CN105233061B - Herbal mixture mouthwash - Google Patents
Herbal mixture mouthwash Download PDFInfo
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- CN105233061B CN105233061B CN201510764177.3A CN201510764177A CN105233061B CN 105233061 B CN105233061 B CN 105233061B CN 201510764177 A CN201510764177 A CN 201510764177A CN 105233061 B CN105233061 B CN 105233061B
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Abstract
The invention discloses herbal mixture mouthwashes, it is related to oral care product technical field, it includes by fresh bamboo sap that its scheme, which is in its mouthwash total composition, the compound Chinese herbal medicinal ingredients of Radix Zanthoxyli extract and Gardenoside composition, weight percent of the fresh bamboo sap in mouthwash total composition is 0.5-10.0%, weight percent of the Radix Zanthoxyli extract in mouthwash total composition is 0.1-3.0%, weight percent of the Gardenoside in mouthwash total composition is 0.1-1.0%, compared with prior art, the present invention is using Chinese medicine compound scheme, traditional Chinese medicine ingredients are more efficient, better hemostasis can be played, anti-inflammatory and analgesia and other effects, mouthfeel is more preferably, alleviate people oral cavity malaise symptoms, keep the good Tiny ecosystem in oral cavity.
Description
Technical field
The present invention relates to oral care product technical fields, especially a kind of to have assisting in preventing and treating gingivitis and bleeding gums
Herbal mixture mouthwash.
Background technique
Mouthwash is the oral-cavity article of people's daily life cleaning and health care, be mainly used for keeping oral cavity and cleaning of teeth,
Promote breath freshening, nursing gum, maintenance good microenvironment in oral cavity etc..
Gingivitis, bleeding, swelling and aching of gum are typical periodontal disease symptoms, and China has 97 percent according to statistics
For crowd there are periodontal disease, periodontal disease is one of the main reason for crowd lost tooth in 35 years old or more.It is strong to improve oral cavity
Health situation has become that China's oral hygiene one important and difficult task.
Gingivitis is common periodontal tissue disease.It is due to not paying attention to oral hygiene, tooth is by food around tooth
Long-time stimulus and incorrect tooth-brushing habit caused by the dental calculus for the soft tartar and hard that the objects such as residue, bacterium are formed,
Caused by the reasons such as hypovitaminosis.35 years old~44 years old age bracket crowd's periodontal health rate in the whole nation is 14.5%, and city is higher than agriculture
Village, women are higher than male, west area highest；Bleeding gums recall rate is 77.3%, and having the tooth number of bleeding gums per capita is 8.77
, women is higher than male, town and country indifference, middle part highest；Oral pocket recall rate is 40.9%, and city is lower than rural area, male
Higher than women, middle part highest；Recall rate of the attachment loss equal to or more than 4 millimeters is 38.9%, and male is higher than women, city
Township's indifference, eastern region highest.
Therefore, a herbal mixture mouthwash that there is prevention of gingivitis and be aided with inflammation-diminishing function is developed, for alleviating people
Oral cavity malaise symptoms, keep the good Tiny ecosystem in oral cavity, slow down human communication pressure etc., be of great significance.
Summary of the invention
To have the problem to be solved by the invention is to provide one kind can be effectively relieved bleeding gums, swelling and aching of gum, inflammation
Herbal mixture mouthwash.
In order to solve the above-mentioned technical problem, the technical scheme adopted by the invention is that: include in its mouthwash total composition
By the compound Chinese herbal medicinal ingredients being made of fresh bamboo sap, Radix Zanthoxyli extract and Gardenoside, the fresh bamboo sap is in mouthwash total composition
In weight percent be 0.5-10.0%, weight percent of the Radix Zanthoxyli extract in mouthwash total composition be
0.1-3.0%, weight percent of the Gardenoside in mouthwash total composition are 0.1-1.0%.
In above-mentioned technical proposal, more specific scheme may also is that the fresh bamboo sap is that henon bamboo is baked with fire and released
Juice, the Radix Zanthoxyli extract are Radix zanthoxyli ethanol extracts, and the Gardenoside is plant cape jasmine berry extract.
Fresh bamboo sap of the present invention is the juice extracted after bamboo is processed, the function with heat-clearing and fire-reducing, sliding phlegm benefit key
Effect, " Mingyi Bielu " are recorded: treating aphtha mesh pain, improving eyesight, sharp nine orifices.
