CN104644845B - Herbal mixture toothpaste - Google Patents
Herbal mixture toothpaste Download PDFInfo
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- CN104644845B CN104644845B CN201310664664.3A CN201310664664A CN104644845B CN 104644845 B CN104644845 B CN 104644845B CN 201310664664 A CN201310664664 A CN 201310664664A CN 104644845 B CN104644845 B CN 104644845B
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- radix zanthoxyli
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- salicin
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Abstract
The present invention discloses a kind of herbal mixture toothpaste, the herbal mixture functional component that weight ratio is 0.33 ~ 1.10% is included in its lotion of toothpaste total composition, the herbal mixture functional component is salicin, Radix Zanthoxyli extract, both herbal function composition salicins：The ratio of Radix Zanthoxyli extract is 1:10, in the lotion of toothpaste total composition, percentage by weight >=0.03% of the salicin in lotion of toothpaste total composition, percentage by weight >=0.003% of Radix zanthoxyli neoherculin and nitidine in lotion of toothpaste total composition, compared with prior art, this herbal mixture toothpaste plays analgesia, anti-inflammatory, removes fire action, can effectively alleviate the uncomfortable situations such as toothache, gum redness, bleeding gums and can meet that consumer prevents oral problem.
Description
Technical field
The present invention relates to a kind of toothpaste, it is especially a kind of can be used to easing pain, the herbal mixture toothpaste of anti-inflammatory.
Background technology
Oral care implement is cleaning indispensable in people's daily life, nursing and health treatment, this kind of product
Species is various, including toothpaste, chewing gum, mouthwash, tooth powder, oral spray etc., be mainly used in keeping oral cavity and cleaning of teeth,
Promote breath freshening, nurse gum, safeguard the good microenvironment in oral cavity, alleviate oral cavity malaise symptoms etc..
Whole world country variant and the people in area, are not perplexed degree by oral problem.Dental pain, gum
Redness, bleeding, inflammation, it is common oral problem.Shown according to China's Third National oral health epidemiological investigation result,
China's oral health issue is mainly carious tooth, dental calculus, bacterial plaque, bleeding gums, dentine hypersensitivity（Dental pain）, tooth it is unclean
The problems such as white.
In recent years, the traditional Chinese medicine in natural drug particularly China is applied in oral care implement as active component solves
Certainly related oral problem, turn into the focus in market and the pursuit of consumer.
Gingivitis is common periodontal tissue disease, is due to not pay attention to oral hygiene, tooth is by food around tooth
Long-time stimulus caused by soft tartar and the dental calculus of hard that the things such as residue, bacterium are formed, and incorrect tooth-brushing habit,
Caused by the reasons such as hypovitaminosis.35 years old~44 years old age bracket crowd's periodontal health rate in the whole nation is 14.5%, and city is higher than agriculture
Village, women are higher than male, west area highest；Bleeding gums recall rate is 77.3%, and the tooth number for having bleeding gums per capita is 8.77
, women is higher than male, town and country indifference, middle part highest；Oral pocket recall rate is 40.9%, and city is less than rural area, male
Higher than women, middle part highest；Recall rate of the attachment loss equal to or more than 4 millimeters is 38.9%, and male is higher than women, city
Township's indifference, eastern region highest.
Toothache refers to tooth pain caused by a variety of causes, is one of symptom common in oral disease, it shows as：
Gum congestion and swelling pain, to the cold Spurs Severe Pain, buccal swelling etc..Toothache is mostly by gingivitis and periodontitis, carious tooth or Fractured teeth
And cause caused by infections of dental pulp.It is found in carious tooth, pulpitis, apical periodontitis and hypersensitive dentin of western medicine etc..Meet
Toothache breaking-out or exacerbation when hot and cold, sour, sweet tea etc. stimulate, belong to " pingival atrophy ", " osteomyelitis of the maxillary bone " category of the traditional Chinese medical science.The traditional Chinese medical science thinks that toothache is
Caused by the reasons such as diseases caused by external factors ailment said due to cold or exposure, exuberance of stomach fire, kidney deficiency hyperactivity of fire, worm-eaten tooth.
