CN105434788A - Traditional Chinese medicine used for treating coronary heart disease angina in anesthesia department, and preparation method thereof - Google Patents
Traditional Chinese medicine used for treating coronary heart disease angina in anesthesia department, and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention provides a traditional Chinese medicine used for treating coronary heart disease angina in anesthesia department, and a preparation method thereof. The traditional Chinese medicine comprises root of griffith condorvine, aristolochia kaempferi willd., viola vaginata maxim., fewflower lysionotus herb, rhizome of fourleaf paris, bothmeria macrophylla Hornem., root of cordateleaf ainsliaea, flos inulae, ambroma augusta, all-grass of cochinchinese excoecaria, root of shinyleaf pricklyash, ceratostigma minus stapf ex prain, all-grass of moldavica dragonhead, armillariella mellea, galium elegans, and bark of girald daphne. The traditional Chinese medicine can be combined with western medicines, and possesses exact curative effect on coronary heart disease angina, and no side or toxic effect.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Anesthesia Department Chinese medicine being used for the treatment of angina pectoris and preparation method thereof.
Background technology
Angina pectoris is comparatively common cardiovascular disease, refers to coronary atherosclerosis and forms luminal stenosis or spasm and cause impatient hypoxic-ischemic or the downright bad and heart disease of precordialgia discomfort that is that cause.There is case fatality rate high, the features such as complication is many.The most commonly encountered diseases kind that coronary heart disease has become outpatient service and has been in hospital, causes serious threat to human health, has also increased considerably medical resource and has expended and expenditure, brought heavy burden to society.
Coronary heart disease belongs to categories such as the traditional Chinese medical science " thoracic obstruction " " pained " " precordial pain with cold limbs " " angina pectoriss ".Heart governing blood and vessels, blood circulation depending on qi flow, the deficiency of vital energy is blood stasis then, in blood stasis arteries and veins, venation stagnation of QI and blood may bring about pain, therefore blood stasis due to qi deficiency, blockage of the cardiac vessels is the main pathogenesis of primary disease; The deficiency of vital energy is this, and blood stasis is mark, and angina pectoris is the disease of deficiency in origin and excess in superficiality.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Anesthesia Department Chinese medicine being used for the treatment of angina pectoris and preparation method thereof, and this Chinese Medicine and Clavicular Western medicine uses, and have definite curative effect to angina pectoris, toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides the Chinese medicine that a kind of Anesthesia Department is used for the treatment of angina pectoris, its raw medicinal material comprises: Radix Marsdeniae griffithii, gold lion rattan, Cor Gigeriae Galli seven, Herba Lysionoti Pauciflori, Rhizoma Paridis tetraphyllae, Herba Boehmeriae platyphllae, Radix Ainsliaeae Bonatii, Flos Inulae, high-spirited, Herba Excoecariae cochinchinensis, Radix Zanthoxyli, Radix Ceratostigmatis mini, Herba Dracocephali, Armillaria mellea, Radix Rubiae Yunnanensis and Daphne giraldii Nitsche.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows: Radix Marsdeniae griffithii 10 ~ 20 parts, 15 ~ 25 parts, golden lion rattan, Cor Gigeriae Galli 7 10 ~ 25 parts, Herba Lysionoti Pauciflori 25 ~ 40 parts, Rhizoma Paridis tetraphyllae 20 ~ 35 parts, Herba Boehmeriae platyphllae 10 ~ 15 parts, Radix Ainsliaeae Bonatii 20 ~ 40 parts, Flos Inulae 15 ~ 30 parts, high-spirited 10 ~ 15 parts, Herba Excoecariae cochinchinensis 20 ~ 30 parts, Radix Zanthoxyli 25 ~ 35 parts, Radix Ceratostigmatis mini 10 ~ 20 parts, Herba Dracocephali 25 ~ 40 parts, Armillaria mellea 15 ~ 20 parts, Radix Rubiae Yunnanensis 20 ~ 30 parts and Daphne giraldii Nitsche 30 ~ 45 parts.