CN107326002A - Dna‑细胞缀合物 - Google Patents

Dna‑细胞缀合物 Download PDF

Info

Publication number
CN107326002A
CN107326002A CN201710671296.3A CN201710671296A CN107326002A CN 107326002 A CN107326002 A CN 107326002A CN 201710671296 A CN201710671296 A CN 201710671296A CN 107326002 A CN107326002 A CN 107326002A
Authority
CN
China
Prior art keywords
cells
cell
nucleic acid
dna
acid moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710671296.3A
Other languages
English (en)
Chinese (zh)
Inventor
萧世嘉
马修·B·弗朗西斯
卡罗伦·贝尔托齐
理查德·马蒂斯
拉维·钱德拉
埃里克·道格拉斯
艾米·特威特
尼古拉斯·托列洛
尾上弘晃
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN107326002A publication Critical patent/CN107326002A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
CN201710671296.3A 2009-04-08 2010-04-08 Dna‑细胞缀合物 Pending CN107326002A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16774809P 2009-04-08 2009-04-08
US61/167,748 2009-04-08
US24312309P 2009-09-16 2009-09-16
US61/243,123 2009-09-16
CN2010800213506A CN102575228A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2010800213506A Division CN102575228A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物

Publications (1)

Publication Number Publication Date
CN107326002A true CN107326002A (zh) 2017-11-07

Family

ID=42936579

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201710671296.3A Pending CN107326002A (zh) 2009-04-08 2010-04-08 Dna‑细胞缀合物
CN202110460486.7A Pending CN113186149A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物
CN2010800213506A Pending CN102575228A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202110460486.7A Pending CN113186149A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物
CN2010800213506A Pending CN102575228A (zh) 2009-04-08 2010-04-08 Dna-细胞缀合物

Country Status (7)

Country Link
US (2) US9327036B2 (https=)
EP (1) EP2417249B1 (https=)
JP (2) JP5964746B2 (https=)
CN (3) CN107326002A (https=)
CA (1) CA2757884C (https=)
ES (1) ES2924287T3 (https=)
WO (1) WO2010118235A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116712556A (zh) * 2023-07-20 2023-09-08 南通大学附属医院 一种靶向中枢神经系统的药物递送载体复合物及其制备方法和应用

