CN107308058A - A kind of mouthwash containing sterculia nobilis's berry extract - Google Patents
A kind of mouthwash containing sterculia nobilis's berry extract Download PDFInfo
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- CN107308058A CN107308058A CN201710632537.3A CN201710632537A CN107308058A CN 107308058 A CN107308058 A CN 107308058A CN 201710632537 A CN201710632537 A CN 201710632537A CN 107308058 A CN107308058 A CN 107308058A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention provides a kind of mouthwash containing sterculia nobilis's berry extract, includes the component of following percentage by weight meter：Sterculia nobilis's berry extract 2.6 3.6%, peach root extract 1.6 2.3%, cape jasmine flower extract 0.5 1.2%, Flos Osmanthi Fragrantis extract 1 2%, licoflavone 0.02 0.4%, vitamin B 0.01 0.3%, ethanol 6 11%, sweetener 0.01 0.1%, surplus is water.The cleanable oral cavity of mouthwash of the present invention, while the effects such as having antimicrobial antiphlogistic, treatment bleeding gums, and mouthwash stable system, preparation method is simple, can be widely popularized.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of mouthwash containing sterculia nobilis's berry extract.
Background technology
With the development and the continuous improvement of living standard of economic society, the oral health consciousness of people is greatly enhanced, mouth
Chamber care product also gradually develops into a variety of care products such as toothpaste, tooth patch, mouthwash by single toothpaste.People consume purpose
Also the U.S. tooth of shield tooth, cleaning oral cavity are changed into by single cleaning tooth and prevent and treat mouth disease.It is relatively conventional in oral disease
There are halitosis, carious tooth, canker sore etc..
The main composition containing triclosan or metronidazole, Tinidazole or hydrogen peroxide or iodine solution etc. of mouthwash conventional at present, this
Class mouthwash is respectively provided with sterilization or bacteriostasis, but be not suitable for being used as common oral care well.U.S.'s food and medicine
The mouthwash of product management board certification is included containing essential oil and containing the class of chlorohexidene two, and the latter, which is used for a long time, easily causes dental calculus formation, facing
Coloring and the sense of taste change.The mouthwash of class containing essential oil has permeability strong, is not in gingival discoloration after use, flora imbalance, secondary
Infection etc., though containing alcoholic ingredient, harmless to oral cavity partial, such mouthwash main function is fresh breath, to preventing and treating mouth
The mouth disease effect such as chamber ulcer, carious tooth is not notable.
The content of the invention
It is an object of the invention to provide a kind of mouthwash containing sterculia nobilis's berry extract.
To achieve the above object, the present invention is adopted the following technical scheme that：
A kind of mouthwash containing sterculia nobilis's berry extract, includes the component of following percentage by weight meter：Sterculia nobilis's berry extract 2.6-
3.6%th, peach root extract 1.6-2.3%, cape jasmine flower extract 0.5-1.2%, Flos Osmanthi Fragrantis extract 1-2%, licoflavone 0.02-
0.4%th, vitamin B 0.01-0.3%, ethanol 6-11%, sweetener 0.01-0.1%, surplus is water.
The preparation method of described sterculia nobilis's berry extract is as follows：
（1）Take sterculia nobilis fruit to clean, be ground into 100-140 mesh, and 15-30min is dried under the conditions of 50 DEG C, add after fruit drying
The 50-60% ethanol of 5-10 times of weight, the ultrasonic extraction 10-20min at 5-10 DEG C, supersonic frequency is 40-50khz；
（2）By step 1）The feed liquid of acquisition is maintained at 40-50 DEG C of temperature, and regulation pH is 4-6, adds weight after fruit is dried
After the completion of 0.1-0.3% cellulase degradation 1-2h, enzymolysis, the pectase of weight 0.1-0.2% after fruit is dried is continuously added
Digest 1-2h；；Then regulation pH is 7.0, and temperature is 45-50 DEG C, and the symbol for continuously adding weight 0.1-0.2% after fruit is dried is answered
Hop protein enzyme digests 5-7h；
（3）By step（2）The enzymolysis liquid of acquisition goes out after enzyme, filtering, obtains filtrate 1 and filter residue 1, standby；
（4）By step（3）Obtained filter residue 1, adds the 65-85% ethanol of 6-10 times of its weight, the 3- extracted at 50-80 DEG C
Filtrate 2 and filter residue 2 are collected in 4h, filtering；Continue as stated above, to take filter residue 2, add the 65-85% ethanol of 6-10 times of its weight,
Filtrate 3 and filter residue 3 are collected in the 3-4h extracted at 50-80 DEG C, filtering；
（5）Merging filtrate 1,2,3, is well mixed, and reclaims mixed liquor centrifugal filtration acquisition filtrate after ethanol, is concentrated into relatively close
The medicinal extract for 1.0-1.2 is spent, then medicinal extract is dried in vacuo in vacuum drying chamber at 40-50 DEG C, sterculia nobilis's berry extract is obtained.