Therefore, exploitation is a has analgesia and is aided with the Chinese medicinal toothpaste of anti-inflammatory and function of reducing internal heat, for alleviating people oral cavity
Malaise symptoms, keep the good Tiny ecosystem in oral cavity, slow down human communication pressure etc., it is significant.
The content of the invention
The present invention, which solves the problems, such as to be to provide, a kind of to be had analgesic and anti-inflammatory effects, can effectively alleviate that gum is inflamed, aches
Pain and the herbal mixture toothpaste that consumer's prevention oral problem can be met.
In order to solve the above-mentioned technical problem, herbal mixture toothpaste of the invention, include in its lotion of toothpaste total composition
Weight ratio is 0.33 ~ 1.10% herbal mixture functional component, and the herbal mixture functional component is salicin, Radix zanthoxyli extraction
Thing, both herbal function composition salicins：The ratio of Radix Zanthoxyli extract is 1:10, the lotion of toothpaste total composition
In, salicin is in percentage by weight >=0.03% of lotion of toothpaste total composition, Radix zanthoxyli neoherculin and nitidine
In percentage by weight >=0.003% of lotion of toothpaste total composition.
More specifically scheme is：The salicin is willow ethanol extract, and the Radix Zanthoxyli extract is Radix zanthoxyli second
Alcohol extracting thing.
Salicin described in the present invention（salicin）Branch or tree for Liu Ke plant weeping willow Salix babylonicaL.
Skin passes through pure natural active material obtained by alcoholic extraction, molecular formula C13H18O7, there is antipyretic, analgesia and anti-inflammatory, antirheumatic etc.
Effect.It is known that willow bark has magical effect of antipyretic-antalgic since ancient times in China and west, people.B.C. 1550
Ancient Egypt's document is recorded, and stops the pain of injury using white willow leaf.《Compendium of Materia Medica》Record：" for Liu Weiben through low-grades, taste bitter and cold is nontoxic,
The diseases such as geomantic omen jaundice, sore and toxic can be treated ".According to《Dictionary of medicinal plant》Record：" willow tender leaf or branches and leaves, its cold in nature, bitter,
It is nontoxic, have and dissipate wind, help wet, clearing away damp-heat, control icteric hepatitis, rheumatic arthritis, eczema, endemicgoiter and other effects ".
According to《Sheng Nong's herbal classic》Carry, Liu Zhigen, skin, branch, leaf can be used as medicine, and have eliminating the phlegm improving eyesight, clearing heat and detoxicating, the windproof effect of diuresis.《This
Grass is picked up any lost article from the road》Record, withy is used for wind-dispelling, diuresis, relieves pain, detumescence.Control arthralgia pain due to rheumatism, gonorrhoea, gonorrhoea, urinary obstruction, infectiousness
Hepatitis, wind swell, furunculosis, erysipelas, dental caries, and gum swells.《Compendium of Materia Medica》Include, withy wine boils, and presses all pains and swells, removes wind, alleviating pain and detumescence.
《Proved recipe is recorded at all times》Include《Control tooth wind dental caries》Side, withy（File）One liter, one liter of soybean.Closing and fry, beans big gun is use up, and it is contained in chinaware,
Call wine three liters of stains it, through three days, platform frequency was told.Have《Peaceful holy benevolent prescription》As evidence, even ear brain is swollen aches withy soup " it is disconnected swollen to control tooth ":Weeping willow
Branch, japanese pagodatree bark, poplar bark each one is held.Medicine-feeding smooth file, half two is often used, with one big small cup of water, decocts to seven points, goes dregs, enter the money of salt one, stir
Make even, heat is told containing cold.
Radix zanthoxyli described in the present invention is the dry of rutaceae Radix zanthoxyli Zanthoxylum nitidum (Roxb.) DC.
It is dry, bitter, pungent, it is mild-natured.With promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, dispelling wind and removing obstruction in the meridians, removing toxicity for detumescence and other effects, damage is flutterred available for falling
Wound, stomachache, toothache, arthralgia pain due to rheumatism etc..Radix zanthoxyli also known as shinyleaf pricklyash root, climing green pepper, two-sided pin, double dorsal stylets etc., first recorded in《Legendary god of farming's sheet
Grass warp》, low-grades are classified as, described in book：" climing green pepper bitter, it is warm-natured, cure mainly wind-cold-dampness arthralgia, acute arthralgia, except four limbs Primordial Qi, goinyalgia ".
