CN102033133A - Automatic precision loading device - Google Patents
Automatic precision loading device Download PDFInfo
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- CN102033133A CN102033133A CN2009101774808A CN200910177480A CN102033133A CN 102033133 A CN102033133 A CN 102033133A CN 2009101774808 A CN2009101774808 A CN 2009101774808A CN 200910177480 A CN200910177480 A CN 200910177480A CN 102033133 A CN102033133 A CN 102033133A
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- slide block
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- adding device
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Abstract
The invention relates to an automatic precision loading device of immunoassay technology. The automatic precision loading device comprises a stepping motor, a screw, a motor clamping plate, a motor front plate, an optical axis guide rail, an injection sliding block, a motor baffle plate, an injector, an optical coupling sensor, an optical coupling sheet and a three-way block, and is characterized in that: the stepping motor and a precision screw kinematic pair are taken as transmission components; the injection sliding block is connected with a piston of the injector and performs back-and-forth linear motion along the optical axis guide rail; and a trigger point of the optical coupling sensor is taken as a completion point of injection action and an initial point of a next action cycle. The design ensures the precision of the device, and particularly reliably ensures repeated precision; and the automatic precision loading device has a simple structure, is convenient to maintain and can realize full automatic quantitative loading of an instrument. The loading device is widely suitable for loading mechanisms such as luminescence detection analyzers, biochemical analyzers, electrolytic analyzers and the like which need quantitative loading instruments.
Description
Technical field
The present invention relates to a kind of quantitatively automatic application of sample constructional device of application of sample such as full-automatic immune detection system sample, reagent and substrate that is used for.
Background technology
Immune detection is to utilize the specific reaction of antigen and antibody to carry out the biomedical a kind of means that detect, utilize isotope, enzyme, chemiluminescent substance etc. that the signal of test sample is amplified and show, therefore, be usually used in biomedical sample detection such as secretion, infectious disease, immunity, tumour, pharmacology.The accuracy of detection of immune detection equipment depends on the precision of quantitative application of sample to a certain extent, has guaranteed the precision of sample, reagent and substrate application of sample amount, just may guarantee to detect data and result's accuracy, and this is the basis of forming the immune detection equipment precision.In semi-automatic immune detection system, the application of sample of sample, reagent and substrate is by manual operation, increased the sizable workload of medical matters and experimenter, owing to be artificial application of sample, on the application of sample amount, bigger error certainly will be arranged, cause the cv value of application of sample excessive, can not get and detect data and result accurately.Progress along with The development in society and economy and Measurement for Biotechnique, the immune detection level is also along with continuous improve, simultaneously, immune detection quantity increases considerably, the treatment capacity of sample also is the order of magnitude and increases, so, full-automatic immune detection equipment that can the automatic ration application of sample should be asked and give birth to, in full-automatic immune detection equipment, quantitatively the work of application of sample is finished automatically by the quantitative sample adding device of equipment, and precision is higher, and good stability, application of sample amount cv value is little, the detection data that draw and as a result the manual application of sample of ratio of precision significantly improve.Because the full-automatic well-equipped performance of immune detection, the market demand is vigorous, but the market share of the overwhelming majority carved up by external a few large group, costs an arm and a leg.
