CN105233061A - Compound traditional Chinese medicine mouth water - Google Patents
Compound traditional Chinese medicine mouth water Download PDFInfo
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- CN105233061A CN105233061A CN201510764177.3A CN201510764177A CN105233061A CN 105233061 A CN105233061 A CN 105233061A CN 201510764177 A CN201510764177 A CN 201510764177A CN 105233061 A CN105233061 A CN 105233061A
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Abstract
The invention discloses compound traditional Chinese medicine mouth water, and relates to the technical field of mouth care products. According to the scheme, the total composition of the mouth water comprises compound traditional Chinese medicine ingredients prepared from, by weight, 0.5%-10.0% of fresh bamboo sap, 0.1%-3.0% of radix zanthoxyli extract and 0.1%-1.0% of geniposide. Compared with the prior art, the traditional Chinese medicine compound scheme is adopted, the traditional Chinese medicine ingredients are more effective, the better hemostasis, anti-inflammatory and analgesia effects can be achieved, the taste is better, the oral cavity discomfort symptoms of people are relieved, and the good micro-ecology of the oral cavity is kept.
Description
Technical field
The present invention relates to oral care product technical field, especially a kind of herbal mixture collutory with assisting in preventing and treating gingivitis and gingival hemorrhage.
Background technology
Collutory is the oral-cavity article that people's daily life cleans and keeps healthy, and is mainly used in keeping oral cavity and cleaning of teeth, promotion breath freshening, nurses gingiva, safeguards the good microenvironment in oral cavity etc.
Gingivitis, hemorrhage, gingival swelling and pain are typical periodontal symptoms, and according to statistics, the state-owned crowd of 97 percent exists periodontal, and periodontal is the one of the main reasons that more than 35 years old crowd loses tooth.Improve oral healthy condition and become the important and difficult task of China's oral hygiene one.
Gingivitis is common periodontal tissue disease.Be owing to not noting oral hygiene, tooth is subject to the long-time stimulus caused by tartar of soft tartar that the things such as around teeth food debris, antibacterial form and hard, and incorrect tooth-brushing habit, and the reasons such as vitamin deficiency caused.35 years old ~ 44 years old age bracket crowd periodontal health rate in the whole nation is 14.5%, and city is higher than rural area, and women is higher than male, and west area is the highest; Gingival hemorrhage recall rate is 77.3%, has the tooth number of gingival hemorrhage to be 8.77 per capita, women higher than male, town and country zero difference, middle part is the highest; Periodontal pocket recall rate is 40.9%, and city is lower than rural area, and male is higher than women, and middle part is the highest; The recall rate that attachment loss is equal to or greater than 4 millimeters is 38.9%, and male is higher than women, and town and country zero difference, eastern region is the highest.
Therefore, develop and aly there is prevention of gingivitis and be aided with the herbal mixture collutory of inflammation-diminishing function, for alleviation people oral cavity malaise symptoms, keep the good Tiny ecosystem in oral cavity, slow down the aspects such as human communication pressure, significant.
Summary of the invention
Problem to be solved by this invention is to provide one to be had and effectively can alleviate gingival hemorrhage, the herbal mixture collutory of gingival swelling and pain, inflammation.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: include the compound Chinese herbal medicinal ingredients be made up of fresh Succus Bambusae, Radix Zanthoxyli extract and jasminoidin in its collutory total composition, the percentage by weight of described fresh Succus Bambusae in collutory total composition is 0.5-10.0%, the percentage by weight of described Radix Zanthoxyli extract in collutory total composition is 0.1-3.0%, and the percentage by weight of described jasminoidin in collutory total composition is 0.1-1.0%.
In technique scheme, scheme can also be more specifically: the juice that described fresh Succus Bambusae is phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle baking and discharges, and described Radix Zanthoxyli extract is Radix Zanthoxyli ethanol extraction, and described jasminoidin is plant fruit of Fructus Gardeniae extract.
Fresh Succus Bambusae of the present invention is the juice that bamboo extracts after processing, and have effect of resolving heat and reducing pathogenic fire, sliding expectorant profit key, " Mingyi Bielu " is recorded: treat aphtha ophthalmalgia, improving eyesight, sharp nine orifices.
Jasminoidin of the present invention is the product using high-tech production technology Hydrolysis kinetics from the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.Jasminoidin is iridoid glycoside compounds, different name geniposide, all Fructus Armeniacae Mume element glucoside geniposide.Jasminoidin has cathartic, analgesia, function of gallbladder promoting, antiinflammatory, treatment soft tissue injury and suppresses gastric secretion and reduce the effects such as pancreatic amylase.
