CN104906223A - Traditional Chinese medicine for treating hypertension - Google Patents
Traditional Chinese medicine for treating hypertension Download PDFInfo
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- CN104906223A CN104906223A CN201510315203.4A CN201510315203A CN104906223A CN 104906223 A CN104906223 A CN 104906223A CN 201510315203 A CN201510315203 A CN 201510315203A CN 104906223 A CN104906223 A CN 104906223A
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Abstract
The invention relates to a traditional Chinese medicine for treating hypertension. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 15 parts of salsola arbuscula, 6 parts of apocynum venetum, 11 parts of selfheal, 8 parts of motherwort fruit, 4 parts of ligusticum wallichii, 12 parts of uncaria and 9 parts of roots of kudzu vine. A clinical experiment proves that the hypertension can be safely and effectively treated.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to one and be used for the treatment of hypertensive Chinese medicine.
Background technology
Hypertension is common clinical, and main manifestations is systolic pressure >=140mmHg or diastolic pressure >=90mmHg, and state of an illness long-run development can cause the grievous injury of the target organs such as the heart, brain, kidney, causes the diseases such as coronary heart disease, apoplexy, renal failure.Hypertensive symptom varies with each individual.Early stage possibility is asymptomatic or symptom is not obvious, and blood pressure can occur after fatigue, psychentonia, anxious state of mind and raise, after having a rest, recovery is normal.Along with the course of disease extends, blood pressure significantly continues to raise, there will be various symptom gradually and be benign hypertension, benign hypertension common clinical symptoms has headache, dizziness, absent minded, hypomnesis, numb limbs and tense tendons, nocturia increase, cardiopalmus, uncomfortable in chest, weak etc.Severe headache, vomiting, cardiopalmus, the symptom such as dizzy is there will be when blood pressure is elevated to a certain degree suddenly, obnubilation, tic can be there is time serious, this just belongs to accelerated hypertension and hypertension critical illness, how can there is infringement and the pathological changes of the organs such as the serious heart, brain, kidney in a short time, as apoplexy, heart infarction, renal failure etc.Symptom there is no consistent relation with the level that blood pressure raises.Current western medical treatment hypertension still needs to take medicine all the life, but easily occurs the situations such as drug resistance, target organ damage and fluctuation of blood pressure., hypertension with traditional Chinese Medical is dialectical belongs to the category such as " dizzy ", " headache ", is that raw in, wind-fire not normal by internal organs imbalance of YIN and YANG, disharmony between QI and blood, ascending or descending movement of vital Qi, the expectorant stasis of blood is handed over caused by resistance.Its disease located in liver, kidney, relevant with the heart, spleen; Characteristic of disease is deficiency in origin and excess in superficiality, empty at liver, kidney, tangible wind, fire, expectorant, gas, the stasis of blood etc.In Hypertension research field, Chinese medicine has unique theoretical system, emphasizes determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treatment must aim at the pathogenesis of disease, and have the advantages such as blood pressure lowering is steadily eased up, patient compliance is good, clinic is applied.
Medical material present Research involved in the present invention is as follows:
The branch and leaf of woody Herba Salsolae Collinae [another name] Rhizoma Atractylodis macrocephalae this Herba Salsolae Collinae [source] chenopod book Herba Salsolae Collinae.The whole year all can gather, and after receiving, cutting is dried.[habitats distribution] is distributed in the ground such as the Inner Mongol, Gansu, Ningxia, Xinjiang.[nature and flavor] are light; Cool in nature.[function cures mainly] suppressing the hyperactive liver; Calm; Blood pressure lowering.Main hypertension.[usage and dosage] takes orally: decoct soup, 15-60g.[extracts] " China's book on Chinese herbal medicine "
Herba Apocyni veneti [another name] Ji Jima, Gaster caprae seu Ovis draw the leaf that angle, Semen astragali sinici, wild tea, Herba Euphorbiae Helioscopiae fiber crops, bluish dogbane [source] are apocynaceae plant Herba Apocyni veneti.Summer, autumn gather, and dry.[nature and flavor] are sweet; Micro-hardship; Cool in nature.[function cures mainly] heat clearing away suppressing the hyperactive liver; Inducing diuresis to remove edema.Main hypertension; Dizzy; Headache; Cardiopalmus; Insomnia; Edema urine water.[usage and dosage] takes orally: decoct soup, 5-10g; Or make tea.[extracts] " China's book on Chinese herbal medicine "