At present, the full-automatic immune detection equipment prematurity mostly still that the design of the full-automatic immune detection device fabrication producer of domestic great majority is produced also has a very big segment distance from international most advanced level, no matter be on precision, or on stability.And cause the factor of present domestic equipment poor-performing, be because that the design on sample adding device is automatically paid attention to is insufficient to a certain extent.The automatic sample adding device that now is used for detecting instrument, existing various ways meets the different needs, as wheel and rack formula automated injection device, and the calibrated shot device of hydraulic manifold block formula, detecting instrument in common chemistry, biology, pharmaceutical field all has application at present, and is especially particularly common in the relevant micro-injection experiment of a small amount of sample of analysis and research.Existing injection device can not satisfy the needs that instrument uses gradually, also demonstrates various inconveniences in its use.Big such as wheel and rack formula automated injection device volume, easily cause unnecessary waste material, it is poor to transmission accuracy to use folk prescription, and wearing and tearing easily in this parts use; The calibrated shot device of hydraulic manifold block formula, cost is higher, and very high to the requirement on machining accuracy of integrated package and each parts, and actual production is difficult to reach requirement, and device context easily has residually during use, and difficult the cleaning influences the shortcomings such as accuracy of testing result.Ubiquitous at the automatic sample adding device of present domestic checkout equipment: low precision, complex structure, poor stability, defective such as cost an arm and a leg, the present invention is based on fundamentally solving the existing variety of issue of present domestic sample adding device, solve automatic in the full-automatic immune detection equipment, stable, accurate application of sample problem, and then better performances is produced in design, the equipment of reasonable price promotes full-automatic immune detection equipment and opens up brand-new market.
Summary of the invention
The present invention mainly is in order to solve full-automatic immune detection system automatic ration application of sample, and high precision, stable problem are made every effort to accomplish high precision, good stability, automaticity height, are easy to promote, simple and practical.
The present invention mainly is made up of stepper motor (joining drive screw), syringe, precise guide rail, slide block (joining linear bearing), injection header board, motor clamp, motor baffle plate, optocoupler sensor and optocoupler sheet, threeway piece etc.It is characterized in that:
During use, high-precision stepper motor is subjected to PC control, transmission nut on the injection slide block of drive screw rod cooperation tool guide function is the transmission mode of power, the injector-actuated piston is done round linear slide, realize accurate automatically quantitative application of sample, stepper motor main shaft and screw rod can be one, and both also can be splits, its connected mode is for being spirally connected riveted joint or pin joint.
Described stepper motor acts on linear bearing and realizes straight reciprocating motion under the digital pulse signal response.
Above-mentioned stepper motor is connected on the injection slide block with transmission guide function, and the injection slide block is parallel to the transmission shaft direction to-and-fro movement of stepper motor.
Linear bearing is installed on the above-mentioned injection slide block and under the guide effect of optical axis guide rail, sliding trace be a rectilinear motion without spin, injection slide block and linear bearing match use, perhaps are used in combination with rectangular guideway.
Described syringe piston is connected with the injection slide block by the mode of being movably hinged, and it extracts and to move parallelly with the arranged direction of optical axis guide rail with pushing, and is on the plane of symmetry of guide rail.
Above-mentioned injection slide block drive optocoupler sheet is followed syringe together and is done parallel to-and-fro movement, and the displacement of optocoupler sheet is exactly the displacement of syringe piston.
Optocoupler sheet on the above-mentioned injection slide block can be cut in the optocoupler of motor baffle plate opposite side when drawback movement, the control system main frame will detect injection slide block syringe piston arrival just mechanical zero, system from then on mechanical zero reorientates, send digital pulse signal, thereby guarantee that syringe piston is at the one way motion pin-point accuracy that moves after tens thousand of times.
Each parts of above-mentioned integral structure characteristic become laterally or vertical layout, and structure connects gathers, and syringe and introduction valve main body are outer at device, and optocoupler sensor and running part are at the device nexine.
Described two injection header boards, two introduction valves and syringe, specification is identical and become 180 ° of symmetric arrangement to be parallel to injection slide block movement direction about the stepper motor screw rod.
The function of the present invention for realizing that automatic accurate application of sample needs, the design proposal principle of sample adding device is: when the needs application of sample, sample needle moves to the target liq the inside, according to the different application of sample amounts that computer is set in advance, system at first continues to send the pulse signal of some to stepper motor, and the motor response is rotated, the drive screw rod rotates, the screw drive slide block drives syringe piston, moves certain displacement along the optical axis guide rail straight line, stops until pulse signal, finishes and extracts quantitative objective liquid; After extraction is finished, sample needle moves to destination agent cup the inside, system is to the instruction of stepper motor counter-rotating, the motor screw backward rotation, and drive slide block and return mobilely along optical axis guide rail, until injection ram is got back to zero point, pulse signal stops, syringe injects target liq to reagent cup, finishes action of injection.