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably as follows: Radix Marsdeniae griffithii 10 ~ 15 parts, 20 ~ 25 parts, gold lion rattan, Cor Gigeriae Galli 7 17 ~ 20 parts, Herba Lysionoti Pauciflori 25 ~ 35 parts, Rhizoma Paridis tetraphyllae 20 ~ 30 parts, Herba Boehmeriae platyphllae 10 ~ 13 parts, Radix Ainsliaeae Bonatii 30 ~ 40 parts, Flos Inulae 25 ~ 30 parts, high-spirited 13 ~ 15 parts, Herba Excoecariae cochinchinensis 20 ~ 25 parts, Radix Zanthoxyli 30 ~ 35 parts, Radix Ceratostigmatis mini 16 ~ 20 parts, Herba Dracocephali 25 ~ 35 parts, Armillaria mellea 15 ~ 18 parts, Radix Rubiae Yunnanensis 19 ~ 28 parts and Daphne giraldii Nitsche 35 ~ 45 parts.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: Radix Marsdeniae griffithii 12 parts, 20 parts, golden lion rattan, Cor Gigeriae Galli 7 19 parts, Herba Lysionoti Pauciflori 33 parts, Rhizoma Paridis tetraphyllae 22 parts, Herba Boehmeriae platyphllae 13 parts, Radix Ainsliaeae Bonatii 37 parts, Flos Inulae 29 parts, high-spirited 13 parts, Herba Excoecariae cochinchinensis 20 parts, Radix Zanthoxyli 30 parts, Radix Ceratostigmatis mini 19 parts, Herba Dracocephali 26 parts, Armillaria mellea 15 parts, Radix Rubiae Yunnanensis 27 parts and Daphne giraldii Nitsche 42 parts.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: Radix Marsdeniae griffithii 15 parts, 24 parts, golden lion rattan, Cor Gigeriae Galli 7 17 parts, Herba Lysionoti Pauciflori 25 parts, Rhizoma Paridis tetraphyllae 27 parts, Herba Boehmeriae platyphllae 10 parts, Radix Ainsliaeae Bonatii 30 parts, Flos Inulae 25 parts, high-spirited 15 parts, Herba Excoecariae cochinchinensis 24 parts, Radix Zanthoxyli 33 parts, Radix Ceratostigmatis mini 17 parts, Herba Dracocephali 30 parts, Armillaria mellea 18 parts, Radix Rubiae Yunnanensis 20 parts and Daphne giraldii Nitsche 35 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Beneficial effect of the present invention: Chinese medicine of the present invention, combined with westem is treated, and has definite curative effect, have no side effect to angina pectoris.
Detailed description of the invention
The invention provides the Chinese medicine that a kind of Anesthesia Department is used for the treatment of angina pectoris, its raw medicinal material comprises: Radix Marsdeniae griffithii, golden lion rattan, Cor Gigeriae Galli seven, Herba Lysionoti Pauciflori, Rhizoma Paridis tetraphyllae, Herba Boehmeriae platyphllae, Radix Ainsliaeae Bonatii, Flos Inulae, high-spirited, Herba Excoecariae cochinchinensis, Radix Zanthoxyli, Radix Ceratostigmatis mini, Herba Dracocephali, Armillaria mellea, Radix Rubiae Yunnanensis and Daphne giraldii Nitsche.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Radix Marsdeniae griffithii: [another name] little Rhizoma Cynanchi Stauntonii, maggot rattan, large DUIJIESHENG, break angle cattle, little BAIYAO greatly.[source] medical material Ji Yuan: be the Herb of dicotyledon medicine asclepiadaceae plant Radix Marsdeniae griffithii.[nature and flavor] acrid in the mouth, hardship, property are flat.[return through] heart; Kidney channel.[function cures mainly] promoting blood circulation to remove obstruction in the collateral; Stopping bleeding and knitting the fractured bone; Removing toxic substances and promoting subsidence of swelling.Main traumatic injury; Fracture; Traumatic hemorrhage; Carbuncle furunculosis.[extracts] " China's book on Chinese herbal medicine "
Gold lion rattan: [another name] Fissistigma bracteolatum Chatt., rattan potato, acute diseases such as cholera and sunstroke medicinal herbs, Radix Aristolochiae yunnanensis, smoked drum rattan.[source] medical material Ji Yuan: be rhizome and the root of aristolochiaceae plant Aristolochia koempeferi.[nature and flavor] are bitter; Pungent; Be slightly cold.[return through] liver; Stomach; Large intestine channel.[function cures mainly] promoting the circulation of QI to relieve pain; Heat-clearing and toxic substances removing; Blood pressure lowering.Main stagnation of QI gastral cavity is swollen; Stomachache; Stomachache; Rheumatic arthritis; Heat-damp in summer dysentery; Carbuncle furuncle and phyma; Venom; Hypertension.[extracts] " China's book on Chinese herbal medicine "
Cor Gigeriae Galli seven: [another name] Huan, Wu Pao company, Viola arcuata, smelly, the female Herba Violae japonicae of goat, Herba Violae arcuatae, red Sedum aizoon L..[source] Violaceae Viola plant sheath handle common violet, with herb, root stock is used as medicine.Adopt after autumn, clean and dry.[nature and flavor] are micro-sweet, cool.[function cures mainly] heat-clearing and toxic substances removing, promoting the flow of QI in the collateral by warming the meridian, promoting blood circulation and hemostasis, synthetism.For traumatic injury, hemoptysis; Mastitis are controlled in external, knife injury, explorative fracture, furuncle swelling toxin.[extracts] " national Chinese herbal medicine compilation "
Herba Lysionoti Pauciflori: [another name] black black bone (" Zhiwu Mingshi Tukao "), Radix Loxostigmatis griffithii (" vegetation is side just "), Lysionotus pauciflorus Maxim., great Jiang bean, little Herba Lycopi (" classifying herbal "), Herba Lysionoti carnosae, rock tea (" Guizhou side's medicine among the people collection "), Herba Ophiorrhizae japonicae (" Kweiyang medicinal herbs among the people "), rock is blue, Ba Yancao, the red grass of lung, honeybee flower, Semen Benincasae are careless, Parmelia saxatilis Ach. (" Hunan medicine will "), and synthetism life, Eupatorium formosanum Hayata., thousand are beaten, tea in puerperal (" register planted by Guangxi medicine ").[source] is the herb of Gesneriaceae Herba Lysionoti Pauciflori.8 ~ JIUYUE is gathered, and dries.[nature and flavor] sweetness and bitterness, cool.[function cures mainly] lung heat clearing expectorant, cooling blood for hemostasis, damp eliminatingization is stagnant, removing obstruction in the collateral to relieve pain.Control cough due to lung-heat, spit blood, metrorrhagia and leukorrhagia, bacillary dysentery, infantile malnutrition, rheumatic arthralgia, traumatic injury.[extracts] " Chinese medicine voluminous dictionary "
Rhizoma Paridis tetraphyllae: [another name] eldest grandson, extra large grandson, contour painting grass, spread, yellow grandson, dusk, Du Meng, dew Rhizoma Trillii Tschonoskii, dewdrops, clear water pearl, Rhizoma Paridis.[source] medical material Ji Yuan: be the rhizome of liliaceous plant Paris bashanensis Wang et Tang.[nature and flavor] are bitter; Pungent; Temperature.[function cures mainly] expelling cold and dampness; Removing obstruction in the collateral to relieve pain; Hemostasia and promoting granulation.Main chronic arthralgia caused by cold-damp, waist cold type of pain, traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Herba Boehmeriae platyphllae: [another name] Debregeasia orientalis C. J. Chen, Sambucus chinensis, DAJIEGU, large glutinous leaf.[source] medical material Ji Yuan: be herb or the root of contrayerva Herba Boehmeriae platyphllae.[nature and flavor] mildly bitter flavor; Pungent; Warm in nature.[function cures mainly] expelling wind and removing dampness; Removing obstruction in the collateral to relieve pain.Main air pain of dampness syndrome; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Radix Ainsliaeae Bonatii: [another name] Cortex Ampelopsis Humulifoliae Radicis, Bulbus Lycoridis Aureae, hair leaf Radix Clematidis, red hair Radix Notoginseng.[source] medical material Ji Yuan: be the root of feverfew lobus cardiacus Ainsliaea fragrans Champ..[nature and flavor] bitter in the mouth; Micro-pungent; Warm in nature.[function cures mainly] expelling wind and removing dampness; Removing obstruction in the collateral to relieve pain.Main air pain of dampness syndrome; Numb limbs and tense tendons; Traumatic injury; Gastralgia.[extracts] " China's book on Chinese herbal medicine "