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013019714A1 (en) 2011-07-29 2013-02-07 The Trustees Of Columbia University In The City Of New York Mems affinity sensor for continuous monitoring of analytes
CA2859914C (en) 2011-12-22 2020-05-26 Becton, Dickinson And Company Methods and apparatus for rapid detection of infectious microorganisms
US9160024B1 (en) * 2012-06-22 2015-10-13 The United States Of America, As Represented By The Secretary Of The Navy Grafting of biomolecules onto microbial fuel cells
WO2014160363A1 (en) * 2013-03-14 2014-10-02 Baylor Research Institute Surface modification of porcine islets
US10732183B2 (en) * 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
EP2799872B1 (en) * 2013-05-01 2017-10-18 F. Hoffmann-La Roche AG Selective release of sub-group of biological units
CN104212758A (zh) * 2013-05-31 2014-12-17 复旦大学 一种构建遗传性状嵌合多细胞结构方法
US11952622B2 (en) 2013-07-18 2024-04-09 The Johns Hopkins University Analysis of DNA-containing samples and resolution of mixed contributor DNA samples
WO2015042539A1 (en) * 2013-09-20 2015-03-26 Board Of Regents, The University Of Texas System Fabrication of iridium oxide ph sensors and sensor arrays
US10744207B2 (en) * 2014-05-02 2020-08-18 Acepodia, Inc. Biological complexes and methods for using same
WO2016022696A1 (en) 2014-08-05 2016-02-11 The Trustees Of Columbia University In The City Of New York Method of isolating aptamers for minimal residual disease detection
CA2993401C (en) * 2014-10-28 2018-09-18 The Governing Council Of The University Of Toronto Electrochemical metabolic activity detecting device
US10655097B2 (en) 2014-12-22 2020-05-19 Saint-Gobain Performance Plastics Corporation T-cell culture double bag assembly
US9926524B2 (en) 2014-12-22 2018-03-27 Saint-Gobain Performance Plastics Corporation Gas permeable material
US10280390B2 (en) 2014-12-22 2019-05-07 Saint-Gobain Performance Plastics Corporation System for culture of cells in a controlled environment
US11427861B2 (en) 2016-03-17 2022-08-30 Massachusetts Institute Of Technology Methods for identifying and modulating co-occurant cellular phenotypes
US11874268B2 (en) * 2016-06-12 2024-01-16 Nanohesgarsazan Salamat Arya Ncubation Center For Equipment And Devices Method and system for metastasis diagnosis and prognosis
US12180546B2 (en) 2017-03-17 2024-12-31 Massachusetts Institute Of Technology Methods for identifying and modulating co-occurant cellular phenotypes
CN107037218B (zh) * 2017-05-04 2019-02-15 中南大学 一种膜蛋白检测制剂、非标记肿瘤纳米探针及使用方法
EP3818151A4 (en) * 2018-07-06 2022-04-20 The Regents of the University of California Lipid-modified oligonucleotides and methods of using the same
US11208648B2 (en) * 2018-11-16 2021-12-28 International Business Machines Corporation Determining position and transcriptomes of biological cells
CA3113841A1 (en) * 2019-03-01 2020-09-10 Illumina, Inc. High-throughput single-nuclei and single-cell libraries and methods of making and of using
BR102019006678A2 (pt) * 2019-04-02 2020-10-06 Universidade Federal de Uberlândia Processo de modificação da superfície de eletrodos para construção de biossensores eletroquímicos
CN110205291A (zh) * 2019-04-28 2019-09-06 蚌埠医学院第一附属医院 一种膜表面工程化nk细胞的制备方法及药物组合物与应用
CN112014361B (zh) * 2019-05-30 2023-09-15 华东理工大学 一种基于多氨基荧光纳米簇的细胞膜唾液酸快速成像标记方法
US12091313B2 (en) 2019-08-26 2024-09-17 The Research Foundation For The State University Of New York Electrodynamically levitated actuator
US20210129134A1 (en) * 2019-11-04 2021-05-06 Rarecyte, Inc. Reference slide
EP4055161A4 (en) 2019-11-04 2024-01-17 Bio-Rad Laboratories, Inc. BARCODE ENCODING OF A CELL FOR SINGLE CELL SEQUENCING
US20240125764A1 (en) * 2019-11-08 2024-04-18 The Regents Of The University Of California Compositions and methods for temporal control of cell modulation
CN111534475B (zh) * 2019-11-28 2022-03-15 厦门诺康得生物科技有限公司 一种细胞表面偶联抗体的方法及其应用
CN112280829B (zh) * 2020-04-07 2023-12-26 南方科技大学 一种试剂盒、样本标记方法、单细胞测序方法
US20230294097A1 (en) * 2020-05-04 2023-09-21 The Regents Of The University Of California Electrochemical cellular circuits
US20240002908A1 (en) * 2020-11-09 2024-01-04 The General Hospital Corporation Methods of determining surface glycan density
CN114574496B (zh) * 2020-12-01 2024-04-09 上海交通大学医学院附属仁济医院 核苷类衍生物改性的核酸适体sgc8
WO2022190733A1 (ja) * 2021-03-10 2022-09-15 ソニーグループ株式会社 生体粒子分析方法及び生体粒子分析用試薬キット
CN113083383B (zh) * 2021-03-18 2022-10-25 华中农业大学 微流控芯片装置、制备方法及土壤微生物群落培养方法
CN113092425B (zh) * 2021-03-29 2022-09-27 上海交通大学 一种基于pH响应的DNA纳米机器建立可编程细胞间通讯的方法
JP7697656B2 (ja) * 2021-05-10 2025-06-24 国立大学法人鳥取大学 人工ウイルスキャプシド
WO2022241227A1 (en) 2021-05-14 2022-11-17 Akoya Biosciences, Inc. Amplification of rna detection signals in biological samples
WO2023014825A1 (en) 2021-08-03 2023-02-09 Akoya Biosciences, Inc. Rna detection by selective labeling and amplification
EP4272764A1 (en) * 2022-05-03 2023-11-08 Scipio Bioscience Method of complexing biological units with particles
CN116242894B (zh) * 2022-07-06 2026-03-10 章毅 捕获与释放含cd44抗原的细胞的组合物及其方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals
DE10019154A1 (de) * 2000-04-18 2001-10-31 Univ Eberhard Karls Zellbindende Nukleinsäuremoleküle (Aptamere)
CN1764721A (zh) * 2003-01-31 2006-04-26 普罗美加公司 官能团与蛋白质的共价束缚
WO2004084950A2 (en) 2003-03-24 2004-10-07 Case Western Reserve University Cell targeting methods and compositions
US20070087400A1 (en) * 2004-07-30 2007-04-19 Aldis Darzins Covalent tethering of functional groups to proteins and substrates therefor
DE102006026191A1 (de) * 2006-05-26 2007-11-29 Eberhard-Karls-Universität Tübingen Universitätsklinikum Vorrichtung und Substanz zur Isolierung von mesenchymalen Stammzellen (MSC)
JP2007319153A (ja) * 2006-06-02 2007-12-13 Takashi Otsu 核酸リガンドと中和剤との組み合わせ製剤
AU2007281479A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116712556A (zh) * 2023-07-20 2023-09-08 南通大学附属医院 一种靶向中枢神经系统的药物递送载体复合物及其制备方法和应用

