CN105148219A - Traditional Chinese medicine for treating myelodysplastic syndrome - Google Patents
Traditional Chinese medicine for treating myelodysplastic syndrome Download PDFInfo
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- CN105148219A CN105148219A CN201510511254.4A CN201510511254A CN105148219A CN 105148219 A CN105148219 A CN 105148219A CN 201510511254 A CN201510511254 A CN 201510511254A CN 105148219 A CN105148219 A CN 105148219A
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Abstract
The invention relates to a traditional Chinese medicine for treating the myelodysplastic syndrome. The traditional Chinese medicine is prepared from raw materials in parts by weight as follows: 15 parts of willowleaf cotoneaster roots, 12 parts of crabgrass, 10 parts of Rhododendron seniavinii, 12 parts of mioga ginger rhizomes, 9 parts of morse luisia and 12 parts of barberry roots. Clinical experiments prove that the traditional Chinese medicine can treat the myelodysplastic syndrome safely and effectively.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of myelodysplastic syndrome.
Background technology
Myelodysplastic syndrome refers to one group of hemopoietic function exception closely relevant with leukemic generation or the disorderly syndrome of hemopoietic function, and it is abnormal that this myeloproliferative disorder does not comprise the bone marrow hematogenesis occurred in general hematopathy.This patient is in the majority with old age, and clinical manifestation is mainly anemia, but also has infectious fever or hemorrhage.Hemogram majority is pancytopenia.Though bone marrow hematogenesis enlivens, three is that the hypertrophy of cell is abnormal, and show as cell abnormity, myeloblast and promyelocyte increase, and have obvious DH.Primary disease pathogenesis more complicated, comprises nature and nurture, and there are again internal injury and diseases caused by exogenous pathogenic factor the day after tomorrow.1 natural endowment is not enough, or because of caused by fetal toxicosis.The kidney being the origin of congenital constitution, natural endowment deficiency and high the moon, high YANG deficiency.Lose for 2 day after tomorrow and support.Spleen is the foundation of acquired constitution, and supporting if lose the day after tomorrow can because of eating and drinking without temperance, and imbalance of slaving all day long with no assurance when the next meal will come, injures taste, involves all void of other internal organs and is subject to exopathogen invasion and attack.3 diseases caused by exogenous pathogenic factor six climate exopathogens, evil poison.Wind and cold heat-damp in summer dryness-fire can be taken advantage of a weak point, and invades bone marrow and falls ill.The kidney being the origin of congenital constitution, hides the essence of five ZANG-organs and six FU-organs gas.Kidney governing bones, the raw marrow of bone, kidney storing essence, blood of refining.The spleen being the foundation of acquired constitution, main transporting and transforming nutrients from foodstuff is precise and tiny.Asthenia of both the spleen and kidney, the source causing hemopoietic is exhausted, and shows as pale complexion, dizzy cardiopalmus, weakly breathes hard, soreness of the waist and knees, dry pharynx for drink, low grade fever night sweat, flushing of cheeks, dysphoria with feverish sensation in the chest palms and soles, spiritlessness and sparing of words, or have aversion to cold and cold limbs, the diseases such as spontaneous perspiration poor appetite.Prolonged illness must be empty, and prolonged illness must the stasis of blood, and insufficiency of vital energy and blood, causes qi depression to blood stasis further, visible sucutaneous nodule, scrofula, mass in abdomen, tongue with ecchymosis etc.Institute's its gas that gathers of heresy must be empty, and body fictitious pole is easily recruited to diseases caused by exogenous pathogenic factor six climate exopathogens, evil poison invasion and attack.
Medical material present Research involved in the present invention is as follows:
Radix cotoneastri salicifolii [another name] wooden broom, Folium Salicis Babylonicae Xun, bavin, mountain rice fiber crops.[source] medical material Ji Yuan: be the Herb of rosaceous plant Folium Salicis Babylonicae Xun.[nature and flavor] are cool in nature, and bitter in the mouth is nontoxic.[return through] lung; Urinary bladder channel.[function cures mainly] clearing away heat and expelling wind, hemostasis diuresis.Trunk coughs aphonia, jaundice caused by damp-heat, discharging fresh blood stool, oliguria.[usage and dosage] takes orally: decoct soup, 15 ~ 30g.[extracts] " China's book on Chinese herbal medicine ".
Herba Digitariae [another name] sheep fiber crops, sheep foxtail millet, horse meal, Herba caryopteridis nepetaefoliae.[source] medical material Ji Yuan: be the herb of grass Herba Digitariae.Gather and store: summer, autumn tap herb, dry.[nature and flavor] are sweet; Cold.[return through] returns Liver Channel.[function cures mainly] improving eyesight lung moistening.Main poor vision; Cough due to lung-heat.[usage and dosage] takes orally: decoct soup, 9 ~ 15g.[extracts] " China's book on Chinese herbal medicine ".
Rhododendron seniavinii [another name] little Hua Rhododendron seniavinii.[source] medical material Ji Yuan: be the root of ericad Radix seu cacumen Rhododendri seniavinii, stem and leaf and flower.Gather and store: root, stem and leaf, the whole year all can adopt, and section is dried; Flower, April adopts, and dries.[nature and flavor] are pungent; Cool in nature.[return through] lung meridian.[function cures mainly] cough-relieving; Eliminate the phlegm; Relieving asthma.Main chronic tracheitis.[usage and dosage] takes orally: decoct soup, 15 ~ 30g.[extracts] " China's book on Chinese herbal medicine ".
Rhizoma zingiberis miogae [another name] pad in shoe Pu, good grass, Weed Ju, Graduate pad in shoe, taro canal, white Rhizoma zingiberis miogae, cover exploitation in Potamogeton, Pu Ju, the positive leaves of pulse plants, sheep leaves of pulse plants Rhizoma Zingiberis Recens, Alpinia japonica (Thunb.) Miq., kwan-yin flower, company's Zingiber zerumbet, Rhizoma Alpiniae Officinarum, Rhizoma Polygonati, soil, wild old ginger, Rhizoma Alpiniae Officinarum, wild Alpinia japonica (Thunb.) Miq., Fructus Hedychii Spicati.[source] medical material Ji Yuan: for Jiang Ke plants the rhizome of thing Rhizoma zingiberis miogae.Gather and store: summer, autumn gather, using fresh herb or section are dried.[nature and flavor] acrid in the mouth; Warm in nature.[return through] lung; Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation; What is said or talked about of dispelling cough-relieving; Removing toxic substances and promoting subsidence of swelling.Main menoxenia; Dysmenorrhea; Traumatic injury; Cough and asthma; Swollen ulcer drug; Scrofula.[usage and dosage] takes orally: decoct soup, 6 ~ 15g.[attention] avoids ferrum.[extracts] " China's book on Chinese herbal medicine ".
Radix Seu Herba Luisiae Morsei [another name] Luisia zeylanica Lindl.[L.teretifolia auct.non Gaudich., 30, Taxillus caloreas (Diels) Danser, worm be parasitic, extra large speckle tiger, Lignum Santali Albi line, stannum friend grass, Stone-wedge bamboo, Herba Poae Sphondylodis.The root that [source] is orchid Radix Seu Herba Luisiae Morsei or herb.[nature and flavor] bitter in the mouth is flat, nontoxic.[return through] enters lung; The heart; Liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main malaria; Carbuncle; Laryngopharynx swelling and pain; Rheumatic arthralgia; Edema; Nebulousurine; Leukorrhagia; Traumatic injury; Medicine or alimentary toxicosis.[usage and dosage] takes orally: decoct soup, 9 ~ 16g.[extracts] " China's book on Chinese herbal medicine ".
Radix Berberidis [another name] draw point thorn, Radix Berberidis soulieanae.[source] medical material Ji Yuan: for Berberidaceae plant berberis poiretii, sting black pearl, blue fruit Radix Berberidis Amurensis, the root of various plants such as cat thorn Radix Berberidis Amurensis, spoonleaf barbarry herb etc., stem and bark.Gather and store: root was gathered in spring, season in autumn two, removing fibrous root, cleans, and section, dries or dry under the weak sun, should not tan by the sun. and formula branch can be adopted the whole year.[nature and flavor] are bitter; Cold in nature; [return through] liver; Stomach; Large intestine channel.[function cures mainly] heat clearing away; Dampness; Eliminating fire and detoxication.Main dysentery due to damp-heat profit; Diarrhoea; Jaundice; Eczema; Skin infection; Aphtha; Conjunctival congestion; Pharyngalgia [usage and dosage] is taken orally: decoct soup, 0.5 ~ 30g.[attention] this product Deficiency and coldness of spleen and stomach person be cautious use of.[extracts] " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of myelodysplastic syndrome, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing myelodysplastic syndrome.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a Chinese medicine for myelodysplastic syndrome, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix cotoneastri salicifolii 15 parts, Herba Digitariae 12 parts, Rhododendron seniavinii 10 Fen, Rhizoma zingiberis miogae 12 parts, Radix Seu Herba Luisiae Morsei 9 parts, Radix Berberidis 12 parts.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Outpatient service is collected and Patients With Myelodysplastic Syndrome 80 example of being in hospital altogether in inventor in October, 2012 ~ 2013 between year October, be divided into treatment group 40 example and matched group 40 example at random, treatment group man 23 example, female 17 example; Matched group man 25 example, female 15 example.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.
Diagnostic criteria
Diagnostic criteria according to the meeting of national myelodysplastic syndrome clinical speciality:
(1), Peripheral blood pancytopenia or be two is minimizing, and visible erythroblast or gigantocyte or other DHs, also can have leukocytosis.
(2), myelosis is active or obviously do not enliven person and account for 90%, and low person accounts for 10%, and bone marrow has at least two to be DH.
(3) DH, caused by other diseases.As erythroleukemia, subacute granulocytic leukemia, myelofibrosis, slow grain, idiopathic thrombocytopenic purpura, megaloblastic anemia etc.
(4), with Drug therapy more than 3 months nonresponders of current therapies anemia.
2, test method
2.1 Therapeutic Method
The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 3 times.25 weeks courses for the treatment of.
The oral all-trans-retinoic acid of matched group: every day 30 ~ 90mg, points 3 times; Vitamin D3: 2.5 ~ 15 μ g/ days; Prednisone, 10mg, every day 3 times.25 weeks courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Clinic control: anemia, bleeding disappear, and hemoglobin reaches 100g/L, and leukocyte reaches 4 × 109/L, platelet reaches 80 × 109/L, bone marrow DH phenomenon significantly alleviates, and bone marrow Central Plains, children's (pouring) cell < 5%, continue to not a half year.
Effective: obviously progressive anemia and bleeding disappear, and hemoglobin reaches 100g/L, leukocyte 3.5 × 109/L, platelet has recovery to a certain degree, bone marrow DH phenomenon alleviates, blood Central Plains, juvenile cell < 5%, maintains at least 3 months.
Effective: anemia and bleeding take a turn for the better, and do not transfuse blood, the modal value that hemoglobin was comparatively treated in the previous moon increases 30g/L, and former, juvenile cell number reduces.
Invalid: progressive person can not to be reached through fully treating.
3.2 therapeutic outcomes are in table 1.
Table 1 liang group comparitive study
Visible, the medicine that the present invention obtains can safe and effective treatment myelodysplastic syndrome, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Radix cotoneastri salicifolii 15 grams, Herba Digitariae 12 grams, Rhododendron seniavinii 10 Ke, Rhizoma zingiberis miogae 12 grams, Radix Seu Herba Luisiae Morsei 9 grams, Radix Berberidis 12 grams.; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of myelodysplastic syndrome.Oral, every bu Morning Afternoon Evening is taken for three times.
Embodiment 2
Take: Radix cotoneastri salicifolii 15 grams, Herba Digitariae 12 grams, Rhododendron seniavinii 10 Ke, Rhizoma zingiberis miogae 12 grams, Radix Seu Herba Luisiae Morsei 9 grams, Radix Berberidis 12 grams.; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of myelodysplastic syndrome.Oral, every bu Morning Afternoon Evening is taken for three times.
Embodiment 3
Take: Radix cotoneastri salicifolii 15 grams, Herba Digitariae 12 grams, Rhododendron seniavinii 10 Ke, Rhizoma zingiberis miogae 12 grams, Radix Seu Herba Luisiae Morsei 9 grams, Radix Berberidis 12 grams.; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of myelodysplastic syndrome.Oral, every bu Morning Afternoon Evening is taken for three times.
Claims (4)
1. be used for the treatment of a Chinese medicine for myelodysplastic syndrome, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix cotoneastri salicifolii 15 parts, Herba Digitariae 12 parts, Rhododendron seniavinii 10 parts, Rhizoma zingiberis miogae 12 parts, Radix Seu Herba Luisiae Morsei 9 parts, Radix Berberidis 12 parts.
2. a kind of Chinese medicine being used for the treatment of myelodysplastic syndrome as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix cotoneastri salicifolii 15 parts, Herba Digitariae 12 parts, Rhododendron seniavinii 10 Fen, Rhizoma zingiberis miogae 12 parts, Radix Seu Herba Luisiae Morsei 9 parts, Radix Berberidis 12 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of Chinese medicine being used for the treatment of myelodysplastic syndrome as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix cotoneastri salicifolii 15 parts, Herba Digitariae 12 parts, Rhododendron seniavinii 10 Fen, Rhizoma zingiberis miogae 12 parts, Radix Seu Herba Luisiae Morsei 9 parts, Radix Berberidis 12 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of Chinese medicine being used for the treatment of myelodysplastic syndrome as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix cotoneastri salicifolii 15 parts, Herba Digitariae 12 parts, Rhododendron seniavinii 10 Fen, Rhizoma zingiberis miogae 12 parts, Radix Seu Herba Luisiae Morsei 9 parts, Radix Berberidis 12 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105343654A (en) * | 2015-12-24 | 2016-02-24 | 刘艳 | Traditional Chinese medicine for treating nodular panniculitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547788A (en) * | 2014-12-30 | 2015-04-29 | 丛培馥 | Traditional Chinese medicine decoction for treating myeloproliferative disorder syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104547788A (en) * | 2014-12-30 | 2015-04-29 | 丛培馥 | Traditional Chinese medicine decoction for treating myeloproliferative disorder syndrome |
Non-Patent Citations (1)
| Title |
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| 李文敬 等: "《自身免疫性疾病中西医治疗学》", 31 January 2007 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343654A (en) * | 2015-12-24 | 2016-02-24 | 刘艳 | Traditional Chinese medicine for treating nodular panniculitis |
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