Spica Prunellae [another name] sunset sentence, Nedong, swallow face, Mai Xia are withered, ferrum color grass, excellent stigma flower, lantern head [source] are labiate Spica Prunellae or long hat Spica Prunellae fruit ear.Spica Prunellae, in the annual 5-6 month, when spica becomes sepia, selects fine day, has cut herb, be bundled into wisp, or cut spica, dries or using fresh herb.[nature and flavor] bitter in the mouth; Pungent; Cold in nature.[return through] returns liver; Gallbladder meridian .[function cures mainly] liver heat removing and eyesight improving; Powder detoxifcation.Argument is photophobia also; Ophthalmalgia; Have a headache dizzy; Tinnitus; Scrofula; Goiter; Acute mastitis; Mumps; Carbuncle furuncle and phyma poison; Acute hepatitis, chronic hepatitis; Hypertension [usage and dosage] is taken orally: decoct soup, 6-15g, heavy dose of available to 30g; Endure cream or enter ball, loose.Use of a specified duration: appropriate, decocts washing or smashes deposited.[extracts] " China's book on Chinese herbal medicine "
The fruit that Fructus Leonuri [another name] Herba Leonuri, the beautiful son of punching, FRUCTUS LEONURI, Fructus Leonuri [source] are labiate Herba Leonuri.Summer, autumn extract Herb when Herb blossom fall, fruit maturation, dry, lay fruit, removing blade, impurity.[nature and flavor] sweet in the mouth; Pungent; Cold nature.[return through] returns Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation; Liver heat removing and eyesight improving.Main menoxenia; Dysmenorrhea; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Liver-heat is had a headache; Dizzy; Conjunctival congestion and swelling pain; The raw cataracta of order.[usage and dosage] takes orally: decoct soup, 6-9g; Or enter ball, loose; Or smash strand extracting juice.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Chuanxiong [another name] mountain is brought up thoroughly, rhizome of chuanxiong chrysanthemum, Oleum Linderae, recklessly Qiong, gag bit, rhizome of chuanxiong Qiong, Medulla passeris rhizome of chuanxiong, capital rhizome of chuanxiong, pass through rhizome of chuanxiong, rhizome that Ligusticum slnense, platform rhizome of chuanxiong, western rhizome of chuanxiong [source] are samphire Rhizoma Chuanxiong.After planting, in late May, the 2nd is to early June, digs out rhizome, shakes off earth, and removing stem and leaf, a heatable brick bed is done.[habitats distribution] Main Cultivation in Sichuan, all there is introducing and planting on Yunnan, Guizhou, Guangxi, Hubei, Hunan, Jiangxi, Zhejiang, Jiangsu, Shaanxi, the ground such as Gansu.[nature and flavor] acrid in the mouth; Warm in nature.[return through] returns liver, gallbladder, pericardium channel [function cures mainly] blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Main menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.[usage and dosage] takes orally: decoct soup, 3-10g; Grind into powder, each 1-1.5g; Or enter ball, loose.External: appropriate, grinds into powder and spreads; Or decoct soup and gargle.[extracts] " China's book on Chinese herbal medicine "
Ramulus Uncariae Cum Uncis [another name] Ramulus Uncariae cum Uncis, hang rattan, Ramulus Uncariae Cum Uncis hook, fishhook rattan, Oriolus chinensis diffusus pawl wind, tender hook hook, golden Ramulus Uncariae Cum Uncis [source] this product are dicotyledon medicine Maguireothamnus speciosus Ramulus Uncariae Cum Uncis or Uncaria sinensis (Oliv.) Havil. and belong to the buckle branch of various plants together.Spring, autumn gather the twig of buckle, cut off the rattan of Wugou, dry, or put steam in pot after dry again.[nature and flavor] sweetness and bitterness; Be slightly cold.[return through] liver; Heart channel.[function cures mainly] heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.Main infantile convulsion; Night cry; Intenseness of heat wind symptom; Eclamposia; Dizziness due to hyperactivity of liver-YANG; Liver-fire distending pain in the head.[usage and dosage] takes orally: decoct soup 6-30g.Should not decoct for a long time; Or enter powder.[extracts] " China's book on Chinese herbal medicine "
The tuber that Radix Puerariae [another name] Radix puerariae, Radix Puerariae, Pachyrhizua angulatus, Ge Gegen, Pueraria montana (Lour.) Merr. are eaten, Ge Zigen, Radix puerariae root, the neat root of chicken [source] this product are legume pueraria lobata or Radix Puerariae rattan.Cultivation 3-4 excavates, and blade is withered and yellow in the winter time carries out afterwards before germination.Tuber is dug out, removes tendril, cut root head and plant, removing silt, scrapes off rough bark, is cut into the inclined tab that 1.5-2cm is thick, dry or dry.After the section of the ground such as Guangdong, Fujian, soak with saline, Alumen water or washing water of rice, then dry after smoking with sulfur, color is more fair and more clear.[nature and flavor] are sweet; Pungent; Flat.[return through] spleen; Stomach; Lung; Urinary bladder channel.[function cures mainly] expelling pathogenic factors from muscles for reducing heat; Deliver and examine; Promoting the production of body fluid to quench thirst; Yang invigorating antidiarrheal.Main fever caused by exogenous pathogens; Rigidity pain on the head and nape; Measles from the beginning of; Rash goes out not smooth; Epidemic febrile disease is thirsty; Diabetes; Have loose bowels; Dysentery; Hypertension; Coronary heart disease.[usage and dosage] takes orally: decoct soup, 10-15g; Or smash juice.External: appropriate, smashes deposited.[extracts] " China's book on Chinese herbal medicine "
Summary of the invention
The present invention aims to provide one and is used for the treatment of hypertensive Chinese medicine, by selecting suitable medical material and proportioning thereof, reaches the hypertensive object of safe and effective healing.