Flos Inulae: [another name] Fu, steal heptan, contain mulberry, wear mulberry, flying apsaras stamen, money, wild oil bloom, drip gold, Xia Ju, money chrysanthemum, tansy, repeatedly sieve Huang, Caulis et folium pavettae hongkongensis, June chrysanthemum, yellow maturity flower, water sunflower, Flos Inulae, again flower, little Hemerocallis citrina Baroni, cat ear flower, donkey ear flower, FLOSINULAE, Fu Hua, flos inulae.[source] medical material Ji Yuan: be the inflorescence of section of district plant Flos Inulae or Inula britannica.[nature and flavor] bitter in the mouth; Pungent; Salty; Tepor.[return through] lung; Stomach; Large intestine channel.[function cures mainly] expectorant row water; Sending down the abnormal ascending QI preventing or arresting vomiting.Main cough with asthma expectorant glues; To tremble eructation; Feeling of stuffiness in chest hypochondriac pain.[each discussion] amplification on Canon of Materia Medica: Flos Inulae, row expectorant water, wind syndrome of ocular connectors due to invasion of pathogenic wind of decaptitating, the medicine of also wandering away also." detailed outline ": Flos Inulae controls all diseases, its merit be only expert at water, the therapeutic method to keep the adverse QI flowing downwards, promoting blood circulation you." Japan hanako materia medica ": improving eyesight, controls wind syndrome of head, promoting blood circulation." the southern regions of the Yunnan Province book on Chinese herbal medicine ": head day of dispelling, all wind and cold was evil, only the sun, positive bright headache, the positive bright galactostasis of row.(controlling) breast carcinoma, acute mastitis, congestion and swelling pain, sudden and violent red acute catarrhal conjunctivitis, order disease pain, dispelling pathogenic wind for improving eyesight, hidden puckery photophobia uncle day, the cough of cold cold and heat.Old expectorant, as glue, walks meridians, and only tremble with fear abdomen pain in face, and diuresis, controls tympanites, phoenix periodontal disease knee pain.[extracts] " China's book on Chinese herbal medicine "
High-spirited: [another name] terrible Cotton Gossypii, cup of looking up to heaven, Debregeasia orientalis C. J. Chen, false Hibisci Mutabilis.[source] medical material Ji Yuan: for Sterculiaceae plant holds high the root of large lotus.Gather and store: autumn, winter take root, wash away silt, section, using fresh herb or dry.[nature and flavor] micro-hardship; Pungent; Flat.[function cures mainly] restores menstrual flow and invigorates blood circulation; Reducing swelling and alleviating pain.Main menoxenia; Skin infection furuncle and phyma; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Excoecariae cochinchinensis: red, the golden trivial jade of [another name] blade back.[source] Euphorbiaceae Herba Excoecariae cochinchinensis, is used as medicine with Herb.[nature and flavor] pungent, micro-hardship, flat.[function cures mainly] dredge the meridian passage, pain relieving.Cure mainly measles, parotitis, tonsillitis, angina pectoris, renal colic, lumbar muscle strain.[extracts] " national Chinese herbal medicine compilation "
Radix Zanthoxyli: [another name] climing green pepper, pig green pepper, pig Jiao, pig green pepper, Canis familiaris L. green pepper, golden green pepper, Taurus are male, both sides pin, Pericarpium Zanthoxyli, the tiger that goes up a hill, Pericarpium Zanthoxyli thorn, Fructus Piperis Jin, Radix Zanthoxyli, enter mountain tiger, horse medicine, Radix Phytolaccae, Taurus mother, two dorsal stylet, zanthoxylum nitidum, llex cornuta, the male thorn of cat, Fructus Linderae Glaucae, leaf under thread a needle, precipice green pepper, Pericarpium Zanthoxyli, two-sided pin, xanthorrhiza, fish shell thorn, rattan green pepper.[source] medical material Ji Yuan: be root or the branch and leaf of rutaceae Radix Zanthoxyli.Gather and store: the whole year all can gather, cleaning, section, dries or using fresh herb.[nature and flavor] are pungent; Bitter; Tepor.[return through] liver; Heart channel.[function cures mainly] dispelling wind and removing obstruction in the collateral; Removing dampness to relieve pain; Subduing swelling and detoxicating.Main anemofrigid-damp arthralgia; Bones and muscles pain; Injury and bone fracture; Colic; Laryngopharynx swelling and pain; Have a stomach-ache; Ascarid Jue suffers from abdominal pain; Toothache; Carbuncle sore scrofula; Scald.[extracts] " China's book on Chinese herbal medicine "