《Compendium of Materia Medica》Fruit portion taste class is taken in,《The south of the Five Ridges is gathered medicinal herbs record》Record " Radix zanthoxyli manages bruise and snakebite, suffers from toothache, and pan-fried water, which contains, to be gargled ",
《Hunan medicine will》Record " the passive dispelling, collateral-activating of Radix zanthoxyli, blood stasis removing analgesic, removing toxicity for detumescence ",《National Chinese herbal medicine compilation》Record
" Radix zanthoxyli is invigorated blood circulation, narcotic analgesic, is cured mainly and is ached caused by neuralgia, taste-blindness rate, stomach and intestine angina, biliary ascariasis
Bitterly, abscess of throat, and it is used for mucocutaneous anesthesia ",《Luchuan book on Chinese herbal medicine》Carry " synthetism, subside a swelling, analgesic, stasis eliminatings.Control injury and bone fracture,
Damage swelling and pain, treating rheumatic ostealgia, heart and stomach pain, toothache.And treating snakebite ".It is among the people to take the two sides crown appropriate, it is decocted in water for oral dose or levigation rushes
Clothes, for controlling headache, toothache etc..
It is of the invention compared with existing toothpaste, have the advantages that：
What is added in lotion of toothpaste is the material of the active composition proposed from the Chinese medicine of natural plants, can not only
Effectively alleviate the uncomfortable situations such as the inflamed, pain of gum, while can also meet that consumer prevents the function of oral problem.
Embodiment
With reference to embodiment, the present invention will be further described.In following examples, involved percentage unless
It is otherwise noted, is calculated in weight percent.
First, the preparation of herbal mixture functional component
Salicin is by willow bark, branch through drying in the shade, and alcoholic extract is purified and obtained, and content is up to more than 90%；Radix zanthoxyli medicinal material is adopted
With 3 years raw above Chinese medicine, ensure that drug effect reaches optimal, Radix Zanthoxyli extract selects extract：Active compound=1:1 Radix zanthoxyli ethanol
Extract.
Herbal mixture functional component is by 1 by salicin and Radix zanthoxyli ethanol extract:10 ratios, which weigh, to be mixed to get.
Above-mentioned herbal mixture functional component：The content of salicin, neoherculin and nitidine is：Salicin >=
90%, neoherculin 0.03%.As long as these herbal mixture functional components account for lotion more than 0.33%, water can be met
Benzasalicin is in percentage by weight >=0.03% of lotion of toothpaste total composition, and Radix zanthoxyli neoherculin and nitidine are in tooth
Percentage by weight >=0.003% of cream lotion total composition.
2nd, the toothpaste constitutive material in embodiment 1 to 4 and weight percent content such as following table：
。
3rd, clinical test part：
Herbal mixture toothpaste clinical test
To the analgesic activity of small white mouse（Hot plate method）：
Sample：
Herbal mixture toothpaste（Embodiment 1, embodiment 3, embodiment 4）, toothpaste bare substrate, blank control（Physiology salt
Water）, double fluorine sweet smell diethylammonium salt emulsion agents.
Method and process：
60 body weight are chosen in 16-22g health Kunming kind white mouse, with GJ-8402 type hot plate pain threshold detectors, regulation temperature is 55
± 0.5 DEG C, small white mouse is placed on to the pain threshold determined on hot plate per mouse.6 groups are randomly divided into, every group 10 is only given in toes painting respectively
Corresponding tested material（0.2g or ml）.Per minor tick 15min, 15min, 30min, 45min measure small white mouse after tested material are given in painting
Threshold value, same period repeat to survey 2 times.As small white mouse 60s is still reactionless, small white mouse is taken out, in order to avoid scald, its pain threshold with
60s is calculated.
As a result：
Each group small white mouse pain threshold is recorded, data carry out statistics T inspections, the results are shown in Table 1.
As a result：
Discuss：The main component " Diclofenac " of double fluorine sweet smell diethylammonium salt emulsion agents is the analgesic goldstandard that doctor generally acknowledges,
Energy effective antiinflammatory analgesia, accelerates to recover.From the point of view of experimental data, herbal mixture toothpaste group and double fluorine sweet smell diethylammonium salt emulsion agent groups
Compareed with preceding and blank group is administered, can significantly improve small white mouse pain threshold；Herbal mixture toothpaste group compared with bare substrate group,
Small white mouse pain threshold can be significantly improved.Show, herbal mixture toothpaste has obvious analgesic activity.And with herbal mixture effect
Component content increase, its analgesic effect are more obvious.
Conclusion：Herbal mixture toothpaste has obvious analgesic activity.
Paraxylene causes the antiinflammatory action of small white mouse ear corridor acute inflammation swelling：
Sample：
Herbal mixture toothpaste（Embodiment 1, embodiment 2, embodiment 4）, toothpaste bare substrate, blank control（Physiology salt
Water）, Fluonex.
Method and process：
Healthy Kunming kind ♂ small white mouses 60 are chosen, are randomly divided into 6 groups, every group 10.
Dimethylbenzene 0.1ml is smeared on two sides during experiment, inside and outside every group of every animal auris dextra corridor makes mouse ear inflammation, and left ear is not added with
Self-blank control group is done in processing.After smearing dimethylbenzene 30min, two sides is uniformly smeared respectively inside and outside every group of every animal auris dextra corridor
Each group tested material sample 0.1g or ml.After giving tested material 1h, the dislocation of small white mouse strength vertebra is put to death, and is cut two ear corridors, is used physiology salt
Auris dextra corridor tested material sample is removed in washing, is cleaned with dry cotton ball, and two circle auricles are taken in same position chisel with card punch.
As a result：
Record each mouse punch and take portion or so auricle weight, it is swelling value that auris dextra sheet weight, which subtracts left auricle weight,.Number
According to statistics T inspections are carried out, 2 are the results are shown in Table.
As a result：
Discuss：Fluonex group has stronger antiinflammatory action, is generally acknowledged anti-inflammatory good medicine, comes from experimental data
See, Fluonex group, herbal mixture toothpaste group can be such that small white mouse acute inflammation swelling ear corridor quality significantly mitigates, hence it is evident that
Small white mouse ear corridor acute inflammation swelling caused by suppressing dimethylbenzene, it is obvious anti-to show that toothpaste containing herbal mixture has to acute inflammation
Inflammation effect.And as the increase of herbal mixture functional component content, its antiphlogistic effects are more obvious.
Conclusion：Herbal mixture toothpaste has obvious antiinflammatory action.
As a result with discussion：
As a result：Summary eases pain and anti-inflammatory experimental result data shows that herbal mixture toothpaste can significantly improve small white mouse
Pain threshold, there is obvious analgesic activity；Small white mouse acute inflammation swelling ear corridor quality can be made significantly to mitigate, hence it is evident that suppress diformazan
The acute inflammation swelling of small white mouse ear corridor, has obvious antiinflammatory action to acute inflammation caused by benzene.
In summary：1. herbal mixture toothpaste has obvious analgesia, antiinflammatory action.
2. with the increase of the herbal mixture toothpaste active ingredient such as salicin, Radix Zanthoxyli extract, the analgesia of toothpaste, anti-inflammatory
Effect is strengthened.
Herbal mixture toothpaste consumer's Clinical practice effect assessment：
To carry out effect assessment to herbal mixture toothpaste, except animal clinical experiment is outer, also carried out with swelling and aching of gum,
The consumer of the oral problems such as bleeding gums, gingivitis uses test.
Consumer selects：
Consumer 120 of the screening with oral problems such as swelling and aching of gum, bleeding gums, gingivitis, M-F 1:
1, and it is randomly divided into 4 groups.
Implementation and process：
Record consumer's oral problem symptom.
Consumer uses the toothpaste of embodiment 1,2,4 and blank control toothpaste respectively.After continuous use one month, pay a return visit simultaneously
Questionnaire is reclaimed, record consumer carries out statistical comparison using the Oral symptoms after test toothpaste.