Also Published As

Publication number Publication date
US9969970B2 (en) 2018-05-15
CA2757884C (en) 2019-10-22
CA2757884A1 (en) 2010-10-14
EP2417249B1 (en) 2022-06-08
JP2016168062A (ja) 2016-09-23
JP5964746B2 (ja) 2016-08-03
JP2012523569A (ja) 2012-10-04
EP2417249A4 (en) 2013-06-26
US20120142088A1 (en) 2012-06-07
ES2924287T3 (es) 2022-10-05
CN102575228A (zh) 2012-07-11
EP2417249A1 (en) 2012-02-15
CN113186149A (zh) 2021-07-30
US20160319238A1 (en) 2016-11-03
WO2010118235A1 (en) 2010-10-14
US9327036B2 (en) 2016-05-03

Similar Documents

Publication Publication Date Title
EP2417249B1 (en) Dna-cell conjugates
Dou et al. Aptamer-functionalized and gold nanoparticle array-decorated magnetic graphene nanosheets enable multiplexed and sensitive electrochemical detection of rare circulating tumor cells in whole blood
Wen et al. Intracellular delivery and sensing system based on electroplated conductive nanostraw arrays
Zhang et al. Programmable hydrogels for controlled cell catch and release using hybridized aptamers and complementary sequences
Lee et al. Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device
Abune et al. Aptamer‐functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing
Tian et al. Nanoparticle counting by microscopic digital detection: selective quantitative analysis of exosomes via surface-anchored nucleic acid amplification
Koo et al. Visualization and quantification of microRNA in a single cell using atomic force microscopy
WO2011068909A2 (en) Aptamer cell compositions
Zheng et al. Homogenous electrochemical method for ultrasensitive detection of tumor cells designed by introduction of poly (A) tails onto cell membranes
Chen et al. Aptamer-directed protein-specific multiple modifications of membrane glycoproteins on living cells
Zhu et al. Dynamically monitoring the clonal evolution of lung cancer based on the molecular characterization of circulating tumor cells using aptamer cocktail-modified nanosubstrates
Fan et al. Electrochemiluminescence aptasensor for Siglec-5 detection based on MoS2@ Au nanocomposites emitter and exonuclease III-powered DNA walker
Zuo et al. Glucometer readout for portable detection of heterogeneous circulating tumor cells in lung cancer captured on a dual aptamer functionalized wrinkled cellulose hydrogel interface
Furst et al. DNA hybridization to control cellular interactions
Wu et al. Nucleic acid-based cell surface engineering strategies and their applications
Diloknawarit et al. Nanoparticle anisotropy increases targeting interactions on live-cell membranes
Zhang et al. Chemical tailoring of aptamer glues with significantly enhanced recognition ability for targeted membrane protein degradation
Guo et al. Living-system-driven evolution of self-assembled-peptide probes: for boosting glioma theranostics
Pokhrel et al. Mechanical stability of DNA corona phase on gold nanospheres
Sun et al. Force-coded strategy for the simultaneous detection of multiple tumor-related proteins
CN110907513A (zh) 干细胞的电化学检测方法
Li et al. A membrane-protein targeted DNA multitasking processor for precise tumor cell imaging
HK40056202A (en) Dna-cell conjugates
Enomoto et al. Catch-and-release of target cells using aptamer-conjugated electroactive zwitterionic oligopeptide SAM

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination