CA2757884C - Conjugates of dna with a native functional group on the cell surface - Google Patents

Conjugates of dna with a native functional group on the cell surface Download PDF

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Publication number
CA2757884C
CA2757884C CA2757884A CA2757884A CA2757884C CA 2757884 C CA2757884 C CA 2757884C CA 2757884 A CA2757884 A CA 2757884A CA 2757884 A CA2757884 A CA 2757884A CA 2757884 C CA2757884 C CA 2757884C
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Prior art keywords
cell
cells
nucleic acid
dna
acid moiety
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CA2757884A
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English (en)
French (fr)
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CA2757884A1 (en
Inventor
Shih-Chia Hsiao
Matthew B. Francis
Carolyn Bertozzi
Richard Mathies
Ravi Chandra
Erik Douglas
Amy Twite
Nicholas Toriello
Hiroaki Onoe
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
CA2757884A 2009-04-08 2010-04-08 Conjugates of dna with a native functional group on the cell surface Active CA2757884C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16774809P 2009-04-08 2009-04-08
US61/167,748 2009-04-08
US24312309P 2009-09-16 2009-09-16
US61/243,123 2009-09-16
PCT/US2010/030397 WO2010118235A1 (en) 2009-04-08 2010-04-08 Dna-cell conjugates

Publications (2)

Publication Number Publication Date
CA2757884A1 CA2757884A1 (en) 2010-10-14
CA2757884C true CA2757884C (en) 2019-10-22

Family

ID=42936579

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2757884A Active CA2757884C (en) 2009-04-08 2010-04-08 Conjugates of dna with a native functional group on the cell surface

Country Status (7)

Country Link
US (2) US9327036B2 (https=)
EP (1) EP2417249B1 (https=)
JP (2) JP5964746B2 (https=)
CN (3) CN107326002A (https=)
CA (1) CA2757884C (https=)
ES (1) ES2924287T3 (https=)
WO (1) WO2010118235A1 (https=)

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WO2014160363A1 (en) * 2013-03-14 2014-10-02 Baylor Research Institute Surface modification of porcine islets
US10732183B2 (en) * 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
EP2799872B1 (en) * 2013-05-01 2017-10-18 F. Hoffmann-La Roche AG Selective release of sub-group of biological units
CN104212758A (zh) * 2013-05-31 2014-12-17 复旦大学 一种构建遗传性状嵌合多细胞结构方法
US11952622B2 (en) 2013-07-18 2024-04-09 The Johns Hopkins University Analysis of DNA-containing samples and resolution of mixed contributor DNA samples
WO2015042539A1 (en) * 2013-09-20 2015-03-26 Board Of Regents, The University Of Texas System Fabrication of iridium oxide ph sensors and sensor arrays
US10744207B2 (en) * 2014-05-02 2020-08-18 Acepodia, Inc. Biological complexes and methods for using same
WO2016022696A1 (en) 2014-08-05 2016-02-11 The Trustees Of Columbia University In The City Of New York Method of isolating aptamers for minimal residual disease detection
CA2993401C (en) * 2014-10-28 2018-09-18 The Governing Council Of The University Of Toronto Electrochemical metabolic activity detecting device
US10655097B2 (en) 2014-12-22 2020-05-19 Saint-Gobain Performance Plastics Corporation T-cell culture double bag assembly
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US10280390B2 (en) 2014-12-22 2019-05-07 Saint-Gobain Performance Plastics Corporation System for culture of cells in a controlled environment
US11427861B2 (en) 2016-03-17 2022-08-30 Massachusetts Institute Of Technology Methods for identifying and modulating co-occurant cellular phenotypes
US11874268B2 (en) * 2016-06-12 2024-01-16 Nanohesgarsazan Salamat Arya Ncubation Center For Equipment And Devices Method and system for metastasis diagnosis and prognosis
US12180546B2 (en) 2017-03-17 2024-12-31 Massachusetts Institute Of Technology Methods for identifying and modulating co-occurant cellular phenotypes
CN107037218B (zh) * 2017-05-04 2019-02-15 中南大学 一种膜蛋白检测制剂、非标记肿瘤纳米探针及使用方法
EP3818151A4 (en) * 2018-07-06 2022-04-20 The Regents of the University of California Lipid-modified oligonucleotides and methods of using the same
US11208648B2 (en) * 2018-11-16 2021-12-28 International Business Machines Corporation Determining position and transcriptomes of biological cells
CA3113841A1 (en) * 2019-03-01 2020-09-10 Illumina, Inc. High-throughput single-nuclei and single-cell libraries and methods of making and of using
BR102019006678A2 (pt) * 2019-04-02 2020-10-06 Universidade Federal de Uberlândia Processo de modificação da superfície de eletrodos para construção de biossensores eletroquímicos
CN110205291A (zh) * 2019-04-28 2019-09-06 蚌埠医学院第一附属医院 一种膜表面工程化nk细胞的制备方法及药物组合物与应用
CN112014361B (zh) * 2019-05-30 2023-09-15 华东理工大学 一种基于多氨基荧光纳米簇的细胞膜唾液酸快速成像标记方法
US12091313B2 (en) 2019-08-26 2024-09-17 The Research Foundation For The State University Of New York Electrodynamically levitated actuator
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US20240125764A1 (en) * 2019-11-08 2024-04-18 The Regents Of The University Of California Compositions and methods for temporal control of cell modulation
CN111534475B (zh) * 2019-11-28 2022-03-15 厦门诺康得生物科技有限公司 一种细胞表面偶联抗体的方法及其应用
CN112280829B (zh) * 2020-04-07 2023-12-26 南方科技大学 一种试剂盒、样本标记方法、单细胞测序方法
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CN114574496B (zh) * 2020-12-01 2024-04-09 上海交通大学医学院附属仁济医院 核苷类衍生物改性的核酸适体sgc8
WO2022190733A1 (ja) * 2021-03-10 2022-09-15 ソニーグループ株式会社 生体粒子分析方法及び生体粒子分析用試薬キット
CN113083383B (zh) * 2021-03-18 2022-10-25 华中农业大学 微流控芯片装置、制备方法及土壤微生物群落培养方法
CN113092425B (zh) * 2021-03-29 2022-09-27 上海交通大学 一种基于pH响应的DNA纳米机器建立可编程细胞间通讯的方法
JP7697656B2 (ja) * 2021-05-10 2025-06-24 国立大学法人鳥取大学 人工ウイルスキャプシド
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WO2023014825A1 (en) 2021-08-03 2023-02-09 Akoya Biosciences, Inc. Rna detection by selective labeling and amplification
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CN116242894B (zh) * 2022-07-06 2026-03-10 章毅 捕获与释放含cd44抗原的细胞的组合物及其方法
CN116712556B (zh) * 2023-07-20 2025-03-28 南通大学附属医院 一种靶向中枢神经系统的药物递送载体复合物及其制备方法和应用

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AU2007281479A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets

Also Published As

Publication number Publication date
US9969970B2 (en) 2018-05-15
CA2757884A1 (en) 2010-10-14
EP2417249B1 (en) 2022-06-08
JP2016168062A (ja) 2016-09-23
JP5964746B2 (ja) 2016-08-03
JP2012523569A (ja) 2012-10-04
EP2417249A4 (en) 2013-06-26
US20120142088A1 (en) 2012-06-07
ES2924287T3 (es) 2022-10-05
CN107326002A (zh) 2017-11-07
CN102575228A (zh) 2012-07-11
EP2417249A1 (en) 2012-02-15
CN113186149A (zh) 2021-07-30
US20160319238A1 (en) 2016-11-03
WO2010118235A1 (en) 2010-10-14
US9327036B2 (en) 2016-05-03

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