket, the second three-way magnetic valve, another pump of duplex pump, third three-way magnetic valve, the 4th three-way magnetic valve and cleaning swab It is sequentially communicated by pipeline, realizes the cleaning of the outer wall of sampling needle；The cleaning swab, the 5th three-way magnetic valve, vacuum pump and Waste liquid barrel is sequentially communicated by pipeline, realizes the discharge of sampling needle cleaning waste liquid；

Further, the liquid channel system further includes that air bubble sensor described in air bubble sensor is set to dilution bucket and On pipeline between one three-way magnetic valve；

Further, the automatic dilution mechanism is stirred mixing using magnetic bead mode；

Further, the automatic dilution mechanism includes linear motor, magnet, magnetic bead, cut-back tank, and cut-back tank is fixed Mechanism and self-locking mechanism, the liquid outlet of the dilution pipeline and the liquid outlet for cleaning liquid pipeline all pass through self-locking structure, self-locking Structure can control dilution pipeline and clean the movement of liquid pipeline, facilitate the replacement of cut-back tank, the output shaft of linear motor Upper connection magnet, magnet are contacted with cut-back tank bottom of cup, and magnetic bead is set in cut-back tank, and cut-back tank fixed mechanism is set It is placed in cut-back tank surrounding；

Further, the storehouse the Fei Ka mechanism is made of two pieces of baffles, and two pieces of baffles are located at reagent card mobile mechanism Motion track the left and right sides；

Further, the storehouse the Fei Ka mechanism is connect with the frame structure by sliding rail.

Compared with the existing technology, the utility model has the following beneficial effects:

1, the fixation number of containers for accommodating reagent card is more, up to 6 all reagent cards that are even more, and being provided with Deck can move together, realize high-throughput detection, and the deck of single reagent card therein can also move alone, that is, meet High-throughput detection also meets the detection for not needing flux.

2, the reagent card mobile mechanism used in the utility model can allow cunning by the cooperation of lead screw and guiding slide bar Shaft direction of the block driven by the motor along guiding slide bar moves back and forth, and then reagent card is moved to detection from plug-in card position Position.Due to having used lead screw and guiding slide bar, when being manually inserted into reagent card, reagent card deck will not be moved, so that reagent The precision of card transmission is high, stability is good, is not easy clamping stagnation；It does not need simultaneously using oversized motor, so that immunity analysis instrument Machine volume can do it is relatively small；It incorporates reagent card mobile mechanism and kicks card structure, solve prior art pilot scale The problems such as transmission accuracy is poor when agent card is driven, easy clamping stagnation and equipment instrument are big, overall structure is simple and compact, and production cost is low.

3, the detection structure used in the utility model, overall structure is simple, the cartridge position of light source position and test strips Design is rationally and consistency and accuracy in order to guarantee testing result, the utility model process object are camera shooting High-definition image information can quickly and accurately extract the entire color development area on reagent card, reduce the uneven band of colour developing The risk come, with the detection structure come test strip information, the precision height of test strips infomation detection, detection data stabilization can It leans on.

4, useless Ka Cang is used in the utility model, having detected and having kicked the card removed can fall into useless card storehouse, and working as need to When collecting useless card, it is only necessary to useless Ka Cang is pulled out from frame structure, so the collection operation of useless card is simpler and conveniently, And instrument overall volume is small.

5, the liquid channel system used in the utility model realizes the automatic sample, automatic dilute of sample only with three pumps Release and the automatic cleaning of liquid path system, and automatic dilution module with automatic dilution module be it is respectively self-existent, Do not intersect between pipeline, structure is simple and repairs simplicity；There is Sample Dilution module in liquid path system, avoids people The error of pollution and experiment caused by operate, and between the dilution bucket and the first three-way magnetic valve in liquid channel system Pipeline on be provided with air bubble sensor, whether detecting the dilution in dilution drum and be finished, prevent the dilution in dilution drum from using It is over, instrument is also operating, and causes the deviation of experimental result；One pump of the duplex pump used in liquid channel system has to injection The accurate quantitative function of dilution in automatic dilution mechanism, ensure that the accuracy of experiment detection.