The invention has the advantages that:
One, adopts accurate structural member and rational type of drive.Stepper motor main shaft of the present invention and drive screw are the integrated design, and it is customized that basic structural member is all special factory, and dimensional tolerence all is controlled at 0.01mm, and the whole assembly precision of device can be controlled in 0.1mm; And adopt screw driven mode, be that the ratio of gear of screw rod is big, with respect to the transmission accuracy height of gear drive, chain drive, band transmission, be fit to carry out precision drive, make as a whole with the stepper motor main shaft, can further reduce driving error, improved controllable precision; Simultaneously, for the step angle control of stepper motor, the present invention has adopted subdivision driver, makes the step angle of high precision stepper motor littler.
Two, stability and robotization control.In the middle of this present invention, we have adopted the function that makes zero of syringe.This mechanical reference of syringe is fixed zero point, is an optocoupler sensor, and the initial position of syringe is just in reference zero, and per injection also all finishes to get back to reference point.This is the key that device is realized the high duplication precision, guaranteed that syringe has oneself a reference frame, the displacement of optocoupler sheet also is the movement travel of syringe, injection each time all has in identical reference point and starting point, reduce error possible between the per injection, guaranteed repeatable accuracy relatively reliably.
Three, simple structure is easy to safeguard.The required number of spare parts of apparatus of the present invention is few, and automatic control mode is simple, assembles easyly, is easy to adjust and maintenance.
Description of drawings
Fig. 1 automatic accurate sample adding device structural representation one of the present invention
Fig. 2 automatic accurate sample adding device structural representation two of the present invention
Each label lists as follows among the figure:
The 1-stepper motor, 2-motor clamp, 3-motor header board, the 4-optical axis guide rail, the 5-syringe, 6-threeway piece, 7-optocoupler sensor, 8-motor baffle plate, 9-light lotus root sheet, 10-injects slide block, 11-optical axis guide rail, 12-screw rod
Embodiment
Below in conjunction with accompanying drawing specific embodiments of the present invention is described in further detail:
Closely cooperate between motor clamp 2 of the present invention, motor header board 3, motor baffle plate 8, two 11, five parts of optical axis guide rail, interconnect the supporting construction of having formed whole sample adding device; Stepper motor 1 is connected on the motor clamp 2, stepper motor 1 supporting accurate screw rod 12 pass motor clamp 2 and motor baffle plate 8, the transmission nut of screw rod 12 be fixed on the injection slide block 10 on; Two pilot holes of linear bearing are being adorned in injection on the slide block 10, cooperates with optical axis guide rail 11, under the driving of stepper motor 1, can be between motor clamp 2 and motor baffle plate 8 along optical axis guide rail 11 steadily, slip freely; Optocoupler sheet 9 is equipped with in injection slide block 10 belows, and the optocoupler sensor 7 with being fixed on motor header board 3 belows is used for the control of position; Syringe 5 is installed in motor header board 3 tops, and the syringe piston free end is fixed on the injection slide block 10, is following injection slide block 10 and is doing rectilinear motion along optical axis guide rail 11 together, and the liquid entrance of injector cylinder is fixedlyed connected with threeway piece 6; Threeway piece 6 is used to sample and switch on the liquid road of application of sample.
