CN105998952A

CN105998952A - Traditional Chinese medicine preparation for treating facioplegia and preparation method thereof

Info

Publication number: CN105998952A
Application number: CN201610447037.8A
Authority: CN
Inventors: 韩文珍; 甄世明; 邱晨
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-06-17
Filing date: 2016-06-17
Publication date: 2016-10-12

Abstract

The invention provides a traditional Chinese medicine preparation for treating facioplegia and a preparation method thereof. The traditional Chinese medicine preparation is prepared from villous themeda roots, all grass of saruma henryi, herb of grace, the root of gourian clematis, all grass of phymatopsis hastate, aerial roots of ficus microcarpa, tender catchweed bedstraw herb, shortwoolled goldsaxifrage, the root of rustyhair raspberry, Japanese polypody rhizomes, die-hard clematis roots, herb of codonacanthus pauciflorus, violet flourishing roots, the root of tuan linden, the root of Nepal gongronema, the root of common javatea, all grass of impatiens duclouxii, the root of Artocarpus styracifolius Pierre. and herb of digitateleaf eria. When the traditional Chinese medicine preparation is combined with Western conventional medicine to treat facioplegia, the traditional Chinese medicine preparation has the advantages that the treatment effect is good, the cure rate is high, and toxic and side effects are avoided.

Description

One treats prosopoplegic Chinese medicine preparation and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, particularly relate to one treat prosopoplegic Chinese medicine preparation and Its preparation method.

Background technology

Facial paralysis, is commonly called as " facial paralysis ", " wapperijaw bar ", " wapperijaw ", " facial paralysis ", Being a kind of commonly encountered diseases with facial expression muscle group dyskinesia as principal character, general symptom is mouth eye Crooked, it is a kind of commonly encountered diseases, frequently-occurring disease, and it is not by age limit.Patient facial region often connects most basic Lift eyebrow, close one's eyes, the drum action such as mouth all cannot complete.Most patients are often in time washing one's face, gargle early morning Catch sight of that side buccal action is ineffective, face is crooked.The sick complete paralytic of side surface part histrionic muscles, forehead Wrinkle disappears, palpebral fissure expands, nasolabial fold is smooth, ptosis of labial angle, and time grinningly, bicker is askew to strong lateral deviation.Sick Can not make wrinkle volume, frown, close mesh, air-blowing and the action such as be in a pout in side.When rousing the cheek and whistle, because of Ipsilateral Lip can not close and leak gas.During feed, food debris is often stranded in the tooth buccal space of disease side, and often Saliva is had to drop down from this side.Owing to lacrimal point is with lower eyelid entropion, make the tear can not be excessive by normal drainage.It It is divided into peripheral with central two kinds (meeting neuroplegic typing).Wherein peripheral facial paralysis sickness rate The highest, and most common person is facial neuritis or Bell's palsy.Usually the facial paralysis that people often say, at majority In the case of refer to facial neuritis for.Because facial paralysis can cause the most strange face, so often by people It is referred to as " disease of disfeaturing ".

The prosopoplegic cause of disease mainly has: (1) infection: mostly infection is by hiding In nervus facialis sensory ganglion, the herpes zoster (VZV) of resting state is activated and causes.(2) ear source property Disease.(3) idiopathic (often claiming Bel l paralysis).(4) tumor.(5) neurogenic.(6) Traumatic.(7) poisoning: such as alcoholism.Long Term Contact Toxic.(8) dysbolismus: such as sugar Urine is sick, vitamin deficiency.(9) vascular function is the most complete.(10) congenital nuclear agenesis.

Facial paralysis is divided into maincenter type and peripheral.1. maincenter type: on core organize (include cortex, Cortex brainstem fibres, capsula interna, pons etc.) impaired time cause, occur focus offside face lower muscle fiber crops Numbness.Show as nasolabial fold from top to bottom to shoal, ptosis of labial angle time grinningly (or claim bicker askew to focus side, I.e. paralysis facial muscle offside), it is impossible to whistle and rouse the cheek etc..It is more common in cerebrovascular disease, the cerebral tumor and brain Scorching etc..2., there is the whole facial muscle of focus homonymy in peripheral: cause during for nucleus of facial nerve or facial nerve damage Paralysis, the volume that shows as from top to bottom wrinkling, frowns, closes mesh, absent corneal reflex, and nasolabial fold shoals, Can not grinningly, drum the cheek, whistle, ptosis of labial angle (or claim bicker askew to focus offside, facial muscle of i.e. paralysing Offside).Be more common in catch cold, peripheral profiles nerve fiber crops that ear or infection of meninges, neurofibroma cause Numbness.Additionally may occur in which 2/3 dysgeusia before tongue.

Summary of the invention

The technical problem to be solved is, it is provided that a kind of therapeutic effect is good and has no side effect Treat prosopoplegic Chinese medicine preparation and preparation method thereof.

In order to solve above-mentioned technical problem, the invention provides one and treat prosopoplegic Chinese medicine preparation And preparation method thereof, described Chinese medicine preparation includes following raw medicinal material: Rhizoma Themedae villosae, connect gas grass, Herba rutae, Radix seu Caulis fici Martinii grass, Herba Lysimachiae Fortunei, Radix Aerio Fici Microcarpae, Galium spurium L., Chrysosplenium lanuginosum Hook. F. Et Thoms, Radix Rubi reflexi, Rhizoma Polypodiodis Nipponicae, iron wire Radix Clematidis, Campanilla grass, Radix campsis, Radix Tiliae, Radix Gongronematis neplansis, Radix Orthosiphonis Wulfenioidis, light dish, storaxleaf artocarpus root and Herba Eriae Panneae.

In described Chinese medicine preparation the ratio of weight and number of each raw medicinal material can be such that Rhizoma Themedae villosae 15～25 parts, Connect gas grass 10～20 parts, Herba rutae 6～15 parts, Radix seu Caulis fici Martinii grass 10～15 parts, Herba Lysimachiae Fortunei 25～40 parts, Radix Aerio Fici Microcarpae 20～ 35 parts, Galium spurium L. 15～25 parts, Chrysosplenium lanuginosum Hook. F. Et Thoms 10～25 parts, Radix Rubi reflexi 15～20 parts, Rhizoma Polypodiodis Nipponicae 25～ 35 parts, iron wire Radix Clematidis 10～15 parts, campanilla grass 20～35 parts, Radix campsis 20～30 parts, Radix Tiliae 10～ 18 parts, Radix Gongronematis neplansis 12～26 parts, Radix Orthosiphonis Wulfenioidis 8～15 parts, light dish 8～14 parts, storaxleaf artocarpus root 15～25 parts With Herba Eriae Panneae 15～20 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be as follows: Rhizoma Themedae villosae 20～25 parts, Connect gas grass 10～15 parts, Herba rutae 6～10 parts, Radix seu Caulis fici Martinii grass 12～15 parts, Herba Lysimachiae Fortunei 25～35 parts, Radix Aerio Fici Microcarpae 25～ 30 parts, Galium spurium L. 15～20 parts, Chrysosplenium lanuginosum Hook. F. Et Thoms 10～15 parts, Radix Rubi reflexi 15～17 parts, Rhizoma Polypodiodis Nipponicae 25～ 30 parts, iron wire Radix Clematidis 10～12 parts, campanilla grass 20～30 parts, Radix campsis 25～30 parts, Radix Tiliae 10～ 15 parts, Radix Gongronematis neplansis 12～18 parts, Radix Orthosiphonis Wulfenioidis 10～15 parts, light dish 8～10 parts, storaxleaf artocarpus root 15～20 Part and Herba Eriae Panneae 15～18 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be as follows: Rhizoma Themedae villosae 21 parts, connects Gas grass 12 parts, Herba rutae 6 parts, Radix seu Caulis fici Martinii grass 14 parts, Herba Lysimachiae Fortunei 28 parts, Radix Aerio Fici Microcarpae 27 parts, Galium spurium L. 17 parts, silk floss Hair 11 parts of waist of gold, Radix Rubi reflexi 17 parts, Rhizoma Polypodiodis Nipponicae 28 parts, iron wire Radix Clematidis 11 parts, campanilla grass 23 parts, Radix campsis Root 29 parts, Radix Tiliae 12 parts, Radix Gongronematis neplansis 14 parts, Radix Orthosiphonis Wulfenioidis 13 parts, light dish 8 parts, storaxleaf artocarpus root 16 Part and Herba Eriae Panneae 16 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be as follows: Rhizoma Themedae villosae 23 parts, connects Gas grass 15 parts, Herba rutae 9 parts, Radix seu Caulis fici Martinii grass 12 parts, Herba Lysimachiae Fortunei 33 parts, Radix Aerio Fici Microcarpae 25 parts, Galium spurium L. 20 parts, silk floss Hair 15 parts of waist of gold, Radix Rubi reflexi 15 parts, Rhizoma Polypodiodis Nipponicae 26 parts, iron wire Radix Clematidis 12 parts, campanilla grass 28 parts, Radix campsis Root 25 parts, Radix Tiliae 15 parts, Radix Gongronematis neplansis 17 parts, Radix Orthosiphonis Wulfenioidis 10 parts, light dish 10 parts, storaxleaf artocarpus root 18 Part and Herba Eriae Panneae 18 parts.

In order to solve above-mentioned technical problem, present invention also offers a kind of any one Chinese medicine preparation above-mentioned Preparation method, wherein: when the dosage form of described Chinese medicine preparation is granule, its preparation method includes following Step:

Step one: mixed in described ratio by described raw medicinal material, adds relative to mixture 4～the alcohol of 8 times Concentration is the ethanol of 85%～95%, is heated to boiling reflux 3～5 hours, filters, with backflow as solvent, With filtering residue as solute, use percolation with the speed slowly percolation of per minute 1～2ml, collect percolate, When being evaporated to 50～60 DEG C subsequently under vacuum 0.06～0.09Mpa relative density be 1.04～ The mastic of 1.10, is spray-dried, the inlet temperature 160 of spray dryer～175 DEG C, leaving air temp 80～ 85 DEG C, it is ground into powder subsequently, makes dried cream powder；

Step 2: add relative to dried cream powder quality 0.2～the cane sugar powder of 0.4 times in the dried cream powder obtained With the dextrin of 0.1～0.2 times, make granule, be dried in 40～50 DEG C, it is thus achieved that granule.

In order to solve above-mentioned technical problem, invention further provides a kind of any one Chinese medicine preparation above-mentioned Preparation method, wherein: when the dosage form of described Chinese medicine preparation is decoction, and its preparation method comprises the following steps:

Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to the dipped medicine of clear water Material upper surface 2-5cm, soaks 3-10 hour；

Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 30-50 minute slowly to medicine The dosage of liquid is 100-300ml, filters, obtains filtrate a, standby；

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour；

Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 25-35 minute slowly to medicine The dosage of liquid is 100-300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.

Beneficial effects of the present invention: the Chinese medicine preparation that the present invention provides combines doctor trained in Western medicine routine medication face god Through paralysis, having therapeutic effect good, cure rate is high, the advantage having no side effect.

Detailed description of the invention

The invention provides one and treat prosopoplegic Chinese medicine preparation, its raw medicinal material includes: sedge Root, connect gas grass, Herba rutae, Radix seu Caulis fici Martinii grass, Herba Lysimachiae Fortunei, Radix Aerio Fici Microcarpae, Galium spurium L., Chrysosplenium lanuginosum Hook. F. Et Thoms, Radix Rubi reflexi, Rhizoma Polypodiodis Nipponicae, iron wire Radix Clematidis, campanilla grass, Radix campsis, Radix Tiliae, Radix Gongronematis neplansis, Radix Orthosiphonis Wulfenioidis, light dish, Storaxleaf artocarpus root and Herba Eriae Panneae.

In in described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Rhizoma Themedae villosae: [another name] villous themeda root, Radix seu herba Heteropogonis Contorti, soil muscle, locust grass roots.[source] medical material Ji Yuan: Rhizome for grass villous themeda.[nature and flavor] acrid in the mouth；Sweet；Warm in nature.[return through] lung；Liver；Kidney； Bladder warp.[function cures mainly] expelling wind and cold；Eliminating dampness and dredging channels；Inducing diuresis to remove edema.Main anemofrigid cold；Rheumatism Numb；Urine leaching pain；Edema；Fracture.[extracts] " China's book on Chinese herbal medicine "

Connect gas grass: [another name] calls leaf Herba Asari, Herba Asari, hair coal, Asarum caulescens Maxim., Herba Asari Maximi together.[come Source] medical material Ji Yuan: for the herb of aristolochiaceae plant short-tail Herba Asari.[nature and flavor] are pungent；Bitter；Temperature.[return Warp] lung；Stomach warp.[function cures mainly] expelling wind and cold；Warming the lung for resolving phlegm；Pain relieving.Main headche due to wind-cold；Expectorant Drink cough with asthma；Cold syndrome of the stomach pain；Stomachache；Toothache；Rheumatic arthralgia；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba rutae: [another name] Common Rue Herb, Common Rue Herb, Common Rue Herb, Rhizoma et radix valerianae, monkey grass.[source] medical material Ji Yuan: for the herb of rutaceae Folium Symplocoris Caudatae.[nature and flavor] acrid in the mouth；Micro-hardship；Cold in nature.[return through] lung； Kidney；Liver；Heart channel.[function cures mainly] expelling wind and clearing away heat；Promoting blood circulation to remove blood stasis；Subduing swelling and detoxicating.Main cold, fever； Infantile hyperpyrexia infantile convulsion；Dysmenorrhea；Amenorrhea；Traumatic injury；Pathopyretic ulcer；Infantile eczema；Snake bite and insect sting. [extracts] " China's book on Chinese herbal medicine "

Radix seu Caulis fici Martinii grass: [another name] Herba Clematidis Lasiandrae, Clematis kerriana Drumm. Et Craiab, Caulis Akebiae.[source] medical material Ji Yuan: for Herba Ranunculi Japonici The rattan of section plant blunt calyx Radix clematidis floridae and leaf.[nature and flavor] bitter in the mouth；Bitter；Cool in nature.[return through] lung, spleen Warp.[function cures mainly] expelling wind and clearing away heat；With network pain relieving.Main rheumatic arthritis；Rubella pruritus；Skin ulcer scabies； Toxic swelling；Acute catarrhal conjunctivitis pain；And dysuria [extracts] " China's book on Chinese herbal medicine "