The preparation method of described peach root extract is：Peach root is taken, the 70-85% ethanol that 4-6 times of its weight is measured is added, plus
Circumfluence distillation 2-3h, filtering, filter residue continuously adds the 70-85% ethanol that 4-6 times of its weight is measured, heating and refluxing extraction 1-2h, mistake
Filter, mixing filtrate twice reclaims ethanol, filtering, and filtrate is concentrated into the medicinal extract that relative density is 1.1-1.2, then by medicinal extract in
Vacuum drying obtains peach root extract.
The preparation method of described cape jasmine flower extract is：Gardenia is taken, the water that 4-6 times of its weight is measured is added, heats back
Stream extracts 2-3h, filtering, and filter residue continuously adds the water that 4-6 times of its weight is measured, and heating and refluxing extraction 1-2h, filtering is mixed twice
Filtrate, filtering, filtrate is concentrated into the medicinal extract that relative density is 1.1-1.2, and medicinal extract then is obtained into gardenia in vacuum drying carries
Take thing.
The preparation method of described Flos Osmanthi Fragrantis extract is：Sweet osmanthus is taken, the water that 4-6 times of its weight is measured is added, is heated to reflux carrying
2-3h is taken, is filtered, filter residue continuously adds the water that 4-6 times of its weight is measured, heating and refluxing extraction 1-2h, filtering mixes filtrate twice,
Filtering, filtrate is concentrated into the medicinal extract that relative density is 1.1-1.2, and medicinal extract then is obtained into Flos Osmanthi Fragrantis extract in vacuum drying.
A kind of mouthwash containing sterculia nobilis's berry extract, includes the component of following percentage by weight meter：Sterculia nobilis's berry extract
3%th, peach root extract 2%, cape jasmine flower extract 1.0%, Flos Osmanthi Fragrantis extract 1.5%, licoflavone 0.2%, vitamin B 0.1%, second
Alcohol 7%, sweetener 0.02%, surplus is water.
A kind of preparation method of the mouthwash containing sterculia nobilis's berry extract, adds sterculia nobilis's berry extract, peach root in ethanol
Then extract, cape jasmine flower extract, Flos Osmanthi Fragrantis extract, licoflavone, vitamin B, vortex mixed add sweetener and water,
It is well mixed, produce mouthwash.
Sterculia nobilis fruit is nutritious, contains abundant starch, protein, fat, vitamin, wherein money material element, seed
In 18 kinds of amino acid it is complete, 8 kinds of amino acid contents that human body must be first are higher, and sterculia nobilis fruit seed is rich in aldehydes matter, with compared with
High DHHP radical scavenging activities, reducing power, metal chelating are made a concerted effort, Hydroxyl radical-scavenging vigor, superoxide radical remove vigor.
With higher nutritive value and stronger oxidation resistance.
Gardenia has the effect of purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.Flower can make the spices of tea, fruit can anti-inflammatory dispel
Heat.
The effect of peach root has clearing heat and promoting diuresis, promoting blood circulation and stopping pain, subduing inflammation.
Sweet osmanthus has functions that warming spleen and stomach for dispelling cold, warm stomach analgesic, resolving sputum scattered silt.It is usually used in treatment stomachache, stomachache, toothache, halitosis
Deng.
Licoflavone has certain anti-inflammatory, antibacterial, the effect of hemostasis, but the consumption in mouthwash is low, so effect
Effect be not it is obvious that and sterculia nobilis fruit, peach root, gardenia, sweet osmanthus have the effects such as certain anti-inflammation, removing pattogenic heat from the blood and toxic material from the body, and
And gardenia and sweet osmanthus carry the delicate fragrance of pleasant, inventor use sterculia nobilis fruit, peach root, gardenia, sweet osmanthus as raw material and
Licoflavone, vitamin B compounded improve mouthwash antimicrobial antiphlogistic, hemostasis, deodorization effect, while for guarantee system
Stabilization, the present invention compounds licoflavone, vitamin B, by not using extracts such as sterculia nobilis fruit, peach root, gardenia, sweet osmanthus
Disconnected research and experiment, finally determines optimal usage ratio, under matching herein, and the mouthwash that the present invention is prepared has
Significant anti-inflammation, the effect of deodorization, and the extract such as sterculia nobilis fruit, peach root, gardenia, sweet osmanthus and licoflavone, tie up life
Plain B etc. wants to combine, and can significantly improve the stability of each composition so that mouthwash of the present invention is placed on room temperature, natural lighting bar
The state of beautiful clear is remained in that after being placed 24 months under part, and denaturalization phenomenon does not occur.In addition, present invention employs
Licoflavone not only acts as the effect of antimicrobial antiphlogistic, also acts as the effect of natural plant preservative, one action two.
The advantage of the invention is that：
Sterculia nobilis's berry extract of the present invention is prepared by methods such as alcohol extracting, enzymolysis, and many of sterculia nobilis fruit are contained in its extract
Plant active ingredient.Contain licoflavone in mouthwash of the present invention, with sterculia nobilis fruit, peach root, gardenia, Flos Osmanthi Fragrantis extract compounding conduct
Implication is simultaneously cleaned in active component, cleanable oral cavity, while effectively alleviating the oral problems such as gingivitis, bleeding gums.The present invention gargles
Saliva, system clear, stably, safely is pure natural without addition essence, preservative etc. in addition with sweet osmanthus fragrance.This
It is more than 90%, the suppression of staphylococcus aureus to the inhibiting rate to Escherichia coli that this mouthwash of verification experimental verification is passed through in invention
Rate is more than 87%.
Embodiment
Embodiment 1
A kind of mouthwash containing sterculia nobilis's berry extract, includes the component of following percentage by weight meter：Sterculia nobilis's berry extract 3%, peach
Root extract 2%, cape jasmine flower extract 1.0%, Flos Osmanthi Fragrantis extract 1.5%, licoflavone 0.2%, vitamin B 0.1%, ethanol 7%,
Sweetener 0.02%, surplus is water.
The preparation method of described sterculia nobilis's berry extract is as follows：
（1）Take sterculia nobilis fruit to clean, be ground into 120 mesh, and 25min is dried under the conditions of 50 DEG C, add 8 times of weight after fruit is dried
55% ethanol, ultrasonic extraction 15min at 5 DEG C, supersonic frequency is 45khz；
（2）By step 1）The feed liquid of acquisition is maintained under temperature 45 C, and regulation pH is 5, adds weight 0.1% after fruit is dried
After the completion of cellulase degradation 2h, enzymolysis, the pectinase enzymatic hydrolysis 2h of weight 0.1 after fruit is dried is continuously added；Then pH is adjusted
For 7.0, temperature is 49 DEG C, continuously adds the symbol compound protease enzymolysis 6h of weight 0.1% after fruit is dried；
（3）By step（2）The enzymolysis liquid of acquisition goes out after enzyme, filtering, obtains filtrate 1 and filter residue 1, standby；
（4）By step（3）Obtained filter residue 1, adds 80% ethanol of 8 times of its weight, and the 4h extracted at 70 DEG C is filtered, collected
Filtrate 2 and filter residue 2；Continue as stated above, to take filter residue 2, add 80% ethanol of 8 times of its weight, the 4h extracted at 70 DEG C,
Filtering, collects filtrate 3 and filter residue 3；
（5）Merging filtrate 1,2,3, is well mixed, and reclaims mixed liquor centrifugal filtration acquisition filtrate after ethanol, is concentrated into relatively close
The medicinal extract for 1.1 is spent, then medicinal extract is dried in vacuo in vacuum drying chamber at 45 DEG C, sterculia nobilis's berry extract is obtained.
The preparation method of described peach root extract is：Peach root is taken, 80% ethanol of 5 times of amounts of its weight is added, is heated to reflux
3h, filtering are extracted, filter residue continuously adds 80% ethanol of 5 times of amounts of its weight, and heating and refluxing extraction 2h, filtering, mixing is filtered twice
Liquid, reclaims ethanol, filtering, and filtrate is concentrated into the medicinal extract that relative density is 1.2, and medicinal extract then is obtained into peach root in vacuum drying carries
Take thing.
The preparation method of described cape jasmine flower extract is：Gardenia is taken, the water of 5 times of amounts of its weight is added, is heated to reflux
3h, filtering are extracted, filter residue continuously adds the water of 5 times of amounts of its weight, and heating and refluxing extraction 2h, filtering mixes filtrate, mistake twice
Filter, filtrate is concentrated into the medicinal extract that relative density is 1.2, and medicinal extract then is obtained into cape jasmine flower extract in vacuum drying.
The preparation method of described Flos Osmanthi Fragrantis extract is：Sweet osmanthus is taken, the water of 5 times of amounts of its weight, heating and refluxing extraction is added
3h, filtering, filter residue continuously adds the water of 5 times of amounts of its weight, and heating and refluxing extraction 2h, filtering mixes filtrate twice, filtered, filter
Liquid is concentrated into the medicinal extract that relative density is 1.2, and medicinal extract then is obtained into Flos Osmanthi Fragrantis extract in vacuum drying.
A kind of preparation method of the mouthwash containing sterculia nobilis's berry extract, adds sterculia nobilis's berry extract, peach root in ethanol
Then extract, cape jasmine flower extract, Flos Osmanthi Fragrantis extract, licoflavone, vitamin B, vortex mixed add sweetener and water,
It is well mixed, produce mouthwash.
Embodiment 2
A kind of mouthwash containing sterculia nobilis's berry extract, includes the component of following percentage by weight meter：Sterculia nobilis's berry extract 2.6%,
Peach root extract 1.6%, cape jasmine flower extract 0.5%, Flos Osmanthi Fragrantis extract 1%, licoflavone 0.02%, vitamin B 0.01%, ethanol
6%th, sweetener 0.01%, surplus is water.
The preparation method of described sterculia nobilis's berry extract is as follows：
（1）Take sterculia nobilis fruit to clean, be ground into 100 mesh, and 15min is dried under the conditions of 50 DEG C, add 5 times of weight after fruit is dried
50% ethanol, ultrasonic extraction 10min at 5 DEG C, supersonic frequency is 40-50khz；
（2）By step 1）The feed liquid of acquisition is maintained at 40 DEG C of temperature, and regulation pH is 4, adds weight 0.2% after fruit is dried
After the completion of cellulase degradation 1h, enzymolysis, the pectinase enzymatic hydrolysis 1h of weight 0.2% after fruit is dried is continuously added；；Then adjust
PH is 7.0, and temperature is 45 DEG C, continuously adds the symbol compound protease enzymolysis 5h of weight 0.2% after fruit is dried；
（3）By step（2）The enzymolysis liquid of acquisition goes out after enzyme, filtering, obtains filtrate 1 and filter residue 1, standby；
（4）By step（3）Obtained filter residue 1, adds 65% ethanol of 6 times of its weight, and the 3h extracted at 50 DEG C is filtered, collected
Filtrate 2 and filter residue 2；Continue as stated above, to take filter residue 2, add 65% ethanol of 6 times of its weight, the 3h extracted at 50 DEG C,
Filtering, collects filtrate 3 and filter residue 3；
（5）Merging filtrate 1,2,3, is well mixed, and reclaims mixed liquor centrifugal filtration acquisition filtrate after ethanol, is concentrated into relatively close
The medicinal extract for 1.2 is spent, then medicinal extract is dried in vacuo in vacuum drying chamber at 40 DEG C, sterculia nobilis's berry extract is obtained.
The preparation method of described peach root extract is：Peach root is taken, 70% ethanol of 4 times of amounts of its weight is added, is heated to reflux
2h, filtering are extracted, filter residue continuously adds 70% ethanol of 4 times of amounts of its weight, and heating and refluxing extraction 1h, filtering, mixing is filtered twice
Liquid, reclaims ethanol, filtering, and filtrate is concentrated into the medicinal extract that relative density is 1.1, and medicinal extract then is obtained into peach root in vacuum drying carries
Take thing.
The preparation method of described cape jasmine flower extract is：Gardenia is taken, the water of 4 times of amounts of its weight is added, is heated to reflux
2h, filtering are extracted, filter residue continuously adds the water of 4 times of amounts of its weight, and heating and refluxing extraction 1h, filtering mixes filtrate, mistake twice
Filter, filtrate is concentrated into the medicinal extract that relative density is 1.1, and medicinal extract then is obtained into cape jasmine flower extract in vacuum drying.
The preparation method of described Flos Osmanthi Fragrantis extract is：Sweet osmanthus is taken, the water of 4 times of amounts of its weight, heating and refluxing extraction is added
2h, filtering, filter residue continuously adds the water of 4 times of amounts of its weight, and heating and refluxing extraction 1h, filtering mixes filtrate twice, filtered, filter
Liquid is concentrated into the medicinal extract that relative density is 1.1, and medicinal extract then is obtained into Flos Osmanthi Fragrantis extract in vacuum drying.
A kind of preparation method of the mouthwash containing sterculia nobilis's berry extract, adds sterculia nobilis's berry extract, peach root in ethanol
Then extract, cape jasmine flower extract, Flos Osmanthi Fragrantis extract, licoflavone, vitamin B, vortex mixed add sweetener and water,
It is well mixed, produce mouthwash.
Embodiment 3
A kind of mouthwash containing sterculia nobilis's berry extract, includes the component of following percentage by weight meter：Sterculia nobilis's berry extract 3.6%,
Peach root extract 2.3%, cape jasmine flower extract 1.2%, Flos Osmanthi Fragrantis extract 2%, licoflavone 0.4%, vitamin B 0.3%, ethanol
11%th, sweetener 0.1%, surplus is water.
The preparation method of described sterculia nobilis's berry extract is as follows：
（1）Take sterculia nobilis fruit to clean, be ground into 140 mesh, and 30min is dried under the conditions of 50 DEG C, add weight 10 after fruit is dried
60% ethanol again, the ultrasonic extraction 20min at 10 DEG C, supersonic frequency is 50khz；
（2）By step 1）The feed liquid of acquisition is maintained under temperature 50 C, and regulation pH is 6, adds weight 0.3% after fruit is dried
After the completion of cellulase degradation 2h, enzymolysis, the pectinase enzymatic hydrolysis 2h of weight 0.2% after fruit is dried is continuously added；Then pH is adjusted
For 7.0, temperature is 50 DEG C, continuously adds the symbol compound protease enzymolysis 7h of weight 0.1% after fruit is dried；
（3）By step（2）The enzymolysis liquid of acquisition goes out after enzyme, filtering, obtains filtrate 1 and filter residue 1, standby；
（4）By step（3）Obtained filter residue 1, adds 85% ethanol of 6-10 times of its weight, and the 4h extracted at 80 DEG C is filtered,
Collect filtrate 2 and filter residue 2；Continue as stated above, to take filter residue 2, add 85% ethanol of 10 times of its weight, extracted at 80 DEG C
4h, filtering collects filtrate 3 and filter residue 3；
（5）Merging filtrate 1,2,3, is well mixed, and reclaims mixed liquor centrifugal filtration acquisition filtrate after ethanol, is concentrated into relatively close
The medicinal extract for 1.2 is spent, then medicinal extract is dried in vacuo in vacuum drying chamber at 50 DEG C, sterculia nobilis's berry extract is obtained.
The preparation method of described peach root extract is：Peach root is taken, 85% ethanol of 6 times of amounts of its weight is added, is heated to reflux
3h, filtering are extracted, filter residue continuously adds 85% ethanol of 6 times of amounts of its weight, and heating and refluxing extraction 2h, filtering, mixing is filtered twice
Liquid, reclaims ethanol, filtering, and filtrate is concentrated into the medicinal extract that relative density is 1.2, and medicinal extract then is obtained into peach root in vacuum drying carries
Take thing.
The preparation method of described cape jasmine flower extract is：Gardenia is taken, the water of 6 times of amounts of its weight is added, is heated to reflux
3h, filtering are extracted, filter residue continuously adds the water of 6 times of amounts of its weight, and heating and refluxing extraction 2h, filtering mixes filtrate, mistake twice
Filter, filtrate is concentrated into the medicinal extract that relative density is 1.2, and medicinal extract then is obtained into cape jasmine flower extract in vacuum drying.
The preparation method of described Flos Osmanthi Fragrantis extract is：Sweet osmanthus is taken, the water of 6 times of amounts of its weight, heating and refluxing extraction is added
3h, filtering, filter residue continuously adds the water of 6 times of amounts of its weight, and heating and refluxing extraction 2h, filtering mixes filtrate twice, filtered, filter
Liquid is concentrated into the medicinal extract that relative density is 1.2, and medicinal extract then is obtained into Flos Osmanthi Fragrantis extract in vacuum drying.
A kind of preparation method of the mouthwash containing sterculia nobilis's berry extract, adds sterculia nobilis's berry extract, peach root in ethanol
Then extract, cape jasmine flower extract, Flos Osmanthi Fragrantis extract, licoflavone, vitamin B, vortex mixed add sweetener and water,
It is well mixed, produce mouthwash.
Test example
1st, halitosis is classified
Halitosis is divided into six grades using direct smell method (direct sniffing-organoleptic method), it is at different levels
Standard be respectively：
One-level：Without halitosis；Two grades：Very slight halitosis；Three-level：Slight halitosis；Level Four：Moderate halitosis；Pyatyi：Strong mouth
It is smelly；Six grades：Halitosis strongly.
2. test mouthwash
Test group：Use the mouth rinse for removing halitosis of embodiment 1；
Control group：Reference substance mouthwash comprising embodiment 1 except sterculia nobilis's berry extract, peach root extract, cape jasmine flower extract,
Other all components outside Flos Osmanthi Fragrantis extract.
3. test method and result
There is the volunteer of level Four or more halitosis with the mouth rinse for removing halitosis of embodiment 1 and control group mouthwash 30 seconds,
Again halitosis classified estimation is received after 2 hours.It is effective that rank, which reduces by two grades or more persons,；It is effective to reduce one-level person；Without change
Change person is invalid.Halitosis rank value of the volunteer before and after gargling is made pairing t- and examined.
Test group result shows that in 100 volunteers gargled using the mouth rinse for removing halitosis of embodiment 1, effective person is
95 people (95%), responder be 5 people (5%), the people of nonresponder 0 (0%), total effective rate is 100%.Match t- and examine knot
Fruit has conspicuousness (P ＜ 0.01).
Control group result shows that, using in 87 volunteers of reference substance mouthwash, effective person is 46 people
(52.9%), responder be 33 people (37.9%), the people of nonresponder 8 (5.7%), total effective rate is 90.8%.Match t- and examine knot
Fruit has conspicuousness (P ＜ 0.01).
4. conclusion
Volunteer through two groups of experiments investigates display, and compared to control group, the halitosis elimination effect of test group volunteer is more notable,
The oral inflammation such as periodontitis has clear improvement simultaneously, and taste is more easy to be received.
Using embodiment 1-3 mouth rinse for removing halitosis, by above-mentioned identical experiment, discovery can also reach good halitosis
Elimination effect, specific data are omitted.
Using anti-inflammatory embodiment
1 materials and methods
1.2 animals, material and reagent
Healthy male mice in kunming（20 ± 2g of weight）, healthy male Wistar rat（180 ± 20g of weight）Purchase
Bordered on the river Pharmaceutical Technology Co., Ltd in Anhui length.
Mouthwash containing sterculia nobilis's berry extract：Prepared by the formula according to embodiment 1；
Evans blue：China Medicine (Group) Shanghai Chemical Reagent Co., lot number F20100913；
Glacial acetic acid：Xuzhou chemical plant, lot number 820809；
Dimethylbenzene：Shanghai chemical reagent work of Jian Xin Chemical Co., Ltd.s, lot number HG-31011-76.
1.2 instrument and equipment
FA2104B electronic analytical balances：Shanghai Yue Ping scientific instrument Co., Ltd；TU-1810 ultraviolet-uisible spectrophotometers：
Beijing Puxi General Instrument Co., Ltd；TG16-WS table model high speed centrifuges：The limited public affairs of Changsha Hunan instrument centrifuge instrument
Department.PV-200 type vola pedis capacity measurers：Chengdu TME Technology Co., Ltd..
1.3 method
1.3.1 the mouthwash paraxylene of embodiment 1 causes the influence of mice auricle swelling
Mouse 40 is taken, the mouthwash group of 5 groups, i.e. embodiment 1 is randomly divided into, without 4 kinds of extract groups, without licoflavone group
And blank control group, every group 10.Gastric infusion, continuous 5d, gavage capacity is 30mL/kg body weight, and blank control group, which gives to wait, to be held
The physiological saline of amount.30min after last coating, dimethylbenzene 0.05mL causes are smeared inside and outside every mouse right ear exterior feature
Inflammation, left ear, which is not applied, to be compared.30min after dimethylbenzene is smeared, cervical dislocation puts to death mouse, a left side is cut with scissors along auricle baseline
Right two ears, lay ears corresponding site auricle with diameter 8mm card punch, weigh, record data, using two auricle weight differences as
Auricle swelling degree, calculates swelling and suppresses percentage.Auricle swelling degree=auris dextra exterior feature weight-left auricle weight, swelling suppresses percentage（%）
=[（Blank control group auricle swelling degree-administration group auricle swelling degree）/ blank control group auricle swelling degree] × 100.
1.3.2 the mouthwash of embodiment 1 causes the influence that mouse peritoneal capillary permeability increases to glacial acetic acid
Male and healthy mouse 40 is taken, the mouthwash group of 4 groups, i.e. embodiment 1 is randomly divided into, without 4 kinds of extract groups, without sweet
Straw colour ketone group and blank control group, every group 10.Gastric infusion, continuous 5d, administration capacity is 30mL/kg body weight, blank pair
According to group to the physiological saline for waiting capacity.30min after last dose, the respectively Yi Wen to every mouse tail vein injection 0.5%
Think indigo plant 10mL/kg, and the acetic acid 10mL/kg of intraperitoneal injection 0.6% immediately.Cervical dislocation puts to death mouse after 30min, uses 6mL
Normal saline flushing abdominal cavity, drawing wash liquid, 3600r/min centrifugation 10min take supernatant to survey absorbance at 590nm
（A）, mouse peritoneal capillary permeability is judged according to Evans blue content in peritoneal fluid.
1.4 results are counted and processing
As a result useRepresent, data statistics uses SPSS17.0FOR WINDOWS software processings, multigroup is compared and adopt
Use one-way analysis of variance.
2 results
The mouthwash paraxylene of 2.1 embodiments 1 causes the influence of mice auricle swelling
As shown in Table 1, the mouthwash group group of embodiment 1 can significantly inhibit the mice auricle swelling as caused by dimethylbenzene, with sky
White control group compares with significant difference（P<0.01）.The mouthwash group auricle edema inhibiting rate of embodiment 1 is 52.29%, its
Inhibitory action is significantly stronger than without 4 kinds of extract groups and without licoflavone group.
Table 1
Note：Compared with blank control group：** P<0.01：Compared with the mouthwash group of embodiment 1：△P<0.01.
The mouthwash of 2.2 embodiments 1 causes the influence that mouse peritoneal capillary permeability increases to glacial acetic acid
As shown in Table 2, the mouthwash group of embodiment 1, without 4 kinds of extract groups, without licoflavone group mouse peritoneal flushing liquor
Absorbance is significantly reduced, and is compared with blank control group with significant difference, and the mouthwash group of embodiment 1 is significantly stronger than and is free of
4 kinds of extract groups and without licoflavone group.
Table 2
Presently preferred embodiments of the present invention is the foregoing is only, all equivalent changes done according to scope of the present invention patent are with repairing
Decorations, should all belong to the covering scope of the present invention.
Claims (7)
1. a kind of mouthwash containing sterculia nobilis's berry extract, it is characterised in that：Include the component of following percentage by weight meter：Sterculia nobilis
Berry extract 2.6-3.6%, peach root extract 1.6-2.3%, cape jasmine flower extract 0.5-1.2%, Flos Osmanthi Fragrantis extract 1-2%, radix glycyrrhizae
Flavones 0.02-0.4%, vitamin B 0.01-0.3%, ethanol 6-11%, sweetener 0.01-0.1%, surplus is water.
2. a kind of mouthwash containing sterculia nobilis's berry extract according to claim 1, it is characterised in that：Described sterculia nobilis fruit
The preparation method of extract is as follows：
（1）Take sterculia nobilis fruit to clean, be ground into 100-140 mesh, and 15-30min is dried under the conditions of 50 DEG C, add after fruit drying
The 50-60% ethanol of 5-10 times of weight, the ultrasonic extraction 10-20min at 5-10 DEG C, supersonic frequency is 40-50khz；
（2）By step 1）The feed liquid of acquisition is maintained at 40-50 DEG C of temperature, and regulation pH is 4-6, adds weight after fruit is dried
After the completion of 0.1-0.3% cellulase degradation 1-2h, enzymolysis, the pectase of weight 0.1-0.2% after fruit is dried is continuously added
Digest 1-2h；Then regulation pH is 7.0, and temperature is 45-50 DEG C, and the symbol for continuously adding weight 0.1-0.2% after fruit is dried is combined
Protease hydrolyzed 5-7h；
（3）By step（2）The enzymolysis liquid of acquisition goes out after enzyme, filtering, obtains filtrate 1 and filter residue 1, standby；
（4）By step（3）Obtained filter residue 1, adds the 65-85% ethanol of 6-10 times of its weight, the 3- extracted at 50-80 DEG C
Filtrate 2 and filter residue 2 are collected in 4h, filtering；Continue as stated above, to take filter residue 2, add the 65-85% ethanol of 6-10 times of its weight,
Filtrate 3 and filter residue 3 are collected in the 3-4h extracted at 50-80 DEG C, filtering；
（5）Merging filtrate 1,2,3, is well mixed, and reclaims mixed liquor centrifugal filtration acquisition filtrate after ethanol, is concentrated into relatively close
The medicinal extract for 1.0-1.2 is spent, then medicinal extract is dried in vacuo in vacuum drying chamber at 40-50 DEG C, sterculia nobilis's berry extract is obtained.
3. a kind of mouthwash containing sterculia nobilis's berry extract according to claim 1, it is characterised in that：Described peach root is carried
The preparation method for taking thing is：Peach root is taken, the 70-85% ethanol that 4-6 times of its weight is measured is added, heating and refluxing extraction 2-3h is filtered,
Filter residue continuously adds the 70-85% ethanol that 4-6 times of its weight is measured, and heating and refluxing extraction 1-2h, filtering mixes filtrate twice, reclaimed
Ethanol, filtering, filtrate is concentrated into the medicinal extract that relative density is 1.1-1.2, and medicinal extract then is obtained into peach root in vacuum drying extracts
Thing.
4. a kind of mouthwash containing sterculia nobilis's berry extract according to claim 1, it is characterised in that：Described gardenia
The preparation method of extract is：Gardenia is taken, the water that 4-6 times of its weight is measured, heating and refluxing extraction 2-3h, filtering, filter residue is added
The water that 4-6 times of its weight is measured is continuously added, heating and refluxing extraction 1-2h, filtering mixes filtrate twice, and filtering, filtrate is concentrated into
Relative density is 1.1-1.2 medicinal extract, and medicinal extract then is obtained into cape jasmine flower extract in vacuum drying.
5. a kind of mouthwash containing sterculia nobilis's berry extract according to claim 1, it is characterised in that：Described sweet osmanthus carries
The preparation method for taking thing is：Sweet osmanthus is taken, the water that 4-6 times of its weight is measured is added, heating and refluxing extraction 2-3h, filtering, filter residue continues
The water that 4-6 times of its weight is measured is added, heating and refluxing extraction 1-2h, filtering mixes filtrate twice, and filtering, filtrate is concentrated into relatively
Density is 1.1-1.2 medicinal extract, and medicinal extract then is obtained into Flos Osmanthi Fragrantis extract in vacuum drying.
6. a kind of mouthwash containing sterculia nobilis's berry extract according to claim 1, it is characterised in that：Including following weight
The component of percentages：It is sterculia nobilis's berry extract 3%, peach root extract 2%, cape jasmine flower extract 1.0%, Flos Osmanthi Fragrantis extract 1.5%, sweet
Straw colour ketone 0.2%, vitamin B 0.1%, ethanol 7%, sweetener 0.02%, surplus is water.
7. a kind of preparation method of the mouthwash containing sterculia nobilis's berry extract as claimed in claim 1, it is characterised in that：Including
Following steps：It is yellow that sterculia nobilis's berry extract, peach root extract, cape jasmine flower extract, Flos Osmanthi Fragrantis extract, radix glycyrrhizae are added in ethanol
Then ketone, vitamin B, vortex mixed add sweetener and water, is well mixed, produces mouthwash.
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Application publication date: 20171103 |