According to the difference of the size of application of sample amount, system all has corresponding pulsed quantity corresponding with it, and different reagent and sample also all have prior programmed position.Each application of sample, sample needle can at first be gone to reagent or sample container the inside, enter the following certain distance of liquid level.At this moment, system all can send pulse signal for stepper motor 1 according to selected required dosage, stepper motor 1 excited target, screw rod 12 rotating drive injections slide block 10 is being with syringe piston along with optical axis guide rail 11 certain displacement of walking back, the pulse signal that sends up to system reaches certain quantity and stops, meanwhile, syringe 5 is also drawn quantitative objective liquid by fluid pressure line.After finishing, sample needle moves to the reaction cup top once more, system continues to stepper motor with the reverse impulse signal then, screw rod 12 rotating drive injection slide block 10 is being with syringe piston to keep straight on along with optical axis guide rail 11, optocoupler sheet 9 on injection slide block 10 enters optocoupler sensor 7 the insides, system stops to send pulse signal to stepper motor 1, stepper motor 1 stop operating (promptly return zero), the target liq of sample needle the inside also injects reaction cup, retract initial position on the sample needle, shot circulation is finished.
In sum, automatic accurate sample adding device of the present invention is reasonable in design, simple in structure, easy to maintenance, be easy to promote, and can realize high precision, stable, full automatic application of sample injection process.This device can be used for instrument and the occasion that various needs carry out quantitative application of sample, has a wide range of applications.At present, the present invention has been applied on the full-automatic chemical luminescence immunoassay instrument, realizes equivalent, the while application of sample of two kinds of substrates, and actual effect shows, this device reaches the purpose and the effect of design fully, really realizes high precision, high stability, function such as full-automatic.
Claims (10)
1. automatic accurate sample adding device: comprise stepper motor, screw rod, motor clamp, injection header board, optical axis guide rail, injection slide block, motor baffle plate, syringe, optocoupler sensor, optocoupler sheet, threeway piece.Stepper motor is fixed on the motor clamp, the motor clamp is connected with injection header board one end, injection header board other direction is connected with the motor baffle plate, the stepper motor main shaft screw rod of ining succession, the injection slide block is arranged on the screw rod, the injection slide block can be done rectilinear motion, is fixing the piston of syringe on the injection slide block, and the import and export of syringe are connecting on the threeway piece that is fixed on the injection header board.This sample adding device is characterised in that: use high-precision stepper motor, assisting a ruler in governing a country with screw drive is the transmission mode of power, promote injection ram and carry out quantitative application of sample, stepper motor main shaft and screw rod can be one, both also can be splits, stepper motor main shaft and screw rod are spirally connected, riveted joint or pin joint.
2. automatic accurate sample adding device according to claim 1 is characterized in that: power source is the high precision stepper motor under the digital pulse signal response, acts on linear bearing and realizes straight reciprocating motion.
3. automatic accurate sample adding device according to claim 2 is characterized in that: stepper motor is connected on the injection slide block with transmission guide function, and the injection slide block is parallel to the transmission shaft direction to-and-fro movement of stepper motor.
4. automatic accurate sample adding device according to claim 3, it is characterized in that: on the injection slide block linear bearing is installed and under the optical axis guide effect, rectilinear motion without spin, injection slide block and linear bearing pairing claim to use, and perhaps are used in combination with rectangular guideway.
5. automatic accurate sample adding device according to claim 1 is characterized in that: the extraction action of syringe piston is parallel with the arranged direction of line slideway, and is on the plane of symmetry of guide rail.The piston rod of syringe is connected with the injection slide block by the mode of being movably hinged.
6. automatic accurate sample adding device according to claim 1 is characterized in that: the injection slide block drives the optocoupler sheet and does parallel to-and-fro movement with syringe together, and the displacement of light lotus root sheet is exactly the displacement of syringe piston.
7. automatic accurate sample adding device according to claim 6, it is characterized in that: the light lotus root sheet on the injection slide block is the optocoupler sensor that can enter into motor baffle plate place at drawback movement, the control system main frame will detect the injection slide block just syringe piston to mechanical zero, system from then on mechanical zero reorientates, send digital pulse signal, thereby guarantee that syringe piston is at the one way motion pin-point accuracy that moves after tens thousand of times.
8. automatic accurate sample adding device according to claim 1 is characterized in that: each parts of its integral structure characteristic become laterally or vertical layout, and structure connects gathers, and syringe is outer at device, and optocoupler and running part are at the device nexine.