Gardenoside of the present invention is to produce work with high-tech from the dry mature fruit of madder wort cape jasmine
Product made of skill Hydrolysis kinetics.Gardenoside is iridoid glycosides compound, different name geniposide, all plum element glucoside
Geniposide.Gardenoside has laxative, analgesia, cholagogue, anti-inflammatory, treatment soft tissue injury and inhibits gastric secretion and reduction
The effects of amylopsin.
Radix zanthoxyli described in the present invention is the dry of rutaceae Radix zanthoxyli Zanthoxylum nitidum (Roxb.) DC.
It is dry, bitter, pungent, it is mild-natured.With activating microcirculation and removing stasis medicinal, promoting qi circulation and relieving pain, dispelling wind and removing obstruction in the meridians, removing toxicity for detumescence and other effects, it can be used for falling and flutter damage
Wound, stomachache, toothache, rheumatic arthralgia etc..Radix zanthoxyli also known as shinyleaf pricklyash root, climing green pepper, two-sided needle, double dorsal stylets etc., first recorded in " legendary god of farming's sheet
Grass warp ", low-grades are classified as, are recorded in book: " climing green pepper bitter, it is warm-natured, wind-cold-dampness arthralgia is cured mainly, acute arthralgia removes four limbs Primordial Qi, goinyalgia ".
Compendium of Material Medica takes in fruit portion taste class, and " south of the Five Ridges gather medicinal herbs record " records " Radix zanthoxyli manages bruise and snakebite, suffers from toothache, decoct water contain gargles ",
" Hunan drug will " records " the passive dispelling, collateral-activating of Radix zanthoxyli, removing blood stasis and acesodyne, removing toxicity for detumescence ", and " national Chinese herbal medicine compilation " is recorded
" Radix zanthoxyli promoting blood circulation, narcotic analgesic cure mainly pain caused by neuralgia, taste-blindness rate, stomach and intestine colic pain, biliary ascariasis
Bitterly, abscess of throat, and it is used for mucocutaneous anesthesia ", " Luchuan book on Chinese herbal medicine " carries " synthetism, detumescence, analgesic, stasis eliminatings.Injury and bone fracture is controlled,
Damage swelling and pain, treating rheumatic ostealgia, heart and stomach pain, toothache.And treating snakebite ".It is civil to take the two sides crown appropriate, it is decocted in water for oral dose or levigation rushes
Clothes, for controlling headache, toothache etc..
The present invention has the following beneficial effects: compared with existing mouthwash
Herbal mixture mouthwash of the invention, using Chinese medicine compounded technology, traditional Chinese medicine ingredients are more efficient, can play more
Hemostasis well, anti-inflammatory and analgesia and other effects, mouthfeel more preferably, alleviate people oral cavity malaise symptoms, keep the good Tiny ecosystem in oral cavity.
Specific embodiment
Below with reference to embodiment, the present invention will be further described, in following examples, related percentage unless
It is otherwise noted, is calculated in weight percent.
Mouthwash constitutive material and weight percent content in embodiment 1 to embodiment 4 are as follows:
In embodiment, stirring and dissolving in edible ethanol first is added in compound Chinese medicine extract, nipalgin mixed ester sodium and is placed on
In temporary pot, sorbierite, deionized water and rilanit special -40 are added in agitated kettle and stirred 10 minutes, it will be in temporary pot
Ethanol solution is added in agitated kettle and stirs 10 minutes, is eventually adding essence and stirs 5 minutes, stops stirring, after sample detection is qualified
It is made.