Radix Ceratostigmatis mini: [another name] Flos Carthami Radix Ceratostigmatis mini, Rhizoma Rohdeae Japonicae, blue to joint, blue flower Rhizoma Rodgersiae, rheumatism grass, little Lan snow, Patrinia villosa rock five Rhizoma Zingiberis Recens, southeast chrysanthemum.[source] medical material Ji Yuan: be the root of the little ceratostigma plumbaginoides Bunge of Plumbaginaceae plant.[nature and flavor] are pungent; Bitter; Warm in nature.[return through] spleen; Heart channel.[function cures mainly] wind-damp dispelling; The meridian dredging; Pain relieving.Main rheumatic numbness; Gastral cavity abdomen hypochondriac pain; Traumatic injury; Fracture; Vasculitis; Parotitis.[extracts] " China's book on Chinese herbal medicine "
Herba Dracocephali: [another name] wild mint, little Cymbidium ensifolium (L.) Sw., fragrant flower flower, smelly blue fragrant, Flos Gardeniae.[source] medical material Ji Yuan: be the herb of labiate Herba Dracocephali.Gather and store: summer, autumn gather, using fresh herb or dry.[nature and flavor] acrid in the mouth; Bitter; Cool in nature.[function cures mainly] wind and heat dispersing; Smooth throat to stop cough; Cool liver hemostasis.Main cold, fever; Headache; Laryngopharynx swelling and pain; Cough clorprenaline; Dysentery subcutaneous ulcer; Spit blood; Epistaxis; Rubella; Skin pruritus.[extracts] " China's book on Chinese herbal medicine "
Armillaria mellea: [another name] sugared gill fungus, Armillariella mellea, nectarine ring bacterium, sweet mushroom, oak bacterium, root rope bacterium, root-rot bacterium, oak gill fungus, Armillariella.[source] medical material Ji Yuan: be the sporophore of Bai Mo section fungus armillariella tabescens.[nature and flavor] are sweet; Flat.[return through] Liver Channel.[function cures mainly] relieves dizziness, high fever, infantile convulsions, epilepsy, etc. suppressing the hyperactive liver; Dispelling wind and removing obstruction in the collateral; Bone and muscle strengthening.Main dizziness; Headache; Insomnia; Numb limbs and tense tendons; Lumbago and skelalgia; Coronary heart disease; Hypertension; Vascular headache; Vertiginous syndrome; Epilepsy.[extracts] " China's book on Chinese herbal medicine "
Radix Rubiae Yunnanensis: [another name] Yunnan Herba Salviae Chinensis, Radix Rubiae Yunnanensis, little red medicine.[source] medical material Ji Yuan: for the root of grass is wished in dicotyledon medicine Maguireothamnus speciosus Yunnan.Gather and store: autumn, winter excavate, cleaning, dry.[nature and flavor] are sweet; Temperature.[return through] Liver Channel.[function cures mainly] relaxing muscles and tendons to promote blood circulation; Promoting tissue regeneration by removing blood stasis; Take good care of QI and blood.Main rheumatalgia; Traumatic injury, menoxenia; Amenorrhea; Leukorrhagia; Puerperal arthralgia; Pulmonary tuberculosis hemoptysis; Dizzy insomnia; Anemia.[extracts] " China's book on Chinese herbal medicine "