In order to achieve the above object, the present invention is by the following technical solutions:
One is used for the treatment of hypertensive Chinese medicine, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: woody Herba Salsolae Collinae 15 parts, Herba Apocyni veneti 6 parts, Spica Prunellae 11 parts, Fructus Leonuri 8 parts, Rhizoma Chuanxiong 4 parts, Ramulus Uncariae Cum Uncis 12 parts, Radix Puerariae 9 parts.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects hyperpietic 92 example of outpatient clinic altogether between in April ,-2014 in March, 2012, all meet Evaluation of Diagnostic Criteria of Hypertension.All patients are divided at random treatment group 46 example and matched group 46 example.The aspects such as two groups of patient ages, sex, courses of disease compare in Table 1-table 3.
Table 1 liang group patient age (year) compare
Table 2 liang group gender comparison
The table 3 liang group course of disease (moon) compares
Compare P by the visible two groups of patient's basic documents of table 1-table 3 and be all greater than 0.05, namely two groups of patient clinical basic document there was no significant differences, have comparability.
1.2 experiment case standards
1.2.1 case inclusive criteria
Meet the patient of Diagnosing Hypertension and Standards of Chinese Medical Syndrome Differentiation, experiment case can be included in, with II phase hypertension for main detection object.
1.2.2 case exclusion standard (comprising inadaptation or rejecting standard)
(1) age is under-18s or more than 70 years old person, gestation or women breast-feeding their children, those who are allergic to this drug;
(2) primary disease, the psychotics such as liver, kidney and hemopoietic system is associated with;
(3) allly do not meet inclusive criteria, not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
1.3 diagnostic criteria
" new Chinese medicine guideline of clinical investigations (trying) " (2002) with reference to Ministry of Health of the People's Republic of China develops and publishes:
Primary symptom: dizzy, headache, xerostomia, soreness of waist and knee, dysphoria with feverish sensation in the chest palms and soles.
Secondary disease: cardiopalmus, insomnia, tinnitus, the few tongue of forgetful, red tongue, stringy and thready pulse and counting.
2, test method
2.1 Therapeutic Method
The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times.Treat 2 courses for the treatment of (4 weeks/course for the treatment of).
The oral Levamlodipine beaylate tablets of matched group (pharmaceutcal corporation, Ltd of Shanxi China), uses according to its description, treats 2 courses for the treatment of (4 weeks/course for the treatment of).
Duration of test all experimenters forbidding is to the medicative Chinese and western drugs of hypertension tool and other Therapeutic Method, run into merging disease and must take other drug treatment, the information such as medicine name (comprising trade name and chemical name), consumption, Slurry pump, access times and time must be recorded in case report form, analyzed during summary and report.
Treatment starts front inspection hematuria routine and hepatic and renal function electrocardiogram etc., and after treatment, the 4th weekend, 8 weekends check hematuria routine and hepatic and renal function and electrocardiogram etc. respectively.All MethodsThe cases enrolled periodic monitor every day blood pressures 2 times.
3, criterion of therapeutical effect and therapeutic outcome
3.1 clinical total effects criterion
With reference to diabetes curative effect evaluation criteria in " new Chinese medicine guideline of clinical investigations " (2002).
(1) cure: diastolic pressure more than decline 10mmHg, though and reach normal range or diastolic pressure is not down to the 20mmHg that normally declined, tcm clinical practice symptom, sign disappear;
(2) effective: diastolic pressure more than decline 10mmHg, though and reach normal range or diastolic pressure is not down to the 20mmHg that normally declined, tcm clinical practice symptom, sign are clearly better;
(3) effective: diastolic pressure declines less than 10mmHg, but reached normal range or diastolic pressure decline 10-19mmHg but do not reached normal range or systolic pressure decline 30mmHg, tcm clinical practice symptom, sign all have and alleviate;
(4) invalid: diastolic pressure declines less than 10mmHg and do not reach normal range, tcm clinical practice symptom, sign are not improved, even increase the weight of.