The said Radix Zanthoxyli of the present invention is the dry root of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxb.) DC., bitter in the mouth, pungent, and property is put down.There is the effects such as blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling wind and removing obstruction in the collateral, removing toxic substances and promoting subsidence of swelling, can be used for injury from falling down, stomachache, toothache, rheumatic arthralgia etc.Radix Zanthoxyli has another name called Radix Zanthoxyli, climing green pepper, two-sided pin, two dorsal stylets etc., and head is loaded in Shennong's Herbal, is classified as low-grades, records in book: " climing green pepper bitter in the mouth, warm in nature, cure mainly anemofrigid-damp arthralgia, acute arthralgia, except extremity Primordial Qi, gonalgia ".Compendium of Material Medica income fruit portion taste class, " south of the Five Ridges gather medicinal herbs record " is recorded " Radix Zanthoxyli reason traumatic injury and snakebite; suffer from toothache; decoct water rinsing the mouth ", " Hunan medicine will " records " the passive dispelling, collateral-activating of Radix Zanthoxyli; eliminating stasis to stop pain; removing toxic substances and promoting subsidence of swelling ", " national Chinese herbal medicine compilation " is recorded " Radix Zanthoxyli is invigorated blood circulation, narcotic analgesic; cure mainly neuralgia, pain, laryngopharynx swelling and pain that taste-blindness rate, gastrointestinal angor, biliary ascariasis cause; and for mucocutaneous anesthesia ", " Luchuan book on Chinese herbal medicine " carries " synthetism, detumescence; pain relieving, blood stasis removing.Control injury and bone fracture, damage is swollen and ache, rheumatic ostalgia, heart peratodynia, toothache.And treating snakebite ".The two sides crown of getting among the people is appropriate, is decocted in water for oral dose or levigation is taken after mixing it with water, for controlling headache, toothache etc.
The present invention, compared with existing collutory, has following beneficial effect:
Herbal mixture collutory of the present invention, employing be Chinese medicine compounded technology, Chinese medicine ingredients is more effective, and can play the effects such as better hemostasis, antiinflammatory and analgesia, mouthfeel is better, alleviates people oral cavity malaise symptoms, keeps the good Tiny ecosystem in oral cavity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, and in following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
Collutory constitutive material in embodiment 1 to embodiment 4 and weight percent content are as following table:
In embodiment, first compound Chinese medicine extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol and is placed in temporary pot, sorbitol, deionized water and castor oil hydrogenated-40 is added in agitated kettle and stir 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stir 10 minutes, finally add essence and stir 5 minutes, stop stirring, make after sampling detection is qualified.
clinical trial part:
The pharmacological evaluation of the hemostasis of herbal mixture collutory, analgesia, antiinflammatory action
One, to the anastalsis of rabbit liver local woanded surface bleeding due to trauma
(1).
Get healthy white rabbit 30, body weight 2.0 ~ 2.5kg, male and female dual-purpose.Slowly inject with 3% pentobarbital sodium 30mg/kg auricular vein, after family's rabbit anesthesia, lie on the back and be fixed on operating-table, abdominal part median incision is about 6 ~ 8cm, exposes and fixes liver, cuts liver organization be about 1cm with operating scissors at leftlobe of liver, wide about 1cm, height is 1cm about, and wound surface is hemorrhage in spraying sample.After wiping the blood of ejection, immediately in wound surface local, hemorrhage wound surface is spread on outside the hospital gauze sheet (5cm × 7cm-8 layer) after soaking into collutory sample, after skin covers with hospital gauze again, with 200g counterweight compressing 1min, counterweight is removed after 1min, observe haemostatic effect, with not hemorrhage for hemostasis, as still hemorrhage, then add after the hospital gauze sheet of collutory sample is soaked in covering and continue pressurization, observe once every 30s, record bleeding stopping period, as still hemorrhage more than 3min, then be designated as and fail to stop blooding, bleeding stopping period is designated as > 3min.Blank group sample normal saline.After each sample test, wash away residual tested material with 37 DEG C of normal saline, make wound surface again hemorrhage, then test next tested material sample.Every rabbit carries out four liver local woanded surface damage hemostasis test experiments, and the drug of topical application of Latin square program pressed by each tested material sample, to reduce the impact of liver local woanded surface damage otch difference and medication order.Each tested material sample amounts to the hemostasis experiment carrying out 20 rabbit liver local woanded surface bleeding due to traumies.Haemostatic effect is designated as score value F by scoring method reciprocal (10/T), and more than 3min fails to stop blooding, and F is designated as 0 without score value.Record and carry out statistics t inspection, the results are shown in Table 2.