Daphne giraldii Nitsche: [another name] Daphne giraldii Nitsche, walk Sima, wire fiber crops, rescue greatly, Buxus sinica (Rehd.et Wils.) skin, Caulis et Folium piperis, Flos Wikstroemiae Nutantis, summer in winter are blue or green, short top top.[source] medical material Ji Yuan: be peel of stem and the root bark of Isolated From Thymelaeaceae Species Daphne Giraldii Nitsche, the sweet winter daphne in Shan and retuseleaf daphne bark.[nature and flavor] acrid in the mouth; Bitter; Warm in nature.[return through] lung; Heart channel.[function cures mainly] dispelling wind and removing obstruction in the collateral; Eliminating stasis to stop pain.Main air pain of dampness syndrome; Numb limbs and tense tendons; Headache; Stomachache; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows: Radix Marsdeniae griffithii 10 ~ 20 parts, 15 ~ 25 parts, golden lion rattan, Cor Gigeriae Galli 7 10 ~ 25 parts, Herba Lysionoti Pauciflori 25 ~ 40 parts, Rhizoma Paridis tetraphyllae 20 ~ 35 parts, Herba Boehmeriae platyphllae 10 ~ 15 parts, Radix Ainsliaeae Bonatii 20 ~ 40 parts, Flos Inulae 15 ~ 30 parts, high-spirited 10 ~ 15 parts, Herba Excoecariae cochinchinensis 20 ~ 30 parts, Radix Zanthoxyli 25 ~ 35 parts, Radix Ceratostigmatis mini 10 ~ 20 parts, Herba Dracocephali 25 ~ 40 parts, Armillaria mellea 15 ~ 20 parts, Radix Rubiae Yunnanensis 20 ~ 30 parts and Daphne giraldii Nitsche 30 ~ 45 parts.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably as follows: Radix Marsdeniae griffithii 10 ~ 15 parts, 20 ~ 25 parts, gold lion rattan, Cor Gigeriae Galli 7 17 ~ 20 parts, Herba Lysionoti Pauciflori 25 ~ 35 parts, Rhizoma Paridis tetraphyllae 20 ~ 30 parts, Herba Boehmeriae platyphllae 10 ~ 13 parts, Radix Ainsliaeae Bonatii 30 ~ 40 parts, Flos Inulae 25 ~ 30 parts, high-spirited 13 ~ 15 parts, Herba Excoecariae cochinchinensis 20 ~ 25 parts, Radix Zanthoxyli 30 ~ 35 parts, Radix Ceratostigmatis mini 16 ~ 20 parts, Herba Dracocephali 25 ~ 35 parts, Armillaria mellea 15 ~ 18 parts, Radix Rubiae Yunnanensis 19 ~ 28 parts and Daphne giraldii Nitsche 35 ~ 45 parts.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: Radix Marsdeniae griffithii 12 parts, 20 parts, golden lion rattan, Cor Gigeriae Galli 7 19 parts, Herba Lysionoti Pauciflori 33 parts, Rhizoma Paridis tetraphyllae 22 parts, Herba Boehmeriae platyphllae 13 parts, Radix Ainsliaeae Bonatii 37 parts, Flos Inulae 29 parts, high-spirited 13 parts, Herba Excoecariae cochinchinensis 20 parts, Radix Zanthoxyli 30 parts, Radix Ceratostigmatis mini 19 parts, Herba Dracocephali 26 parts, Armillaria mellea 15 parts, Radix Rubiae Yunnanensis 27 parts and Daphne giraldii Nitsche 42 parts.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably as follows again: Radix Marsdeniae griffithii 15 parts, 24 parts, golden lion rattan, Cor Gigeriae Galli 7 17 parts, Herba Lysionoti Pauciflori 25 parts, Rhizoma Paridis tetraphyllae 27 parts, Herba Boehmeriae platyphllae 10 parts, Radix Ainsliaeae Bonatii 30 parts, Flos Inulae 25 parts, high-spirited 15 parts, Herba Excoecariae cochinchinensis 24 parts, Radix Zanthoxyli 33 parts, Radix Ceratostigmatis mini 17 parts, Herba Dracocephali 30 parts, Armillaria mellea 18 parts, Radix Rubiae Yunnanensis 20 parts and Daphne giraldii Nitsche 35 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Radix Marsdeniae griffithii 120g, golden lion rattan 200g, Cor Gigeriae Galli seven 190g, Herba Lysionoti Pauciflori 330g, Rhizoma Paridis tetraphyllae 220g, Herba Boehmeriae platyphllae 130g, Radix Ainsliaeae Bonatii 370g, Flos Inulae 290g, high-spirited 130g, Herba Excoecariae cochinchinensis 200g, Radix Zanthoxyli 300g, Radix Ceratostigmatis mini 190g, Herba Dracocephali 260g, Armillaria mellea 150g, Radix Rubiae Yunnanensis 270g and Daphne giraldii Nitsche 420g.
Prepare according to the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.23 times, 0.08 times of lactose, the starch of 0.18 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.025 times of magnesium stearate, granulate, tabletting, makes.
Embodiment 2: capsule
Get Radix Marsdeniae griffithii 150g, golden lion rattan 240g, Cor Gigeriae Galli seven 170g, Herba Lysionoti Pauciflori 250g, Rhizoma Paridis tetraphyllae 270g, Herba Boehmeriae platyphllae 100g, Radix Ainsliaeae Bonatii 300g, Flos Inulae 250g, high-spirited 150g, Herba Excoecariae cochinchinensis 240g, Radix Zanthoxyli 330g, Radix Ceratostigmatis mini 170g, Herba Dracocephali 300g, Armillaria mellea 180g, Radix Rubiae Yunnanensis 200g and Daphne giraldii Nitsche 350g.