9. automatic accurate sample adding device according to claim 8 is characterized in that: syringe one end is the threeway piece that is spirally connected, and an end is to be movably articulated in the injection slide block.
10. automatic accurate sample adding device according to claim 1 is characterized in that: the whole assembly precision of the automatic sample adding device running part of checkout equipment is positive and negative 0.1mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101774808A CN102033133A (en) | 2009-09-30 | 2009-09-30 | Automatic precision loading device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101774808A CN102033133A (en) | 2009-09-30 | 2009-09-30 | Automatic precision loading device |
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| CN102033133A true CN102033133A (en) | 2011-04-27 |
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| CN2009101774808A Pending CN102033133A (en) | 2009-09-30 | 2009-09-30 | Automatic precision loading device |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102968135A (en) * | 2012-10-26 | 2013-03-13 | 北京众驰伟业科技发展有限公司 | Microsample injection control system |
| CN103033604A (en) * | 2012-12-23 | 2013-04-10 | 浙江伯利恒仪器设备有限公司 | Automatic water adding device of farinograph |
| CN104237496A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay substrate adding device |
| CN104942813A (en) * | 2015-06-29 | 2015-09-30 | 湖南三德科技股份有限公司 | Air suction type mechanical arm for taking and conveying samples |
| CN105059920A (en) * | 2015-06-29 | 2015-11-18 | 湖南三德科技股份有限公司 | Air-suction type sample storing and taking device |
| CN107446808A (en) * | 2017-08-23 | 2017-12-08 | 苏州思维医疗科技有限公司 | Gene sequencer |
| CN109085147A (en) * | 2018-09-27 | 2018-12-25 | 湖南华南光电科技股份有限公司 | Propulsion analytic structure based on fluorescence sense technology trace explosive detector |
| CN109387652A (en) * | 2017-08-04 | 2019-02-26 | 河北艾驰生物科技有限公司 | A kind of novel injection pump |
| CN110488036A (en) * | 2019-09-06 | 2019-11-22 | 南京颐兰贝生物科技有限责任公司 | Biochemical Analyzer injection device |
| CN113311149A (en) * | 2021-05-28 | 2021-08-27 | 武汉优恩生物科技有限公司 | A device for immunochromatography |
-
2009
- 2009-09-30 CN CN2009101774808A patent/CN102033133A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102968135A (en) * | 2012-10-26 | 2013-03-13 | 北京众驰伟业科技发展有限公司 | Microsample injection control system |
| CN103033604A (en) * | 2012-12-23 | 2013-04-10 | 浙江伯利恒仪器设备有限公司 | Automatic water adding device of farinograph |
| CN104237496A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay substrate adding device |
| CN104942813A (en) * | 2015-06-29 | 2015-09-30 | 湖南三德科技股份有限公司 | Air suction type mechanical arm for taking and conveying samples |
| CN105059920A (en) * | 2015-06-29 | 2015-11-18 | 湖南三德科技股份有限公司 | Air-suction type sample storing and taking device |
| CN109387652A (en) * | 2017-08-04 | 2019-02-26 | 河北艾驰生物科技有限公司 | A kind of novel injection pump |
| CN107446808A (en) * | 2017-08-23 | 2017-12-08 | 苏州思维医疗科技有限公司 | Gene sequencer |
| CN107446808B (en) * | 2017-08-23 | 2023-09-29 | 成都万众壹芯生物科技有限公司 | Gene sequencer |
| CN109085147A (en) * | 2018-09-27 | 2018-12-25 | 湖南华南光电科技股份有限公司 | Propulsion analytic structure based on fluorescence sense technology trace explosive detector |
| CN110488036A (en) * | 2019-09-06 | 2019-11-22 | 南京颐兰贝生物科技有限责任公司 | Biochemical Analyzer injection device |
| CN113311149A (en) * | 2021-05-28 | 2021-08-27 | 武汉优恩生物科技有限公司 | A device for immunochromatography |
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Application publication date: 20110427 |