Bleeding gums are evaluated with gingival sulcus bleeding index SBI, gingivitis is commented with gingival index GI and dental plaque index PLI
Valency, analgesic effect are evaluated with percentage.
Consumer evaluation's effect：
Consumer is to herbal mixture toothpaste analgesic effect evaluation result：
After continuous use one month, consumer is shown in Table 3 to herbal mixture toothpaste analgesic effect evaluation result.
Consumer mitigates gingivitis effect assessment result to herbal mixture toothpaste
After continuous use one month, consumer mitigates gingivitis effect assessment to herbal mixture toothpaste and the results are shown in Table 4, table 5.
Discuss：Herbal mixture toothpaste, which has, preferably mitigates gingivitis effect, can preferably alleviate swelling and aching of gum, gum
The symptoms such as inflammation, bleeding gums and reduction bacterial plaque；With the increase of the active principle content such as salicin, Radix zanthoxyli, mitigate
Gingivitis effect is more obvious.
Conclusion：Herbal mixture toothpaste, which has, preferably mitigates gingivitis effect.
As a result with discussion
Summary herbal mixture toothpaste consumer's practical effect observed data shows that herbal mixture toothpaste has bright
Aobvious analgesic activity；Mitigate gingivitis effect with preferable, can preferably alleviate swelling and aching of gum, various focusing depths represented, gum and go out
The symptom such as blood and reduction bacterial plaque.
With the increase of the herbal mixture toothpaste active ingredient such as salicin, Radix Zanthoxyli extract, the analgesia of toothpaste, alleviate tooth
The effect of the symptoms such as gum swelling and pain, various focusing depths represented, bleeding gums and reduction bacterial plaque is strengthened.
4th, conclusion
Herbal mixture analgesia toothpaste has obvious analgesic activity, and with preferably alleviation swelling and aching of gum, gum hair
Scorching, bleeding gums and the effect for reducing the symptoms such as bacterial plaque.
Claims (2)
- A kind of 1. herbal mixture toothpaste, it is characterised in that：Include in its lotion of toothpaste total composition weight ratio for 0.33 ~ 1.10% herbal mixture functional component, the herbal mixture functional component is salicin, Radix Zanthoxyli extract, both Chinese medicines Functional component salicin：The ratio of Radix Zanthoxyli extract is 1:10, in the lotion of toothpaste total composition, salicin is in toothpaste cream Percentage by weight >=0.03% of body total composition, Radix zanthoxyli neoherculin and nitidine always combine in lotion of toothpaste Percentage by weight >=0.003% of thing.
- 2. herbal mixture toothpaste according to claim 1, it is characterised in that：The salicin is willow ethanol extract, The Radix Zanthoxyli extract is Radix zanthoxyli ethanol extract.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1582890A (en) * | 2004-05-21 | 2005-02-23 | 江西航天日用化工发展有限责任公司 | Herbal composite toothpaste |
| CN102772342A (en) * | 2012-08-22 | 2012-11-14 | 柳州两面针股份有限公司 | Traditional Chinese medicine toothpaste capable of diminishing inflammation and relieving pain |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09268117A (en) * | 1996-04-02 | 1997-10-14 | Lion Corp | Composition for oral cavity |
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2013
- 2013-12-11 CN CN201310664664.3A patent/CN104644845B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1582890A (en) * | 2004-05-21 | 2005-02-23 | 江西航天日用化工发展有限责任公司 | Herbal composite toothpaste |
| CN102772342A (en) * | 2012-08-22 | 2012-11-14 | 柳州两面针股份有限公司 | Traditional Chinese medicine toothpaste capable of diminishing inflammation and relieving pain |
Non-Patent Citations (2)
| Title |
|---|
| 中草药在牙膏中的应用现状;何沁桂;《牙膏工业》;20061231(第4期);42-45 * |
| 复方中草药牙粉治疗慢性龈缘炎的疗效;陈洪、王星晓;《南昌大学学报（医学版）》;20101231;第50卷(第8期);52-54 * |
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