Total effective rate=(cure+effective+effectively)/total number of cases * 100%
3.2 therapeutic outcome
Two groups of tcm syndrome comparitive study after treatment in 8 weeks, treatment group clinical recovery rate is 50.00%, and obvious effective rate is 30.43%, and effective percentage is 15.22%; Matched group clinical recovery rate is 28.26%, and obvious effective rate is 23.91%, effective percentage 28.26%.Two groups of total effective rates are through X 2 test P=0.02 < 0.05, and namely treatment group is better than matched group in TCM syndrome curative effect, specifically in table 4.
The table 4 liang clinical total effects of group compares
Be used for the treatment of hypertension cure rate by the visible the present invention of above result high, there is the value applied.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: woody Herba Salsolae Collinae 15 grams, Herba Apocyni veneti 6 grams, Spica Prunellae 11 grams, Fructus Leonuri 8 grams, Rhizoma Chuanxiong 4 grams, Ramulus Uncariae Cum Uncis 12 grams, Radix Puerariae 9 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of hypertension.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: woody Herba Salsolae Collinae 15 grams, Herba Apocyni veneti 6 grams, Spica Prunellae 11 grams, Fructus Leonuri 8 grams, Rhizoma Chuanxiong 4 grams, Ramulus Uncariae Cum Uncis 12 grams, Radix Puerariae 9 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of hypertension.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 3
Take: woody Herba Salsolae Collinae 15 grams, Herba Apocyni veneti 6 grams, Spica Prunellae 11 grams, Fructus Leonuri 8 grams, Rhizoma Chuanxiong 4 grams, Ramulus Uncariae Cum Uncis 12 grams, Radix Puerariae 9 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of hypertension.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. be used for the treatment of a hypertensive Chinese medicine, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: woody Herba Salsolae Collinae 15 parts, Herba Apocyni veneti 6 parts, Spica Prunellae 11 parts, Fructus Leonuri 8 parts, Rhizoma Chuanxiong 4 parts, Ramulus Uncariae Cum Uncis 12 parts, Radix Puerariae 9 parts.
2. one as claimed in claim 1 is used for the treatment of hypertensive Chinese medicine, and it is characterized in that, its preparation method is: take: woody Herba Salsolae Collinae 15 parts, Herba Apocyni veneti 6 parts, Spica Prunellae 11 parts, Fructus Leonuri 8 parts, Rhizoma Chuanxiong 4 parts, Ramulus Uncariae Cum Uncis 12 parts, Radix Puerariae 9 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. one as claimed in claim 1 is used for the treatment of hypertensive Chinese medicine, and it is characterized in that, its preparation method is: take: woody Herba Salsolae Collinae 15 parts, Herba Apocyni veneti 6 parts, Spica Prunellae 11 parts, Fructus Leonuri 8 parts, Rhizoma Chuanxiong 4 parts, Ramulus Uncariae Cum Uncis 12 parts, Radix Puerariae 9 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. one as claimed in claim 1 is used for the treatment of hypertensive Chinese medicine, and it is characterized in that, its preparation method is: take: woody Herba Salsolae Collinae 15 parts, Herba Apocyni veneti 6 parts, Spica Prunellae 11 parts, Fructus Leonuri 8 parts, Rhizoma Chuanxiong 4 parts, Ramulus Uncariae Cum Uncis 12 parts, Radix Puerariae 9 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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| CN201510315203.4A CN104906223A (en) | 2015-06-06 | 2015-06-06 | Traditional Chinese medicine for treating hypertension |
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| CN201510315203.4A CN104906223A (en) | 2015-06-06 | 2015-06-06 | Traditional Chinese medicine for treating hypertension |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895530A (en) * | 2011-07-29 | 2013-01-30 | 陈冠卿 | Hypertension-treating medicine |
| JP2013209351A (en) * | 2012-03-30 | 2013-10-10 | Sunstar Inc | Antioxidant function enhancer |
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- 2015-06-06 CN CN201510315203.4A patent/CN104906223A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895530A (en) * | 2011-07-29 | 2013-01-30 | 陈冠卿 | Hypertension-treating medicine |
| JP2013209351A (en) * | 2012-03-30 | 2013-10-10 | Sunstar Inc | Antioxidant function enhancer |
Non-Patent Citations (2)
| Title |
|---|
| 冯愉态: "《心血管疾病》", 31 May 2003, 广州出版社 * |
| 瞿岳云: "《中医补益全书【珍藏本】超值版》", 31 August 2013, 湖南科学技术出版社 * |
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Application publication date: 20150916 |