Herba Lysimachiae Fortunei: [another name] Phymatopsis hastata (Thunb.) Kitag., duck foot grass, duck sole, duck foot perfume, Radix Parthenocissi Heterophyllae, chicken Foot fork, trident sword, Herba Lepisori Thunbergiani.The false close net Cyclosorus plant Herba Lysimachiae Fortunei of [source] Polypodiaceae, with herb It is used as medicine.Xia Qiu gathers, and cleans using fresh herb or dries.[nature and flavor] are bitter, micro-pungent, cool.[function cures mainly] Expelling wind and clearing away heat, eliminating damp, detoxifying.For infantile convulsion, cold cough, children's bronchopneumonia, swelling throat Bitterly, tonsillitis, heatstroke stomachache, dysentery, diarrhoea, urinary system infection, bones and muscles pain；Carbuncle is controlled in external Furuncle, furuncle, venom.[extracts] " whole nation Chinese herbal medicine compilation "

Radix Aerio Fici Microcarpae: hang [another name] half a day, banyan root hair, hang wind root, Ficus microcarpa Linn. f must, Ficus microcarpa Linn. f throw root, Ficus microcarpa Linn. f Hang palpus, Wu Song, Lao Gongxu, hang upside down Radix Pini massonianae root.[source] medical material Ji Yuan: for moraceae plants Ficus microcarpa Linn. f Aerial root.[nature and flavor] bitter in the mouth, property are flat.[return through] lung；Spleen；Kidney channel.[function cures mainly] dissipates wind Heat；Wind-damp dispelling；Promoting blood circulation and stopping pain.Main flow sense；Pertussis；Measles without adequate eruption；Tonsillitis；Conjunctivitis； Rheumatic ostalgia；Eruptive disease is suffered from abdominal pain；Chronic dysentery；Stomachache；Leucorrhea；Eczema；Pudendal pruritus；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Galium spurium L.: [another name] Herba Galii Teneri.[source] medical material Ji Yuan: for Maguireothamnus speciosus Galium spurium L. Herb.[nature and flavor] are sweet；Pungent；Micro-hardship；Flat.[function cures mainly] heat-clearing and toxic substances removing；Promoting blood circulation to remove obstruction in the collateral；Only Blood is treating stranguria.Main stranguria；Hematuria；Appendicitis；Paronychia；Traumatic injury；Bones and muscles pain.[extracts] " China's book on Chinese herbal medicine "

Chrysosplenium lanuginosum Hook. F. Et Thoms: [source] medical material Ji Yuan: for the herb of saxifragaceae plant Chrysosplenium lanuginosum Hook. F. Et Thoms.[property Taste] sweet；Cold.[return through] lung, stomach two warp.[function cures mainly] heat-clearing and toxic substances removing, promoting tissue regeneration by astringents, work Blood dredging collateral.It is mainly used to ecthyma, burn and scald, traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Rubi reflexi: [another name] seven refers to wind.[source] medical material Ji Yuan: for dicotyledon medicine Rosaceae The root of plant Radix Rubi reflexi.[nature and flavor] are bitter, puckery, acid, flat.[return through] lung, Liver Channel.[function master Control] expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Main anemofrigid-damp arthralgia, membra arthralgia, apoplectic hemiplegia, numb limbs and tense tendons, Moving obstacle.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Polypodiodis Nipponicae: [another name] Rhizoma Humatae Tyermanni (" detailed outline is picked up any lost article from the road "), Phryganeajaponica Ml., stable thick (" middle traditional Chinese medicines Plant will "), Herba Scindapsi Officinalis, rock chicken tail, human hair's (" Guizhou folk medicine "), Thalictrum omeiense W. T. Wang et S. H. Wang, pake purpke, Rhizoma Drynariae, stone Thalictrum omeiense W. T. Wang et S. H. Wang, blue or green Thalictrum omeiense W. T. Wang et S. H. Wang (" register planted by Guangxi medicine "), der Kapaun tail, Semen phaseoli radiati stalk is (" expensive State medical herbs "), Green Dragon bone, green foot are red (" Jiangxi medical herbs ") for bone, Semen Hoveniae (Fructus Hoveniae) Dendrobium nobile Lindl, SHILONG (" Shan Western Chinese herbal medicine "), cordierite silkworm (" Zhejiang traditional herbal medicine "), Radix Loxostigmatis griffithii, cordierite lotus (" sky, Zhejiang Mesh Rhizoma Dioscoreae plants will ").[source] is the rhizome of Plants of Polypodiaceae Rhizoma Polypodiodis Nipponicae.The whole year can adopt.Adopt Rear removing fibrous root and blade, cutting, dry.[nature and flavor] are bitter, cool.[function cures mainly] removing dampness, clearly Heat, dispels the wind, dredging collateral, controls that acute diseases such as cholera and sunstroke is dirty has loose bowels, dysentery, gonorrhea nebulousurine, migratory arthralgia, lumbago, acute catarrhal conjunctivitis, and skin ulcer swells. [extracts] " Chinese medicine voluminous dictionary "