Table 2 herbal mixture collutory to the haemostatic effect of rabbit liver local woanded surface bleeding due to trauma (
± S)
Note: compare with blank group: ###P < 0.001, ▲ P > 0.05.
Compare with collutory bare substrate group: * * * P < 0.001, △ P > 0.05.
Experimental result shows, herbal mixture collutory group and YUNNAN BAIYAO DING group all have obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, have obvious anastalsis, shows that herbal mixture collutory sample has obvious anastalsis.
Two, to the analgesic activity (hot plate method) of white mice.
Choose body weight 18 ~ 22g healthy Kunming kind ♀ white mice, with GJ-8402 type hot plate dolorimeter, regulable control temperature is at 55 ± 0.5 DEG C, white mice is placed on the pain threshold (white mice contact hot plate is to the time of licking metapedes) hot plate measuring every Mus, allly lick the metapedes time and be less than 5 seconds (S) or be greater than 30 seconds (S) and leaper gives it up, select qualified white mice 60, divide equally 6 groups at random, often organize 10.Blank group, collutory bare substrate group, positive drug YUNNAN BAIYAO DING group, 3 Radix Zanthoxyli Chinese medicine mouth wash groups.Each group of white mice repeats the normal pain threshold that 2 times measure white mice by the same method, and every minor tick 15min, gets twice normal pain threshold meansigma methods, as the pain threshold before this group white mice administration.Be coated with respectively at the sufficient sole of the foot of the every Mus of each treated animal 4 and only give corresponding tested material 0.2ml/, blank group is coated with only gives normal saline 0.2ml/, be coated with 15min, 30min, 45min after giving tested material and measure the pain threshold of white mice by the same method respectively, as still reactionless in white mice 60 seconds (S), white mice is taken out, in order to avoid scald, its pain threshold calculates with 60 seconds (s), record each group of white mice pain threshold, data carry out statistics t inspection, the results are shown in Table 3.
Table 3 herbal mixture collutory to the analgesic activity (hot plate method) of white mice (
± S, n=10)
Note: compare with before administration: * P < 0.05, * * P < 0.01, △ P > 0.05.
Compare with blank group: #P < 0.05, ##P < 0.01, ▲ P > 0.05.
Compare with collutory bare substrate group: aP < 0.05, bP > 0.05.
Experimental result shows, compound recipe collutory group and YUNNAN BAIYAO DING group with before administration and blank group compare, all can significantly improve white mice pain threshold, show that herbal mixture collutory sample has obvious analgesic activity.
Three, xylol causes the antiinflammatory action of white mice auricle acute inflammation swelling.
Choose body weight 18 ~ 22g healthy Kunming kind ♂ white mice 60, divide equally 6 groups at random, often organize 10.Blank group (normal saline 0.1ml/ only), collutory bare substrate group (collutory bare substrate 0.1ml/ only), positive drug YUNNAN BAIYAO DING group (YUNNAN BAIYAO DING 0.1ml/ is only), 3 Radix Zanthoxyli Chinese medicine mouth wash groups (3 Radix Zanthoxyli Chinese medicine mouth wash 0.1ml/ are only).Respectively organize two sides uniform application dimethylbenzene 0.1ml/ inside and outside every animal auris dextra exterior feature during experiment and only cause inflammation, left ear does not add process and does self-blank contrast.After smearing dimethylbenzene 30min, uniform application group tested material sample 0.1ml/ respectively, two sides inside and outside each group every animal auris dextra exterior feature.After giving tested material 1h, white mice cervical dislocation is put to death, cut two auricles, wash away the wide tested material sample of auris dextra with normal saline, dry cotton ball is cleaned, overlapping two auricles, two circle auricles are got at same position cutter with the card punch of internal diameter 8mm, weigh on FA1004 type electronic analytical balance respectively, it is swelling value that auris dextra sheet weight deducts left auricle weight, and data carry out statistics t inspection.The results are shown in Table 4.