Clinical test part:
The hemostasis of herbal mixture mouthwash, analgesia, anti-inflammatory effect pharmacological evaluation
One, to the anastalsis of rabbit liver local woanded surface bleeding due to trauma(1)。
Healthy white rabbit 30,2.0~2.5kg of weight are taken, male and female dual-purpose.With 3% yellow Jackets 30mg/kg ear edge
Vein is slowly injected into, and after family's rabbit anesthesia, is lain on the back and is fixed on operating table, and abdomen median incision is about 6~8cm, and exposure is simultaneously fixed
Liver cuts liver organization in left lobe of liver with operating scissors and is about 1cm, wide about 1cm, high about 1cm, and the surface of a wound is in injection sample bleeding.It wipes
After removing the blood sprayed, immediately in surface of a wound part, it is applied with the hospital gauze piece (8 layers of 5cm × 7cm -) being impregnated with after gargling water sample
In the bleeding surface of a wound, after outer layer is covered with hospital gauze again, 1min is oppressed with 200g counterweight, counterweight, observation hemostasis are removed after 1min
Effect, with not bleeding be hemostasis, such as still bleeding, then plus covering be impregnated with the hospital gauze piece for water sample of gargling after continue to pressurize, often
It is primary every 30s observation, it records bleeding stopping period and is then denoted as such as more than 3min still bleeding and fails to stop blooding, bleeding stopping period is denoted as >
3min.Blank control group sample physiological saline.After each sample test, residual tested material is washed away with 37 DEG C of physiological saline, is made
Surface of a wound bleeding again, the lower tested material sample of re-test.It is real that every rabbit carries out four liver local woanded surface damage hemostasis tests
It tests, each tested material sample presses the topical application of drug of Latin equation, to reduce the shadow of liver local woanded surface damage notch difference and medication sequence
It rings.Each tested material sample amounts to the hemostasis experiment for carrying out 20 rabbit liver local woanded surface bleeding due to trauma.Haemostatic effect is by inverse
Point-score (10/T) is denoted as score value F, and 3min or more fails to stop blooding, and F is denoted as 0 without score value.Statistics t inspection is recorded and carried out, is tied
Fruit is shown in Table 2.
2 herbal mixture mouthwash of table to the haemostatic effect of rabbit liver local woanded surface bleeding due to trauma (± S)
Note: compared with blank control group: ### P < 0.001, ▲ P > 0.05.
Compared with mouthwash bare substrate group: * * * P < 0.001, △ P > 0.05.
The experimental results showed that herbal mixture mouthwash group and YUNNAN BAIYAO DING group are to rabbit liver local woanded surface bleeding due to trauma
There is apparent haemostatic effect, there is apparent anastalsis, shows that herbal mixture gargles water sample with apparent anastalsis.
Two, to the analgesic activity of small white mouse (hot plate method).
18~22g of weight health Kunming kind ♀ small white mouse is chosen, with 8402 type hot plate pain threshold detector of GJ-, adjusts control temperature
At 55 ± 0.5 DEG C, small white mouse is placed on to the pain threshold (small white mouse contacts hot plate to the time for licking metapedes) that every mouse is measured on hot plate,
It is all to lick the metapedes time less than 5 seconds (S) or be greater than 30 seconds (S) and leaper and give it up, select qualified small white mouse 60, it is random
Divide 6 groups, every group 10.Blank control group, mouthwash bare substrate group, positive drug YUNNAN BAIYAO DING group, 3 Radix zanthoxyli Chinese medicines are gargled
Saliva group.Each group small white mouse is repeated 2 times the normal pain threshold of measurement small white mouse by the same method, and every minor tick 15min takes two subnormal
Pain threshold average value, the pain threshold before being administered as this group of small white mouse.Respectively at the 4 vola pedis painting of the every mouse of groups of animals give accordingly by
Try object 0.2ml/ only, blank control group painting gives physiological saline 0.2ml/ only, and 15min, 30min, 45min are by same after tested material is given in painting
Method measures the pain threshold of small white mouse respectively, and if small white mouse 60 seconds (S) are still reactionless, small white mouse is taken out, in order to avoid scald, the threshold of pain
Value was calculated with 60 seconds (s), recorded each group small white mouse pain threshold, and data carry out statistics t inspection, the results are shown in Table 3.
3 herbal mixture mouthwash of table to the analgesic activity (hot plate method) of small white mouse (± S, n=10)
Note: compared with before administration: * P < 0.05, * * P < 0.01, △ P > 0.05.
Compared with blank control group: #P < 0.05, ##P < 0.01, ▲ P > 0.05.
Compared with mouthwash bare substrate group: a P < 0.05, b P > 0.05.
The experimental results showed that compound mouthwash group and YUNNAN BAIYAO DING group with before administration and compared with blank control group, equal energy
Small white mouse pain threshold is significantly improved, shows that herbal mixture gargles water sample with apparent analgesic activity.
Three, paraxylene causes the anti-inflammatory effect of small white mouse auricle acute inflammation swelling.