Prepare according to the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 895%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.38:0.42, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 24-34g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.96g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 44.8 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>44.8 crude drug/kg of the present invention, every day, maximum dosage-feeding was 89.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.143g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 29g) oral administration gavage Chinese medicine of the present invention is 626 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 15.82,23.66 and 45.86g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: 128 routine patients are my institute inpatient, are divided into two groups at random according to medical order.Wherein treatment group 64 example, man 34 example, female 30 example, age 26-69 year, the course of disease 2 months-9 years; First hair style angina pectoris 5 example, stable type angina pectoris 37 example, deterioration type angina pectoris 9 example, spontaneous angina pectoris 13 example.Matched group 64 example, man 35 example, female 29 example, age 25-68 year, the course of disease 1 month-8 years, first hair style angina pectoris 6 example, stable type angina pectoris 38 example, deterioration type angina pectoris 8 example, spontaneous angina pectoris 12 example.Two groups of cases are difference there are no significant meaning (P > 0.05) in sex, age, the course of disease, the state of an illness, has comparability.
Diagnostic criteria: meet the diagnostic criteria in " guideline of clinical investigations of new Chinese medicine treatment angina pectoris " in " new Chinese medicine guideline of clinical investigations " (trying).
Therapeutic Method:
Matched group: oral trimetazidine tablets, each 20mg, every day 3 times; Oral diltiazem sheet, each 30mg, every day 3 times; It within 14 days, is a course for the treatment of.
Treatment group: on treatment of control group basis, takes the tablet of the embodiment of the present invention 1 simultaneously, each 3, every day 3 times, within 14 days, is a course for the treatment of.
Curative effect judging standard: effective: transference cures such as uncomfortable in chest after medication, chest pain or substantially disappear, angina pectoris attacks number of times comparatively reduces more than 80% before medication, and electrocardiogram recovers normal substantially.Effective: the symptoms such as uncomfortable in chest after medication, chest pain are obviously improved, angina pectoris attacks number of times comparatively reduces 50%-80%, ECG ST section rise >=0.05mV before medication, or T ripple becomes upright from smooth, or the inverted T ripple of leading connection shoals more than 50%.Invalid: before and after medication, symptom is not improved or increases the weight of, comparatively the front minimizing of medication is less than 50% for angina pectoris attacks number of times, and electrocardiogram is unchanged.
Therapeutic outcome, sees the following form:
| Group | n | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 64 | 36 | 22 | 6 | 58(90.63％) |
| Matched group | 64 | 19 | 31 | 14 | 50(78.13％) |
As seen from the above table, treatment group curative effect is obviously better than matched group, and namely medicine of the present invention uses in conjunction with matched group Western medicine, can significantly improve the treatment curative effect of angina pectoris.
Concrete case: Fan, man, 49 years old, suffer from angina pectoris and have a surplus for 6 years, take Western medicine, disease did not have clear improvement always, seeks medical advice to the court.Oral trimetazidine tablets, each 20mg, every day 3 times; Oral diltiazem sheet, each 30mg, every day 3 times; Take the tablet of the embodiment of the present invention 1, each 3, every day 3 times, medication 14 days, the transference cures such as uncomfortable in chest, chest pain, angina pectoris attacks number of times comparatively reduces more than 80% before medication, and electrocardiogram recovers normal, effective simultaneously.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. Anesthesia Department is used for the treatment of a Chinese medicine for angina pectoris, it is characterized in that, in described Chinese medicine, each raw medicinal material comprises: Radix Marsdeniae griffithii, gold lion rattan, Cor Gigeriae Galli seven, Herba Lysionoti Pauciflori, Rhizoma Paridis tetraphyllae, Herba Boehmeriae platyphllae, Radix Ainsliaeae Bonatii, Flos Inulae, high-spirited, Herba Excoecariae cochinchinensis, Radix Zanthoxyli, Radix Ceratostigmatis mini, Herba Dracocephali, Armillaria mellea, Radix Rubiae Yunnanensis and Daphne giraldii Nitsche.