The impact of white mice auricle acute inflammation swelling caused by a table 43 Radix Zanthoxyli Chinese medicine mouth wash xylol (
± S, n=10)
Note: compare with blank group: #P < 0.05, ##P < 0.01, ▲ P > 0.05.
Compare with collutory bare substrate group: * P < 0.05, * * P < 0.01, △ P > 0.05.
Experimental result shows, compound recipe collutory group and YUNNAN BAIYAO DING group all can make white mice acute inflammation swelling auricle weight significantly alleviate, white mice auricle acute inflammation swelling caused by obvious suppression dimethylbenzene, shows that herbal mixture collutory sample has obvious antiinflammatory action to acute inflammation.
Claims (2)
1. a herbal mixture collutory, it is characterized in that: in its collutory total composition, include the compound Chinese herbal medicinal ingredients be made up of fresh Succus Bambusae, Radix Zanthoxyli extract and jasminoidin, the percentage by weight of described fresh Succus Bambusae in collutory total composition is 0.5-10.0%, the percentage by weight of described Radix Zanthoxyli extract in collutory total composition is 0.1-3.0%, and the percentage by weight of described jasminoidin in collutory total composition is 0.1-1.0%.
2. herbal mixture collutory according to claim 1, it is characterized in that: the juice that described fresh Succus Bambusae is phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle baking and discharges, described Radix Zanthoxyli extract is Radix Zanthoxyli ethanol extraction, and described jasminoidin is plant fruit of Fructus Gardeniae extract.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510764177.3A CN105233061B (en) | 2015-11-11 | 2015-11-11 | Herbal mixture mouthwash |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726407A (en) * | 2016-03-28 | 2016-07-06 | 两面针（江苏）实业有限公司 | Tooth-bushing assembly and preparation method thereof |
| CN107308058A (en) * | 2017-07-28 | 2017-11-03 | 张可池 | A kind of mouthwash containing sterculia nobilis's berry extract |
| CN107468619A (en) * | 2017-09-14 | 2017-12-15 | 南通荣成医药化工有限公司 | A kind of mouthwash |
| CN114470110A (en) * | 2022-03-31 | 2022-05-13 | 浙江中医药大学 | A Chinese medicinal composition with analgesic effect for treating rhinitis |
| CN114569548A (en) * | 2022-03-03 | 2022-06-03 | 湖南有美生物科技有限公司 | Preparation method of traditional Chinese medicine oral ulcer gargle containing electrostatic spinning fibers |
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| CN101366688A (en) * | 2008-09-23 | 2009-02-18 | 江西诚志日化有限公司 | Sarcandra glabra fresh succus Bambusae toothpaste |
| CN104622708A (en) * | 2015-01-30 | 2015-05-20 | 柳州两面针股份有限公司 | Application of geniposide in preparation of oral care health products |
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Patent Citations (2)
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|---|---|---|---|---|
| CN101366688A (en) * | 2008-09-23 | 2009-02-18 | 江西诚志日化有限公司 | Sarcandra glabra fresh succus Bambusae toothpaste |
| CN104622708A (en) * | 2015-01-30 | 2015-05-20 | 柳州两面针股份有限公司 | Application of geniposide in preparation of oral care health products |
Non-Patent Citations (2)
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726407A (en) * | 2016-03-28 | 2016-07-06 | 两面针（江苏）实业有限公司 | Tooth-bushing assembly and preparation method thereof |
| CN105726407B (en) * | 2016-03-28 | 2018-06-01 | 两面针（江苏）实业有限公司 | A kind of preparation method for combination of brushing teeth |
| CN107308058A (en) * | 2017-07-28 | 2017-11-03 | 张可池 | A kind of mouthwash containing sterculia nobilis's berry extract |
| CN107468619A (en) * | 2017-09-14 | 2017-12-15 | 南通荣成医药化工有限公司 | A kind of mouthwash |
| CN114569548A (en) * | 2022-03-03 | 2022-06-03 | 湖南有美生物科技有限公司 | Preparation method of traditional Chinese medicine oral ulcer gargle containing electrostatic spinning fibers |
| CN114470110A (en) * | 2022-03-31 | 2022-05-13 | 浙江中医药大学 | A Chinese medicinal composition with analgesic effect for treating rhinitis |
| CN114470110B (en) * | 2022-03-31 | 2023-12-19 | 浙江中医药大学 | Anti-rhinitis traditional Chinese medicine composition with pain relieving effect |
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| CN105233061B (en) | 2019-04-02 |
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