Iron wire Radix Clematidis: [another name] iron wire root, iron Radix Clematidis, radix smilacis sieboldi.[source] medical material Ji Yuan: for liliaceous plant short stalk Rhizoma Smilacis Chinensis, East China Rhizoma Smilacis Chinensis, smilax nigrescens Wang et Tang and the root and rhizome of sheath handle Rhizoma Smilacis Chinensis. [nature and flavor] are pungent；Micro-hardship；Flat.[function cures mainly] expelling wind and removing dampness；Promoting blood circulation to remove obstruction in the collateral；Detoxicating and resolving stagnation of pathogens.Main Rheumatic arthralgia；Articular instability；Furuncle；Toxic swelling；Scrofula.[extracts] " China's book on Chinese herbal medicine "

Campanilla grass: [another name] Radix Aristolochiae grass.[source] medical material Ji Yuan: for acanthaceous plant campanilla grass Herb.[nature and flavor] bitter in the mouth；Micro-pungent；Cool in nature.[function cures mainly] clearing away heart-fire；Promoting blood circulation to remove obstruction in the collateral.Main Aphtha of the mouth and tongue；Rheumatic arthralgia；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix campsis: [another name] Radix Campsis.[source] medical material Ji Yuan: reach the clouds for Bignoniaceae plant or The root reached the clouds in America.[nature and flavor] sweet in the mouth；Pungent；Cold in nature.[return through] liver；Spleen；Kidney channel.[function Cure mainly] cooling blood, expelling wind；Promoting blood circulation to remove obstruction in the collateral.Main blood hot air wind producing；Itching over the body；Rubella；Waist foot is unsuccessful；Gout； Rheumatic arthralgia；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Tiliae: [another name] Helwingia himalaica root.[source] medical material Ji Yuan: blue or green for Cornaceae plant The root of pod leaf Himalaya Helaingia Helwingia chinensis.[nature and flavor] acrid in the mouth；Micro-sweet；Property flat.[function cures mainly] Relieving cough and asthma；Promoting blood circulation to remove obstruction in the collateral.Main chronic cough dyspnea due to deficiency；Impairment caused by overstrain lumbago；Rheumatic arthralgia；Treating swelling and pain by traumatic injury；Stomachache； Menoxenia；Puerperal abdonimal pain.[extracts] " China's book on Chinese herbal medicine "

Radix Gongronematis neplansis: [another name] thin Cornu Caprae seu Ovis, drowsily Taurus, Herba Christiae, Fici hispidae, big Radix Stephaniae Tetrandrae, people Pheretima, Lac caprae seu ovis rattan, thin Cornu Caprae seu Ovis.[source] medical material Ji Yuan: fine for dicotyledon Yao Luo section plant The Herb of hat rattan.[nature and flavor] sweet in the mouth；Micro-pungent；Slightly warm in nature.[return through] Liver Channel.[function cures mainly] Wind-damp dispelling；Promoting blood circulation to remove obstruction in the collateral；Lactogenesis.Main lumbar muscle strain；Arthralgia；Agalactia；Uterine prolapse. [extracts] " China's book on Chinese herbal medicine "

Radix Orthosiphonis Wulfenioidis: [another name] chervil, change long-pending medicine, calabash, soil is yellow, change worm disappears, Arisaema balansae Engl. grass. [source] medical material Ji Yuan: for the root of labiate Radix Orthosiphonis Wulfenioidis.[nature and flavor] acrid in the mouth；Sweet；Property flat. [function cures mainly] expelling wind and removing dampness；Promoting blood circulation to remove obstruction in the collateral；Killing insect and eliminating accumulation.Main air pain of dampness syndrome；Stranguria；Edema； Traumatic injury；Fracture；Dyspeptic abdominal distention；Abdominal pain due to worm stagnation.[extracts] " China's book on Chinese herbal medicine "

Light dish: [source] medical material Ji Yuan: for the herb of Balsaminaceae plant south of road Flos Impatientis.[merit Can cure mainly] promoting blood circulation to remove obstruction in the collateral；Removing toxic substances.Main traumatic injury；Venom.[extracts] " China's book on Chinese herbal medicine "

Storaxleaf artocarpus root: [source] medical material Ji Yuan: for the root of moraceae plants two color Fructus Artocarpi Heterophylli.[nature and flavor] are sweet； Warm in nature.[function cures mainly] dispels the wind removing dampness；Promoting blood circulation to remove obstruction in the collateral.Main air pain of dampness syndrome；Lumbago；Hemiplegia； Traumatic injury congestive edema.[extracts] " China's book on Chinese herbal medicine "

Herba Eriae Panneae: [another name] stone Herba Alii fistulosi, Herba pteridis vittatae (" choosing of Yunnan Chinese herbal medicine "), Herba Oberoniae Myosuri (" think by Yunnan Thatch Chinese herbal medicine selects ").[source] is the herb that orchid refers to leaf hair orchid.The whole year can adopt.Clean, Using fresh herb or dry levigation.[nature and flavor] 1. " choosing of Yunnan Chinese herbal medicine ": " bitter, cool ".2. " Simao, Yunnan Chinese herbal medicine selects ": " light, cool ".[function cures mainly] promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing.Control traumatic injury, Fracture, ulcerative carbuncle furuncle and phyma, scald." mountain of papers Chinese herbal medicine ": " removing toxic substances, spasmolytic ".[extracts] " Chinese medicine Voluminous dictionary "

Present invention also offers the preparation method of a kind of any one Chinese medicine preparation above-mentioned, wherein: when described When the dosage form of Chinese medicine preparation is granule, its preparation method comprises the following steps:

Invention further provides the preparation method of a kind of any one Chinese medicine preparation above-mentioned, wherein: when described The dosage form of Chinese medicine preparation is decoction, and its preparation method comprises the following steps:

Hereinafter use embodiment to describe embodiments of the present invention in detail, fully understand that the present invention is such as whereby What application technology means solves technical problem, and reaches technique effect and implement according to this.

Embodiment 1: granule

Take Rhizoma Themedae villosae 210g, connect gas grass 120g, Herba rutae 60g, Radix seu Caulis fici Martinii grass 140g, Herba Lysimachiae Fortunei 280g, Radix Aerio Fici Microcarpae 270g, Galium spurium L. 170g, Chrysosplenium lanuginosum Hook. F. Et Thoms 110g, Radix Rubi reflexi 170g, Rhizoma Polypodiodis Nipponicae 280g, iron wire Radix Clematidis 110g, Campanilla grass 230g, Radix campsis 290g, Radix Tiliae 120g, Radix Gongronematis neplansis 140g, Radix Orthosiphonis Wulfenioidis 130g, light Dish 80g, storaxleaf artocarpus root 160g and Herba Eriae Panneae 160g.

Its preparation method comprises the following steps:

Step one: mixed in described ratio by described raw medicinal material, adds the determining alcohol relative to 6 times of mixture It is the ethanol of 95%, is heated to boiling reflux 5 hours, filter, with backflow as solvent, be molten with filtering residue Matter, uses percolation with the speed slowly percolation of 1ml per minute, collects percolate, subsequently in vacuum Being evaporated to relative density when 60 DEG C under 0.09Mpa is the mastic of 1.04, is spray-dried, spray dryer Inlet temperature 175 DEG C, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder；

Step 2: add the cane sugar powder and 0.2 relative to dried cream powder quality 0.4 times in the dried cream powder obtained Dextrin again, makes granule, is dried in 50 DEG C, it is thus achieved that granule.

Embodiment 2: decoction

Take Rhizoma Themedae villosae 23g, connect gas grass 15g, Herba rutae 9g, Radix seu Caulis fici Martinii grass 12g, Herba Lysimachiae Fortunei 33g, Radix Aerio Fici Microcarpae 25g, Galium spurium L. 20g, Chrysosplenium lanuginosum Hook. F. Et Thoms 15g, Radix Rubi reflexi 15g, Rhizoma Polypodiodis Nipponicae 26g, iron wire Radix Clematidis 12g, campanilla grass 28g, Radix campsis 25g, Radix Tiliae 15g, Radix Gongronematis neplansis 17g, Radix Orthosiphonis Wulfenioidis 10g, light dish 10g, storaxleaf artocarpus root 18g With Herba Eriae Panneae 18g.

Its preparation method comprises the following steps:

Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to the dipped medicine of clear water Material upper surface 5cm, soaks 5 hours；

Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 40 minutes slowly to medicinal liquid Dosage be 200ml, filter, obtain filtrate a, standby；