2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Marsdeniae griffithii 10 ~ 20 parts, 15 ~ 25 parts, gold lion rattan, Cor Gigeriae Galli 7 10 ~ 25 parts, Herba Lysionoti Pauciflori 25 ~ 40 parts, Rhizoma Paridis tetraphyllae 20 ~ 35 parts, Herba Boehmeriae platyphllae 10 ~ 15 parts, Radix Ainsliaeae Bonatii 20 ~ 40 parts, Flos Inulae 15 ~ 30 parts, high-spirited 10 ~ 15 parts, Herba Excoecariae cochinchinensis 20 ~ 30 parts, Radix Zanthoxyli 25 ~ 35 parts, Radix Ceratostigmatis mini 10 ~ 20 parts, Herba Dracocephali 25 ~ 40 parts, Armillaria mellea 15 ~ 20 parts, Radix Rubiae Yunnanensis 20 ~ 30 parts and Daphne giraldii Nitsche 30 ~ 45 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Marsdeniae griffithii 10 ~ 15 parts, 20 ~ 25 parts, gold lion rattan, Cor Gigeriae Galli 7 17 ~ 20 parts, Herba Lysionoti Pauciflori 25 ~ 35 parts, Rhizoma Paridis tetraphyllae 20 ~ 30 parts, Herba Boehmeriae platyphllae 10 ~ 13 parts, Radix Ainsliaeae Bonatii 30 ~ 40 parts, Flos Inulae 25 ~ 30 parts, high-spirited 13 ~ 15 parts, Herba Excoecariae cochinchinensis 20 ~ 25 parts, Radix Zanthoxyli 30 ~ 35 parts, Radix Ceratostigmatis mini 16 ~ 20 parts, Herba Dracocephali 25 ~ 35 parts, Armillaria mellea 15 ~ 18 parts, Radix Rubiae Yunnanensis 19 ~ 28 parts and Daphne giraldii Nitsche 35 ~ 45 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Marsdeniae griffithii 12 parts, 20 parts, gold lion rattan, Cor Gigeriae Galli 7 19 parts, Herba Lysionoti Pauciflori 33 parts, Rhizoma Paridis tetraphyllae 22 parts, Herba Boehmeriae platyphllae 13 parts, Radix Ainsliaeae Bonatii 37 parts, Flos Inulae 29 parts, high-spirited 13 parts, Herba Excoecariae cochinchinensis 20 parts, Radix Zanthoxyli 30 parts, Radix Ceratostigmatis mini 19 parts, Herba Dracocephali 26 parts, Armillaria mellea 15 parts, Radix Rubiae Yunnanensis 27 parts and Daphne giraldii Nitsche 42 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Marsdeniae griffithii 15 parts, 24 parts, gold lion rattan, Cor Gigeriae Galli 7 17 parts, Herba Lysionoti Pauciflori 25 parts, Rhizoma Paridis tetraphyllae 27 parts, Herba Boehmeriae platyphllae 10 parts, Radix Ainsliaeae Bonatii 30 parts, Flos Inulae 25 parts, high-spirited 15 parts, Herba Excoecariae cochinchinensis 24 parts, Radix Zanthoxyli 33 parts, Radix Ceratostigmatis mini 17 parts, Herba Dracocephali 30 parts, Armillaria mellea 18 parts, Radix Rubiae Yunnanensis 20 parts and Daphne giraldii Nitsche 35 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963528A (en) * | 2016-06-23 | 2016-09-28 | 娄明晓 | ASD (atrial septal defect) postoperation traditional Chinese medicine and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596302A (en) * | 2009-07-20 | 2009-12-09 | 王江雪 | A kind of treatment treating coronary heart disease and angina pectoris and preparation method thereof |
| CN102210807A (en) * | 2010-04-08 | 2011-10-12 | 北京以岭药业有限公司 | Application of traditional Chinese medicine composition in preparation of medicaments for treating angina pectoris |
| CN103071111A (en) * | 2012-12-26 | 2013-05-01 | 林杨 | Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596302A (en) * | 2009-07-20 | 2009-12-09 | 王江雪 | A kind of treatment treating coronary heart disease and angina pectoris and preparation method thereof |
| CN102210807A (en) * | 2010-04-08 | 2011-10-12 | 北京以岭药业有限公司 | Application of traditional Chinese medicine composition in preparation of medicaments for treating angina pectoris |
| CN103071111A (en) * | 2012-12-26 | 2013-05-01 | 林杨 | Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963528A (en) * | 2016-06-23 | 2016-09-28 | 娄明晓 | ASD (atrial septal defect) postoperation traditional Chinese medicine and preparation method thereof |
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