Detection sample in the utility model includes various biological samples, such as: cell, bacterium solution, whole blood, animal tissue's homogenate Liquid, plant tissue homogenate liquid, serum, blood plasma, tissue extract, swab washing lotion, urine, virus-culturing fluid.

Obviously, above content according to the present utility model, according to the ordinary technical knowledge and customary means of this field, not It is detached under the premise of the above-mentioned basic fundamental thought of the utility model, the modification, replacement or change of other diversified forms can also be made.

The specific embodiment of form by the following examples remakes the above content of the utility model further detailed It describes in detail bright.But the range that this should not be interpreted as to the above-mentioned theme of the utility model is only limitted to example below.It is all practical based on this The technology that novel above content is realized belongs to the scope of the utility model.

Detailed description of the invention

Fig. 1 is the positive structure schematic of the utility model；

Fig. 2 is the structure schematic diagram of the utility model；

Fig. 3 is the reagent card mobile mechanism in the utility model；

Fig. 4 is the structural schematic diagram of the deck of the reagent card in the utility model；

Fig. 5 is to kick card structure in the reagent card mobile mechanism in the utility model；

Fig. 6 is the motion process figure of the reagent card moving structure in the utility model；

Fig. 7 is the detection structure schematic diagram in the utility model；

Fig. 8 is the detection structure schematic diagram in the utility model；

Fig. 9 is the sample adding device structural schematic diagram in the utility model；

Figure 10 is the external structure schematic diagram of the liquid channel system in the utility model；

Figure 11 is the schematic diagram of internal structure of the liquid channel system in the utility model；

Figure 12 is the structural schematic diagram of the automatic dilution mechanism in the utility model.

Wherein:

1, frame structure；2, automatic dilution mechanism；3, sample adding device；4, the storehouse Fei Ka mechanism；5, liquid channel system；6, it detects Structure；7, first motor；81, starting stave；82, bottom plate；83, the second riser；9, it is oriented to slide bar；10, two pieces of baffles；11, silk Thick stick；12, reflection and opposite type sensor integrated circuit board；13, the deck of reagent card；14, it is open；15, screw；16, after cabinet Plate；17, camera bellows mechanism；18, partition；19, camera；20, LED light；21, cabinet；22, swab is cleaned；23, position sensor； 24, sample adding device rack；25, the second motor；26, two synchronous pulleys；27, synchronous belt；28, synchronous belt；29, linear guide； 30, linear bearing；31, five three-way magnetic valves；311, the first three-way magnetic valve；312, the second three-way magnetic valve；313, third Three-way magnetic valve；314, the 4th three-way magnetic valve；315, the 5th three-way magnetic valve；32, duplex pump；321, a pump of duplex pump； 322, another pump of duplex pump；33, three excessively hardened structures；34, vacuum pump；35, micro-injection pump；36, dilution bucket；37, clear Washing lotion bucket；38, waste liquid barrel；39, automatic dilution mechanism；391, linear motor；392, magnet；393, cut-back tank fixed mechanism； 394, cut-back tank；395, self-locking mechanism；40, air bubble sensor；41, the liquid outlet of dilution pipeline；42, liquid pipeline is cleaned Liquid outlet.

Specific embodiment

As shown in Figures 1 and 2, the utility model provides a kind of immune quantitative analyzer, including with lower component: rack machine Structure 1, for fixing moving parts all in immune quantitative analyzer；Reagent card mobile mechanism 2, can be successively according to reagent card Plug-in card position, detection reagent card position with kick except sequentially moved as reagent card position be added dropwise detection sample reagent card, if Set the deck of 6 reagent cards；Sample adding device 3, including sample needle mechanism and sample needle mechanism mobile device, the sample needle machine Structure and sample needle mechanism mobile device complete the suction sample of detection sample, spit sample and movement；Detection structure 6, for detecting examination Information above agent card, including camera bellows mechanism and optical facilities, the camera bellows mechanism include at least two casees being adjacently positioned Body, the optical facilities are set in the camera bellows mechanism；Liquid channel system 5, for controlling liquid in immune quantitative analyzer Flowing and the automatic cleaning for completing to detect pipeline in the automatic dilution and liquid channel system of sample；The storehouse Fei Ka mechanism 4, for accommodating Completed test and kicked the reagent card removed, the storehouse Fei Ka mechanism is located at the lower section of the reagent card mobile mechanism, and The volume of detection structure described in the volumetric ratio of the storehouse Fei Ka mechanism is big, having detected and can by the reagent card removed is kicked in order to ensure It falls in useless card storehouse.

As shown in figure 3, reagent card mobile mechanism includes mounting rack, first motor 7, lead screw 11, sliding block, reflection and passes to penetrating Sensor integrated circuit board 12, the deck 13 for carrying reagent card and guiding slide bar 9, mounting rack includes bottom plate 82, and fixed The starting stave 81 and the second riser 83 being mounted on bottom plate, first motor are mounted on the outside of starting stave, and lead screw one end passes through Starting stave is fixedly connected with the power output shaft of first motor, and the lead screw other end is installed on the second riser；The reagent card Deck be fixedly mounted on sliding block, sliding block be equipped with through-hole, number be three, guiding slide bar pass through slider throughbores, guiding slide Bar is two, and lead screw and two guiding slide bars constitute triangle in vertical face, one of through hole in parallel be provided with axle sleeve, It is provided with screw thread corresponding with lead screw in axle sleeve, if lead screw is external screw thread, then internal screw thread is set in axle sleeve, lead screw is realized with this Movement with movable slider, the both ends for being oriented to slide bar are separately mounted on starting stave and the second riser, pass through first motor, lead screw With the cooperation of guiding slide bar, sliding block is moved back and forth in the shaft direction of the drive lower edge guiding slide bar of first motor, Reflection is set to this end of reagent card plug-in card position, reflection and opposite type sensor integrated circuit with opposite type sensor integrated circuit board Plate can be recognized either with or without insertion reagent card on reagent card pallet, and when there is reagent card insertion, the state of reflection optical coupler occurs Jump, system can determine whether reagent card insertion, and controllable reagent card moves to corresponding position, the effect of opposite type sensor It is to reset, reset optocoupler therein provides accurate reset position for card feed mechanism, when the deck of reagent card is arrived by motor drive When the front end of instrument, the subsidiary baffle of the deck of reagent card can block opposite type sensor, and the state of sensor is made to change, with Instruction has arrived at reset position, and stability is poor when this reagent card mobile mechanism solves reagent card movement in the prior art, passes The problem of dynamic low precision, easy clamping stagnation.

As shown in figure 5, reagent card mobile mechanism further includes kicking mechanism for card, kicks mechanism for card and be set to cabinet in detection structure It 16 in back plate, kicks fastener and is preferably set to screw 15, be also possible to a small machine and add part, sheet metal component or die sinking part etc., as schemed institute Show, 6 screws be set, as shown in Fig. 4 and Fig. 6, an opening 14 is equipped on the opposite other side of the deck card inserting mouth of reagent card, Card is kicked in cooperation realization by kicking card structure and deck opening, kicks fastener by setting one, so that the useless card of reagent card can be automatic It rejects, it is excessive to solve the problems, such as that useless card collects cumbersome and equipment instrument.

As shown in figure 3, the storehouse the Fei Ka mechanism being located at below reagent card mobile mechanism is made of two pieces of baffles 10, this two pieces gears Piece is located at the left and right sides of the motion track of reagent card mobile mechanism, and the storehouse Fei Ka mechanism is connect with frame structure by sliding rail, when When needing to clear up the useless card in useless card storehouse, it is only necessary to pull out useless Ka Cang, and when the volume of useless card reaches immune quantitative point When the maximum receiving volume of analyzer setting, immune quantitative analyzer meeting automatic alarm, so the collection operation of useless card is simpler Conveniently.

As shown in fig. 7, camera bellows mechanism 17 is isolated into three cabinets 21 with two pieces of partitions, 18 4 side of partition is and in cabinet Side wall fitting, in box cover lower surface middle position, setting camera 19 works as reagent card for acquiring the information on reagent card When one reagent card is moved in a cabinet by mobile mechanism, LED light 20 (light source) is located at Optical Dark Solitary Pulse box cover lower surface simultaneously Positioned at the surface of the deck of test card, as shown in figure 8, when two reagent cards are moved to a cabinet by reagent card mobile mechanism When middle, LED light (light source) be located at Optical Dark Solitary Pulse box cover lower surface and be located at two test strips deck line medium positions just on Side, the illumination for being subject to two test strips decks is consistent, cabinet surfaces externally and internally use dumb light coating, light interior not Reflection can be generated, good airproof performance, external stray light cannot be introduced into inside camera bellows, prevents the influence reflected light source, makes interior lights System is reliable and stable, improves the precision of test strips detection, and consistency and accuracy in order to guarantee testing result, this reality It is the high-definition image information of camera shooting with novel process object, it can be by the entire color development area on reagent card quickly and accurately It extracts, reduces the uneven bring risk of colour developing.

As shown in figure 9, the device that moves up and down in sample needle mechanism mobile device is synchronous belt wheel device and slide block device； The sample adding device includes cleaning swab 22, sampling needle, position sensor 23, sample adding device rack 24, the second motor 25, and two A synchronous pulley 26, synchronous belt 27, sliding block 28, linear guide 29 and linear bearing 30, it is preferred that linear guide and straight line Bearing is respectively two, and two synchronous pulleys are separately fixed on the output shaft of second motor and the sample adding device machine The lower section of frame, synchronous belt are wound on two synchronous pulleys, and sliding block is fixed on synchronous belt side by tabletting, and sampling needle one end is fixed On sliding block, the sampling needle other end passes through cleaning swab, and position sensor is set to close second motor of sample adding device rack This end, the effect of this position sensor are to reset, and when sliding block slides into the upper end of instrument, the subsidiary baffle of sliding block can be sensing Device blocks, and the state of sensor is made to change, and has arrived at reset position with instruction, two linear guides, which pass through, to be each passed through Two linear bearings, linear bearing are set in sample adding device rack, realize the upper and lower and left of the sample needle mechanism with this It moves right.

As shown in Figure 10, liquid channel system includes five three-way magnetic valves 31 (respectively the first three-way magnetic valve, the second threeways Solenoid valve, third three-way magnetic valve, the 4th three-way magnetic valve and the 5th three-way magnetic valve), vacuum pump 34, duplex pump 32 and micro Syringe pump 35, three excessively hardened structures 33 are crossed plate connector for three and are connected respectively with dilution bucket 36, cleaning solution bucket 37 and waste liquid barrel 38 Logical, as shown in figure 11, liquid channel system further includes sampling needle, cleaning swab 22 and automatic dilution mechanism 39, cleaning swab, automatic dilute Release mechanism, dilution bucket, cleaning solution bucket, waste liquid barrel, the dilution bucket, the first three-way magnetic valve 311, duplex pump a pump 321 are sequentially communicated with automatic dilution mechanism by dilution pipeline, realize the dilution of detection sample；Cleaning solution bucket, the second threeway Solenoid valve 312, another pump 322 of duplex pump, a pump of duplex pump, the first three-way magnetic valve and automatic dilution mechanism pass through cleaning Liquid pipeline connection, realizes the cleaning of automatic dilution mechanism；Automatic dilution mechanism, the 5th three-way magnetic valve 315, vacuum pump and waste liquid Bucket is sequentially communicated by pipeline, realizes the discharge of automatic dilution mechanism cleaning waste liquid；It is cleaning solution bucket, the second three-way magnetic valve, double Another pump, third three-way magnetic valve 313, the 4th three-way magnetic valve 314, micro-injection pump 35 and the sampling needle for joining pump pass through pipeline It is sequentially communicated, realizes the cleaning of the inner wall of sampling needle；Cleaning solution bucket, the second three-way magnetic valve, another pump of duplex pump, the three or three Three-way electromagnetic valve, the 4th three-way magnetic valve are sequentially communicated with cleaning swab by pipeline, realize the cleaning of the outer wall of sampling needle；Separately Outside, swab, the 5th three-way magnetic valve, vacuum pump and waste liquid barrel are cleaned to be sequentially communicated by pipeline, realizes that sampling needle cleans waste liquid Discharge, air bubble sensor 40 is installed on the pipeline between dilution bucket and the first three-way magnetic valve, for detecting dilution Whether the dilution in bucket is finished.