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 3 Hour；

Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts 35 minutes slowly to medicinal liquid Dosage be 150ml, filter, obtain filtrate b, filtrate a and filtrate b mixed.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20-28g, carries out acute poison Property test.Mice is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours before experiment, incite somebody to action this The Chinese medicine granules of inventive embodiment 1 preparation is dissolved in water, (concentration is 7.28g crude drug/ml, High concentration) gavage, gavage volume is 5ml/kg (i.e. unit dosage form is 36.4 crude drugs/kg), right Give normal saline according to group, within one day, be administered 2 times, delivery time 6 hours, after administration continuously Observe 14 days, and record mice toxic reaction and death toll.Test result indicate that: with matched group ratio Relatively, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, Drinking-water, body weight increase the most normal.Granule LD50 > 36.4 crude drugs/the kg of the Mouse oral gavage present invention, Every day, maximum dosage-feeding was 72.8 crude drugs/kg/ day.The Chinese medicine preparation clinical application amount of the present invention is 2.4g Crude drug/day/people, adult's body weight is in terms of 60KG, and average dosage is 0.04g crude drug/kg/ day.Press body Restatement: the dosis tolerata of the Chinese medicine preparation of mice (average weight is counted with 24g) the oral administration gavage present invention is for facing 910 times of bed consumption.Therefore the Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: mice is pressed 12.18,21.32 and 38.26g crude drug by Chinese medicine preparation of the present invention After 15 weeks (1.0ml/100g body weight, every day 2 times) of/kg continuous use and drug withdrawal 4 weeks, result shows: Chinese medicine preparation of the present invention is to the hair of rat, behavior, defecation, body weight, organ weights, hemogram, liver The indexs such as renal function, blood glucose, blood fat all have no significant effect, and internal organs naked eyes do not find difference change and group Knitting and check that result shows, after medication 15 weeks and drug withdrawal 4 weeks, each internal organs of rat are all without obvious change.Say Bright Chinese medicine preparation of the present invention is little to toxicity after rat long-term prescription, does not also have difference reaction, application after drug withdrawal Safety.

Clinical data:

Case selection: whole 105 example patients are the patient that my institute is medical.Wherein, male 47 examples, female 58 examples, age 16-73 year；Peripheral 71 examples, central 34 example.All patients are randomly divided into two groups, Wherein, treatment group 55 example, male 25 examples, female 30 example, age 16-73 year；Peripheral 37 examples, in Pivot 18 example.Matched group 50 example, male 22 examples, female 28 example, age 16-71 year；Peripheral 34 Example, central 16 example.Two groups of physical data contrast no significant differences, have comparability.

Diagnostic criteria: " clinical disease diagnosis and the curative effect judging standard " write with reference to hospital associate of Hunan Province Prosopoplegic diagnostic criteria in (Wang Weiwen chief editor).

Therapeutic Method: matched group: take cefalexin 0.25g, prednisone 10mg, vitamin B₁20mg, Bendazol 10mg, 3 times/day, oral, within 2 weeks, it is 1 course for the treatment of.

Treatment group: take the granule of the embodiment of the present invention 1 on the basis of matched group, 2 bags/time are (every Bag 15g), 3 times/day, 2 weeks be 1 course for the treatment of.

Curative effect judging standard: use H-B grade scale.Recovery from illness: reach H-B I grade, bilateral volume stricture of vagina, nose Labial groove recovers symmetry, closes one's eyes normal, and during the drum cheek, bicker is air tight, show tooth without crooked, facial expression is normal； Effective: to reach H-B II grade, i.e. bilateral volume stricture of vagina and nasolabial fold almost symmetry, eye Guan Bi is owed real, is seen when showing tooth Bicker is the most asymmetric, and during the drum cheek, bicker is air tight；Take a turn for the better: be improved as after treatment by H-B IV～VI grade More than III grade；Invalid: to remain in H-B after treatment more than IV grade.

Therapeutic outcome: be shown in Table 1.

After 1 liang of table group treats two courses for the treatment of respectively, curative effect is as follows:

Group	Number of cases	Recovery from illness	Effective	Take a turn for the better	Invalid	Total effective rate
							Treatment group	55	48	4	3	0	55 (100%)
Matched group	50	30	7	5	8	42 (84%)

By table 1, treatment group curative effect is higher than matched group, Chinese Medicine and Clavicular doctor trained in Western medicine routine medicine the most of the present invention Thing can be effectively improved the therapeutic effect of Western medicine.

Concrete case: Zhang, women, 38 years old, because the symptoms such as distortion of commissure occurring to the court after blowing air-conditioning Seeing a doctor, left side face is stiff, left side masticatory atonia, food entrapment in oral cavity, left side, and have left side ear after Paroxysmal electric shock sample pain, the most acute, it is not radiated to other position.Without sialorrhea, without facial numbness pain, Facial rash without a head, without hemiplegia, aphasia, without dizzy, have a headache, twitch, gatism.It is diagnosed as Facial paralysis (peripheral).On the basis of the western medicine of matched group, take the embodiment of the present invention 1 simultaneously Granule, 2 bags/time (every bag of 15g), 3 times/day, after 2 weeks fully recover, follow up a case by regular visits to 3 months not recur.

The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention, Still fall within the protection domain of technical solution of the present invention.

Claims

1. one kind treat prosopoplegic Chinese medicine preparation, it is characterised in that described Chinese medicine preparation include with Lower raw medicinal material: Rhizoma Themedae villosae, connect gas grass, Herba rutae, Radix seu Caulis fici Martinii grass, Herba Lysimachiae Fortunei, Radix Aerio Fici Microcarpae, Galium spurium L., silk floss Hair gold waist, Radix Rubi reflexi, Rhizoma Polypodiodis Nipponicae, iron wire Radix Clematidis, campanilla grass, Radix campsis, Radix Tiliae, Radix Gongronematis neplansis, Radix Orthosiphonis Wulfenioidis, light dish, storaxleaf artocarpus root and Herba Eriae Panneae.