18~22g of weight health Kunming kind ♂ small white mouse 60 is chosen, it is random to divide equally 6 groups, every group 10.Blank control group
(physiological saline 0.1ml/ is only), mouthwash bare substrate group (mouthwash bare substrate 0.1ml/ is only), positive drug YUNNAN BAIYAO DING
Group (YUNNAN BAIYAO DING 0.1ml/only), 3 Radix zanthoxyli Chinese medicine mouth wash groups (3 Radix zanthoxyli Chinese medicine mouth wash 0.1ml/ are only).It is real
Dimethylbenzene 0.1ml/cause inflammation is uniformly smeared on two sides inside and outside every animal auris dextra exterior feature of each group when testing, and left ear is untreated to make itself
Blank control.After smearing dimethylbenzene 30min, each group tested material sample is uniformly smeared on two sides respectively inside and outside every animal auris dextra exterior feature of each group
Product 0.1ml/ is only.After giving tested material 1h, small white mouse cervical dislocation is put to death, and cuts two auricles, washes away auris dextra exterior feature with physiological saline
Tested material sample, dry cotton ball are cleaned, and two auricles are overlapped, and take two circle auricles in same position chisel with the punch of internal diameter 8mm, respectively
It weighs on FA1004 type electronic analytical balance, it is swelling value that auris dextra sheet weight, which subtracts left auricle weight, and data carry out statistics t
It examines.It the results are shown in Table 4.
Small white mouse auricle acute inflammation swelling caused by 43 Radix zanthoxyli Chinese medicine mouth wash paraxylene of table influence (±
S, n=10)
Note: compared with blank control group: #P < 0.05, ##P < 0.01, ▲ P > 0.05.
Compared with mouthwash bare substrate group: * P < 0.05, * * P < 0.01, △ P > 0.05.
The experimental results showed that compound mouthwash group and YUNNAN BAIYAO DING group can make small white mouse acute inflammation swelling auricle weight
Amount is significant to be mitigated, hence it is evident that is inhibited small white mouse auricle acute inflammation swelling caused by dimethylbenzene, is shown that herbal mixture is gargled water sample pair
Acute inflammation has apparent anti-inflammatory effect.
Claims (2)
1. a kind of herbal mixture mouthwash, it is characterised in that: include to be mentioned by fresh bamboo sap, Radix zanthoxyli in its mouthwash total composition
Take what object and Gardenoside formed there is hemostasis, anti-inflammatory and analgesic activity compound Chinese herbal medicinal ingredients, the fresh bamboo sap is total in mouthwash
Weight percent in composition is 0.5-10.0%, weight percent of the Radix Zanthoxyli extract in mouthwash total composition
Than for 0.1-3.0%, weight percent of the Gardenoside in mouthwash total composition is 0.1-1.0%.
2. herbal mixture mouthwash according to claim 1, it is characterised in that: the fresh bamboo sap is that henon bamboo is baked with fire and released
The juice of releasing, the Radix Zanthoxyli extract are Radix zanthoxyli ethanol extracts, and the Gardenoside is plant cape jasmine berry extract.
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| CN201510764177.3A CN105233061B (en) | 2015-11-11 | 2015-11-11 | Herbal mixture mouthwash |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105726407B (en) * | 2016-03-28 | 2018-06-01 | 两面针（江苏）实业有限公司 | A kind of preparation method for combination of brushing teeth |
| CN107308058A (en) * | 2017-07-28 | 2017-11-03 | 张可池 | A kind of mouthwash containing sterculia nobilis's berry extract |
| CN107468619A (en) * | 2017-09-14 | 2017-12-15 | 南通荣成医药化工有限公司 | A kind of mouthwash |
| CN114470110B (en) * | 2022-03-31 | 2023-12-19 | 浙江中医药大学 | Anti-rhinitis traditional Chinese medicine composition with pain relieving effect |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366688A (en) * | 2008-09-23 | 2009-02-18 | 江西诚志日化有限公司 | Sarcandra glabra fresh bamboo drop toothpaste |
| CN104622708A (en) * | 2015-01-30 | 2015-05-20 | 柳州两面针股份有限公司 | Application of geniposide in preparation of oral care health products |
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2015
- 2015-11-11 CN CN201510764177.3A patent/CN105233061B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366688A (en) * | 2008-09-23 | 2009-02-18 | 江西诚志日化有限公司 | Sarcandra glabra fresh bamboo drop toothpaste |
| CN104622708A (en) * | 2015-01-30 | 2015-05-20 | 柳州两面针股份有限公司 | Application of geniposide in preparation of oral care health products |
Non-Patent Citations (2)
| Title |
|---|
| 含两面针的漱口液;黄光伟;《牙膏工业》;20020228;第32页第二节第1小节和第34页第五节 |
| 鲜竹沥在婴儿肺炎口腔护理中的作用;徐兰花;《张家口医学院学报》;19951231;第160页右栏第2段 |
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