As shown in figure 12, automatic dilution mechanism includes linear motor 391, magnet 392, magnetic bead, cut-back tank 394, dilution Container fixed mechanism 393 and self-locking mechanism 395, the liquid outlet 41 of the dilution pipeline and clean the liquid outlet 42 of liquid pipeline all Across self-locking structure, self-locking structure can control dilution pipeline and clean the movement of liquid pipeline, facilitate the replacement of cut-back tank, Magnet is connected on the output shaft of linear motor, magnet is contacted with cut-back tank bottom of cup, when linear motor rotation, drives magnetic Magnetic bead rotation in iron rotation, magnet rotors and then drive cut-back tank reaches the stirring to the detection sample in cut-back tank, And then reaching diluted effect, cut-back tank fixed mechanism is set to cut-back tank surrounding, is used for fixed dilution container.

The motion process of the utility model utility model immune quantitative analyzer is specific as follows, when the higher needs of concentration of specimens When being diluted to sample, the second motor in sample needle mechanism mobile device is rotated, and drives synchronous pulley rotation, synchronous pulley Rotation is further driven to the movement of sliding block, and slide block movement then realizes moving up and down for sampling needle, then realizes sampling needle to detection sample This acquisition, it is when sample needle mechanism passes through the linear bearing being mounted thereon when two linear guides move above, then real Existing sample needle mechanism moves left and right, then realizes that will test sample is transferred in cut-back tank, controls on the first three-way magnetic valve The opening and closing in three channels, the motion control dilution of duplex pump flow into cut-back tank, by controlling micro-injection pump Movement sample injections are entered in cut-back tank, by the rotation of the linear motor in automatic dilution mechanism, with moving magnet turn Dynamic, the rotation of magnet is further driven to the rotation of the magnetic bead in cut-back tank, finally reach detection sample in cut-back tank and The mixing of dilution passes through the opening and closing in three channels on the second three-way magnetic valve of control, another pump of duplex pump, third On three-way magnetic valve on the opening and closing in three channels and the 4th three-way magnetic valve three channels opening and closing, cleaning Liquid stream enters to clean swab total water inlet, and water is divided into two-way after entering total water inlet, goes on water inlet all the way, and another way is gone down into water Mouthful, lower water inlet is divided into two strands of left and right further through annular groove, and upper and lower two path water passes through outlet stream up and down respectively and goes out, to be formed Two strands of cleaning solutions, when sampling needle moves up and down in cleaning swab, cleaning solution passes through control second to sampling needle outer wall washing The opening and closing of three-way magnetic valve, another pump of duplex pump, the opening and closing in three channels on third three-way magnetic valve, The opening and closing in three channels and micro-injection pump on four three-way magnetic valves, when the pinpoint movement of sampling needle is to cleaning swab Inner wall water outlet is remain stationary, and for wash liquid stream into micro-injection pump, cleaning solution is injected into sampling needle from micro-injection pump In, when cleaning to sampling needle inner wall, the needle point of sampling needle is located in cleaning swab, so last cleaning solution flows into cleaning In swab, finally also needs the cleaning waste liquid that will be cleaned in swab to be discharged, at this moment need to control on the 5th three-way magnetic valve three The opening and closing in channel and vacuum pump finally reach the discharge of the waste liquid of cleaning sampling needle inside and outside wall, finally control sample-adding Needle mechanism moves up and down, and realizes acquisition of the sampling needle to dilution detection sample, by controlling moving left and right for sample needle mechanism, Realize sampling needle to dilution detection sample dropwise addition, at this moment control the opening and closing in three channels on the second three-way magnetic valve, The opening and closing in three channels on another pump and third three-way magnetic valve of duplex pump are realized to clear inside cut-back tank It washes；At this moment opening and closing and the vacuum pump for needing to control on the 5th three-way magnetic valve three channels, are realized in cut-back tank Clean the discharge of waste liquid；Being added dropwise has the reagent card of dilution detection sample mobile by reagent card mobile mechanism, specific motion process It is as follows: the first motor driving lead screw rotation in reagent card mobile mechanism, it is assumed that the screw thread of lead screw is external screw thread, is then set in axle sleeve There is corresponding internal screw thread, the rotation of lead screw can be oriented to the moving direction that slide bar is used to fix sliding block, make with the movement of movable slider Sliding block can move back and forth in the shaft direction that the drive lower edge of first motor is oriented to slide bar, so that reagent card deck edge be driven to lead It moves back and forth to the shaft direction of slide bar, when it is implemented, the screw thread of lead screw is also possible to internal screw thread, is then equipped in axle sleeve corresponding External screw thread.Other than adding the structure of lead screw with first motor, it can also be substituted with the cooperation of rotating electric machine and ball-screw Common lead screw stepper motor, but the cost is relatively high, and reagent card moves in the cabinet in detection structure, and camera is uniform Light source under the image in reagent card is acquired, after Image Acquisition is complete, reagent card is continued to move to, and is set when being moved on cabinet When the screw set, since deck is provided with an opening, the deck of reagent card continues to kick fastener towards fastener movement is kicked and pass through at this time It contacts, reagent card is smoothly kicked out of from the deck of reagent card, the reagent card kicked out of, which is fallen into, to be set with reagent card after deck opening It is placed in the storehouse the Fei Ka mechanism below reagent card mobile mechanism, when the reagent card in the mechanism of the storehouse Fei Ka is filled, instrument can be automatic At this moment alarm is needed the storehouse Fei Ka mechanism pulling out fuselage, then can be cleared up the useless card in useless card storehouse, i.e., convenient to prevent again Pollution.The operating procedure of the above instrument is not fixing step, can also realize the detection of reagent card in other orders.

When concentration of specimens does not need dilution, do not have in instrument side operating procedure to detect Sample Dilution, cut-back tank it is clear These steps of the discharge of cut-back tank waste liquid are washed and clean, the operation of instrument walks when other steps and concentration of specimens need to dilute It is rapid the same.

Claims (29)

1. a kind of immune quantitative analyzer, it is characterised in that: mainly by being formed with lower component:

Reagent card mobile mechanism: can be according to the mobile reagent card that detection sample is added dropwise of motion track；The motion track includes The reagent card plug-in card position being arranged successively, detection reagent card position and is kicked except reagent card position, the reagent card mobile mechanism packet Include the deck for carrying reagent card；

Sample adding device: including sample needle mechanism and sample needle mechanism mobile device, the sample needle mechanism and sample needle machine Structure mobile device completes the suction sample of detection sample, spits sample and movement；

Detection structure: for the information above detection reagent card, including camera bellows mechanism and optical facilities, camera bellows mechanism packet At least two cabinets being adjacently positioned are included, the optical facilities are set in the camera bellows mechanism；

Liquid channel system: for controlling the flowing of liquid in immune quantitative analyzer and completing the automatic dilution and liquid of detection sample The automatic cleaning of pipeline in the system of road.

2. immune quantitative analyzer as described in claim 1, it is characterised in that: the immune quantitative analyzer further includes useless card Storehouse mechanism and frame structure, the storehouse the Fei Ka mechanism are described for accommodating having completed to test and being kicked the reagent card removed Frame structure is for fixing moving parts all in immune quantitative analyzer.

3. immune quantitative analyzer as claimed in claim 2, it is characterised in that: the storehouse the Fei Ka mechanism is located at the reagent card The lower section of mobile mechanism.

4. immune quantitative analyzer as claimed in claim 3, it is characterised in that: examined described in the volumetric ratio of the storehouse the Fei Ka mechanism The volume of geodesic structure is big.

5. immune quantitative analyzer as described in claim 1, it is characterised in that: also wrapped including the reagent card mobile mechanism Include mounting rack, first motor, lead screw, sliding block, reflection and opposite type sensor integrated circuit board and guiding slide bar, the first motor It is installed on mounting rack with guiding slide bar, one end of the lead screw is fixedly connected with the power output shaft of first motor, described The deck of reagent card is fixedly mounted on sliding block, and the sliding block and lead screw are connected through a screw thread, sliding block be equipped with through-hole, reflection with Opposite type sensor integrated circuit board is set to this end of reagent card plug-in card position.

6. immune quantitative analyzer as claimed in claim 5, it is characterised in that: the number of the through-hole is three, and guiding is slided Bar passes through slider throughbores, and the guiding slide bar is arranged two, the through-hole that lead screw passes through.

7. immune quantitative analyzer as claimed in claim 6, it is characterised in that: the lead screw is with two guiding slide bars vertical Face constitutes triangle.

8. immune quantitative analyzer as claimed in claim 7, it is characterised in that: the mounting rack includes bottom plate and fixed peace Starting stave and the second riser on bottom plate；The first motor is mounted on the outside of starting stave, and one end of lead screw passes through Starting stave is fixedly connected with the power output shaft of motor, and the lead screw other end is installed on the second riser；The guiding slide bar Both ends are separately mounted on starting stave and the second riser.

9. immune quantitative analyzer as claimed in claim 8, it is characterised in that: the deck of the reagent card has 6.

10. immune quantitative analyzer as claimed in claim 5, it is characterised in that: the reagent card mobile mechanism further includes Card structure is kicked, the card structure of kicking is set in the detection structure in the back plate of cabinet, and the back plate is located at reagent card The opposite side of deck card inserting mouth.

11. immune quantitative analyzer as claimed in claim 10, it is characterised in that: in opposite another of the deck card inserting mouth Side is equipped with an opening, and card is kicked in the cooperation realization by kicking card structure and deck opening.

12. immune quantitative analyzer as claimed in claim 11, it is characterised in that: the card structure of kicking is screw, the spiral shell Follow closely promising 6.

13. immune quantitative analyzer as described in claim 1, it is characterised in that: in sample needle mechanism mobile device It moves up and down device and function is moved up and down by synchronous belt wheel device and slide block device realization.

14. immune quantitative analyzer as claimed in claim 13, it is characterised in that: the sample adding device includes cleaning swab, Sampling needle, position sensor, sample adding device rack, the second motor, two synchronous pulleys, synchronous belt, sliding block, linear guide and Linear bearing.

15. immune quantitative analyzer as claimed in claim 14, it is characterised in that: the linear guide and linear bearing point Wei not be 2, two synchronous pulleys are separately fixed on the output shaft of second motor and under the sample adding device rack Side, synchronous belt are wound on two synchronous pulleys, and sliding block is fixed on synchronous belt side by tabletting, and sampling needle one end is fixed on sliding block On, the sampling needle other end pass through cleaning swab, position sensor be set to the sample adding device rack close to the second motor this End, two linear guides are each passed through two linear bearings, and the linear bearing is set in sample adding device rack.

16. immune quantitative analyzer as described in claim 1, it is characterised in that: the cabinet being adjacently positioned is by N block partition Optics camera bellows to be isolated, N block partition is vertically equidistantly located in optics camera bellows, optics camera bellows is isolated into N+1 cabinet, Four side of partition is bonded with Optical Dark Solitary Pulse box inner wall.

17. immune quantitative analyzer as claimed in claim 16, it is characterised in that: the partition is arranged two pieces, by Optical Dark Solitary Pulse Case is isolated into three cabinets.

18. immune quantitative analyzer as described in claim 1, it is characterised in that: the optical facilities include light source and take the photograph As head, the camera is located at box cover lower surface middle position.

19. immune quantitative analyzer as claimed in claim 18, it is characterised in that: a reagent card is set under each cabinet, The light source is located at Optical Dark Solitary Pulse box cover lower surface and is located at the surface of the deck of test card.

20. immune quantitative analyzer as claimed in claim 19, it is characterised in that: two reagent cards are set under each cabinet, The light source is located at Optical Dark Solitary Pulse box cover lower surface and is located at the surface of two test strips deck line medium positions, makes two The illumination that test strips deck is subject to is consistent.

21. immune quantitative analyzer as claimed in claim 20, it is characterised in that: the cabinet surfaces externally and internally is applied using dumb light Layer, the light source are LED light, halogen lamp or xenon lamp.

22. immune quantitative analyzer as claimed in claim 14, it is characterised in that: the liquid channel system includes the one or three energization Magnet valve, the second three-way magnetic valve, third three-way magnetic valve, the 4th three-way magnetic valve, the 5th three-way magnetic valve, vacuum pump, duplex A pump, another pump of duplex pump, micro-injection pump, sampling needle, cleaning swab, automatic dilution mechanism, the dilution bucket, cleaning of pump Liquid bucket, waste liquid barrel；The dilution bucket, the first three-way magnetic valve, a pump of duplex pump and automatic dilution mechanism pass through dilution Pipeline is sequentially communicated, and realizes the dilution of detection sample.

23. immune quantitative analyzer as claimed in claim 22, it is characterised in that: the cleaning solution bucket, the second threeway electromagnetism Valve, another pump of duplex pump, third three-way magnetic valve and automatic dilution mechanism realize automatic dilution by cleaning solution pipeline connection The cleaning of mechanism；The automatic dilution mechanism, the 5th three-way magnetic valve, vacuum pump and waste liquid barrel are sequentially communicated by pipeline, real The discharge of existing automatic dilution mechanism cleaning waste liquid.

24. immune quantitative analyzer as claimed in claim 22, it is characterised in that: the cleaning solution bucket, the second threeway electromagnetism Valve, another pump of duplex pump, third three-way magnetic valve, the 4th three-way magnetic valve, micro-injection pump and sampling needle by pipeline according to The cleaning of the inner wall of sampling needle is realized in secondary connection；The cleaning solution bucket, the second three-way magnetic valve, another pump of duplex pump, third Three-way magnetic valve, the 4th three-way magnetic valve are sequentially communicated with cleaning swab by pipeline, realize the cleaning of the outer wall of sampling needle；Institute It states cleaning swab, the 5th three-way magnetic valve, vacuum pump and waste liquid barrel to be sequentially communicated by pipeline, realizes sampling needle cleaning waste liquid Discharge.

25. immune quantitative analyzer as claimed in claim 22, it is characterised in that: the liquid channel system further includes bubble sensing Air bubble sensor described in device is set between dilution bucket and the first three-way magnetic valve.

26. immune quantitative analyzer as claimed in claim 25, it is characterised in that: the automatic dilution mechanism uses magnetic bead Mode is stirred mixing.

27. immune quantitative analyzer as claimed in claim 26, it is characterised in that: the automatic dilution mechanism includes straight-line electric Machine, magnet, magnetic bead, cut-back tank, cut-back tank fixed mechanism and self-locking mechanism, the liquid outlet of the dilution pipeline and cleaning The liquid outlet of liquid pipeline all passes through self-locking structure, and self-locking structure can control dilution pipeline and clean the movement of liquid pipeline, side Just the replacement of cut-back tank connects magnet on the output shaft of linear motor, and magnet is contacted with cut-back tank bottom of cup, and magnetic bead is set It is placed in cut-back tank, cut-back tank fixed mechanism is set to cut-back tank surrounding.

28. immune quantitative analyzer as claimed in claim 2, it is characterised in that: the storehouse the Fei Ka mechanism is by two pieces of baffle structures At two pieces of baffles are located at the left and right sides of the motion track of reagent card mobile mechanism.

29. immune quantitative analyzer as claimed in claim 28, it is characterised in that: the storehouse the Fei Ka mechanism and the rack machine Structure is connected by sliding rail.