2. Chinese medicine preparation as claimed in claim 1, it is characterised in that each raw material in described Chinese medicine preparation The ratio of weight and number of medical material is as follows: Rhizoma Themedae villosae 15～25 parts, connect gas grass 10～20 parts, Herba rutae 6～15 parts, Radix seu Caulis fici Martinii grass 10～15 parts, Herba Lysimachiae Fortunei 25～40 parts, Radix Aerio Fici Microcarpae 20～35 parts, Galium spurium L. 15～25 parts, MIAOMAO Gold waist 10～25 parts, Radix Rubi reflexi 15～20 parts, Rhizoma Polypodiodis Nipponicae 25～35 parts, iron wire Radix Clematidis 10～15 parts, clock Flowers and plants 20～35 parts, Radix campsis 20～30 parts, Radix Tiliae 10～18 parts, Radix Gongronematis neplansis 12～26 parts, mountain Semen Arecae 8～15 parts, light dish 8～14 parts, storaxleaf artocarpus root 15～25 parts and Herba Eriae Panneae 15～20 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterised in that each former in described Chinese medicine preparation The ratio of weight and number of material medical material is as follows: Rhizoma Themedae villosae 20～25 parts, connect gas grass 10～15 parts, Herba rutae 6～10 Part, Radix seu Caulis fici Martinii grass 12～15 parts, Herba Lysimachiae Fortunei 25～35 parts, Radix Aerio Fici Microcarpae 25～30 parts, Galium spurium L. 15～20 parts, Chrysosplenium lanuginosum Hook. F. Et Thoms 10～15 parts, Radix Rubi reflexi 15～17 parts, Rhizoma Polypodiodis Nipponicae 25～30 parts, iron wire Radix Clematidis 10～12 parts, Campanilla grass 20～30 parts, Radix campsis 25～30 parts, Radix Tiliae 10～15 parts, Radix Gongronematis neplansis 12～18 parts, Radix Orthosiphonis Wulfenioidis 10～15 parts, light dish 8～10 parts, storaxleaf artocarpus root 15～20 parts and Herba Eriae Panneae 15～18 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterised in that each former in described Chinese medicine preparation Material medical material ratio of weight and number as follows: Rhizoma Themedae villosae 21 parts, connect gas grass 12 parts, Herba rutae 6 parts, Radix seu Caulis fici Martinii grass 14 Part, Herba Lysimachiae Fortunei 28 parts, Radix Aerio Fici Microcarpae 27 parts, Galium spurium L. 17 parts, Chrysosplenium lanuginosum Hook. F. Et Thoms 11 parts, Radix Rubi reflexi 17 parts, water Os Draconis 28 parts, iron wire Radix Clematidis 11 parts, campanilla grass 23 parts, Radix campsis 29 parts, Radix Tiliae 12 parts, fine hat 14 parts of rattan, Radix Orthosiphonis Wulfenioidis 13 parts, light dish 8 parts, storaxleaf artocarpus root 16 parts and Herba Eriae Panneae 16 parts.

5. Chinese medicine preparation as described in Claims 1-4, it is characterised in that each raw material in described Chinese medicine preparation The ratio of weight and number of medical material is as follows: Rhizoma Themedae villosae 23 parts, connect gas grass 15 parts, Herba rutae 9 parts, Radix seu Caulis fici Martinii grass 12 parts, Herba Lysimachiae Fortunei 33 parts, Radix Aerio Fici Microcarpae 25 parts, Galium spurium L. 20 parts, Chrysosplenium lanuginosum Hook. F. Et Thoms 15 parts, Radix Rubi reflexi 15 parts, Rhizoma Polypodiodis Nipponicae 26 parts, iron wire Radix Clematidis 12 parts, campanilla grass 28 parts, Radix campsis 25 parts, Radix Tiliae 15 parts, Radix Gongronematis neplansis 17 Part, Radix Orthosiphonis Wulfenioidis 10 parts, light dish 10 parts, storaxleaf artocarpus root 18 parts and Herba Eriae Panneae 18 parts.

6. a Chinese medicine preparation described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine preparation is Granule, its preparation method comprises the following steps:

7. Chinese medicine preparation as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine preparation is Decoction, its preparation method comprises the following steps:

8. the preparation method of Chinese medicine preparation described in a claim 1 to 5, it is characterised in that described Chinese medicine The dosage form of preparation is granule, and its preparation method comprises the following steps:

9. the preparation method of Chinese medicine preparation described in a claim 1 to 5, it is characterised in that described Chinese medicine The dosage form of preparation is decoction, and its preparation method comprises the following steps: