CN107308132B - 一种磷脂壳聚糖药物递送系统及其制备方法和用途 - Google Patents
一种磷脂壳聚糖药物递送系统及其制备方法和用途 Download PDFInfo
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- CN107308132B CN107308132B CN201610265188.1A CN201610265188A CN107308132B CN 107308132 B CN107308132 B CN 107308132B CN 201610265188 A CN201610265188 A CN 201610265188A CN 107308132 B CN107308132 B CN 107308132B
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Abstract
Description
指标 | 0个月 | 1个月 | 3个月 |
外观 | 淡黄色澄明溶液 | 淡黄色澄明溶液 | 淡黄色澄明溶液 |
平均粒径(nm) | 170~185nm | 170~185m | 170~185m |
Zeta电位(mV) | 33~36 | 33~36 | 33~36 |
含量(%) | 100% | 102% | 100% |
包封率(%) | 83% | 82% | 82% |
指标 | 0个月 | 1个月 | 3个月 |
外观 | 澄明溶液 | 澄明溶液 | 澄明溶液 |
平均粒径(nm) | 200~215nm | 200~215m | 200~215m |
Zeta电位(mV) | 40~45 | 40~45 | 40~45 |
含量(%) | 100% | 100% | 103% |
包封率(%) | 92% | 91% | 92% |
指标 | 0个月 | 1个月 | 3个月 |
外观 | 澄明溶液 | 澄明溶液 | 澄明溶液 |
平均粒径(nm) | 150~180nm | 150~180m | 150~180m |
Zeta电位(mV) | 39~43 | 39~43 | 39~43 |
含量(%) | 100% | 98% | 102% |
包封率(%) | 93% | 94% | 94% |
指标 | 0个月 | 1个月 | 3个月 |
外观 | 澄明溶液 | 澄明溶液 | 澄明溶液 |
平均粒径(nm) | 170~185nm | 170~185m | 170~185m |
Zeta电位(mV) | 32~35 | 32~36 | 32~36 |
含量(%) | 100% | 101% | 99% |
包封率(%) | 90% | 89% | 92% |
Claims (18)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110939458.3A CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
CN201610265188.1A CN107308132B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
PCT/CN2017/081486 WO2017186065A1 (zh) | 2016-04-26 | 2017-04-21 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
Applications Claiming Priority (1)
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CN201610265188.1A CN107308132B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
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CN202110939458.3A Division CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN107308132A CN107308132A (zh) | 2017-11-03 |
CN107308132B true CN107308132B (zh) | 2021-08-17 |
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CN201610265188.1A Active CN107308132B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
CN202110939458.3A Active CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
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CN202110939458.3A Active CN113768901B (zh) | 2016-04-26 | 2016-04-26 | 一种磷脂壳聚糖药物递送系统及其制备方法和用途 |
Country Status (2)
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CN (2) | CN107308132B (zh) |
WO (1) | WO2017186065A1 (zh) |
Families Citing this family (17)
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CN108620428B (zh) * | 2018-04-08 | 2020-12-18 | 王微静 | 一种基于离子液体的土壤重金属淋洗液及其制备方法 |
CN111281871A (zh) * | 2018-12-10 | 2020-06-16 | 赵美淇 | 一种含千金藤碱的药用组合物 |
CN114617968B (zh) | 2019-04-09 | 2023-10-03 | 北京五和博澳药业股份有限公司 | 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途 |
CN110151691A (zh) * | 2019-06-19 | 2019-08-23 | 宁夏医科大学 | 一种千金藤素纳米混悬液及其制备方法 |
CN110251687B (zh) * | 2019-07-10 | 2023-09-22 | 大连医科大学 | 一种电荷反转口服壳聚糖纳米药物制剂及其制备方法 |
CN112043670B (zh) * | 2019-10-08 | 2021-10-29 | 中国药科大学 | 一种线粒体靶向型外用药物制剂 |
CN111077247A (zh) * | 2019-12-24 | 2020-04-28 | 广西五和博澳药业有限公司 | 一种植物提取物或其制剂的检测方法 |
US20230181624A1 (en) * | 2020-04-24 | 2023-06-15 | Intact Therapeutics, Inc. | Compositions and methods for treatment of gastrointestinal bleeding |
CN112972403B (zh) * | 2021-03-24 | 2022-03-29 | 齐鲁工业大学 | 一种含牛血清白蛋白的脂质纳米抗肿瘤药物及其制备方法 |
CN113397032B (zh) * | 2021-05-24 | 2023-03-10 | 江苏省农业科学院 | 基于牛蒡糖蛋白的营养素递送体系及其制备方法和应用 |
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CN114403267A (zh) * | 2022-01-24 | 2022-04-29 | 浙江欣诺医药有限公司 | 一种莓茶活性粉及其固体饮料 |
CN114680334A (zh) * | 2022-04-11 | 2022-07-01 | 四川农业大学 | 一种壳聚糖修饰肉桂精油脂质体的制备方法 |
CN115212182A (zh) * | 2022-07-01 | 2022-10-21 | 广州长生康生物科技有限公司 | 一种大豆磷脂软胶囊及其制备方法和应用 |
CN115444835B (zh) * | 2022-09-05 | 2023-11-24 | 中国海洋大学 | 壳聚糖-磷脂复合纳米铁补铁剂及其制备方法 |
CN116211827B (zh) * | 2023-03-17 | 2024-04-05 | 浙江大学 | 一种特立帕肽固体脂质纳米粒及其制备方法和应用 |
CN116617220B (zh) * | 2023-07-26 | 2023-09-22 | 南京农业大学 | 抗青霉素类耐药菌的绿原酸-小檗碱纳米药物、药物组合物及其制备方法 |
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CN101088524B (zh) * | 2006-06-12 | 2013-01-02 | 北京五和博澳医药科技发展有限公司 | 黄芩天然活性成分的磷脂复合物及其制备方法和制剂 |
CN102988484B (zh) * | 2006-06-12 | 2016-08-10 | 北京五和博澳药业有限公司 | 黄芩天然活性成分的磷脂复合物及其制备方法和制剂 |
CN101396343B (zh) * | 2007-09-26 | 2011-12-07 | 中国医学科学院药物研究所 | 以脂质复合物为中间载体的紫杉醇亚微乳 |
KR101801426B1 (ko) * | 2010-07-14 | 2017-12-20 | 인스티투트 오브 마타리아 메디카, 차이니즈 아카데미 오브 메디칼 사이언스 | 인슐린-지질 복합물 및 그의 제조방법과 그의 제제 |
CN105250244A (zh) * | 2014-07-18 | 2016-01-20 | 西南大学 | 一种肺部吸入的姜黄素磷脂复合物壳聚糖微球及其制备方法 |
-
2016
- 2016-04-26 CN CN201610265188.1A patent/CN107308132B/zh active Active
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Non-Patent Citations (1)
Title |
---|
槲皮素磷脂—壳聚糖纳米粒制剂及其经皮给药的研究;谭启;《中国优秀硕士学位论文全文数据库,医药卫生科技辑》;20130215(第2期);E079-57 * |
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